Hiroshi Nishihara

2013

Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors

Nanjo, S., Yamada, T., Nishihara, H., Takeuchi, S., Sano, T., Nakagawa, T., Ishikawa, D., Zhao, L., Ebi, H., Yasumoto, K., Matsumoto, K. & Yano, S., 2013 12月 26, In: PloS one. 8, 12, 0084700.

研究成果: Article › 査読

Open Access

44 被引用数 (Scopus)

Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier

Miura, Y., Takenaka, T., Toh, K., Wu, S., Nishihara, H., Kano, M. R., Ino, Y., Nomoto, T., Matsumoto, Y., Koyama, H., Cabral, H., Nishiyama, N. & Kataoka, K., 2013 10月 22, In: ACS Nano. 7, 10, p. 8583-8592 10 p.

研究成果: Article › 査読

355 被引用数 (Scopus)

Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET

Mitamura, T., Watari, H., Wang, L., Kanno, H., Hassan, M. K., Miyazaki, M., Katoh, Y., Kimura, T., Tanino, M., Nishihara, H., Tanaka, S. & Sakuragi, N., 2013, In: Oncogenesis. 2, e40.

研究成果: Article › 査読

Open Access

104 被引用数 (Scopus)

Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma

Kanno, H., Nishihara, H., Wang, L., Yuzawa, S., Kobayashi, H., Tsuda, M., Kimura, T., Tanino, M., Terasaka, S. & Tanaka, S., 2013 7月, In: Neuro-oncology. 15, 7, p. 853-864 12 p.

研究成果: Article › 査読

Open Access

18 被引用数 (Scopus)

Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine

Kato, Y., Nishihara, H., Yuzawa, S., Mohri, H., Kanno, H., Hatanaka, Y., Kimura, T., Tanino, M. & Tanaka, S., 2013 7月, In: Brain tumor pathology. 30, 3, p. 167-174 8 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma

Kohsaka, S., Takahashi, K., Wang, L., Tanino, M., Kimura, T., Nishihara, H. & Tanaka, S., 2013 4月 30, In: Cancer Letters. 331, 1, p. 68-75 8 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

Intracranial mass-forming lesion associated with dural thickening and hypophysitis

Kanno, H., Tanino, M., Watanabe, K., Ozaki, Y., Itoh, T., Kimura, T., Nishihara, H., Itoh, T., Narita, T., Nagashima, K. & Tanaka, S., 2013 4月, In: Neuropathology. 33, 2, p. 213-216 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL

Miyazaki, M., Nishihara, H., Hasegawa, H., Tashiro, M., Wang, L., Kimura, T., Tanino, M., Tsuda, M. & Tanaka, S., 2013 11月 29, In: Biochemical and Biophysical Research Communications. 441, 4, p. 953-957 5 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Pathophysiological characteristics of melanoma in-transit metastasis in a lymphedema mouse model

Oashi, K., Furukawa, H., Nishihara, H., Ozaki, M., Oyama, A., Funayama, E., Hayashi, T., Kuge, Y. & Yamamoto, Y., 2013 2月, In: Journal of Investigative Dermatology. 133, 2, p. 537-544 8 p.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Relationship between Methyl CpG binding protein 2 and JC viral proteins

Takahashi, K., Orba, Y., Kimura, T., Wang, L., Kohsaka, S., Tsuda, M., Tanino, M., Nishihara, H., Nagashima, K., Sawa, H. & Tanaka, S., 2013, In: Japanese Journal of Infectious Diseases. 66, 2, p. 126-132 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

2012

A case of central nervous system lymphomatoid granulomatosis successfully treated with corticosteroids

Shimada, S., Ueno, H., Yamasaki, F., Sugiyama, K., Yasutomi, H., Sekine, M., Ohshita, T., Kurashige, T., Nakamura, T., Nishihara, H., Yamawaki, T., Kurisu, K. & Matsumoto, M., 2012 1月 1, In: Brain and Nerve. 64, 1, p. 85-87 3 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

A case of clear cell variant of solid-pseudopapillary tumor of the pancreas in an adult male patient

Tanino, M., Kohsaka, S., Kimura, T., Tabu, K., Nishihara, H., Sawa, H., Kawami, H., Kamada, H., Shimizu, M. & Tanaka, S., 2012 4月, In: Annals of Diagnostic Pathology. 16, 2, p. 134-140 7 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma

Kimura, T., Wang, L., Tabu, K., Nishihara, H., Mashita, Y., Kikuchi, N., Tanino, M., Hiraga, H. & Tanaka, S., 2012 6月, In: Cancer Investigation. 30, 5, p. 390-397 8 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion

Yanagi, H., Wang, L., Nishihara, H., Kimura, T., Tanino, M., Yanagi, T., Fukuda, S. & Tanaka, S., 2012 2月 3, In: Biochemical and Biophysical Research Communications. 418, 1, p. 104-109 6 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells

Muraki, C., Ohga, N., Hida, Y., Nishihara, H., Kato, Y., Tsuchiya, K., Matsuda, K., Totsuka, Y., Shindoh, M. & Hida, K., 2012 1月 11, In: International Journal of Cancer. 130, 1, p. 59-70 12 p.

研究成果: Article › 査読

Open Access

49 被引用数 (Scopus)

Engineering fibrotic tissue in pancreatic cancer: A novel three-dimensional model to investigate nanoparticle delivery

Hosoya, H., Kadowaki, K., Matsusaki, M., Cabral, H., Nishihara, H., Ijichi, H., Koike, K., Kataoka, K., Miyazono, K., Akashi, M. & Kano, M. R., 2012 3月 2, In: Biochemical and Biophysical Research Communications. 419, 1, p. 32-37 6 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Expression of O⁶-methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors

Kanno, H., Nishihara, H., Oikawa, M., Ozaki, Y., Murata, J., Sawamura, Y., Kato, M., Kubota, K., Tanino, M., Kimura, T., Nagashima, K., Itoh, T. & Tanaka, S., 2012 12月, In: Neuropathology. 32, 6, p. 647-653 7 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer

Kawamata, F., Kamachi, H., Einama, T., Homma, S., Tahara, M., Miyazaki, M., Tanaka, S., Kamiyama, T., Nishihara, H., Taketomi, A. & Todo, S., 2012 12月, In: International journal of oncology. 41, 6, p. 2109-2118 10 p.

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer

Einama, T., Homma, S., Kamachi, H., Kawamata, F., Takahashi, K., Takahashi, N., Taniguchi, M., Kamiyama, T., Furukawa, H., Matsuno, Y., Tanaka, S., Nishihara, H., Taketomi, A. & Todo, S., 2012 6月 26, In: British Journal of Cancer. 107, 1, p. 137-142 6 p.

研究成果: Article › 査読

Open Access

49 被引用数 (Scopus)

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

Yuzawa, S., Kano, M. R., Einama, T. & Nishihara, H., 2012 12月, In: Medical Oncology. 29, 4, p. 2824-2830 7 p.

研究成果: Article › 査読

52 被引用数 (Scopus)

Pericyte-coverage of human tumor vasculature and nanoparticle permeability

Zhang, L., Nishihara, H. & Kano, M. R., 2012 5月, In: Biological and Pharmaceutical Bulletin. 35, 5, p. 761-766 6 p.

研究成果: Article › 査読

Open Access

35 被引用数 (Scopus)

Prognostic implication of histological oligodendroglial tumor component: Clinicopathological analysis of 111 cases of malignant gliomas

Kanno, H., Nishihara, H., Narita, T., Yamaguchi, S., Kobayashi, H., Tanino, M., Kimura, T., Terasaka, S. & Tanaka, S., 2012 7月 24, In: PloS one. 7, 7, e41669.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression

Kohsaka, S., Wang, L., Yachi, K., Mahabir, R., Narita, T., Itoh, T., Tanino, M., Kimura, T., Nishihara, H. & Tanaka, S., 2012 6月, In: Molecular cancer therapeutics. 11, 6, p. 1289-1299 11 p.

研究成果: Article › 査読

Open Access

132 被引用数 (Scopus)

The impact of extent of resection and histological subtype on the outcome of adult patients with high-grade gliomas

Yamaguchi, S., Kobayashi, H., Terasaka, S., Ishii, N., Ikeda, J., Kanno, H., Nishihara, H., Tanaka, S. & Houkin, K., 2012 4月, In: Japanese journal of clinical oncology. 42, 4, p. 270-277 8 p., hys016.

