年別の研究成果
年別の研究成果
検索結果
-
2021
Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants
Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 6, In: Drug Metabolism And Pharmacokinetics. 38, 100384.研究成果: Article › 査読
1 被引用数 (Scopus) -
Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors
Sato, R., Akiyoshi, T., Morita, T., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A. & Ohtani, H., 2021 12, In: Drug Metabolism And Pharmacokinetics. 41, 100416.研究成果: Article › 査読
-
Estimation of absolute oral bioavailability without performing an intravenous clinical study
Ohtani, H., Iwata, R., Imaoka, A. & Akiyoshi, T., 2021 6, In: Drug Metabolism And Pharmacokinetics. 38, 100392.研究成果: Article › 査読
-
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report
Hibino, H., Makino, Y., Sakiyama, N., Makihara-Ando, R., Hashimoto, H., Akiyoshi, T., Imaoka, A., Fujiwara, Y., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2021 4, In: International journal of clinical pharmacology and therapeutics. 59, 4, p. 328-332 5 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach
Koinuma, K., Tsuchitani, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2021 3, In: International journal of clinical pharmacology and therapeutics. 59, 3, p. 231-238 8 p.研究成果: Article › 査読
-
2020
Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides
Morita, T., Akiyoshi, T., Sato, R., Uekusa, Y., Katayama, K., Yajima, K., Imaoka, A., Sugimoto, Y., Kiuchi, F. & Ohtani, H., 2020 12 2, In: Journal of agricultural and food chemistry. 68, 48, p. 14182-14191 10 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs
Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1529-1536 8 p.研究成果: Article › 査読
-
pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2
Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 4, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Profile of the inhibitory effects of gefitinib in CYP2D6 variants in vitro
Semba, Y., Akiyoshi, T., Hibino, H., Imaoka, A. & Ohtani, H., 2020 10, In: International journal of clinical pharmacology and therapeutics. 58, 10, p. 539-542 4 p.研究成果: Article › 査読
-
2019
Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats
Ogata, Y., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 1 1, In: Drug Metabolism And Pharmacokinetics.研究成果: Article › 査読
-
Inhibitory kinetics of fruit components on CYP2C19 activity
Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 6, In: Drug Metabolism And Pharmacokinetics. 34, 3, p. 181-186 6 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate
Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 11 1, In: Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats
Imaoka, A., Seki, K., Akiyoshi, T. & Ohtani, H., 2019 2, In: Drug Metabolism And Pharmacokinetics. 34, 1, p. 108-110 3 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2018
5-Fluororacil–Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate
Tsujii, K., Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2018 5, In: Journal of Pharmaceutical Sciences. 107, 5, p. 1430-1433 4 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2017
5-Fluorouracil treatment alters the expression of intestinal transporters in rats
Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.研究成果: Article › 査読
5 被引用数 (Scopus) -
Analysis of the mechanism of prolonged persistence of drug interaction between terbinafine and amitriptyline or nortriptyline
Mikami, A., Hori, S., Ohtani, H. & Sawada, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 7, p. 1010-1020 11 p.研究成果: Article › 査読
-
Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan
Ohtani, H., Mitsui, R., Akiyoshi, T., Imaoka, A., Abe, Y., Kanke, M., Nakamura, T., Foster, P. & Mochizuki, M., 2017 5, In: Currents in Pharmacy Teaching and Learning. 9, 3, p. 452-459 8 p.研究成果: Article › 査読
-
Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice
Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In: Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.研究成果: Article › 査読
-
Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin
Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 10, In: Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2016
In silico evaluation of warfarin–bucolome therapy
Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In: Biopharmaceutics and Drug Disposition. p. 233-242 10 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
2015
Current status of illegal trade in pharmaceutical products on internet auction sites in japan and responses of site administrators to such transactions
