坂口光洋記念講座(オルガノイド医学)

研究成果 2000 2019

2019
1 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases
1 引用 (Scopus)

Cnnm4 deficiency suppresses Ca 2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5 16, : : Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article

Colon
Epithelium
Cell Proliferation
Capsaicin
Epidermal Growth Factor Receptor
1 引用 (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 1 1, : : Digestion.

研究成果: Article

Indigo Carmine
Suppositories
Ulcerative Colitis
Therapeutics
Rectum
1 引用 (Scopus)
Ulcerative Colitis
Recurrence
Colonoscopy
Therapeutics
Blood Vessels
17 引用 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. および2人, Sato, T. & Kanai, T., 2019 1 1, (Accepted/In press) : : Nature Microbiology.

研究成果: Article

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
1 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Steroids
Placebos
Leukocyte L1 Antigen Complex
1 引用 (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 7 1, : : Cancer science. 110, 7, p. 2156-2165 10 p.

研究成果: Article

公開
Interleukin-13
Carcinogenesis
Obesity
Colorectal Neoplasms
Cytokines
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma
2 引用 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. および5人, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 1 1, : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Review article

Inflammatory Bowel Diseases
Erythrocyte Indices
Leukopenia
Leukocyte Count
Genotype
8 引用 (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 2 1, : : Gastroenterology. 156, 3, p. 562-576 15 p.

研究成果: Review article

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Technology
Digestive System Diseases
Stem Cell Niche
2018
24 引用 (Scopus)

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018 1 1, : : CMGH. 5, 1, p. 51-60 10 p.

研究成果: Review article

Organoids
Regenerative Medicine
Technology
Intestines
Tissue Scaffolds
18 引用 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2 1, : : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Peyer's Patches
Cell Differentiation
Epithelium
Organoids
25 引用 (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. および3人, Koo, B. K., Kanai, T. & Sato, T., 2018 8 9, : : Cell. 174, 4, p. 856-869.e17

研究成果: Article

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
26 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Randomized Controlled Trials
Placebos
Pulmonary Hypertension
Organoids
Genetic engineering
Genetic Engineering
Electroporation
Plasmids
19 引用 (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 3 13, : : Stem Cell Reports. 10, 3, p. 1088-1101 14 p.

研究成果: Article

Organoids
Stem Cells
Tissue
Medical problems
Insulin
1 引用 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10 1, : : PLoS One. 13, 10, e0204632.

研究成果: Article

Crohn disease
Crohn Disease
tumor necrosis factors
therapeutics
Tumor Necrosis Factor-alpha
1 引用 (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 1 1, : : Intestinal Research. 16, 1, p. 142-146 5 p.

研究成果: Article

Clostridium Infections
Clostridium difficile
Ulcerative Colitis
Dysbiosis
Recurrence
5 引用 (Scopus)

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models

Kawasaki, K., Fujii, M. & Sato, T., 2018 2 26, : : Disease models & mechanisms. 11, 2

研究成果: Review article

Gene therapy
Neoplasm Genes
Genetic Therapy
Neoplasms
Organoids
11 引用 (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 12 6, : : Cell Stem Cell. 23, 6, p. 787-793.e6

研究成果: Article

Organoids
Small Cytoplasmic RNA
Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Sequence Analysis
67 引用 (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 1 1, (Accepted/In press) : : Cell Stem Cell.

研究成果: Article

Organoids
Stem Cell Niche
Stem Cell Factor
Disease Progression
Adenocarcinoma
9 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific Reports. 8, 1, 2821.

研究成果: Article

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
3 引用 (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 1 1, : : Glycobiology. 28, 1, p. 21-31 11 p.

研究成果: Article

Colorectal Neoplasms
Cell growth
Binding Sites
Cells
Carbohydrates
24 引用 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2 1, : : Cell Stem Cell. 22, 2, p. 171-176.e5

研究成果: Article

Colon
Epithelium
Organoids
Stem Cells
Heterografts
2017
35 引用 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. および19人, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5 1, : : Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article

Epithelial Cells
Filamins
Mitochondrial Membrane Potential
Intestinal Mucosa
Lactic Acid
2 引用 (Scopus)
Colorectal Neoplasms
Stem Cells
Research
Organoids
Intestinal Mucosa
11 引用 (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 3 13, (Accepted/In press) : : Endoscopy.

研究成果: Article

Ulcerative Colitis
Rectum
Biopsy
Light
12 引用 (Scopus)
Mucous Membrane
Sigmoid Colon
Colonoscopy
Ulcerative Colitis
Rectum
6 引用 (Scopus)

Establishment of 3D intestinal organoid cultures from intestinal stem cells

Sugimoto, S. & Sato, T., 2017, Methods in Molecular Biology. Humana Press Inc., 巻 1612. p. 97-105 9 p. (Methods in Molecular Biology; 巻数 1612).

