• 46358 引用
  • 109 h指数
1984 …2020
Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1984 2020

2020
1 引用 (Scopus)

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

Grandjean, J., Canella, C., Anckaerts, C., Ayrancı, G., Bougacha, S., Bienert, T., Buehlmann, D., Coletta, L., Gallino, D., Gass, N., Garin, C. M., Nadkarni, N. A., Hübner, N. S., Karatas, M., Komaki, Y., Kreitz, S., Mandino, F., Mechling, A. E., Sato, C., Sauer, K. および28人, Shah, D., Strobelt, S., Takata, N., Wank, I., Wu, T., Yahata, N., Yeow, L. Y., Yee, Y., Aoki, I., Chakravarty, M. M., Chang, W. T., Dhenain, M., von Elverfeldt, D., Harsan, L. A., Hess, A., Jiang, T., Keliris, G. A., Lerch, J. P., Meyer-Lindenberg, A., Okano, H., Rudin, M., Sartorius, A., Van der Linden, A., Verhoye, M., Weber-Fahr, W., Wenderoth, N., Zerbi, V. & Gozzi, A., 2020 1 15, : : NeuroImage. 205, 116278.

研究成果: Article

公開
Magnetic Resonance Imaging
Brain
Medetomidine
Equipment and Supplies
Isoflurane
Tight Junctions
Cochlea
Inner Ear
Primates
Endolymph

Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

Okano, H., Yasuda, D., Fujimori, K., Morimoto, S. & Takahashi, S., 2020 1 1, (Accepted/In press) : : Trends in Pharmacological Sciences.

研究成果: Review article

公開
Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Stem cells
Neurodegenerative diseases
Pharmaceutical Preparations
2019

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Akiyama, T., Suzuki, N., Ishikawa, M., Fujimori, K., Sone, T., Kawada, J., Funayama, R., Fujishima, F., Mitsuzawa, S., Ikeda, K., Ono, H., Shijo, T., Osana, S., Shirota, M., Nakagawa, T., Kitajima, Y., Nishiyama, A., Izumi, R., Morimoto, S., Okada, Y. および11人, Kamei, T., Nishida, M., Nogami, M., Kaneda, S., Ikeuchi, Y., Mitsuhashi, H., Nakayama, K., Fujii, T., Warita, H., Okano, H. & Aoki, M., 2019 7 1, : : EBioMedicine. 45, p. 362-378 17 p.

研究成果: Article

公開
Amyotrophic Lateral Sclerosis
Motor Neurons
Sarcoma
Neurons
Axons

A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition

Sho, M., Ichiyanagi, N., Imaizumi, K., Ishikawa, M., Morimoto, S., Watanabe, H. & Okano, H., 2019 1 1, (Accepted/In press) : : Neuroscience Research.

研究成果: Article

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Carotenoids
Amyloid
Induced Pluripotent Stem Cells
6 引用 (Scopus)

A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

Lin, M. K., Takahashi, Y. S., Huo, B. X., Hanada, M., Nagashima, J., Hata, J., Tolpygo, A. S., Ram, K., Lee, B. C., Miller, M. I., Rosa, M. G., Sasaki, E., Iriki, A., Okano, H. & Mitra, P., 2019 2 5, : : eLife. 8

研究成果: Article

公開
Callithrix
Brain
Pipelines
Throughput
Atlases

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

Kinoshita, M., Fujimoto, C., Iwasaki, S., Kashio, A., Kikkawa, Y. S., Kondo, K., Okano, H. & Yamasoba, T., 2019 10 25, : : Frontiers in Cellular Neuroscience. 13, 481.

研究成果: Article

公開
Semicircular Ducts
Alopecia
Gentamicins
Regeneration
Guinea Pigs

Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging

Hata, J., Endo, K., Tsuji, O., Arakawa, S., Sato, M., Yagi, K., Fujiyoshi, K., Okano, H. & Nakamura, M., 2019 1 1, : : Journal of Orthopaedic Science.

