Hiroshi Itoh

1988

γ-Atrial natriuretic polypeptide (γANP)-Derived peptides in human plasma: Cosecretion of n-terminal γANP fragment and αANP

Itoh, H., Nakao, K., Sugawara, A., Saito, Y., Mukoyama, M., Morii, N., Yamada, T., Shiono, S., Arai, H., Hosoda, K. & Imura, H., 1988 9月, In: Journal of Clinical Endocrinology and Metabolism. 67, 3, p. 429-437 9 p.

研究成果: Article › 査読

83 被引用数 (Scopus)

1989

A family of natriuretic peptides (ANP.BNP)

Nakao, K., Itoh, H., Saito, Y., Yamada, T., Mukoyama, M., Arai, H., Hosoda, K., Shirakami, G., Suga, S. & Jougasaki, M., 1989 9月, In: Nippon rinsho. Japanese journal of clinical medicine. 47, 9, p. 1987-1995 9 p.

研究成果: Article › 査読

Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart

Saito, Y., Nakao, K., Arai, H., Nishimura, K., Okumura, K., Obata, K., Takemura, G., Fujiwara, H., Sugawara, A., Yamada, T., Itoh, H., Mukoyama, M., Hosoda, K., Kawai, C., Ban, T., Yasue, H. & Imura, H., 1989, In: Journal of Clinical Investigation. 83, 1, p. 298-305 8 p.

研究成果: Article › 査読

Open Access

212 被引用数 (Scopus)

Brain natriuretic peptide is a novel cardiac hormone

Saito, Y., Nakao, K., Itoh, H., Yamada, T., Mukoyama, M., Arai, H., Hosoda, K., Shirakami, G., Suga, S. I., Minamino, N., Kangawa, K., Matsuo, H. & Imura, H., 1989 1月 31, In: Biochemical and Biophysical Research Communications. 158, 2, p. 360-368 9 p.

研究成果: Article › 査読

205 被引用数 (Scopus)

Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and deoxycorticosterone acetate-salt-hypertensive rats

Itoh, H., Nakao, K., Mukoyama, M., Yamada, T., Hosoda, K., Shirakami, G., Morii, N., Sugawara, A., Saito, Y., Shiono, S., Arai, H., Yoshida, I. & Imura, H., 1989, In: Journal of Clinical Investigation. 84, 1, p. 145-154 10 p.

研究成果: Article › 査読

Open Access

52 被引用数 (Scopus)

Detection and characterization of endothelin-1-like immunoreactivity in rat plasma

Saito, Y., Nakao, K., Shirakami, G., Jougasaki, M., Yamada, T., Itoh, H., Mukoyama, M., Arai, H., Hosoda, K., Suga, S. I., Ogawa, Y. & Imura, H., 1989 9月 29, In: Biochemical and Biophysical Research Communications. 163, 3, p. 1512-1516 5 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Effects of naloxone on vasopressin secretion in conscious rats: Evidence for inhibitory role of endogenous opioid peptides in vasopressin secretion

Yamada, T., Nakao, K., Itoh, H., Shirakami, G., Sugawara, A., Saito, Y., Mukoyama, M., Arai, H., Hosoda, K., Shiono, S., Eigyo, M., Matsushita, A. & Imura, H., 1989 8月, In: Endocrinology. 125, 2, p. 785-790 6 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

Endothelin in human plasma and culture medium of aortic endothelial cells-Detection and characterization with radioimmunoassay using monoclonal antibody

Saito, Y., Nakao, K., Itoh, H., Yamada, T., Mukoyama, M., Arai, H., Hosoda, K., Shirakami, G., Suga, S. I., Jougasaki, M., Morichika, S. & Imura, H., 1989 5月 30, In: Biochemical and Biophysical Research Communications. 161, 1, p. 320-326 7 p.

