Hiroshi Itoh

1998

Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells

Masatsugu, K., Itoh, H., Chun, T. H., Ogawa, Y., Tamura, N., Yamashita, J., Doi, K., Inoue, M., Fukunaga, Y., Sawada, N., Saito, T., Korenaga, R., Ando, J. & Nakao, K., 1998, In: Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S42-S45

研究成果: Article › 査読

32 被引用数 (Scopus)

Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress

Nanno, H., Sagawa, N., Itoh, H., Matsumoto, T., Terakawa, K., Mise, H., Okumura, K. K., Mori, T., Itoh, H. & Nakao, K., 1998 4月, In: Prenatal and Neonatal Medicine. 3, 2, p. 222-226 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages

Suga, S. I., Itoh, H., Komatsu, Y., Ishida, H., Igaki, T., Yamashita, J., Doi, K., Chun, T. H., Yoshimasa, T., Tanaka, I. & Nakao, K., 1998, In: Endocrinology. 139, 4, p. 1920-1926 7 p.

研究成果: Article › 査読

Open Access

28 被引用数 (Scopus)

Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide

Suda, M., Ogawa, Y., Tanaka, K., Tamura, N., Yasoda, A., Takigawa, T., Uehira, M., Nishimoto, H., Itoh, H., Saito, Y., Shiota, K. & Nakao, K., 1998 3月 3, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2337-2342 6 p.

研究成果: Article › 査読

143 被引用数 (Scopus)

The nocturnal secretion of cardiac natriuretic peptides during obstructive sleep apnoea and its response to therapy with nasal continuous positive airway pressure

Kita, H., Ohi, M., Chin, K., Noguchi, T., Otsuka, N., Tsuboi, T., Itoh, H., Nakao, K. & Kuno, K., 1998, In: Journal of Sleep Research. 7, 3, p. 199-207 9 p.

研究成果: Article › 査読

95 被引用数 (Scopus)

The Significance of the Trp 64 Arg mutation of the β₃-Adrenergic receptor gene in impaired glucose tolerance, non-isulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects

Azuma, N., Yoshimasa, Y., Nishimura, H., Yamamoto, Y., Masuzaki, H., Suga, J., Shigemoto, M., Matsuoka, N., Tanaka, T., Satoh, N., Igaki, T., Miyamoto, Y., Itoh, H., Yoshimasa, T., Hosoda, K., Nishi, S. & Nakao, K., 1998, In: Metabolism: clinical and experimental. 47, 4, p. 456-460 5 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: Possible pathophysiological significance of VEGF in progression of atherosclerosis

Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., Doi, K., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Chun, T. H., Masatsugu, K., Becker, A. E. & Nakao, K., 1998 11月 17, In: Circulation. 98, 20, p. 2108-2116 9 p.

研究成果: Article › 査読

Open Access

422 被引用数 (Scopus)

1999

Down regulation of peroxisome proliferator-activated receptorγ expression by inflammatory cytokines and its reversal by thiazolidinediones

Tanaka, T., Itoh, H., Doi, K., Fukunaga, Y., Hosoda, K., Shintani, M., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K., Sawada, N., Saito, T., Inoue, G., Nishimura, H., Yoshimasa, Y. & Nakao, K., 1999, In: Diabetologia. 42, 6, p. 702-710 9 p.

研究成果: Article › 査読

110 被引用数 (Scopus)

Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides

Ozaki, J., Shimizu, H., Hashimoto, Y., Itoh, H., Nakao, K. & Inui, K. I., 1999 4月 16, In: European journal of pharmacology. 370, 3, p. 307-312 6 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Expression of C-type natriuretic peptide during development of rat lung

Nakanishi, K., Tajima, F., Itoh, H., Nakata, Y., Hama, N., Nakagawa, O., Nakao, K., Kawai, T., Torikata, C., Suga, T., Takishima, K., Aurues, T. & Ikeda, T., 1999 11月, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 5 21-5, p. L996-L1002

研究成果: Article › 査読

18 被引用数 (Scopus)

Hypertension and insulin resistance: Role of peroxisome proliferator- activated receptor γ

Itoh, H., Kentaro, D., Tanaka, T., Fukunaga, Y., Hosoda, K., Inoue, G., Nishimura, H., Yoshimasa, Y., Yamori, Y. & Nakao, K., 1999 7月 14, In: Clinical and Experimental Pharmacology and Physiology. 26, 7, p. 558-560 3 p.