研究成果: Article

Leg
Skeletal Muscle
Magnetic Resonance Imaging
Exercise
Anisotropy
7 引用 (Scopus)
公開
spinal cord injuries
Hepatocyte Growth Factor
Spinal Cord Injuries
roads
Rats
3 引用 (Scopus)

Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health

O'Day, E., Hosta-Rigau, L., Oyarzún, D. A., Okano, H., de Lorenzo, V., von Kameke, C., Alsafar, H., Cao, C., Chen, G. Q., Ji, W., Roberts, R. J., Ronaghi, M., Yeung, K., Zhang, F. & Lee, S. Y., 2019 1 1, : : Biotechnology Journal. 14, 1, 1800195.

研究成果: Review article

公開
glimepiride
Biotechnology
Hip
Hip Replacement Arthroplasties
Metformin

atlasBREX: Automated template-derived brain extraction in animal MRI

Lohmeier, J., Kaneko, T., Hamm, B., Makowski, M. R. & Okano, H., 2019 12 1, : : Scientific reports. 9, 1, 12219.

研究成果: Article

公開
Brain
Rodentia
Callithrix
Atlases
Macaca

A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology

Yoshimatsu, S., Sone, T., Nakajima, M., Sato, T., Okochi, R., Ishikawa, M., Nakamura, M., Sasaki, E., Shiozawa, S. & Okano, H., 2019 1 1, : : PloS one. 14, 8, e0221164.

研究成果: Article

公開
Gene Targeting
gene targeting
Callithrix
Genes
Stem cells
1 引用 (Scopus)

Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease

Kuzumaki, N., Suda, Y., Iwasawa, C., Narita, M., Sone, T., Watanabe, M., Maekawa, A., Matsumoto, T., Akamatsu, W., Igarashi, K., Tamura, H., Takeshima, H., Tawfik, V. L., Ushijima, T., Hattori, N., Okano, H. & Narita, M., 2019 6 1, : : Brain : a journal of neurology. 142, 6, p. 1675-1689 15 p.

研究成果: Article

Catechol O-Methyltransferase
Dopaminergic Neurons
Parkinson Disease
Induced Pluripotent Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
公開
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Stem cells
Spinal Cord Injuries
Cytology
Callithrix
Brain
Macaca
Poles
Epidural Space
2 引用 (Scopus)

Comparative principles for next-generation neuroscience

Miller, C. T., Hale, M. E., Okano, H., Okabe, S. & Mitra, P., 2019 1 30, : : Frontiers in Behavioral Neuroscience. 13, 12.

研究成果: Article

公開
Neurosciences
Nervous System
Technology
Molecular Biology
History
Inner Ear
Ear
Injections
Photons
Pharmaceutical Preparations
Optogenetics
Corpus Striatum
Microscopy
Neurons
Diffusion Tensor Imaging

Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila

Kanda, H., Shimamura, R., Koizumi-Kitajima, M. & Okano, H., 2019 6 28, : : iScience. 16, p. 218-229 12 p.

研究成果: Article

公開
Matrix Metalloproteinase 2
Blood-Brain Barrier
Drosophila
Extracellular Matrix
Epithelial-Mesenchymal Transition

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers

Serizawa, T., Isotani, A., Matsumura, T., Nakanishi, K., Nonaka, S., Shibata, S., Ikawa, M. & Okano, H., 2019 1 1, : : Development (Cambridge). 146, 21, dev174938.

研究成果: Article

公開
Germ Layers
Embryonic Structures
Neural Stem Cells
Cell Lineage
Embryonic Development

Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation

Sone, T., Shin, M., Ouchi, T., Sasanuma, H., Miyamoto, A., Ohte, S., Tsukamoto, S., Nakanishi, M., Okano, H., Katagiri, T. & Mitani, K., 2019 12 1, : : Scientific reports. 9, 1, 9705.

