• 5669 引用
  • 35 h指数
19992020

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

2020

Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas

Tian, Y., Arai, E., Makiuchi, S., Tsuda, N., Kuramoto, J., Ohara, K., Takahashi, Y., Ito, N., Ojima, H., Hiraoka, N., Gotoh, M., Yoshida, T. & Kanai, Y., 2020, (Accepted/In press) : : Journal of Cancer Research and Clinical Oncology. 146, 10, p. 2461-2477 17 p.

研究成果: Article

公開
1 引用 (Scopus)

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 2020 2 6, : : Nature. 578, 7793, p. 82-93 12 p.

研究成果: Article

公開
109 引用 (Scopus)
3 引用 (Scopus)
1 引用 (Scopus)
2019
7 引用 (Scopus)

Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma

Kawai-Kitahata, F., Asahina, Y., Kaneko, S., Tsuchiya, J., Sato, A., Miyoshi, M., Tsunoda, T., Inoue-Shinomiya, E., Murakawa, M., Nitta, S., Itsui, Y., Nakagawa, M., Azuma, S., Kakinuma, S., Tanabe, M., Sugawara, E., Takemoto, A., Ojima, H., Sakamoto, M., Muraoka, M. および4人, Takano, S., Maekawa, S., Enomoto, N. & Watanabe, M., 2019 12 1, : : Hepatology Research. 49, 12, p. 1466-1474 9 p.

研究成果: Article

1 引用 (Scopus)

Deregulation of the histone lysine-specific demethylase 1 is involved in human hepatocellular carcinoma

Kim, S., Bolatkan, A., Kaneko, S., Ikawa, N., Asada, K., Komatsu, M., Hayami, S., Ojima, H., Abe, N., Yamaue, H. & Hamamoto, R., 2019 12, : : Biomolecules. 9, 12, 810.

研究成果: Article

公開
2 引用 (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 4 23, : : Cell Reports. 27, 4, p. 1265-1276.e4

研究成果: Article

公開
19 引用 (Scopus)

Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features

Hatano, M., Ojima, H., Masugi, Y., Tsujikawa, H., Hiraoka, N., Kanai, Y., Shimada, K., Shinoda, M. & Sakamoto, M., 2019 4 1, : : Human Pathology. 86, p. 222-232 11 p.

研究成果: Article

4 引用 (Scopus)
公開
2018

Epigenome mapping of human normal purified hepatocytes: Personal epigenome variation and genome-epigenome correlation

Arai, E., Miura, F., Totoki, Y., Yamashita, S., Tian, Y., Gotoh, M., Ojima, H., Nakagawa, H., Takahashi, Y., Nakamura, H., Hama, N., Kato, M., Kimura, H., Suzuki, Y., Ito, T., Shibata, T. & Kanai, Y., 2018 7, : : Epigenomics. 10, 7, p. 955-979 25 p.

研究成果: Article

1 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific reports. 8, 1, 2821.

研究成果: Article

13 引用 (Scopus)
48 引用 (Scopus)

Mesenchymal–epithelial transition of pancreatic cancer cells at perineural invasion sites is induced by Schwann cells

Nishimura, Y., Yamazaki, K., Masugi, Y., Douguchi, J., Kurebayashi, Y., Kubota, N., Ojima, H., Kitago, M., Shinoda, M., Hashiguchi, A. & Sakamoto, M., 2018 4 1, : : Pathology International. 68, 4, p. 214-223 10 p.

研究成果: Article

7 引用 (Scopus)

PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay

Sakamoto, Y., Yamagishi, S., Tanizawa, Y., Tajimi, M., Okusaka, T. & Ojima, H., 2018 4 1, : : Japanese Journal of Clinical Oncology. 48, 4, p. 396-399 4 p.

研究成果: Article

5 引用 (Scopus)

The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses

Kanai, Y., Nishihara, H., Miyagi, Y., Tsuruyama, T., Taguchi, K., Katoh, H., Takeuchi, T., Gotoh, M., Kuramoto, J., Arai, E., Ojima, H., Shibuya, A., Yoshida, T., Akahane, T., Kasajima, R., Morita, K. I., Inazawa, J., Sasaki, T., Fukayama, M. & Oda, Y., 2018 2 1, : : Pathology international. 68, 2, p. 63-90 28 p.

研究成果: Article

13 引用 (Scopus)
2017

Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: A single-institutional methylome analysis using 1007 tissue specimens

Ohara, K., Arai, E., Takahashi, Y., Ito, N., Shibuya, A., Tsuta, K., Kushima, R., Tsuda, H., Ojima, H., Fujimoto, H., Watanabe, S. I., Katai, H., Kinoshita, T., Shibata, T., Kohno, T. & Kanai, Y., 2017 3 1, : : Carcinogenesis. 38, 3, p. 241-251 11 p.