研究成果: Article › 査読

83 被引用数 (Scopus)

Insulin autoantibodies in mouse models of insulin-dependent diabetes

Maruyama, T., Takei, I., Asaba, Y., Yanagawa, T., Takahashi, T., Itoh, H., Suzuki, Y., Kataoka, K., Saruta, T. & Ishii, T., 1989, In: Diabetes Research. 11, 2, p. 61-65 5 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Isolation and sequence determination of rat cardiac natriuretic peptide

Kambayashi, Y., Nakao, K., Itoh, H., Hosoda, K., Saito, Y., Yamada, T., Mukoyama, M., Arai, H., Shirakami, G., Suga, S. I., Ogawa, Y., Jougasaki, M., Minamino, N., Kangawa, K., Matsuo, H., Inouye, K. & Imura, H., 1989 8月 30, In: Biochemical and Biophysical Research Communications. 163, 1, p. 233-240 8 p.

研究成果: Article › 査読

61 被引用数 (Scopus)

Occurrence of a novel cardiac natriuretic peptide in rats

Itoh, H., Nakao, K., Kambayashi, Y., Hosoda, K., Saito, Y., Yamada, T., Mukoyama, M., Arai, H., Shirakami, G., Suga, S. I., Yoshida, I., Inouye, K. & Imura, H., 1989 6月 15, In: Biochemical and Biophysical Research Communications. 161, 2, p. 732-739 8 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Radioimmunoassay for brain natriuretic peptide (BNP) detection of BNP in canine brain

Itoh, H., Nakao, K., Saito, Y., Yamada, T., Shirakami, G., Mukoyama, M., Arai, H., Hosoda, K., Suga, S. I., Minamino, N., Kangawa, K., Matsuo, H. & Imura, H., 1989 1月 16, In: Biochemical and Biophysical Research Communications. 158, 1, p. 120-128 9 p.

研究成果: Article › 査読

49 被引用数 (Scopus)

Reduction of sodium intake by intracerebroventricular injection of brain natriuretic peptide (BNP) in salt-depleted rats

Shirakami, G., Nakao, G., Yamada, T., Itoh, H., Sugawara, A., Saito, Y., Mukoyama, M., Arai, H., Hosoda, K., Suga, S. I., Mori, K. & Imura, H., 1989 12月 1, In: Biomedical Research. 10, SUPPL. 3, p. 341-348 8 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Relationship between ventricular expression of atrial natriuretic polypeptide gene and hemodynamic parameter in old myocardial infarction

Saito, Y., Nakao, K., Arai, H., Nishimura, K., Takemura, G., Fujiwara, H., Sugawara, A., Yamada, T., Itoh, H., Makoyama, M., Hosoda, K., Shirakami, G., Kawai, C., Ban, T. & Imura, H., 1989 1月 1, In: Journal of Cardiovascular Pharmacology. 13, SUPPL. 6, p. S1-S4

研究成果: Article › 査読

2 被引用数 (Scopus)

Role of endogenous opioid peptides in control of vasopressin secretion

Yamada, T., Shirakami, G., Mukoyama, M., Suga, S. I., Nakao, K., Su gawara, A., Arai, H., Imura, H., Itoh, H., Saito, Y. & Hosoda, K., 1989, In: Therapeutic Research. 10, 11, p. 85-91 7 p.

研究成果: Article › 査読

1990

Application of monoclonal antibodies for endothelin to hypertensive research

Saito, Y., Nakao, K., Mukoyama, M., Shirakami, G., Itoh, H., Yamada, T., Arai, H., Hosoda, K., Suga, S. I., Jougasaki, M., Ogawa, Y., Nakajima, S., Ueda, M. & Imura, H., 1990 6月, In: Hypertension. 15, 6, p. 734-738 5 p.

研究成果: Article › 査読

Open Access

64 被引用数 (Scopus)

Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells

Itoh, H., Pratt, R. E. & Dzau, V. J., 1990 11月, In: Journal of Clinical Investigation. 86, 5, p. 1690-1697 8 p.