研究成果: Article

公開
Osteoblasts
Induced Pluripotent Stem Cells
Osteocalcin
Venus
Bone and Bones
1 引用 (Scopus)

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Kumita, W., Sato, K., Suzuki, Y., Kurotaki, Y., Harada, T., Zhou, Y., Kishi, N., Sato, K., Aiba, A., Sakakibara, Y., Feng, G., Okano, H. & Sasaki, E., 2019 12 1, : : Scientific reports. 9, 1, 12719.

研究成果: Article

公開
Clustered Regularly Interspaced Short Palindromic Repeats
Callithrix
Embryonic Structures
Gene Knockout Techniques
Primates
1 引用 (Scopus)

Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming

Nakajima, M., Yoshimatsu, S., Sato, T., Nakamura, M., Okahara, J., Sasaki, E., Shiozawa, S. & Okano, H., 2019 1 1, : : Biochemical and Biophysical Research Communications.

研究成果: Article

Induced Pluripotent Stem Cells
Callithrix
Fibroblasts
Stem cells
RNA
1 引用 (Scopus)
Audition
Sirolimus
Cell death
Cells
Stem cells

Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs

Yoshimatsu, S., Nakamura, M., Nakajima, M., Nemoto, A., Sato, T., Sasaki, E., Shiozawa, S. & Okano, H., 2019 1 1, (Accepted/In press) : : Neuroscience Research.

研究成果: Article

Induced Pluripotent Stem Cells
Callithrix
Embryonic Stem Cells
Pluripotent Stem Cells
Neurosciences

Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex

Arai, Y., Cwetsch, A. W., Coppola, E., Cipriani, S., Nishihara, H., Kanki, H., Saillour, Y., Freret-Hodara, B., Dutriaux, A., Okada, N., Okano, H., Dehay, C., Nardelli, J., Gressens, P., Shimogori, T., D'Onofrio, G. & Pierani, A., 2019 10 15, : : Cell Reports. 29, 3, p. 645-658.e5

研究成果: Article

公開
Cerebral Cortex
Primates
Neurons
Brain
Genes
1 引用 (Scopus)

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

Ide, M., Ohnishi, T., Toyoshima, M., Balan, S., Maekawa, M., Shimamoto-Mitsuyama, C., Iwayama, Y., Ohba, H., Watanabe, A., Ishii, T., Shibuya, N., Kimura, Y., Hisano, Y., Murata, Y., Hara, T., Morikawa, M., Hashimoto, K., Nozaki, Y., Toyota, T., Wada, Y. および17人, Tanaka, Y., Kato, T., Nishi, A., Fujisawa, S., Okano, H., Itokawa, M., Hirokawa, N., Kunii, Y., Kakita, A., Yabe, H., Iwamoto, K., Meno, K., Katagiri, T., Dean, B., Uchida, K., Kimura, H. & Yoshikawa, T., 2019 1 1, (Accepted/In press) : : EMBO Molecular Medicine. e10695.

研究成果: Article

公開
Hydrogen Sulfide
Schizophrenia
Sulfides
Inbred C3H Mouse
Energy Metabolism

Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis

Kobayashi, J., Hasegawa, T., Sugeno, N., Yoshida, S., Akiyama, T., Fujimori, K., Hatakeyama, H., Miki, Y., Tomiyama, A., Kawata, Y., Fukuda, M., Kawahata, I., Yamakuni, T., Ezura, M., Kikuchi, A., Baba, T., Takeda, A., Kanzaki, M., Wakabayashi, K., Okano, H. および1人, Aoki, M., 2019 9 1, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 10240-10256 17 p.

研究成果: Article

Synucleins
Dopamine Plasma Membrane Transport Proteins
Endocytosis
Neurons
Parkinson Disease

Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation

Cheng, Y. F., Chan, Y. H., Hu, C. J., Lu, Y. C., Saeki, T., Hosoya, M., Saegusa, C., Fujioka, M., Okano, H., Weng, S. M., Hsu, C. J., Chang, K. H. & Wu, C. C., 2019 10 1, : : Stem Cell Research. 40, 101524.

