Hiroshi Itoh

2011

A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse

Tada, A., Shimada, A., Yamada, T., Oikawa, Y., Yamada, Y., Okubo, Y., Irie, J., Bluestone, J. A. & Itoh, H., 2011 11月 15, In: Journal of Immunology. 187, 10, p. 4947-4953 7 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice

Maki, T., Ihara, M., Fujita, Y., Nambu, T., Miyashita, K., Yamada, M., Washida, K., Nishio, K., Ito, H., Harada, H., Yokoi, H., Arai, H., Itoh, H., Nakao, K., Takahashi, R. & Tomimoto, H., 2011 4月, In: Stroke. 42, 4, p. 1122-1128 7 p.

研究成果: Article › 査読

62 被引用数 (Scopus)

Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring

Fujii, T., Yura, S., Tatsumi, K., Kondoh, E., Mogami, H., Fujita, K., Kakui, K., Aoe, S., Itoh, H., Sagawa, N., Fujii, S. & Konishi, I., 2011 6月, In: Journal of Developmental Origins of Health and Disease. 2, 3, p. 176-183 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1

Suda, N., Shibata, H., Kurihara, I., Ikeda, Y., Kobayashi, S., Yokota, K., Murai-Takeda, A., Nakagawa, K., Oya, M., Murai, M., Rainey, W. E., Saruta, T. & Itoh, H., 2011 6月, In: Endocrinology. 152, 6, p. 2266-2277 12 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Differential effects in cardiovascular markers between high-dose angiotensin II receptor blocker monotherapy and combination therapy of ARB with calcium channel blocker in hypertension (DEAR Trial)

Kinouchi, K., Ichihara, A., Bokuda, K., Kurosawa, H. & Itoh, H., 2011, In: International Journal of Hypertension. 2011, 284823.

研究成果: Article › 査読

5 被引用数 (Scopus)

Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: A preliminary, observational, open-label study

Kawai, T., Takei, I., Shimada, A., Hirata, T., Tanaka, K., Saisho, Y., Irie, J., Horimai, C., Matsumoto, H. & Itoh, H., 2011 3月 14, In: Clinical Drug Investigation. 31, 4, p. 237-245 9 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Glycated albumin to glycated hemoglobin ratio reflects postprandial glucose excursion and relates to beta cell function in both type 1 and type 2 diabetes

Saisho, Y., Tanaka, K., Abe, T., Shimada, A., Kawai, T. & Itoh, H., 2011 10月 1, In: Diabetology International. 2, 3, p. 146-153 8 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Higher level of serum vascular endothelial growth factor in type 2 diabetic patients with diabetic retinopathy hospitalized for hyperglycemic state

Takamiya, Y., Oikawa, Y., Hirose, H., Shimada, A. & Itoh, H., 2011 3月, In: Diabetology International. 2, 1, p. 19-25 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling

Kaneko, H., Anzai, T., Nagai, T., Anzai, A., Takahashi, T., Mano, Y., Morimoto, K., Maekawa, Y., Itoh, H., Yoshikawa, T., Ogawa, S. & Fukuda, K., 2011 8月 1, In: Cardiovascular Research. 91, 3, p. 546-555 10 p.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension

Ryuzaki, M., Ichihara, A., Ohshima, Y., Sakoda, M., Kurauchi-Mito, A., Narita, T., Kinouchi, K., Murohashi-Bokuda, K., Nishiyama, A. & Itoh, H., 2011 3月, In: Hypertension Research. 34, 3, p. 301-307 7 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Watanabe, M., Horai, Y., Houten, S. M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., Itoh, H. & Auwerx, J., 2011 7月 29, In: Journal of Biological Chemistry. 286, 30, p. 26913-26920 8 p.

研究成果: Article › 査読

201 被引用数 (Scopus)

Management of prehypertension: Current status and future strategies

Sasamura, H., Itoh, H. & Julius, S., 2011 9月, In: Current Hypertension Reviews. 7, 2, p. 118-124 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure

Cao, Y., Nakata, M., Okamoto, S., Takano, E., Yada, T., Minokoshi, Y., Hirata, Y., Nakajima, K., Iskandar, K., Hayashi, Y., Ogawa, W., Barsh, G. S., Hosoda, H., Kangawa, K., Itoh, H., Noda, T., Kasuga, M. & Nakae, J., 2011, In: PloS one. 6, 4, e18324.