研究成果: Article › 査読

Open Access

295 被引用数 (Scopus)

Na⁺, K⁺-ATPase inhibitory activity of fractionated urine during changes in dietary sodium intake in man

Imafuku, T., Ogawa, Z., Itoh, H., Suzuki, H. & Saruta, T., 1990, In: Endocrinologia Japonica. 37, 1, p. 39-46 8 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Preparation of monoclonal antibodies against brain natriuretic peptide and their application to radioimmunoassay and passive immunization

Itoh, H., Nakao, K., Mukoyama, M., Saito, Y., Yamada, T., Shirakami, G., Arai, H., Hosoda, K., Suga, S. I., Yoshida, I. & Imura, H., 1990, In: Endocrinology. 127, 3, p. 1292-1300 9 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Rat brain natriuretic peptide: Isolation from rat heart and tissue distribution

Nakao, K., Itoh, H., Kambayashi, Y., Hosoda, K., Saito, Y., Yamada, T., Mukoyama, M., Arai, H., Shirakami, G., Suga, S. I., Jougasaki, M., Ogawa, Y., Inouye, K. & Imura, H., 1990 6月, In: Hypertension. 15, 6, p. 774-778 5 p.

研究成果: Article › 査読

Open Access

37 被引用数 (Scopus)

Rat brain natriuretic peptide — tissue distribution and molecular form —

Ogawa, Y., Nakao, K., Mukoyama, M., Shirakami, G., Itoh, H., Hosoda, K., Saito, Y., Arai, H., Suga, S. I., Jougasaki, M., Yamada, T., Kambayashi, Y., Inouye, K. & Imura, H., 1990 4月, In: Endocrinology. 126, 4, p. 2225-2227 3 p.

研究成果: Article › 査読

116 被引用数 (Scopus)

1991

Atrial natriuretic peptide in acute hypoxia-induced pulmonary hypertension in rats

Jin, H., Yang, R. H., Chen, Y. F., Jackson, R. M., Itoh, H., Mukoyama, M., Nakao, K., Imura, H. & Oparil, S., 1991, In: Journal of Applied Physiology. 71, 3, p. 807-814 8 p.

研究成果: Article › 査読

38 被引用数 (Scopus)

Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth

Itoh, H., Pratt, R. E. & Dzau, V. J., 1991 5月 15, In: Biochemical and Biophysical Research Communications. 176, 3, p. 1601-1609 9 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Immunohistochemical study using specific monoclonal antibodies

Hasegawa, K., Fujiwara, H., Itoh, H., Nakao, K., Fujiwara, T., Imura, H. & Kawai, C., 1991 1月 1, In: Circulation. 84, 3, p. 1203-1209 7 p.

研究成果: Article › 査読

Open Access

69 被引用数 (Scopus)

Pathophysiological role of augmented atrial natriuretic polypeptide gene expression in doca-salt hypertension effects of atrial natriuretic polypeptide monoclonal antibody

Itoh, H., Nakao, K., Mukoyama, M., Arai, H., Yamada, T., Saito, Y., Shiono, S., Hosoda, K., Shirakami, G., Suga, S. & Imura, H., 1991 4月, In: American journal of hypertension. 4, 1, p. 39-41 3 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Role of angiotensin in the control of vascular smooth muscle growth

Pratt, R. E., Itoh, H., Gibbons, G. H. & Dzau, V. J., 1991 1月 1, In: Journal of Vascular Medicine and Biology. 3, 1, p. 25-29 5 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

1992

Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells

Itoh, H., Pratt, R. E., Ohno, M. & Dzau, V. J., 1992 6月, In: Hypertension. 19, 6, p. 758-761 4 p.

研究成果: Article › 査読

Open Access

129 被引用数 (Scopus)

Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β. Possible existence of 'vascular natriuretic peptide system'

Suga, S. I., Nakao, K., Itoh, H., Komatsu, Y., Ogawa, Y., Hama, N. & Imura, H., 1992, In: Journal of Clinical Investigation. 90, 3, p. 1145-1149 5 p.

