Hideyuki Okano

2011

Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells

Tabuse, M., Ota, S., Ohashi, Y., Fukaya, R., Misawa, A., Yoshida, K., Kawase, T., Saya, H., Thirant, C., Chneiweiss, H., Matsuzaki, Y., Okano, H., Kawakami, Y. & Toda, M., 2011 5月 22, In: Molecular Cancer. 10, 60.

研究成果: Article › 査読

53 被引用数 (Scopus)

Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus

Imaizumi, Y., Sakaguchi, M., Morishita, T., Ito, M., Poirier, F., Sawamoto, K. & Okano, H., 2011, In: Molecular brain. 4, 1, 7.

研究成果: Article › 査読

23 被引用数 (Scopus)

Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation

Fujioka, M., Tokano, H., Fujioka, K. S., Okano, H. & Edge, A. S. B., 2011 6月 1, In: Journal of Clinical Investigation. 121, 6, p. 2462-2469 8 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Generation of human melanocytes from induced pluripotent stem cells

Ohta, S., Imaizumi, Y., Okada, Y., Akamatsu, W., Kuwahara, R., Ohyama, M., Amagai, M., Matsuzaki, Y., Yamanaka, S., Okano, H. & Kawakami, Y., 2011, In: PloS one. 6, 1, e16182.

研究成果: Article › 査読

80 被引用数 (Scopus)

Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells

Yoshida, S., Yasuda, M., Miyashita, H., Ogawa, Y., Yoshida, T., Matsuzaki, Y., Tsubota, K., Okano, H. & Shimmura, S., 2011 12月 9, In: PloS one. 6, 12, e28856.

研究成果: Article › 査読

27 被引用数 (Scopus)

Gene targeting and subsequent site-specific transgenesis at the β-actin (ACTB) locus in common marmoset embryonic stem cells

Shiozawa, S., Kawai, K., Okada, Y., Tomioka, I., Maeda, T., Kanda, A., Shinohara, H., Suemizu, H., James Okano, H., Sotomaru, Y., Sasaki, E. & Okano, H., 2011 9月 1, In: Stem Cells and Development. 20, 9, p. 1587-1599 13 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Yamanaka, S., Nakamura, M. & Okano, H., 2011 10月 4, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16825-16830 6 p.

研究成果: Article › 査読

377 被引用数 (Scopus)

Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production

Fukuda, H., Mochizuki, S., Abe, H., Okano, H. J., Hara-Miyauchi, C., Okano, H., Yamaguchi, N., Nakayama, M., D'Armiento, J. & Okada, Y., 2011 11月 8, In: British Journal of Cancer. 105, 10, p. 1615-1624 10 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury

Kitamura, K., Fujiyoshi, K., Yamane, J. I., Toyota, F., Hikishima, K., Nomura, T., Funakoshi, H., Nakamura, T., Aoki, M., Toyama, Y., Okano, H. & Nakamura, M., 2011 11月 29, In: PloS one. 6, 11, e27706.

研究成果: Article › 査読

78 被引用数 (Scopus)

Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells

Kawase, S., Imai, T., Miyauchi-Hara, C., Yaguchi, K., Nishimoto, Y., Fukami, S. I., Matsuzaki, Y., Miyawaki, A., Itohara, S. & Okano, H., 2011, In: Molecular brain. 4, 1, 14.

研究成果: Article › 査読

18 被引用数 (Scopus)

Impaired spatial and contextual memory formation in galectin-1 deficient mice

Sakaguchi, M., Arruda-Carvalho, M., Kang, N. H., Imaizumi, Y., Poirier, F., Okano, H. & Frankland, P. W., 2011, In: Molecular brain. 4, 1, 33.

研究成果: Article › 査読

17 被引用数 (Scopus)

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

Kubota, Y., Takubo, K., Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. & Suda, T., 2011 5月, In: Journal of Experimental Medicine. 208, 5, p. 949-960 12 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells

Nakamura, M., Tsuji, O., Bregman, B. S., Toyama, Y. & Okano, H., 2011, In: PloS one. 6, 6, e20717.

研究成果: Article › 査読

8 被引用数 (Scopus)

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H. & Suzuki, N., 2011 12月, In: Human molecular genetics. 20, 23, p. 4530-4539 10 p., ddr394.