研究成果: Article › 査読

Open Access

30 被引用数 (Scopus)

2011

A case of atypical teratoid/rhabdoid tumor in an adult, with long survival

Takahashi, K., Nishihara, H., Katoh, M., Yoshinaga, T., Mahabir, R., Kanno, H., Kimura, T., Tanino, M., Ikeda, J., Sawamura, Y., Nagashima, K. & Tanaka, S., 2011 2月, In: Brain tumor pathology. 28, 1, p. 71-76 6 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

A case of lymphoplasmacyte-rich meningioma of the jugular foramen

Kanno, H., Nishihara, H., Hara, K., Ozaki, Y., Itoh, T., Kimura, T., Tanino, M. & Tanaka, S., 2011 10月, In: Brain tumor pathology. 28, 4, p. 341-345 5 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

A population of BJ fibroblasts escaped from Ras-induced senescence susceptible to transformation

Kohsaka, S., Sasai, K., Takahashi, K., Akagi, T., Tanino, M., Kimura, T., Nishihara, H. & Tanaka, S., 2011 7月 15, In: Biochemical and Biophysical Research Communications. 410, 4, p. 878-884 7 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma

Einama, T., Kamachi, H., Nishihara, H., Homma, S., Kanno, H., Takahashi, K., Sasaki, A., Tahara, M., Okada, K., Muraoka, S., Kamiyama, T., Matsuno, Y., Ozaki, M. & Todo, S., 2011 11月, In: Pancreas. 40, 8, p. 1276-1282 7 p.

研究成果: Article › 査読

70 被引用数 (Scopus)

Prenatal diagnosis of short-rib Polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography

Yamada, T., Nishimura, G., Nishida, K., Sawai, H., Omatsu, T., Kimura, T., Nishihara, H., Shono, R., Shimada, S., Morikawa, M., Mizushima, M., Yamada, T., Cho, K., Tanaka, S., Shirato, H. & Minakami, H., 2011 2月, In: Journal of Obstetrics and Gynaecology Research. 37, 2, p. 151-155 5 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

2010

Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks

Tabu, K., Kimura, T., Sasai, K., Wang, L., Bizen, N., Nishihara, H., Taga, T. & Tanaka, S., 2010 2月 19, In: Molecular Cancer. 9, 39.

研究成果: Article › 査読

Open Access

61 被引用数 (Scopus)

Clinicopathologic application of lectin histochemistry: Bisecting GlcNAc in glioblastoma

Aoyanagi, E., Sasai, K., Nodagashira, M., Wang, L., Nishihara, H., Ihara, H., Ikeda, Y. & Tanaka, S., 2010 12月, In: Applied Immunohistochemistry and Molecular Morphology. 18, 6, p. 518-525 8 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma

Wang, L., Nishihara, H., Kimura, T., Kato, Y., Tanino, M., Nishio, M., Obara, M., Endo, T., Koike, T. & Tanaka, S., 2010 4月, In: Biochemical and Biophysical Research Communications. 395, 1, p. 111-115 5 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12-deficient harlequin ichthyosis model mice

Yanagi, T., Akiyama, M., Nishihara, H., Ishikawa, J., Sakai, K., Miyamura, Y., Naoe, A., Kitahara, T., Tanaka, S. & Shimizu, H., 2010 7月, In: American Journal of Pathology. 177, 1, p. 106-118 13 p.

研究成果: Article › 査読

Open Access

40 被引用数 (Scopus)

Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome

Takiyama, A., Wang, L., Tanino, M., Kimura, T., Kawagishi, N., Kunieda, Y., Katano, H., Nakajima, N., Hasegawa, H., Takagi, T., Nishihara, H., Sata, T. & Tanaka, S., 2010, In: Japanese Journal of Infectious Diseases. 63, 1, p. 72-74 3 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Treating "intractable" tumours using nanoDDS and TGF-beta inhibitor

Kano, M. R., Nishihara, H., Kataoka, K. & Miyazono, K., 2010 11月, In: European Cells and Materials. 20, SUPPL.3, p. 134 1 p.