研究成果: Article

公開
Induced Pluripotent Stem Cells
Cell Line
Mutation
Genes
Germ Layers
3 引用 (Scopus)

Increased cytotoxicity of herpes simplex virus thymidine kinase expression in human induced pluripotent stem cells

Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., Okano, H. & Miyoshi, H., 2019 2 2, : : International Journal of Molecular Sciences. 20, 4, 810.

研究成果: Article

公開
Induced Pluripotent Stem Cells
thymidine
Thymidine Kinase
stem cells
Human Herpesvirus 1
1 引用 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 2 12, : : Stem Cell Reports. 12, 2, p. 305-318 14 p.

研究成果: Article

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Fibroblast Growth Factor 4
Stem Cells
1 引用 (Scopus)
公開
Meningomyelocele
Hepatocyte Growth Factor
Amniotic Fluid
Cell- and Tissue-Based Therapy
Spinal Cord

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019 9 1, : : eNeuro. 6, 5

研究成果: Article

公開
Induced Pluripotent Stem Cells
Bipolar Disorder
Schizophrenia
Neurons
Psychiatry
2 引用 (Scopus)
公開
Neurogenesis
Stem Cells
Modulation
Neural Stem Cells
Brain

Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy

Shibata, S., Iseda, T., Mitsuhashi, T., Oka, A., Shindo, T., Moritoki, N., Nagai, T., Otsubo, S., Inoue, T., Sasaki, E., Akazawa, C., Takahashi, T., Schalek, R., Lichtman, J. W. & Okano, H., 2019 4 24, : : Frontiers in Neural Circuits. 13, 29.

研究成果: Article

公開
Electron Scanning Microscopy
Electron Microscopy
Fluorescence
Electrons
Light
Induced Pluripotent Stem Cells
Parkinson Disease
Dopaminergic Neurons
Substantia Nigra
Neurodegenerative Diseases

Mr imaging properties of ex vivo common marmoset brain after formaldehyde fixation

Haga, Y., Hata, J., Uematsu, A., Seki, F., Komaki, Y., Mizumura, M., Nishio, M., Kaneko, T., Kishi, N., Okano, H. & Furukawa, A., 2019 1 1, : : Magnetic Resonance in Medical Sciences. 18, 4, p. 253-259 7 p.

研究成果: Article

公開
Callithrix
Formaldehyde
Brain
Tissue Fixation
Anisotropy
1 引用 (Scopus)

Neuroethical Issues of the Brain/MINDS Project of Japan

Sadato, N., Morita, K., Kasai, K., Fukushi, T., Nakamura, K., Nakazawa, E., Okano, H. & Okabe, S., 2019 2 6, : : Neuron. 101, 3, p. 385-389 5 p.

研究成果: Short survey

公開
Biological Models
Brain Diseases
Japan
Biomarkers
Brain

Noninvasive technique to evaluate the muscle fiber characteristics using q-space imaging

Hata, J., Nakashima, D., Tsuji, O., Fujiyoshi, K., Yasutake, K., Sera, Y., Komaki, Y., Hikishima, K., Nagura, T., Matsumoto, M., Okano, H. & Nakamura, M., 2019 4 1, : : PloS one. 14, 4, e0214805.

研究成果: Article

公開
muscle fibers
Muscle
image analysis
Skeletal Muscle
Imaging techniques

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Nakamura, M., Shiozawa, S., Tsuboi, D., Amano, M., Watanabe, H., Maeda, S., Kimura, T., Yoshimatsu, S., Kisa, F., Karch, C. M., Miyasaka, T., Takashima, A., Sahara, N., Hisanaga, S. I., Ikeuchi, T., Kaibuchi, K. & Okano, H., 2019 10 8, : : Stem cell reports. 13, 4, p. 684-699 16 p.

研究成果: Article

公開
tau Proteins
Frontotemporal Dementia
Pathology
Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
4 引用 (Scopus)

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

Iwasawa, C., Kuzumaki, N., Suda, Y., Kagawa, R., Oka, Y., Hattori, N., Okano, H. & Narita, M., 2019 1 18, : : Molecular Brain. 12, 1, 5.

