Hiroshi Itoh

2000

Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

Sawada, N., Itoh, H., Ueyama, K., Yamashita, J., Doi, K., Chun, T. H., Inoue, M., Masatsugu, K., Saito, T., Fukunaga, Y., Sakaguchi, S., Arai, H., Ohno, N., Komeda, M. & Nakao, K., 2000 5月 2, In: Circulation. 101, 17, p. 2030-2033 4 p.

研究成果: Article › 査読

Open Access

184 被引用数 (Scopus)

Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin

Chun, T. H., Itoh, H., Saito, T., Yamahara, K. I., Doi, K., Mori, Y., Ogawa, Y., Yamashita, J., Tanaka, T., Inoue, M., Masatsugu, K., Sawada, N., Fukunaga, Y. & Nakao, K., 2000 1月 1, In: Journal of hypertension. 18, 5, p. 575-580 6 p.

研究成果: Article › 査読

80 被引用数 (Scopus)

1999

Down regulation of peroxisome proliferator-activated receptorγ expression by inflammatory cytokines and its reversal by thiazolidinediones

Tanaka, T., Itoh, H., Doi, K., Fukunaga, Y., Hosoda, K., Shintani, M., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K., Sawada, N., Saito, T., Inoue, G., Nishimura, H., Yoshimasa, Y. & Nakao, K., 1999, In: Diabetologia. 42, 6, p. 702-710 9 p.

研究成果: Article › 査読

110 被引用数 (Scopus)

Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides

Ozaki, J., Shimizu, H., Hashimoto, Y., Itoh, H., Nakao, K. & Inui, K. I., 1999 4月 16, In: European journal of pharmacology. 370, 3, p. 307-312 6 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Expression of C-type natriuretic peptide during development of rat lung

Nakanishi, K., Tajima, F., Itoh, H., Nakata, Y., Hama, N., Nakagawa, O., Nakao, K., Kawai, T., Torikata, C., Suga, T., Takishima, K., Aurues, T. & Ikeda, T., 1999 11月, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 5 21-5, p. L996-L1002

研究成果: Article › 査読

18 被引用数 (Scopus)

Hypertension and insulin resistance: Role of peroxisome proliferator- activated receptor γ

Itoh, H., Kentaro, D., Tanaka, T., Fukunaga, Y., Hosoda, K., Inoue, G., Nishimura, H., Yoshimasa, Y., Yamori, Y. & Nakao, K., 1999 7月 14, In: Clinical and Experimental Pharmacology and Physiology. 26, 7, p. 558-560 3 p.

研究成果: Article › 査読

59 被引用数 (Scopus)

New members of uncoupling protein family implicated in energy metabolism

Hosoda, K., Matsuda, J., Itoh, H., Cheol, S., Kentaro, D., Tanaka, T., Fukunaga, Y., Yamori, Y. & Nakao, K., 1999 7月 14, In: Clinical and Experimental Pharmacology and Physiology. 26, 7, p. 561-562 2 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Vascular stress response and endothelial vasoactive factors for vascular remodelling

Itoh, H. & Nakao, K., 1999 9月, In: Diabetes Research and Clinical Practice. 45, 2-3, p. 83-88 6 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

1998

Effect of neutral endopeptidase inhibition on the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney

Yamaguchi, M., Hashimoto, Y., Itoh, H., Nakao, K. & Inui, K. I., 1998, In: Pharmaceutical research. 15, 9, p. 1499-1502 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Endothelial nitric oxide synthase gene is positively associated with essential hypertension

Miyamoto, Y., Saito, Y., Kajiyama, N., Yoshimura, M., Shimasaki, Y., Nakayama, M., Kamitani, S., Harada, M., Ishikawa, M., Kuwahara, K., Ogawa, E., Hamanaka, I., Takahashi, N., Kaneshige, T., Teraoka, H., Akamizu, T., Azuma, N., Yoshimasa, Y., Yoshimasa, T., Itoh, H., & 3 othersMasuda, I., Yasue, H. & Nakao, K., 1998 7月, In: Hypertension. 32, 1, p. 3-8 6 p.