研究成果: Article › 査読

59 被引用数 (Scopus)

New members of uncoupling protein family implicated in energy metabolism

Hosoda, K., Matsuda, J., Itoh, H., Cheol, S., Kentaro, D., Tanaka, T., Fukunaga, Y., Yamori, Y. & Nakao, K., 1999 7月 14, In: Clinical and Experimental Pharmacology and Physiology. 26, 7, p. 561-562 2 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Vascular stress response and endothelial vasoactive factors for vascular remodelling

Itoh, H. & Nakao, K., 1999 9月, In: Diabetes Research and Clinical Practice. 45, 2-3, p. 83-88 6 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

2000

Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats

Fukunaga, Y., Itoh, H., Hosoda, K., Doi, K., Matsuda, J., Son, C., Yamashita, J., Chun, T. H., Tanaka, T., Inoue, M., Masatsugu, K., Saito, T., Sawada, N. & Nakao, K., 2000 1月 1, In: Journal of hypertension. 18, 9, p. 1233-1238 6 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Cardiac fibrosis in mice lacking brain natriuretic peptide

Tamura, N., Ogawa, Y., Chusho, H., Nakamura, K., Nakao, K., Suda, M., Kasahara, M., Hashimoto, R., Katsuura, G., Mukoyama, M., Itoh, H., Saito, Y., Tanaka, I., Otani, H., Katsuki, M. & Nakao, K., 2000 4月 11, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4239-4244 6 p.

研究成果: Article › 査読

504 被引用数 (Scopus)

Current topics in pheochromocytoma

Nakao, K., Itoh, H. & Takaya, K., 2000 6月, In: Biomedicine and Pharmacotherapy. 54, SUPPL. 1, p. 124s-128s

研究成果: Article › 査読

8 被引用数 (Scopus)

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Utsugi, T., Ohno, T., Ohyama, Y., Uchiyama, T., Saito, Y., Matsumura, Y., Aizawa, H., Itoh, H., Kurabayashi, M., Kawazu, S., Tomono, S., Oka, Y., Suga, T., Kuro-o, M., Nabeshima, Y. & Nagai, R., 2000, In: Metabolism: clinical and experimental. 49, 9, p. 1118-1123 6 p.

研究成果: Article › 査読

124 被引用数 (Scopus)

Expression of prostaglandin E receptor EP₄ subtype in rat adrenal zona glomerulosa: Involvement in aldosterone release

Muro, S., Tanaka, I., Usui, T., Kotani, M., Koide, S., Mukoyama, M., Fukata, J., Itoh, H., Narumiya, S., Kawata, M. & Nakao, K., 2000, In: Endocrine journal. 47, 4, p. 429-436 8 p.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., Naito, M., Nakao, K. & Nishikawa, S. I., 2000 11月 2, In: Nature. 408, 6808, p. 92-96 5 p.

研究成果: Article › 査読

1175 被引用数 (Scopus)

Genetic models reveal that brain natriuretic peptide can signal through different tissue-specific receptor-mediated pathways

Chusho, H., Ogawa, Y., Tamura, N., Suda, M., Yasoda, A., Miyazawa, T., Kishimoto, I., Komatsu, Y., Itoh, H., Tanaka, K., Saito, Y., Garbers, D. L. & Nakao, K., 2000, In: Endocrinology. 141, 10, p. 3807-3813 7 p.

研究成果: Article › 査読

Open Access

35 被引用数 (Scopus)

Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

Sawada, N., Itoh, H., Ueyama, K., Yamashita, J., Doi, K., Chun, T. H., Inoue, M., Masatsugu, K., Saito, T., Fukunaga, Y., Sakaguchi, S., Arai, H., Ohno, N., Komeda, M. & Nakao, K., 2000 5月 2, In: Circulation. 101, 17, p. 2030-2033 4 p.