研究成果: Article › 査読

28 被引用数 (Scopus)

Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus

Meguro, S., Tomita, M., Katsuki, T., Kato, K., Oh, H., Ainai, A., Ito, R., Takeda, S., Kawai, T., Atsumi, Y., Itoh, H. & Hasegawa, H., 2011, In: International Journal of Endocrinology. 2011, 362981.

研究成果: Article › 査読

21 被引用数 (Scopus)

Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes

Saisho, Y., Kou, K., Tanaka, K., Abe, T., Kurosawa, H., Shimada, A., Meguro, S., Kawai, T. & Itoh, H., 2011, In: Endocrine journal. 58, 4, p. 315-322 8 p.

研究成果: Article › 査読

65 被引用数 (Scopus)

Proatherogenic effect of interleukin-18 is exerted with high-fat diet, but not with normal diet in spontaneously hyperlipidemic mice

Imai, T., Oikawa, Y., Shimada, A., Oguchi, S., Takamiya, Y., Katsuki, T., Okubo, Y., Osaki, T., Tahara, H., Matsushima, Y., Miyazaki, J. I. & Itoh, H., 2011 12月 22, In: Journal of atherosclerosis and thrombosis. 18, 12, p. 1090-1101 12 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway

Liu, G., Hitomi, H., Hosomi, N., Shibayama, Y., Nakano, D., Kiyomoto, H., Ma, H., Yamaji, Y., Kohno, M., Ichihara, A., Itoh, H. & Nishiyama, A., 2011 4月, In: Journal of hypertension. 29, 4, p. 696-705 10 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Prorenin receptor is essential for normal podocyte structure and function

Oshima, Y., Kinouchi, K., Ichihara, A., Sakoda, M., Kurauchi-Mito, A., Bokuda, K., Narita, T., Kurosawa, H., Sun-Wada, G. H., Wada, Y., Yamada, T., Takemoto, M., Saleem, M. A., Quaggin, S. E. & Itoh, H., 2011 12月, In: Journal of the American Society of Nephrology. 22, 12, p. 2203-2212 10 p.

研究成果: Article › 査読

147 被引用数 (Scopus)

Renal amyloidosis caused by apolipoprotein A-II without a genetic mutation in the coding sequence

Morizane, R., Monkawa, T., Konishi, K., Hashiguchi, A., Ueda, M., Ando, Y., Tokuyama, H., Hayashi, K., Hayashi, M. & Itoh, H., 2011 10月, In: Clinical and experimental nephrology. 15, 5, p. 774-779 6 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch

Hara, Y., Wakino, S., Tanabe, Y., Saito, M., Tokuyama, H., Washida, N., Tatematsu, S., Yoshioka, K., Homma, K., Hasegawa, K., Minakuchi, H., Fujimura, K., Hosoya, K., Hayashi, K., Nakayama, K. & Itoh, H., 2011 1月 25, In: Science Signaling. 4, 157, ra3.

研究成果: Article › 査読

72 被引用数 (Scopus)

Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis

Washida, N., Wakino, S., Tonozuka, Y., Homma, K., Tokuyama, H., Hara, Y., Hasegawa, K., Minakuchi, H., Fujimura, K., Hosoya, K., Hayashi, K. & Itoh, H., 2011 9月, In: Nephrology Dialysis Transplantation. 26, 9, p. 2770-2779 10 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of an Aldosterone-Producing Adenoma

Sonoyama, T., Sone, M., Miyashita, K., Tamura, N., Yamahara, K., Park, K., Oyamada, N., Taura, D., Inuzuka, M., Kojima, K., Honda, K., Fukunaga, Y., Kanamoto, N., Miura, M., Yasoda, A., Arai, H., Itoh, H. & Nakao, K., 2011 9月, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. 2771-2778 8 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells

Yamaguchi, S., Yamahara, K., Homma, K., Suzuki, S., Fujii, S., Morizane, R., Monkawa, T., Matsuzaki, Y., Kangawa, K. & Itoh, H., 2011 12月, In: Atherosclerosis. 219, 2, p. 468-474 7 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis

Kaneko, H., Anzai, T., Horiuchi, K., Morimoto, K., Anzai, A., Nagai, T., Sugano, Y., Maekawa, Y., Itoh, H., Yoshikawa, T., Okada, Y., Ogawa, S. & Fukuda, K., 2011 10月, In: Circulation Journal. 75, 10, p. 2482-2490 9 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Use of serum and urine metabolome analysis for the detection of metabolic changes in patients with stage 1-2 chronic kidney disease

Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T. & Itoh, H., 2011, In: Nephro-Urology Monthly. 3, 3, p. 164-171 8 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

2012

[The 39th scientific meeting: perspectives of internal medicine; the cutting edge of treatment of medical disorders encountered in clinical practice; 10. Summary].