研究成果: Article

4 引用 (Scopus)

Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: Comparison with hepatitis virus-related carcinogenesis

Kuramoto, J., Arai, E., Tian, Y., Funahashi, N., Hiramoto, M., Nammo, T., Nozaki, Y., Takahashi, Y., Ito, N., Shibuya, A., Ojima, H., Sukeda, A., Seki, Y., Kasama, K., Yasuda, K. & Kanai, Y., 2017 3 1, : : Carcinogenesis. 38, 3, p. 261-270 10 p.

研究成果: Article

13 引用 (Scopus)

Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

Iwao, Y., Ojima, H., Kobayashi, T., Kishi, Y., Nara, S., Esaki, M., Shimada, K., Hiraoka, N., Tanabe, M. & Kanai, Y., 2017 11 18, : : World Journal of Hepatology. 9, 32, p. 1227-1238 12 p.

研究成果: Article

1 引用 (Scopus)

Pathological Findings of NASH and NAFLD: for Guidebook of NASH and NAFLD, 2015: The Japan Society of Hepatology

Working Group & Association of Pathologists** for Guidebook of NASH and NAFLD, 2015: The Japan Society of Hepatology, 2017 1 1, : : Hepatology Research. 47, 1, p. 3-10 8 p.

研究成果: Article

4 引用 (Scopus)

Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease

Sakamoto, M., Tsujikawa, H., Effendi, K., Ojima, H., Harada, K., Zen, Y., Kondo, F., Nakano, M., Kage, M., Sumida, Y., Hashimoto, E., Yamada, G., Okanoue, T. & Koike, K., 2017 1 1, : : Pathology international. 67, 1, p. 1-7 7 p.

研究成果: Editorial

10 引用 (Scopus)
10 引用 (Scopus)
2016

Antibody-based proteomics to identify an apoptosis signature for early recurrence of hepatocellular carcinoma

Morofuji, N., Ojima, H., Hiraoka, N., Okusaka, T., Esaki, M., Nara, S., Shimada, K., Kishi, Y. & Kondo, T., 2016 10 24, : : Clinical Proteomics. 13, 1, p. 1-12 12 p.

研究成果: Article

2 引用 (Scopus)

Early hepatocellular carcinoma with high-grade atypia in small vaguely nodular lesions

Ojima, H., Masugi, Y., Tsujikawa, H., Emoto, K., Fujii-Nishimura, Y., Hatano, M., Kawaida, M., Itano, O., Kitagawa, Y. & Sakamoto, M., 2016 4 1, : : Cancer science. 107, 4, p. 543-550 8 p.

研究成果: Article

4 引用 (Scopus)

Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer (Nature Genetics (2016) DOI: 10.1038/ng.3547)

Fujimoto, A., Furuta, M., Totoki, Y., Tsunoda, T., Kato, M., Shiraishi, Y., Tanaka, H., Taniguchi, H., Kawakami, Y., Ueno, M., Gotoh, K., Ariizumi, S. I., Wardell, C. P., Hayami, S., Nakamura, T., Aikata, H., Arihiro, K., Boroevich, K. A., Abe, T., Nakano, K. および31人, Maejima, K., Sasaki-Oku, A., Ohsawa, A., Shibuya, T., Nakamura, H., Hama, N., Hosoda, F., Arai, Y., Ohashi, S., Urushidate, T., Nagae, G., Yamamoto, S., Ueda, H., Tatsuno, K., Ojima, H., Hiraoka, N., Okusaka, T., Kubo, M., Marubashi, S., Yamada, T., Hirano, S., Yamamoto, M., Ohdan, H., Shimada, K., Ishikawa, O., Yamaue, H., Chayama, K., Miyano, S., Aburatani, H., Shibata, T. & Nakagawa, H., 2016 6 1, : : Nature genetics. 48, 6, 1 p.

研究成果: Comment/debate

Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies

Ojima, H., Yamagishi, S., Shimada, K. & Shibata, T., 2016 10 28, : : World Journal of Gastroenterology. 22, 40, p. 9035-9038 4 p.