研究成果: Article › 査読

Open Access

184 被引用数 (Scopus)

Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin

Chun, T. H., Itoh, H., Saito, T., Yamahara, K. I., Doi, K., Mori, Y., Ogawa, Y., Yamashita, J., Tanaka, T., Inoue, M., Masatsugu, K., Sawada, N., Fukunaga, Y. & Nakao, K., 2000 1月 1, In: Journal of hypertension. 18, 5, p. 575-580 6 p.

研究成果: Article › 査読

80 被引用数 (Scopus)

2001

cGMP-dependent protein kinase phosphorylates and inactivates RhoA

Sawada, N., Itoh, H., Yamashita, J., Doi, K., Inoue, M., Masatsugu, K., Fukunaga, Y., Sakaguchi, S., Sone, M., Yamahara, K. I., Yurugi, T. & Nakao, K., 2001, In: Biochemical and Biophysical Research Communications. 280, 3, p. 798-805 8 p.

研究成果: Article › 査読

200 被引用数 (Scopus)

Changes in atrial natriuretic peptide and brain natriuretic peptide associated with hypobaric hypoxia-induced pulmonary hypertension in rats

Nakanishi, K., Tajima, F., Itoh, H., Nakata, Y., Osada, H., Hama, N., Nakagawa, O., Nakao, K., Kawai, T., Takishima, K., Aurues, T. & Ikeda, T., 2001, In: Virchows Archiv. 439, 6, p. 808-817 10 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells

Saito, T., Itoh, H., Chun, T. H., Fukunaga, Y., Yamashita, J., Doi, K., Tanaka, T., Inoue, M., Masatsugu, K., Sawada, N., Sakaguchi, S., Arai, H., Mukoyama, M., Tojo, K., Hosoya, T. & Nakao, K., 2001, In: American Journal of Physiology - Heart and Circulatory Physiology. 281, 3 50-3, p. H1364-H1371

研究成果: Article › 査読

43 被引用数 (Scopus)

C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization

Doi, K., Ikeda, T., Itoh, H., Ueyama, K., Hosoda, K., Ogawa, Y., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K., Sawada, N., Fukunaga, Y., Saito, T., Sone, M., Yamahara, K., Kook, H., Komeda, M., Ueda, M. & Nakao, K., 2001, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 21, 6, p. 930-936 7 p.

研究成果: Article › 査読

66 被引用数 (Scopus)

Dwarfism and early death in mice lacking C-type natriuretic peptide

Chusho, H., Tamura, N., Ogawa, Y., Yasoda, A., Suda, M., Miyazawa, T., Nakamura, K., Nakao, K., Kurihara, T., Komatsu, Y., Itoh, H., Tanaka, K., Saito, Y., Katsuki, M. & Nakao, K., 2001 3月 27, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 7, p. 4016-4021 6 p.

研究成果: Article › 査読

367 被引用数 (Scopus)

Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-γ

Inoue, M., Itoh, H., Tanaka, T., Chun, T. H., Doi, K., Fukunaga, Y., Sawada, N., Yamshita, J., Masatsugu, K., Saito, T., Sakaguchi, S., Sone, M., Yamahara, K. I., Yurugi, T. & Nakao, K., 2001, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 21, 4, p. 560-566 7 p.

研究成果: Article › 査読

154 被引用数 (Scopus)

Role of adrenomedullin and its receptor system in renal pathophysiology

Mukoyama, M., Sugawara, A., Nagae, T., Mori, K., Murabe, H., Itoh, H., Tanaka, I. & Nakao, K., 2001, In: Peptides. 22, 11, p. 1925-1931 7 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Thiazolidinediones, peroxisome proliferator-activated receptor γ agonists, regulate endothelial cell growth and secretion of vasoactive peptides

Fukunaga, Y., Itoh, H., Doi, K., Tanaka, T., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K., Sawada, N., Saito, T., Hosoda, K., Kook, H., Ueda, M. & Nakao, K., 2001, In: Atherosclerosis. 158, 1, p. 113-119 7 p.