Itoh, H., 2012 3月 10, In: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 101, 3, p. 654-655 2 p.

研究成果: Article › 査読

Open Access

A case of autoimmune polyglandular syndrome type 3 with plasma glucose and c-peptide levels observed before and after diabetes onset

Soeda, Y., Tanaka, K., Saisho, Y., Meguro, S., Shimada, A., Kawai, T. & Itoh, H., 2012 5月 30, In: Journal of the Japan Diabetes Society. 55, 5, p. 340-344 5 p.

研究成果: Article › 査読

A case of trimethoprim-induced hyperkalemia complicating ANCA-associated vasculitis

Shishido, T., Ryuzaki, M., Futatsugi, K., Takimoto, C., Kobayashi, E., Handa, M. & Itoh, H., 2012 8月 29, In: Japanese Journal of Nephrology. 54, 5, p. 615-621 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

A large coronary aneurysm and its probable precursor lesions in a patient with autosomal dominant polycystic kidney disease: An implication for the process of aneurysmogenesis

Ohara, K., Kimura, T., Karasawa, T., Tokuyama, H., Wakino, S., Hayashi, K., Itoh, H. & Okada, Y., 2012 11月 1, In: Pathology international. 62, 11, p. 758-762 5 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Antepartum oral disposition index as a predictor of glucose intolerance postpartum

Saisho, Y., Miyakoshi, K., Tanaka, M., Matsumoto, T., Minegishi, K., Yoshimura, Y. & Itoh, H., 2012 4月, In: Diabetes care. 35, 4, p. e32

研究成果: Article › 査読

6 被引用数 (Scopus)

Association between total serum bilirubin concentration and vascular complication risk in type 2 diabetes mellitus

Tanaka, M. & Itoh, H., 2012 4月 1, In: Journal of the Japan Diabetes Society. 55, 4, p. 243-248 6 p.

研究成果: Article › 査読

Baro-excited neurons in the caudal ventrolateral medulla (CVLM) recorded using the whole-cell patch-clamp technique

Oshima, N., Kumagai, H., Iigaya, K., Onimaru, H., Kawai, A., Nishida, Y., Saruta, T. & Itoh, H., 2012 5月, In: Hypertension Research. 35, 5, p. 500-506 7 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

Watanabe, M., Morimoto, K., Houten, S. M., Kaneko-Iwasaki, N., Sugizaki, T., Horai, Y., Mataki, C., Sato, H., Murahashi, K., Arita, E., Schoonjans, K., Suzuki, T., Itoh, H. & Auwerx, J., 2012 8月 29, In: PloS one. 7, 8, e38286.

研究成果: Article › 査読

85 被引用数 (Scopus)

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

Ichikawa, R., Takayama, T., Yoneno, K., Kamada, N., Kitazume, M. T., Higuchi, H., Matsuoka, K., Watanabe, M., Itoh, H., Kanai, T., Hisamatsu, T. & Hibi, T., 2012 6月, In: Immunology. 136, 2, p. 153-162 10 p.

研究成果: Article › 査読

81 被引用数 (Scopus)

Coenzyme Q ₁₀ reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance

Muraki, A., Miyashita, K., Mitsuishi, M., Tamaki, M., Tanaka, K. & Itoh, H., 2012 8月 1, In: Journal of Applied Physiology. 113, 3, p. 479-486 8 p.

研究成果: Article › 査読

63 被引用数 (Scopus)

Decrease in vascular endothelial growth factor expression area in islets may be associated with type 2 diabetes development

Takamiya, Y., Oikawa, Y., Yamada, T., Shimada, A. & Itoh, H., 2012 12月 1, In: Diabetology International. 3, 4, p. 202-208 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: A possible link suggested by cross-sectional analysis

Saisho, Y., Tanaka, K., Abe, T., Shimada, A., Kawai, T. & Itoh, H., 2012, In: Endocrine journal. 59, 3, p. 187-195 9 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Factors associated with the decline of kidney function differ among eGFR strata in subjects with type 2 diabetes mellitus

Meguro, S., Tomita, M., Kabeya, Y., Katsuki, T., Oikawa, Y., Shimada, A., Kawai, T., Itoh, H. & Atsumi, Y., 2012, In: International Journal of Endocrinology. 2012, 687867.