研究成果: Article

2 引用 (Scopus)

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Fujimoto, A., Furuta, M., Totoki, Y., Tsunoda, T., Kato, M., Shiraishi, Y., Tanaka, H., Taniguchi, H., Kawakami, Y., Ueno, M., Gotoh, K., Ariizumi, S. I., Wardell, C. P., Hayami, S., Nakamura, T., Aikata, H., Arihiro, K., Boroevich, K. A., Abe, T., Nakano, K. および31人, Maejima, K., Sasaki-Oku, A., Ohsawa, A., Shibuya, T., Nakamura, H., Hama, N., Hosoda, F., Arai, Y., Ohashi, S., Urushidate, T., Nagae, G., Yamamoto, S., Ueda, H., Tatsuno, K., Ojima, H., Hiraoka, N., Okusaka, T., Kubo, M., Marubashi, S., Yamada, T., Hirano, S., Yamamoto, M., Ohdan, H., Shimada, K., Ishikawa, O., Yamaue, H., Chayama, K., Miyano, S., Aburatani, H., Shibata, T. & Nakagawa, H., 2016 5 1, : : Nature genetics. 48, 5, p. 500-509 10 p.

研究成果: Article

268 引用 (Scopus)
2015

Genomic spectra of biliary tract cancer

Nakamura, H., Arai, Y., Totoki, Y., Shirota, T., Elzawahry, A., Kato, M., Hama, N., Hosoda, F., Urushidate, T., Ohashi, S., Hiraoka, N., Ojima, H., Shimada, K., Okusaka, T., Kosuge, T., Miyagawa, S. & Shibata, T., 2015 8 27, : : Nature Genetics. 47, 9, p. 1003-1010 8 p.

研究成果: Article

337 引用 (Scopus)

Heat shock protein 90 is a potential therapeutic target in cholangiocarcinoma

Shirota, T., Ojima, H., Hiraoka, N., Shimada, K., Rokutan, H., Arai, Y., Kanai, Y., Miyagawa, S. & Shibata, T., 2015 9 1, : : Molecular cancer therapeutics. 14, 9, p. 1985-1993 9 p.

研究成果: Article

13 引用 (Scopus)

Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells

Sakamoto, A., Hino, S., Nagaoka, K., Anan, K., Takase, R., Matsumori, H., Ojima, H., Kanai, Y., Arita, K. & Nakao, M., 2015 4 1, : : Cancer Research. 75, 7, p. 1445-1456 12 p.

研究成果: Article

39 引用 (Scopus)

Optimal Indications for Additional Resection of the Invasive Cancer-Positive Proximal Bile Duct Margin in Cases of Advanced Perihilar Cholangiocarcinoma

Oguro, S., Esaki, M., Kishi, Y., Nara, S., Shimada, K., Ojima, H. & Kosuge, T., 2015 6 1, : : Annals of Surgical Oncology. 22, 6, p. 1915-1924 10 p.

研究成果: Article

15 引用 (Scopus)

The excision repair cross-complementation group 1

Sakamoto, Y., Ojima, H., Morizane, C., Kanai, Y. & Okusaka, T., 2015 3 1, : : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 485-490 6 p.

研究成果: Article

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

Fujimoto, A., Furuta, M., Shiraishi, Y., Gotoh, K., Kawakami, Y., Arihiro, K., Nakamura, T., Ueno, M., Ariizumi, S. I., Nguyen, H. H., Shigemizu, D., Abe, T., Boroevich, K. A., Nakano, K., Sasaki, A., Kitada, R., Maejima, K., Yamamoto, Y., Tanaka, H., Shibuya, T. および18人, Shibata, T., Ojima, H., Shimada, K., Hayami, S., Shigekawa, Y., Aikata, H., Ohdan, H., Marubashi, S., Yamada, T., Kubo, M., Hirano, S., Ishikawa, O., Yamamoto, M., Yamaue, H., Chayama, K., Miyano, S., Tsunoda, T. & Nakagawa, H., 2015, : : Nature communications. 6, 6120.

研究成果: Article

100 引用 (Scopus)
2014

Axitinib (AG-013736), an oral specific VEGFR TKI, shows potential therapeutic utility against cholangiocarcinoma

Takahashi, H., Ojima, H., Shimizu, H., Furuse, J., Furukawa, H. & Shibata, T., 2014 6, : : Japanese journal of clinical oncology. 44, 6, p. 570-578 9 p., hyu045.

研究成果: Article

18 引用 (Scopus)

Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)"

Nakanuma, Y., Sato, Y., Ojima, H., Kanai, Y., Aishima, S., Yamamoto, M., Ariizumi, S. I., Furukawa, T., Hayashi, H., Unno, M., Ohta, T. & Tsubouchi, H., 2014, : : International Journal of Clinical and Experimental Pathology. 7, 6, p. 3112-3122 11 p.