研究成果: Article › 査読

Open Access

484 被引用数 (Scopus)

Expression and distribution of brain natriuretic peptide in human right atria

Doyama, K., Fukumoto, M., Takemura, G., Tanaka, M., Oda, T., Hasegawa, K., Inada, T., Ohtani, S., Fujiwara, T., Itoh, H., Nakao, K., Sasayama, S. & Fujiwara, H., 1998 12月, In: Journal of the American College of Cardiology. 32, 7, p. 1832-1838 7 p.

研究成果: Article › 査読

67 被引用数 (Scopus)

Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy

Yamashita, J., Yoshimasa, T., Arai, H., Hiraoka, J., Takaya, K., Miyamoto, Y., Ogawa, Y., Itoh, H. & Nakao, K., 1998 6月 26, In: Journal of Biological Chemistry. 273, 26, p. 15993-15999 7 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptide in human plasma

Numata, Y., Dohi, K., Furukawa, A., Kikuoka, S., Asada, H., Fukunaga, T., Taniguchi, Y., Sasakura, K., Tsuji, T., Inouye, K., Yoshimura, M., Itoh, H., Mukoyama, M., Yasue, H. & Nakao, K., 1998, In: Clinical Chemistry. 44, 5, p. 1008-1013 6 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes

Matsuda, J., Hosoda, K., Itoh, H., Son, C., Doi, K., Hanaoka, I., Inoue, G., Nishimura, H., Yoshimasa, Y., Yamori, Y., Odaka, H. & Nakao, K., 1998, In: Diabetes. 47, 11, p. 1809-1814 6 p.

研究成果: Article › 査読

69 被引用数 (Scopus)

Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture

Harada, M., Saito, Y., Kuwahara, K., Ogawa, E., Ishikawa, M., Nakagawa, O., Miyamoto, Y., Kamitani, S., Hamanaka, I., Kajiyama, N., Takahashi, N., Masuda, I., Itoh, H. & Nakao, K., 1998 1月 1, In: Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S357-S359

研究成果: Article › 査読

53 被引用数 (Scopus)

Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: Possible transient down-regulation of nitric oxide synthesis

Nanno, H., Sagawa, N., Itoh, H., Matsumoto, T., Terakawa, K., Mori, T., Itoh, H. & Nakao, K., 1998 6月, In: Molecular Human Reproduction. 4, 6, p. 609-616 8 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Oxidative stress suppresses the endothelial secretion of endothelin

Saito, T., Itoh, H., Chun, T., Igaki, T., Mori, Y., Yamashita, J., Doi, K., Tanaka, T., Inoue, M., Masatsugu, K., Fukunaga, Y., Sawada, N., Tojo, K., Saito, Y., Hosoya, T. & Nakao, K., 1998, In: Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S345-S347

研究成果: Article › 査読

18 被引用数 (Scopus)

Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells

Masatsugu, K., Itoh, H., Chun, T. H., Ogawa, Y., Tamura, N., Yamashita, J., Doi, K., Inoue, M., Fukunaga, Y., Sawada, N., Saito, T., Korenaga, R., Ando, J. & Nakao, K., 1998, In: Journal of Cardiovascular Pharmacology. 31, SUPPL. 1, p. S42-S45

研究成果: Article › 査読

32 被引用数 (Scopus)

Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress

Nanno, H., Sagawa, N., Itoh, H., Matsumoto, T., Terakawa, K., Mise, H., Okumura, K. K., Mori, T., Itoh, H. & Nakao, K., 1998 4月, In: Prenatal and Neonatal Medicine. 3, 2, p. 222-226 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages

Suga, S. I., Itoh, H., Komatsu, Y., Ishida, H., Igaki, T., Yamashita, J., Doi, K., Chun, T. H., Yoshimasa, T., Tanaka, I. & Nakao, K., 1998, In: Endocrinology. 139, 4, p. 1920-1926 7 p.