研究成果: Article › 査読

418 被引用数 (Scopus)

Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation

Kawahara, H., Okada, Y., Imai, T., Iwanami, A., Mischel, P. S. & Okano, H., 2011 5月 6, In: Journal of Biological Chemistry. 286, 18, p. 16121-16130 10 p.

研究成果: Article › 査読

61 被引用数 (Scopus)

Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction

Tamura, Y., Matsumura, K., Sano, M., Tabata, H., Kimura, K., Ieda, M., Arai, T., Ohno, Y., Kanazawa, H., Yuasa, S., Kaneda, R., Makino, S., Nakajima, K., Okano, H. & Fukuda, K., 2011 3月, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 582-589 8 p.

研究成果: Article › 査読

46 被引用数 (Scopus)

Novel concept of motor functional analysis for spinal cord injury in adult mice

Nakamura, M., Shinozaki, M., Takahashi, Y., Mukaino, M., Saito, N., Toyama, Y. & Okano, H., 2011, In: Journal of Biomedicine and Biotechnology. 2011, 157458.

研究成果: Article › 査読

5 被引用数 (Scopus)

Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

Hikishima, K., Quallo, M. M., Komaki, Y., Yamada, M., Kawai, K., Momoshima, S., Okano, H. J., Sasaki, E., Tamaoki, N., Lemon, R. N., Iriki, A. & Okano, H., 2011 2月 14, In: NeuroImage. 54, 4, p. 2741-2749 9 p.

研究成果: Article › 査読

69 被引用数 (Scopus)

Properties of dopaminergic neurons in organotypic mesencephalic-striatal co-cultures - evidence for a facilitatory effect of dopamine on the glutamatergic input mediated by α-1 adrenergic receptors

Cucchiaroni, M. L., Freestone, P. S., Berretta, N., Viscomi, M. T., Bisicchia, E., Okano, H., Molinari, M., Bernardi, G., Lipski, J., Mercuri, N. B. & Guatteo, E., 2011 5月 1, In: European Journal of Neuroscience. 33, 9, p. 1622-1636 15 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Purified mesenchymal stem cells are an efficient source for iPS cell induction

Niibe, K., Kawamura, Y., Araki, D., Morikawa, S., Miura, K., Suzuki, S., Shimmura, S., Sunabori, T., Mabuchi, Y., Nagai, Y., Nakagawa, T., Okano, H. & Matsuzaki, Y., 2011, In: PloS one. 6, 3, e17610.

研究成果: Article › 査読

43 被引用数 (Scopus)

Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing

Nagoshi, N., Shibata, S., Hamanoue, M., Mabuchi, Y., Matsuzaki, Y., Toyama, Y., Nakamura, M. & Okano, H., 2011 5月, In: Glia. 59, 5, p. 771-784 14 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Schwann-spheres derived from injured peripheral nerves in adult mice - their in vitro characterization and therapeutic potential

Takagi, T., Ishii, K., Shibata, S., Yasuda, A., Sato, M., Nagoshi, N., Saito, H., Okano, H. J., Toyama, Y., Okano, H. & Nakamura, M., 2011, In: PloS one. 6, 6, e21497.

研究成果: Article › 査読

9 被引用数 (Scopus)

Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord

Yasuda, A., Tsuji, O., Shibata, S., Nori, S., Takano, M., Kobayashi, Y., Takahashi, Y., Fujiyoshi, K., Hara, C. M., Miyawaki, A., Okano, H. J., Toyama, Y., Nakamura, M. & Okano, H., 2011 12月, In: Stem Cells. 29, 12, p. 1983-1994 12 p.

研究成果: Article › 査読

115 被引用数 (Scopus)

Strategic approaches to regeneration of a damaged central nervous system

Okano, H., 2011 10月 1, In: Cornea. 30, 10 SUPPL. 1, p. S15-S18

研究成果: Article › 査読

7 被引用数 (Scopus)

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex

Yamasaki, T., Kawasaki, H., Arakawa, S., Shimizu, K., Shimizu, S., Reiner, O., Okano, H., Nishina, S., Azuma, N., Penninger, J. M., Katada, T. & Nishina, H., 2011 11月 16, In: Journal of Neuroscience. 31, 46, p. 16872-16883 12 p.