研究成果: Article

Induced Pluripotent Stem Cells
Interneurons
Somatostatin
Parkinson Disease
GABAergic Neurons

Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets

Huo, B. X., Zeater, N., Lin, M. K., Takahashi, Y. S., Hanada, M., Nagashima, J., Lee, B. C., Hata, J., Zaheer, A., Grünert, U., Miller, M. I., Rosa, M. G. P., Okano, H., Martin, P. R. & Mitra, P. P., 2019 1 1, (Accepted/In press) : : European Journal of Neuroscience.

研究成果: Article

Pulvinar
Geniculate Bodies
Callithrix
Calbindins
Visual Cortex
4 引用 (Scopus)

Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system

Yoshimatsu, S., Okahara, J., Sone, T., Takeda, Y., Nakamura, M., Sasaki, E., Kishi, N., Shiozawa, S. & Okano, H., 2019 12 1, : : Scientific Reports. 9, 1, 1528.

研究成果: Article

Clustered Regularly Interspaced Short Palindromic Repeats
Callithrix
Embryonic Stem Cells
Embryonic Structures
Homologous Recombination
3 引用 (Scopus)

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

Muraoka, N., Nara, K., Tamura, F., Kojima, H., Yamakawa, H., Sadahiro, T., Miyamoto, K., Isomi, M., Haginiwa, S., Tani, H., Kurotsu, S., Osakabe, R., Torii, S., Shimizu, S., Okano, H., Sugimoto, Y., Fukuda, K. & Ieda, M., 2019 12 1, : : Nature communications. 10, 1, 674.

研究成果: Article

Receptors, Prostaglandin E, EP4 Subtype
prostaglandins
fibroblasts
Cyclooxygenase 2
Fibroblasts

Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment

Takahashi, S., Morimoto, S. & Okano, H., 2019 9 1, : : Brain and nerve = Shinkei kenkyu no shinpo. 71, 9, p. 943-952 10 p.

研究成果: Article

Amyotrophic Lateral Sclerosis
Induced Pluripotent Stem Cells
Pharmaceutical Preparations
Motor Neurons
RNA-Binding Protein FUS

Ropinirole Hydrochloride for ALS

Takahashi, S., Morimoto, S., Fukushima, K., Nakahara, J. & Okano, H., 2019 11 1, : : Brain and nerve = Shinkei kenkyu no shinpo. 71, 11, p. 1279-1288 10 p.

研究成果: Article

Induced Pluripotent Stem Cells
Motor Neurons
Pharmaceutical Preparations
Placebos
Clinical Trials
2 引用 (Scopus)
公開
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

Semi-supervised deep learning of brain tissue segmentation

Ito, R., Nakae, K., Hata, J., Okano, H. & Ishii, S., 2019 8 1, : : Neural Networks. 116, p. 25-34 10 p.

研究成果: Article

Brain
Tissue
Atlases
Image segmentation
Anatomists

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Iida, M., Sahashi, K., Kondo, N., Nakatsuji, H., Tohnai, G., Tsutsumi, Y., Noda, S., Murakami, A., Onodera, K., Okada, Y., Nakatochi, M., Tsukagoshi Okabe, Y., Shimizu, S., Mizuno, M., Adachi, H., Okano, H., Sobue, G. & Katsuno, M., 2019 9 19, : : Nature communications. 10, 1, 1 p.

研究成果: Article

公開
Atrophic Muscular Disorders
atrophy
degeneration
Androgen Receptors
mice

Tau isoform expression and phosphorylation in marmoset brains

Sharma, G., Huo, A., Kimura, T., Shiozawa, S., Kobayashi, R., Sahara, N., Ishibashi, M., Ishigaki, S., Saito, T., Ando, K., Murayama, S., Hasegawa, M., Sobue, G., Okano, H. & Hisanaga, S. I., 2019 1 1, : : Journal of Biological Chemistry. 294, 30, p. 11433-11444 12 p.

研究成果: Article

公開
Callithrix
Phosphorylation
Brain
Protein Isoforms
Neurodegenerative diseases