研究成果: Article › 査読

Open Access

28 被引用数 (Scopus)

Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide

Suda, M., Ogawa, Y., Tanaka, K., Tamura, N., Yasoda, A., Takigawa, T., Uehira, M., Nishimoto, H., Itoh, H., Saito, Y., Shiota, K. & Nakao, K., 1998 3月 3, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2337-2342 6 p.

研究成果: Article › 査読

143 被引用数 (Scopus)

The nocturnal secretion of cardiac natriuretic peptides during obstructive sleep apnoea and its response to therapy with nasal continuous positive airway pressure

Kita, H., Ohi, M., Chin, K., Noguchi, T., Otsuka, N., Tsuboi, T., Itoh, H., Nakao, K. & Kuno, K., 1998, In: Journal of Sleep Research. 7, 3, p. 199-207 9 p.

研究成果: Article › 査読

95 被引用数 (Scopus)

The Significance of the Trp 64 Arg mutation of the β₃-Adrenergic receptor gene in impaired glucose tolerance, non-isulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects

Azuma, N., Yoshimasa, Y., Nishimura, H., Yamamoto, Y., Masuzaki, H., Suga, J., Shigemoto, M., Matsuoka, N., Tanaka, T., Satoh, N., Igaki, T., Miyamoto, Y., Itoh, H., Yoshimasa, T., Hosoda, K., Nishi, S. & Nakao, K., 1998, In: Metabolism: clinical and experimental. 47, 4, p. 456-460 5 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: Possible pathophysiological significance of VEGF in progression of atherosclerosis

Inoue, M., Itoh, H., Ueda, M., Naruko, T., Kojima, A., Komatsu, R., Doi, K., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Chun, T. H., Masatsugu, K., Becker, A. E. & Nakao, K., 1998 11月 17, In: Circulation. 98, 20, p. 2108-2116 9 p.

研究成果: Article › 査読

Open Access

422 被引用数 (Scopus)

1997

Adenovirus-mediated gene transfer of C-type natriuretic peptide causes G1 growth inhibition of cultured vascular smooth muscle cells

Doi, K., Itoh, H., Ikeda, T., Hosoda, K., Ogawa, Y., Igaki, T., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K., Matsuda, K., Ohmori, K. & Nakao, K., 1997 10月 29, In: Biochemical and Biophysical Research Communications. 239, 3, p. 889-894 6 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency

Yoshimine, K., Horiuchi, M., Suzuki, S., Kobayashi, K., Abdul, J. M., Masuda, M., Tomomura, M., Ogawa, Y., Itoh, H., Nakao, K., Osame, M. & Saheki, T., 1997 2月, In: Journal of Molecular and Cellular Cardiology. 29, 2, p. 571-578 8 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: Their gene expression in rats fed high-fat diet

Matsuda, J., Hosoda, K., Itoh, H., Son, C., Doi, K., Tanaka, T., Fukunaga, Y., Inoue, G., Nishimura, H., Yoshimasa, Y., Yamori, Y. & Nakao, K., 1997 11月 24, In: FEBS Letters. 418, 1-2, p. 200-204 5 p.

研究成果: Article › 査読

Open Access

181 被引用数 (Scopus)

Expression of natriuretic peptide system during embryonic stem cell vasculogenesis

Doi, K., Itoh, H., Nakagawa, O., Igaki, T., Yamashita, J., Chun, T. H., Inoue, M., Masatsugu, K. & Nakao, K., 1997 12月 1, In: Heart and vessels. 12, SUPPL. 12, p. 18-22 5 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Impaired guanosine 3',5'-cyclic phosphate production in severe pregnancy-induced hypertension with high plasma levels of atrial and brain natriuretic peptides

Itoh, H., Sagawa, N., Nanno, H., Mori, T., Mukoyama, M., Itoh, H. & Nakao, K., 1997 6月, In: Endocrine journal. 44, 3, p. 389-393 5 p.