研究成果: Article

34 引用 (Scopus)
4 引用 (Scopus)

Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula

Iwao, Y., Ojima, H., Onaya, H., Sakamoto, Y., Kishi, Y., Nara, S., Esaki, M., Mizuguchi, Y., Ushigome, M., Asahina, D., Hiraoka, N., Shimada, K., Kosuge, T. & Kanai, Y., 2014 6, : : Hepatology Research. 44, 6, p. 700-706 7 p.

研究成果: Article

4 引用 (Scopus)

Emerging drugs for biliary cancer

Okusaka, T., Ojima, H., Morizane, C., Ikeda, M. & Shibata, T., 2014 3, : : Expert Opinion on Emerging Drugs. 19, 1, p. 11-24 14 p.

研究成果: Review article

4 引用 (Scopus)

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Arai, Y., Totoki, Y., Hosoda, F., Shirota, T., Hama, N., Nakamura, H., Ojima, H., Furuta, K., Shimada, K., Okusaka, T., Kosuge, T. & Shibata, T., 2014 4, : : Hepatology. 59, 4, p. 1427-1434 8 p.

研究成果: Article

189 引用 (Scopus)

Global PROTOMAP profiling to search for biomarkers of early-recurrent hepatocellular carcinoma

Taoka, M., Morofuji, N., Yamauchi, Y., Ojima, H., Kubota, D., Terukina, G., Nobe, Y., Nakayama, H., Takahashi, N., Kosuge, T., Isobe, T. & Kondo, T., 2014 11 7, : : Journal of Proteome Research. 13, 11, p. 4847-4858 12 p.

研究成果: Article

8 引用 (Scopus)

Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma

Sato, Y., Ojima, H., Onaya, H., Mori, T., Hiraoka, N., Kishi, Y., Nara, S., Esaki, M., Shimada, K., Kosuge, T., Sugihara, K. & Kanai, Y., 2014 10 1, : : Hepatology Research. 44, 11, p. 1119-1129 11 p.

研究成果: Article

1 引用 (Scopus)

Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct

Matsubara, A., Nara, S., Sekine, S., Ojima, H., Kosuge, T., Shimada, K., Kushima, R., Kanai, Y. & Hiraoka, N., 2014 1, : : Pathology international. 64, 1, p. 39-44 6 p.

研究成果: Article

4 引用 (Scopus)

Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia

Sato, Y., Sasaki, M., Harada, K., Aishima, S., Fukusato, T., Ojima, H., Kanai, Y., Kage, M., Nakanuma, Y. & Tsubouchi, H., 2014 1, : : Journal of gastroenterology. 49, 1, p. 64-72 9 p.

研究成果: Review article

33 引用 (Scopus)

Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis

Takaki, Y., Saito, Y., Takasugi, A., Toshimitsu, K., Yamada, S., Muramatsu, T., Kimura, M., Sugiyama, K., Suzuki, H., Arai, E., Ojima, H., Kanai, Y. & Saito, H., 2014 10 1, : : Cancer science. 105, 10, p. 1254-1260 7 p.

研究成果: Article

44 引用 (Scopus)

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Totoki, Y., Tatsuno, K., Covington, K. R., Ueda, H., Creighton, C. J., Kato, M., Tsuji, S., Donehower, L. A., Slagle, B. L., Nakamura, H., Yamamoto, S., Shinbrot, E., Hama, N., Lehmkuhl, M., Hosoda, F., Arai, Y., Walker, K., Dahdouli, M., Gotoh, K., Nagae, G. および28人, Gingras, M. C., Muzny, D. M., Ojima, H., Shimada, K., Midorikawa, Y., Goss, J. A., Cotton, R., Hayashi, A., Shibahara, J., Ishikawa, S., Guiteau, J., Tanaka, M., Urushidate, T., Ohashi, S., Okada, N., Doddapaneni, H., Wang, M., Zhu, Y., Dinh, H., Okusaka, T., Kokudo, N., Kosuge, T., Takayama, T., Fukayama, M., Gibbs, R. A., Wheeler, D. A., Aburatani, H. & Shibata, T., 2014 12 11, : : Nature genetics. 46, 12, p. 1267-1273 7 p.

研究成果: Article

333 引用 (Scopus)
2013

A case of pathological complete response after combination chemotherapy by sorafenib and cisplatin hepatic arterial infusion for an advanced hepatocellular carcinoma

Oguro, S., Nara, S., Kondo, S., Hori, S., Kishi, Y., Esaki, M., Shimada, K., Kosuge, T., Okusaka, T. & Ojima, H., 2013 12 20, : : Japanese Journal of Gastroenterological Surgery. 46, 12, p. 915-923 9 p.

研究成果: Article