研究成果: Article › 査読

Open Access

492 被引用数 (Scopus)

Specific blockade of basic fibroblast growth factor gene expression in endothelial cells by antisense oligonucleotide

Itoh, H., Mukoyama, M., Pratt, R. E. & Dzau, V. J., 1992 11月 16, In: Biochemical and Biophysical Research Communications. 188, 3, p. 1205-1213 9 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

1993

Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

Shirakami, G., Itoh, H., Suga, S. I., Komatsu, Y., Hama, N., Mori, K. & Nakao, K., 1993 9月 3, In: Neuroscience Letters. 159, 1-2, p. 25-28 4 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells--evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells

Suga, S. I., Itoh, H., Komatsu, Y., Ogawa, Y., Hama, N., Yoshimasa, T. & Nakao, K., 1993 12月, In: Endocrinology. 133, 6, p. 3038-3041 4 p.

研究成果: Article › 査読

213 被引用数 (Scopus)

Downregulation of C-receptor by natriuretic peptides via ANP-B receptor in vascular smooth muscle cells

Kishimoto, I., Nakao, K., Suga, S. I., Hosoda, K., Yoshimasa, T., Itoh, H. & Imura, H., 1993 1月 1, In: American Journal of Physiology - Heart and Circulatory Physiology. 265, 4 34-4, p. H1373-H1379

研究成果: Article › 査読

40 被引用数 (Scopus)

Enzymuria in non-insulin-dependent diabetic patients: Signs of tubular cell dysfunction

Ikenaga, H., Suzuki, H., Ishii, N., Itoh, H. & Saruta, T., 1993, In: Clinical Science. 84, 4, p. 469-475 7 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II

Itoh, H., Mukoyama, M., Pratt, R. E., Gibbons, G. H. & Dzau, V. J., 1993 5月, In: Journal of Clinical Investigation. 91, 5, p. 2268-2274 7 p.

研究成果: Article › 査読

Open Access

462 被引用数 (Scopus)

1994

A monoclonal antibody to C-type natriuretic peptide - Preparation and application to radioimmunoassay and neutralization experiment

Hama, N., Itoh, H., Suga, S., Komatsu, Y., Yoshimasa, T. & Nakao, K., 1994, In: Journal of Endocrinology. 141, 3, p. 473-479 7 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling

Itoh, H. & Nakao, K., 1994 1月 1, In: Blood Pressure, Supplement. 3, 5, p. 49-53 5 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients

Hama, N., Itoh, H., Shirakami, G., Suga, S. I., Komatsu, Y., Yoshimasa, T., Tanaka, I., Mori, K. & Nakao, K., 1994 2月 14, In: Biochemical and Biophysical Research Communications. 198, 3, p. 1177-1182 6 p.

研究成果: Article › 査読

134 被引用数 (Scopus)

Expression of Biologically Active Receptors for Natriuretic Peptides in the Human Uterus during Pregnancy

Itoh, H., Sagawa, N., Hasegawa, M., Nanno, H., Kobayashi, F., Ihara, Y., Mori, T., Komatsu, Y., Suga, S. I., Yoshimasa, T., Itoh, H. & Nakao, K., 1994 1月 1, In: Biochemical and Biophysical Research Communications. 203, 1, p. 602-607 6 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Functional evidence for an apical ANP receptor in LLC-PK₁ kidney epithelial cells

Yukiya Hashimoto, H., Junko Ozaki, O., Masato Yasuhara, Y., Ryohei Hori, H., Shin-ichi Suga, S., Hiroshi Itoh, I., Kazuwa Nakao, N. & Ken-inchi Inui, I., 1994 8月 16, In: European Journal of Pharmacology: Molecular Pharmacology. 268, 3, p. 443-445 3 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Molecular biology of brain natriuretic peptide

Ogawa, Y., Itoh, H. & Nakao, K., 1994, In: japanese heart journal. 35, 4, p. 496-497 2 p.

研究成果: Article › 査読

Open Access

Molecular cloning and chromosomal assignment of the mouse C-Type natriuretic peptide (CNP) gene (NPPC): Comparison with the human CNP gene (NPPC)

Ogawa, Y., Itoh, H., Yoshitake, Y., Inoue, M., Yoshimasa, T., Serikawa, T. & Nakao, K., 1994 11月 15, In: Genomics. 24, 2, p. 383-387 5 p.