研究成果: Article › 査読

Open Access

23 被引用数 (Scopus)

Opposite regulation of Gax homeobox expression by angiotensin II and C- type natriuretic peptide

Yamashita, J., Itoh, H., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Doi, K., Chun, T. H., Inoue, M., Masatsugu, K. & Nakao, K., 1997 1月, In: Hypertension. 29, 1 II, p. 381-387 7 p.

研究成果: Article › 査読

Open Access

34 被引用数 (Scopus)

Plasma levels of brain and atrial natriuretic peptides elevate in proportion to left ventricular end-systolic wall stress in patients with aortic stenosis.

Ikeda, T., Matsuda, K., Itoh, H., Shirakami, G., Miyamoto, Y., Yoshimasa, T., Nakao, K. & Ban, T., 1997 3月, In: American heart journal. 133, 3, p. 307-314 8 p.

研究成果: Article › 査読

116 被引用数 (Scopus)

Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy

Harada, M., Saito, Y., Nakagawa, O., Miyamoto, Y., Ishikawa, M., Kuwahara, K., Ogawa, E., Nakayama, M., Kamitani, S., Hamanaka, I., Kajiyama, N., Masuda, I., Itoh, H., Tanaka, I. & Nakao, K., 1997 12月 1, In: Heart and vessels. 12, SUPPL. 12, p. 198-200 3 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Shear stress augments expression of C-type natriuretic peptide and adrenomedullin

Chun, T. H., Itoh, H., Ogawa, Y., Tamura, N., Takaya, K., Igaki, T., Yamashita, J., Doi, K., Inoue, M., Masatsugu, K., Korenaga, R., Ando, J. & Nakao, K., 1997 6月, In: Hypertension. 29, 6, p. 1296-1302 7 p.

研究成果: Article › 査読

183 被引用数 (Scopus)

Significance of vascular natriuretic peptide system in vascular remodeling in humans and its application to gene therapy

Itoh, H., Suga, S. I., Ogawa, Y., Komatsu, Y., Tamura, N., Igaki, T., Yamashita, J., Ikeda, T., Doi, K., Chun, T. H., Inoue, M., Matsuda, K., Yoshimasa, T., Ueda, M., Ban, T. & Nakao, K., 1997, In: Annals of the New York Academy of Sciences. 811, p. 533-541 9 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes

Harada, M., Itoh, H., Nakagawa, O., Ogawa, Y., Miyamoto, Y., Kuwahara, K., Ogawa, E., Igaki, T., Yamashita, J., Masuda, I., Yoshimasa, T., Tanaka, I., Saito, Y. & Nakao, K., 1997 11月 18, In: Circulation. 96, 10, p. 3737-3744 8 p.

研究成果: Article › 査読

213 被引用数 (Scopus)

1996

Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts

Miyamoto, Y., Yoshimasa, T., Arai, H., Takaya, K., Ogawa, Y., Itoh, H. & Nakao, K., 1996 2月 1, In: Biochemical Journal. 313, 3, p. 795-801 7 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

cDNA cloning and gene expression of human type Iα cGMP-dependent protein kinase

Tamura, N., Itoh, H., Ogawa, Y., Nakagawa, O., Harada, M., Chun, T. H., Suga, S. I., Yoshimasa, T. & Nakao, K., 1996 3月, In: Hypertension. 27, 3 II, p. 552-557 6 p.

研究成果: Article › 査読

67 被引用数 (Scopus)

C-type natriuretic peptide as an autocrine/paracrine regulator of osteoblast: Evidence for possible presence of bone natriuretic peptide system

Suda, M., Tanaka, K., Fukushima, M., Natsui, K., Yasoda, A., Komatsu, Y., Ogawa, Y., Itoh, H. & Nakao, K., 1996 6月 5, In: Biochemical and Biophysical Research Communications. 223, 1, p. 1-6 6 p.