研究成果: Article › 査読

53 被引用数 (Scopus)

The dual origin of the peripheral olfactory system: Placode and neural crest

Katoh, H., Shibata, S., Fukuda, K., Sato, M., Satoh, E., Nagoshi, N., Minematsu, T., Matsuzaki, Y., Akazawa, C., Toyama, Y., Nakamura, M. & Okano, H., 2011, In: Molecular brain. 4, 1, 34.

研究成果: Article › 査読

64 被引用数 (Scopus)

Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the mongolian gerbil

Yamane, J., Ishibashi, S., Sakaguchi, M., Kuroiwa, T., Kanemura, Y., Nakamura, M., Miyoshi, H., Sawamoto, K., Toyama, Y., Mizusawa, H. & Okano, H., 2011, In: Molecular brain. 4, 1, 35.

研究成果: Article › 査読

12 被引用数 (Scopus)

2010

ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development

Doi, Y., Shinzawa, N., Fukumoto, S., Okano, H. & Kanuka, H., 2010 7月, In: Biochemical and Biophysical Research Communications. 397, 4, p. 668-672 5 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells

Terashima, M., Kobayashi, M., Motomiya, M., Inoue, N., Yoshida, T., Okano, H., Iwasaki, N., Minami, A. & Matsuoka, I., 2010 5月 15, In: Journal of neuroscience research. 88, 7, p. 1387-1393 7 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation

Mukaino, M., Nakamura, M., Yamada, O., Okada, S., Morikawa, S., Renault-Mihara, F., Iwanami, A., Ikegami, T., Ohsugi, Y., Tsuji, O., Katoh, H., Matsuzaki, Y., Toyama, Y., Liu, M. & Okano, H., 2010 8月, In: Experimental Neurology. 224, 2, p. 403-414 12 p.

研究成果: Article › 査読

86 被引用数 (Scopus)

Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea

Wakabayashi, K., Fujioka, M., Kanzaki, S., Okano, H. J., Shibata, S., Yamashita, D., Masuda, M., Mihara, M., Ohsugi, Y., Ogawa, K. & Okano, H., 2010 4月, In: Neuroscience Research. 66, 4, p. 345-352 8 p.

研究成果: Article › 査読

103 被引用数 (Scopus)

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H. & Nakashima, K., 2010 4月 5, In: Journal of Cell Biology. 189, 1, p. 159-170 12 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

"color Timer" mice: Visualization of neuronal differentiation with fluorescent proteins

Kanki, H., Shimabukuro, M. K., Miyawaki, A. & Okano, H., 2010, In: Molecular brain. 3, 1, 5.

研究成果: Article › 査読

10 被引用数 (Scopus)

Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells

Tao, O., Shimazaki, T., Okada, Y., Naka, H., Kohda, K., Yuzaki, M., Mizusawa, H. & Okano, H., 2010 2月 1, In: Journal of neuroscience research. 88, 2, p. 234-247 14 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

Expression and proliferation-promoting role of diversin in the neuronally committed precursor cells migrating in the adult mouse brain

Ikeda, M., Hirota, Y., Sakaguchi, M., Yamada, O., Kida, Y. S., Ogura, T., Otsuka, T., Okano, H. & Sawamoto, K., 2010 11月, In: Stem Cells. 28, 11, p. 2017-2026 10 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., 2010 2月 5, In: Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells

Sato, T., Shimazaki, T., Naka, H., Fukami, S. I., Satoh, Y., Okano, H., Irit, L., Schlessinger, J. & Gotoh, N., 2010 9月, In: Stem Cells. 28, 9, p. 1661-1673 13 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28

Tomioka, I., Maeda, T., Shimada, H., Kawai, K., Okada, Y., Igarashi, H., Oiwa, R., Iwasaki, T., Aoki, M., Kimura, T., Shiozawa, S., Shinohara, H., Suemizu, H., Sasaki, E. & Okano, H., 2010 9月, In: Genes to Cells. 15, 9, p. 959-969 11 p.