研究成果: Article › 査読

73 被引用数 (Scopus)

Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides

Tamura, N., Ogawa, Y., Itoh, H., Arai, H., Suga, S. I., Nakagawa, O., Komatsu, Y., Kishimoto, I., Takaya, K., Yoshimasa, T., Shiono, S. & Nakao, K., 1994, In: Journal of Clinical Investigation. 94, 3, p. 1059-1068 10 p.

研究成果: Article › 査読

Open Access

31 被引用数 (Scopus)

Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system

Nakagawa, O., Tanaka, I., Usui, T., Harada, M., Sasaki, Y., Itoh, H., Yoshimasa, T., Namba, T., Narumiya, S. & Nakao, K., 1994 10月, In: Circulation. 90, 4 I, p. 1643-1647 5 p.

研究成果: Article › 査読

Open Access

100 被引用数 (Scopus)

Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene

Ogawa, Y., Itoh, H., Tamura, N., Suga, S. I., Yoshimasa, T., Uehira, M., Matsuda, S., Shiono, S., Nishimoto, H. & Nakao, K., 1994 5月, In: Journal of Clinical Investigation. 93, 5, p. 1911-1921 11 p.

研究成果: Article › 査読

Open Access

161 被引用数 (Scopus)

Natriuretic peptide clearance receptor is transcriptionally down-regulated by β₂-adrenergic stimulation in vascular smooth muscle cells

Kishimoto, I., Yoshimasa, T., Suga, S. I., Ogawa, Y., Komatsu, Y., Nakagawa, O., Itoh, H. & Nakao, K., 1994 11月 11, In: Journal of Biological Chemistry. 269, 45, p. 28300-28308 9 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart Failure

Yasuhara, M., Yamaguchi, M., Shimizu, H., Hashimoto, Y., Hama, N., Itoh, H., Nakao, K. & Hori, R., 1994 12月, In: Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11, 12, p. 1726-1730 5 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Plasma atrial and brain natriuretic peptide concentrations in a case of malignant hypertension

Tamura, N., Itoh, H., Takahashi, A., Iwai, K., Yoshimasa, T., Masuda, I., Arai, H., Suga, S., Ogawa, Y., Kishimoto, I., Komatsu, Y., Nakagawa, O., Hama, N., Takaya, K., Miyamoto, Y., Igaki, T., Harada, M., Yamashita, J. & Nakao, K., 1994 1月 1, In: Therapeutic Research. 15, 7, p. 197-204 8 p.

研究成果: Article › 査読

Transforming growth factor-beta stimulates, and glucocorticoids and epidermal growth factor inhibit brain natriuretic peptide secretion from cultured human amnion cells

Itoh, H., Sagawa, N., Hasegawa, M., Inamori, K., Ueda, H., Kitagawa, K., Nanno, H., Ihara, Y., Kobayashi, F., Mori, T., Suga, S. I., Yoshimasa, T., Itoh, H. & Nakao, K., 1994 7月, In: Journal of Clinical Endocrinology and Metabolism. 79, 1, p. 176-182 7 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

1995

ALTERED GENE EXPRESSION OF NATRIURETIC PEPTIDE RECEPTOR SUBTYPES IN THE KIDNEY OF STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Goto, M., Itoh, H., Tanaka, I., Suga, S. ., Ogawa, Y., Kishimoto, I., Nakagawa, M., Sugawara, A., Yoshimasa, T., Mukoyama, M. & Nakao, K., 1995 11月, In: Clinical and Experimental Pharmacology and Physiology. 22, p. S177-S179

研究成果: Article › 査読

6 被引用数 (Scopus)

AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Hiraoka, J., Arai, H., Yoshimasa, T., Takaya, K., Miyamoto, Y., Yamashita, J., Suga, S. ., Ogawa, Y., Shirakami, G., Itoh, H., Yamori, Y. & Nakao, K., 1995 11月, In: Clinical and Experimental Pharmacology and Physiology. 22, p. S191-S192

研究成果: Article › 査読

2 被引用数 (Scopus)

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伊藤裕