研究成果: Article › 査読

64 被引用数 (Scopus)

C-type natriuretic peptide in chronic renal failure and its action in humans

Igaki, T., Itoh, H., Suga, S., Hama, N., Ogawa, Y., Komatsu, Y., Mukoyama, M., Sugawara, A., Yoshimasa, T., Tanaka, I. & Nakao, K., 1996 1月 1, In: Kidney International, Supplement. 55, p. S-144-S-147

研究成果: Article › 査読

62 被引用数 (Scopus)

C-type natriuretic peptide in human coronary atherosclerotic lesions

Naruko, T., Ueda, M., Van der Wal, A. C., Van der Loos, C. M., Itoh, H., Nakao, K. & Becker, A. E., 1996, In: Circulation. 94, 12, p. 3103-3108 6 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin

Takaya, K., Yoshimasa, T., Arai, H., Tamura, N., Miyamoto, Y., Itoh, H. & Nakao, K., 1996 10月 25, In: Journal of Molecular Medicine. 74, 10, p. 617-621 5 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide

Igaki, T., Itoh, H., Suga, S. I., Komatsu, Y., Ogawa, Y., Doi, K., Yoshimasa, T. & Nakao, K., 1996, In: Diabetes. 45, 3 SUPPL., p. S62-S64

研究成果: Article › 査読

31 被引用数 (Scopus)

Natriuretic peptide receptors in human artery and vein and rabbit vein graft

Ikeda, T., Itoh, H., Komatsu, Y., Hanyu, M., Yoshimasa, T., Matsuda, K., Nakao, K. & Ban, T., 1996 3月, In: Hypertension. 27, 3 II, p. 833-837 5 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Regulation of endothelial production of C-type natriuretic peptide in coculture with vascular smooth muscle cells: Role of the vascular natriuretic peptide system in vascular growth inhibition

Komatsu, Y., Itoh, H., Suga, S. I., Ogawa, Y., Hama, N., Kishimoto, I., Nakagawa, O., Igaki, T., Doi, K., Yoshimasa, T. & Nakao, K., 1996 4月, In: Circulation research. 78, 4, p. 606-614 9 p.

研究成果: Article › 査読

85 被引用数 (Scopus)

Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells

Komatsu, Y., Itoh, H., Suga, S. I., Igaki, T., Ogawa, Y., Kishimoto, I., Nakagawa, O., Yoshimasa, T. & Nakao, K., 1996 6月 7, In: Journal of hypertension. 14, 5, p. 585-592 8 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Roles of natriuretic peptides in heart failure

Nakao, K., Saito, Y., Itoh, H., Ogawa, Y., Nakagawa, O., Harada, M., Masuda, I. & Yoshimasa, T., 1996, In: Journal of Cardiac Failure. 2, SUPPL. 1, p. S129-S133

研究成果: Article › 査読

3 被引用数 (Scopus)

The RET proto-oncogene in sporadic pheochromocytomas

Takaya, K., Yoshimasa, T., Arai, H., Tamura, N., Miyamoto, Y., Itoh, H. & Nakao, K., 1996 6月, In: Internal Medicine. 35, 6, p. 449-452 4 p.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Two cardiac natriuretic peptide genes (Atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes

Tamura, N., Ogawa, Y., Yasoda, A., Itoh, H., Saito, Y. & Nakao, K., 1996 8月, In: Journal of Molecular and Cellular Cardiology. 28, 8, p. 1811-1815 5 p.

研究成果: Article › 査読

77 被引用数 (Scopus)

Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy

Matsumoto, T., Sagawa, N., Mukoyama, M., Tanaka, I., Itoh, H., Goto, M., Itoh, H., Horiuchi, M., Dzau, V. J., Mori, T. & Nakao, K., 1996 12月 19, In: Journal of Clinical Endocrinology and Metabolism. 81, 12, p. 4366-4372 7 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion

Doi, K., Itoh, H., Komatsu, Y., Igaki, T., Chun, T. H., Takaya, K., Yamashita, J., Inoue, M., Yoshimasa, T. & Nakao, K., 1996 3月, In: Hypertension. 27, 3 II, p. 811-815 5 p.

研究成果: Article › 査読

45 被引用数 (Scopus)

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伊藤裕