研究成果: Article › 査読

102 被引用数 (Scopus)

Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes

Son, C., Hosoda, K., Matsuda, J., Fujikura, J., Yonemitsu, S., Iwakura, H., Masuzaki, H., Ogawa, Y., Hayashi, T., Itoh, H., Nishimura, H., Inoue, G., Yoshimasa, Y., Yamori, Y. & Nakao, K., 2001, In: Endocrinology. 142, 10, p. 4189-4194 6 p.

研究成果: Article › 査読

Open Access

80 被引用数 (Scopus)

2002

Accelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit jugular vein grafts by adenovirus-mediated gene transfer of C-type natriuretic peptide

Ohno, N., Itoh, H., Ikeda, T., Ueyama, K., Yamahara, K., Doi, K., Yamashita, J., Inoue, M., Masatsugu, K., Sawada, N., Fukunaga, Y., Sakaguchi, S., Sone, M., Yurugi, T., Kook, H., Komeda, M. & Nakao, K., 2002 4月 9, In: Circulation. 105, 14, p. 1623-1626 4 p.

研究成果: Article › 査読

75 被引用数 (Scopus)

New diagnostic procedure for primary aldosteronism: Adrenal venous sampling under adrenocorticotropic hormone and angiotensin II receptor blocker - Application to a case of bilateral multiple adrenal microadenomas

Yamahara, K., Itoh, H., Yamamoto, A., Sasano, H., Masatsugu, K., Sawada, N., Fukunaga, Y., Sakaguchi, S., Sone, M., Yurugi, T. & Nakao, K., 2002, In: Hypertension Research. 25, 2, p. 145-152 8 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

2003

Adrenomedullin promotes proliferation and migration of cultured endothelial cells

Miyashita, K., Itoh, H., Sawada, N., Fukunaga, Y., Sone, M., Yamahara, K., Yurugi, T. & Nakao, K., 2003 2月, In: Hypertension Research. 26, SUPPL., p. S93-S98

研究成果: Article › 査読

68 被引用数 (Scopus)

Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo

Miyashita, K., Itoh, H., Sawada, N., Fukunaga, Y., Sone, M., Yamahara, K., Yurugi-Kobayashi, T., Park, K. & Nakao, K., 2003 6月 5, In: FEBS Letters. 544, 1-3, p. 86-92 7 p.

研究成果: Article › 査読

70 被引用数 (Scopus)

Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells

Sone, M., Itoh, H., Yamashita, J., Yurugi-Kobayashi, T., Suzuki, Y., Kondo, Y., Nonoguchi, A., Sawada, N., Yamahara, K., Miyashita, K., Park, K., Shibuya, M., Nito, S., Nishikawa, S. I. & Nakao, K., 2003 4月 29, In: Circulation. 107, 16, p. 2085-2088 4 p.

研究成果: Article › 査読

76 被引用数 (Scopus)

Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage

Yurugi-Kobayashi, T., Itoh, H., Yamashita, J., Yamahara, K., Hirai, H., Kobayashi, T., Ogawa, M., Nishikawa, S., Nishikawa, S. I. & Nakao, K., 2003 4月 1, In: Blood. 101, 7, p. 2675-2678 4 p.

研究成果: Article › 査読

61 被引用数 (Scopus)

Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy

Chun, T. H., Itoh, H., Subramanian, L., Iñiguez-Lluhí, J. A. & Nakao, K., 2003 6月 13, In: Circulation research. 92, 11, p. 1201-1208 8 p.