研究成果: Article › 査読

98 被引用数 (Scopus)

Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Kanazawa, H., Ieda, M., Kimura, K., Arai, T., Kawaguchi-Manabe, H., Matsuhashi, T., Endo, J., Sano, M., Kawakami, T., Kimura, T., Monkawa, T., Hayashi, M., Iwanami, A., Okano, H., Okada, Y., Ishibashi-Ueda, H., Ogawa, S. & Fukuda, K., 2010 2月 1, In: Journal of Clinical Investigation. 120, 2, p. 408-421 14 p.

研究成果: Article › 査読

97 被引用数 (Scopus)

Identification of genes required for neural-specific glycosylation using functional genomics

Yamamoto-Hino, M., Kanie, Y., Awano, W., Aoki-Kinoshita, K. F., Yano, H., Nishihara, S., Okano, H., Ueda, R., Kanie, O. & Goto, S., 2010 12月, In: PLoS Genetics. 6, 12, p. 1-11 11 p., e1001254.

研究成果: Article › 査読

24 被引用数 (Scopus)

Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture

Aihara, Y., Hayashi, Y., Hirata, M., Ariki, N., Shibata, S., Nagoshi, N., Nakanishi, M., Ohnuma, K., Warashina, M., Michiue, T., Uchiyama, H., Okano, H., Asashima, M. & Furue, M. K., 2010, In: International Journal of Developmental Biology. 54, 8-9, p. 1287-1294 8 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Investigation of regeneration of damaged CNS and neurological diseases mechanisms using iPS cells

Okano, H., 2010, In: Clinical Neurology. 50, 11, p. 887 1 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Molecular identity of periglomerular and short axon cells

Kiyokage, E., Pan, Y. Z., Shao, Z., Kobayashi, K., Szabo, G., Yanagawa, Y., Obata, K., Okano, H., Toida, K., Puche, A. C. & Shipley, M. T., 2010 1月 20, In: Journal of Neuroscience. 30, 3, p. 1185-1196 12 p.

研究成果: Article › 査読

159 被引用数 (Scopus)

Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia

Oki, K., Kaneko, N., Kanki, H., Imai, T., Suzuki, N., Sawamoto, K. & Okano, H., 2010 4月, In: Neuroscience Research. 66, 4, p. 390-395 6 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival

Wang, X. Y., Penalva, L. O. F., Yuan, H., Linnoila, R. I., Lu, J., Okano, H. & Glazer, R. I., 2010 8月 21, In: Molecular Cancer. 9, 221.

研究成果: Article › 査読

111 被引用数 (Scopus)

Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression

Kuwako, K. I., Kakumoto, K., Imai, T., Igarashi, M., Hamakubo, T., Sakakibara, S. I., Tessier-Lavigne, M., Okano, H. J. & Okano, H., 2010 8月, In: Neuron. 67, 3, p. 407-421 15 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

New insight into cancer therapeutics: Induction of differentiation by regulating the Musashi/Numb/Notch pathway

Nishimoto, Y. & Okano, H., 2010 10月, In: Cell Research. 20, 10, p. 1083-1085 3 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain

Kaneko, N., Marín, O., Koike, M., Hirota, Y., Uchiyama, Y., Wu, J. Y., Lu, Q., Tessier-Lavigne, M., Alvarez-Buylla, A., Okano, H., Rubenstein, J. L. R. & Sawamoto, K., 2010 7月, In: Neuron. 67, 2, p. 213-223 11 p.

研究成果: Article › 査読

167 被引用数 (Scopus)

Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II

Hirota, Y., Meunier, A., Huang, S., Shimozawa, T., Yamada, O., Kida, Y. S., Inoue, M., Ito, T., Kato, H., Sakaguchi, M., Sunabori, T., Nakaya, M. A., Nonaka, S., Ogura, T., Higuchi, H., Okano, H., Spassky, N. & Sawamoto, K., 2010 9月 15, In: Development. 137, 18, p. 3037-3046 10 p.

研究成果: Article › 査読

76 被引用数 (Scopus)

Regional Spinal Cord Cooling Using a Countercurrent Closed-Lumen Epidural Catheter

Shimizu, H., Mori, A., Yamada, T., Ishikawa, A., Okano, H., Takeda, J. & Yozu, R., 2010 4月, In: Annals of Thoracic Surgery. 89, 4, p. 1312-1313 2 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

岡野 栄之

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岡野栄之