研究成果: Article › 査読

12 被引用数 (Scopus)

Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance

Kawano, Y., Nakae, J., Watanabe, N., Fujisaka, S., Iskandar, K., Sekioka, R., Hayashi, Y., Tobe, K., Kasuga, M., Noda, T., Yoshimura, A., Onodera, M. & Itoh, H., 2012 8月, In: Diabetes. 61, 8, p. 1935-1948 14 p.

研究成果: Article › 査読

48 被引用数 (Scopus)

Mineralocorticoid receptor-associated hypertension and its organ damage: Clinical relevance for resistant hypertension

Shibata, H. & Itoh, H., 2012 5月, In: American journal of hypertension. 25, 5, p. 514-523 10 p.

研究成果: Article › 査読

79 被引用数 (Scopus)

MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: Case report

Morizane, R., Konishi, K., Hashiguchi, A., Tokuyama, H., Wakino, S., Kawabe, H., Hayashi, M., Hayashi, K. & Itoh, H., 2012, In: BMC Nephrology. 13, 1, 32.

研究成果: Article › 査読

5 被引用数 (Scopus)

Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection

Kurihara, T., Shimizu-Hirota, R., Shimoda, M., Adachi, T., Shimizu, H., Weiss, S. J., Itoh, H., Hori, S., Aikawa, N. & Okada, Y., 2012 12月 18, In: Circulation. 126, 25, p. 3070-3080 11 p.

研究成果: Article › 査読

169 被引用数 (Scopus)

Novel repressor regulates insulin sensitivity through interaction with Foxo1

Nakae, J., Cao, Y., Hakuno, F., Takemori, H., Kawano, Y., Sekioka, R., Abe, T., Kiyonari, H., Tanaka, T., Sakai, J., Takahashi, S. I. & Itoh, H., 2012 5月 16, In: EMBO Journal. 31, 10, p. 2275-2295 21 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Regression of atherosclerosis in apolipoprotein E-deficient mice is feasible using high-dose angiotensin receptor blocker, candesartan

Hayashi, K., Sasamura, H., Azegami, T. & Itoh, H., 2012, In: Journal of atherosclerosis and thrombosis. 19, 8, p. 736-746 11 p.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

Relationship between treatment satisfaction and intension to drop out in outpatients with type 2 diabetes

Saisho, Y. & Itoh, H., 2012 10月 1, In: Journal of the Japan Diabetes Society. 55, 10, p. 768-773 6 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury

Tokuyama, H., Wakino, S., Hara, Y., Washida, N., Fujimura, K., Hosoya, K., Yoshioka, K., Hasegawa, K., Minakuchi, H., Homma, K., Hayashi, K. & Itoh, H., 2012 8月, In: International Journal of Obesity. 36, 8, p. 1062-1071 10 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Selective depletion of mouse kidney proximal straight tubule cells causes acute kidney injury

Sekine, M., Monkawa, T., Morizane, R., Matsuoka, K., Taya, C., Akita, Y., Joh, K., Itoh, H., Hayashi, M., Kikkawa, Y., Kohno, K., Suzuki, A. & Yonekawa, H., 2012 2月, In: Transgenic research. 21, 1, p. 51-62 12 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

Triglyceride-rich lipoproteins in chronic kidney disease patients undergoing maintenance haemodialysis treatment

Homma, K., Homma, Y., Yamaguchi, S., Shiina, Y., Wakino, S., Hayashi, K., Hori, S. & Itoh, H., 2012 4月 1, In: International Journal of Clinical Practice. 66, 4, p. 394-398 5 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy

Azegami, T., Sasamura, H., Hayashi, K. & Itoh, H., 2012 5月, In: Hypertension Research. 35, 5, p. 492-499 8 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

Vitamin E decreases bone mass by stimulating osteoclast fusion

Fujita, K., Iwasaki, M., Ochi, H., Fukuda, T., Ma, C., Miyamoto, T., Takitani, K., Negishi-Koga, T., Sunamura, S., Kodama, T., Takayanagi, H., Tamai, H., Kato, S., Arai, H., Shinomiya, K., Itoh, H., Okawa, A. & Takeda, S., 2012 4月, In: Nature medicine. 18, 4, p. 589-594 6 p.

研究成果: Article › 査読

133 被引用数 (Scopus)

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伊藤裕