研究成果: Article › 査読

53 被引用数 (Scopus)

Physiological concentration of atrial natriuretic peptide induces endothelial regeneration in vitro

Kook, H., Itoh, H., Choi, B. S., Sawada, N., Doi, K., Hwang, T. J., Kim, K. K., Arai, H., Baik, Y. H. & Nakao, K., 2003 4月 1, In: American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4, p. H1388-H1397

研究成果: Article › 査読

80 被引用数 (Scopus)

Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress

Masatsugu, K., Itoh, H., Chun, T. H., Saito, T., Yamashita, J., Doi, K., Inoue, M., Sawada, N., Fukunaga, Y., Sakaguchi, S., Sone, M., Yamahara, K., Yurugi, T. & Nakao, K., 2003 3月 28, In: Regulatory Peptides. 111, 1-3, p. 13-19 7 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration

Yamahara, K., Itoh, H., Chun, T. H., Ogawa, Y., Yamashita, J., Sawada, N., Fukunaga, Y., Sone, M., Yurugi-Kobayashi, T., Miyashita, K., Tsujimoto, H., Kook, H., Feil, R., Garbers, D. L., Hofmann, F. & Nakao, K., 2003 3月 18, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 6, p. 3404-3409 6 p.

研究成果: Article › 査読

139 被引用数 (Scopus)

Successful treatment of primary aldosteronism due to computed tomography-negative microadenoma

Nishizawa, K., Nakamura, E., Kobayashi, T., Kamoto, T., Terai, A., Terachi, T., Ogawa, O., Itoh, H. & Nakao, K., 2003 10月 1, In: International Journal of Urology. 10, 10, p. 544-546 3 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2004

Cyclic mechanical stretching and interleukin-1α synergistically up-regulate prostacyclin secretion in cultured human uterine myometrial cells

Korita, D., Itoh, H., Sagawa, N., Yura, S., Yoshida, M., Kakui, K., Takemura, M., Nuamah, M. A. & Fujii, S., 2004 3月, In: Gynecological Endocrinology. 18, 3, p. 130-137 8 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Significant roles of natriuretic peptides in vascular physiology

Miyashita, K., Itoh, H. & Nakao, K., 2004 9月, In: Nippon rinsho. Japanese journal of clinical medicine. 62 Suppl 9, p. 51-55 5 p.

研究成果: Article › 査読

2005

Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice

Iwakura, H., Hosoda, K., Son, C., Fujikura, J., Tomita, T., Noguchi, M., Ariyasu, H., Takaya, K., Masuzaki, H., Ogawa, Y., Hayashi, T., Inoue, G., Akamizu, T., Hosoda, H., Kojima, M., Itoh, H., Toyokuni, S., Kangawa, K. & Nakao, K., 2005 4月 15, In: Journal of Biological Chemistry. 280, 15, p. 15247-15256 10 p.

研究成果: Article › 査読

61 被引用数 (Scopus)

Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK)

Saito, T., Itoh, H., Yamashita, J., Doi, K., Chun, T. H., Tanaka, T., Inoue, M., Masatsugu, K., Fukunaga, Y., Sawada, N., Sakaguchi, S., Arai, H., Tojo, K., Tajima, N., Hosoya, T. & Nakao, K., 2005 4月 15, In: Regulatory Peptides. 127, 1-3, p. 159-167 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading

Huang, H., Nakayama, Y., Qin, K., Yamamoto, K., Ando, J., Yamashita, J., Itoh, H., Kanda, K., Yaku, H., Okamoto, Y. & Nemoto, Y., 2005 8月, In: Journal of Artificial Organs. 8, 2, p. 110-118 9 p.

研究成果: Article › 査読

74 被引用数 (Scopus)

Experimental transplantation study for possible transformation of bone marrow cells in the mouse placenta

Kakui, K., Itoh, H., Sagawa, N., Yura, S., Takemura, M., Kawamura, M. & Fujii, S., 2005 9月, In: Placenta. 26, 8-9, p. 678-685 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Expression of the adrenomedullin gene in adipose tissue

Nambu, T., Arai, H., Komatsu, Y., Yasoda, A., Moriyama, K., Kanamoto, N., Itoh, H. & Nakao, K., 2005 12月 15, In: Regulatory Peptides. 132, 1-3, p. 17-22 6 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Papillary thyroid carcinoma without metastases manifesting as an autonomously functioning thyroid nodule

Majima, T., Doi, K., Komatsu, Y., Itoh, H., Fukao, A., Shigemoto, M., Takagi, C., Corners, J., Mizuta, N., Kato, R. & Nakao, K., 2005 6月, In: Endocrine journal. 52, 3, p. 309-316 8 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

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伊藤裕