研究成果: Article › 査読

2009

A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings

Nishihara, H., Nakasato, M., Sawa, H., Murakami, H., Yamamoto, D., Moriyama, K., Kato, N., Hashimoto, I., Kamada, H. & Tanaka, S., 2009, In: Journal of Neuro-Oncology. 93, 2, p. 275-278 4 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Colonic metastasis from primary carcinoma of the lung: Report of a case and review of Japanese literature

Ono, H., Okabe, M., Kimura, T., Kawakami, M., Nakamura, K., Danjo, Y., Takasugi, H. & Nishihara, H., 2009 4月, In: Clinical journal of gastroenterology. 2, 2, p. 89-95 7 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration

Watanabe, T., Tsuda, M., Makino, Y., Konstantinou, T., Nishihara, H., Majima, T., Minami, A., Feller, S. M. & Tanaka, S., 2009 5月, In: Cell Research. 19, 5, p. 638-650 13 p.

研究成果: Article › 査読

Open Access

29 被引用数 (Scopus)

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

Kimura, T., Sakai, M., Tabu, K., Wang, L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S. & Nakayama, K. I., 2009 6月, In: Laboratory Investigation. 89, 6, p. 645-656 12 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2008

A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult

Nishihara, H., Ozaki, Y., Ito, T., Yoshinaga, T., Tabu, K., Tanino, M., Nagashima, K. & Tanaka, S., 2008, In: Brain tumor pathology. 25, 1, p. 45-49 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: Relationship between immunohistochemistry and methylation analysis

Sasai, K., Nodagashira, M., Nishihara, H., Aoyanagi, E., Wang, L., Katoh, M., Murata, J., Ozaki, Y., Ito, T., Fujimoto, S., Kaneko, S., Nagashima, K. & Tanaka, S., 2008 8月, In: American Journal of Surgical Pathology. 32, 8, p. 1220-1227 8 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements

Takiyama, A., Nishihara, H., Tateishi, U., Kimura, T., Lei, W., Marukawa, K., Itoh, T., Hashino, S., Nagashima, K. & Tanaka, S., 2008 12月, In: Neuropathology. 28, 6, p. 640-644 5 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects

Yanagi, T., Akiyama, M., Nishihara, H., Sakai, K., Nishie, W., Tanaka, S. & Shimizu, H., 2008, In: Human molecular genetics. 17, 19, p. 3075-3083 9 p.

研究成果: Article › 査読

Open Access

58 被引用数 (Scopus)

Hypopharyngeal squamous cell carcinoma producing both granulocyte colony-stimulating factor and parathyroid hormone-related protein

Tamura, K., Yoshinaga, T., Tanino, M., Kimura, T., Yamada, N., Nishimura, M., Fukuda, S., Nishihara, H., Shindoh, M. & Tanaka, S., 2008 10月, In: Pathology international. 58, 10, p. 652-656 5 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Promoter hypomethylation regulates CD133 expression in human gliomas

Tabu, K., Sasai, K., Kimura, T., Wang, L., Aoyanagi, E., Kohsaka, S., Tanino, M., Nishihara, H. & Tanaka, S., 2008 10月, In: Cell Research. 18, 10, p. 1037-1046 10 p.

研究成果: Article › 査読

Open Access

89 被引用数 (Scopus)

2007

Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis

Nishihara, H., Tateishi, U., Itoh, T., Nagashima, K. & Tanaka, S., 2007 10月, In: Neuropathology. 27, 5, p. 413-418 6 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4

Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H. & Tanaka, S., 2007 11月 3, In: Biochemical and Biophysical Research Communications. 362, 4, p. 976-981 6 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Type I interferon prolongs cell cycle progression via p21 ^WAF1/CIP1 induction in human colon cancer cells

Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S. & Todo, S., 2007 9月, In: International journal of oncology. 31, 3, p. 613-620 8 p.

研究成果: Article › 査読

Open Access

29 被引用数 (Scopus)

2006

A case report of solitary trichodiscoma

Fujioka, H., Sekido, M., Kimura, T. & Nishihara, H., 2006 9月, In: Japanese Journal of Plastic and Reconstructive Surgery. 49, 9, p. 1005-1008 4 p.

研究成果: Article › 査読

2004

Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid

Tsuda, M., Makino, Y., Iwahara, T., Nishihara, H., Sawa, H., Nagashima, K., Hanafusa, H. & Tanaka, S., 2004 11月 5, In: Journal of Biological Chemistry. 279, 45, p. 46843-46850 8 p.

研究成果: Article › 査読

Open Access

24 被引用数 (Scopus)

西原 広史

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西原広史