研究成果: Chapter

Organoids
Intestinal Mucosa
Stem Cells
Genetic Models
Mammals
21 引用 (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 6 1, : : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

研究成果: Article

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
13 引用 (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 8 15, : : Cell Reports. 20, 7, p. 1513-1524 12 p.

研究成果: Article

Dysbiosis
Alopecia
Lactobacillus
Biotin
Physiology
2 引用 (Scopus)

Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids

Sasaki, N., Sato, T. & Clevers, H., 2017 4 14, Biology and Engineering of Stem Cell Niches. Elsevier Inc., p. 111-125 15 p.

研究成果: Chapter

Organoids
Stem Cell Niche
Stem cells
Stem Cells
Precision Medicine
13 引用 (Scopus)

Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno, S., Nanki, K., Matsuoka, K., Saigusa, K., Ono, K., Arai, M., Sugimoto, S., Kiyohara, H., Nakashima, M., Takeshita, K., Naganuma, M., Suda, W., Hattori, M. & Kanai, T., 2017, : : Intestinal Research. 15, 1, p. 68-74 7 p.

研究成果: Article

Ulcerative Colitis
Information Services
Tissue Donors
Dysbiosis
Clinical Trials
6 引用 (Scopus)
Mesalamine
colitis
relapse
remission
Ulcerative Colitis
151 引用 (Scopus)

Visualization and targeting of LGR5 + human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 5 11, : : Nature. 545, 7653, p. 187-192 6 p.

研究成果: Article

Neoplastic Stem Cells
Colonic Neoplasms
Neoplasms
Colorectal Neoplasms
Organoids
2016
152 引用 (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 6 2, : : Cell Stem Cell. 18, 6, p. 827-838 12 p.

研究成果: Article

Organoids
Colorectal Neoplasms
Carcinogenesis
Transcriptome
Heterografts
46 引用 (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 2 23, : : eLife. 5, FEBRUARY2016, e11621.

研究成果: Article

Wnt Proteins
Colony-Forming Units Assay
Detergents
Albumins
Assays
32 引用 (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 3 10, (Accepted/In press) : : Digestion. p. 193-201 9 p.

研究成果: Article

Ulcerative Colitis
Prospective Studies
Safety
Indigo Carmine
Occult Blood
19 引用 (Scopus)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 9 21, : : Nature Communications. 7, 12887.

研究成果: Article

Hedgehogs
notches
Tyrosine
tyrosine
Phosphorylation
Immersion
Colonoscopy
Pain
Water
13 引用 (Scopus)

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, : : Journal of Cell Biology. 212, 3, p. 297-306 10 p.

研究成果: Article

Carrier Proteins
Epithelial Cells
Small Intestine
Dynamins
Lysosomes
1 引用 (Scopus)

Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission

Naganuma, M., Hisamatsu, T., Matsuoka, K., Kiyohara, H., Arai, M., Sugimoto, S., Mori, K., Nanki, K., Ohno, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Inoue, N., Iwao, Y., Ogata, H. & Kanai, T., 2016 1 1, : : Digestion. 93, 1, p. 66-71 6 p.

研究成果: Article

Crohn Disease
Recurrence
Colonoscopy
C-Reactive Protein
Cohort Studies
45 引用 (Scopus)
Ulcerative Colitis
Indigo Carmine
Tryptophan
Aryl Hydrocarbon Receptors
indole
15 引用 (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 5 4, : : Scientific Reports. 6, 25311.

研究成果: Article

Organoids
DNA Methylation
Neoplasms
DNA
Interferons
9 引用 (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. および5人, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 8 4, : : Cell Stem Cell. 19, 2, p. 205-216 12 p.

研究成果: Article

Stem Cell Niche
Wnt Signaling Pathway
Equidae
Colorectal Neoplasms
Stem Cells
15 引用 (Scopus)
Ulcerative Colitis
Mesalamine
Therapeutics
Tumor Necrosis Factor-alpha
Adrenal Cortex Hormones
35 引用 (Scopus)

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 4 4, : : Developmental Cell. 37, 1, p. 47-57 11 p.

研究成果: Article

Catenins
Regeneration
Carcinogenesis
Methylation
Proteins
25 引用 (Scopus)
Ulcerative Colitis
Colonoscopy
Recurrence
Hemorrhage
C-Reactive Protein
11 引用 (Scopus)

Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

Saigusa, K., Matsuoka, K., Sugimoto, S., Arai, M., Kiyohara, H., Takeshita, K., Mizuno, S., Mori, K., Nanki, K., Takeshita, T., Nakazato, Y., Yajima, T., Naganuma, M., Hisamatsu, T., Ogata, H., Iwao, Y. & Kanai, T., 2016 9 1, : : Digestive Endoscopy. 28, 6, p. 665-670 6 p.

研究成果: Article

Ulcerative Colitis
Therapeutics
Observer Variation
Infliximab
Colonoscopy