Ohtani, H., Imaoka, A. & Akiyoshi, T., 2015 3 1, In: Yakugaku Zasshi. 135, 3, p. 529-534 6 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6
Akiyoshi, T., Ishiuchi, M., Imaoka, A. & Ohtani, H., 2015 8 1, In: Drug Metabolism And Pharmacokinetics. 30, 4, p. 321-324 4 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2014
Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption
Imaoka, A., Hattori, M., Akiyoshi, T. & Ohtani, H., 2014, In: Drug Metabolism And Pharmacokinetics. 29, 5, p. 414-418 5 p.研究成果: Article › 査読
4 被引用数 (Scopus) -
Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice
Kogure, N., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2014 10 1, In: Biopharmaceutics and Drug Disposition. 35, 7, p. 373-381 9 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2013
Characterization of transplacental transfer of paroxetine in perfused human placenta: Development of a pharmacokinetic model to evaluate tapered dosing
Nagai, M., Ohtani, H., Satoh, H., Matsuoka, S., Hori, S., Fujii, T., Taketani, Y. & Sawada, Y., 2013 12, In: Drug Metabolism and Disposition. 41, 12, p. 2124-2132 9 p.研究成果: Article › 査読
7 被引用数 (Scopus) -
Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population
Akiyoshi, T., Shimomura, Y., Masuda, S., Okamoto, Y., Hiura, S., Kato, H., Asayama, T. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 446-450 5 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants
Akiyoshi, T., Ito, M., Murase, S., Miyazaki, M., Peter Guengerich, F., Nakamura, K., Yamamoto, K. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 411-415 5 p.研究成果: Article › 査読
19 被引用数 (Scopus) -
Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine
Mikami, A., Ohtani, H., Hori, S. & Sawada, Y., 2013 5 1, In: International Journal of Clinical Pharmacology and Therapeutics. 51, 5, p. 374-382 9 p.研究成果: Article › 査読
8 被引用数 (Scopus) -
2012
Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies
Shintaku, K., Hori, S., Satoh, H., Tsukimori, K., Nakano, H., Fujii, T., Taketani, Y., Ohtani, H. & Sawada, Y., 2012 2, In: British journal of clinical pharmacology. 73, 2, p. 248-256 9 p.研究成果: Article › 査読
11 被引用数 (Scopus) -
2011
Bottom-up modeling and simulation of tacrolimus clearance: Prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power
Ohtani, H., Barter, Z., Minematsu, T., Makuuchi, M., Sawada, Y. & Rostami-Hodjegan, A., 2011 12, In: Biopharmaceutics and Drug Disposition. 32, 9, p. 498-506 9 p.研究成果: Article › 査読
6 被引用数 (Scopus) -
Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants
Akiyoshi, T., Saito, T., Murase, S., Miyazaki, M., Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2011 4, In: Drug Metabolism and Disposition. 39, 4, p. 724-728 5 p.研究成果: Article › 査読
21 被引用数 (Scopus) -
Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile
Watanabe, T., Satoh, H., Hori, S., Miki, A., Ohtani, H. & Sawada, Y., 2011, In: Yakugaku Zasshi. 131, 10, p. 1483-1492 10 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
2010
Drug interactions
Ohtani, H., 2010 7, In: Japanese Journal of Clinical Pharmacology and Therapeutics. 41, 4, p. 159-165 7 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids
Tamaki, H., Satoh, H., Hori, S., Ohtani, H. & Sawada, Y., 2010, In: Drug Metabolism And Pharmacokinetics. 25, 2, p. 170-179 10 p.研究成果: Article › 査読
43 被引用数 (Scopus) -
Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam
Toi, A., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2010 6, In: International journal of clinical pharmacology and therapeutics. 48, 6, p. 356-366 11 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Saturable binding of finasteride to steroid 5a-reductase as determinant of nonlinear pharmacokinetics
Suzuki, R., Satoh, H., Ohtani, H., Hori, S. & Yasufumi, S., 2010 1 1, In: Drug Metabolism And Pharmacokinetics. 25, 2, p. 208-213 6 p.研究成果: Article › 査読
9 被引用数 (Scopus) -
2009
Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
Suzuki, K., Doki, K., Homma, M., Tamaki, H., Hori, S., Ohtani, H., Sawada, Y. & Kohda, Y., 2009 1, In: British journal of clinical pharmacology. 67, 1, p. 44-49 6 p.研究成果: Article › 査読
117 被引用数 (Scopus) -
Development and evaluation of an internet-based educational system about herbs and dietary supplements through periodical distribution of information to health professionals
Asahina, Y., Hori, S., Ohtani, H. & Sawada, Y., 2009 6, In: Yakugaku Zasshi. 129, 6, p. 773-780 8 p.研究成果: Article › 査読
4 被引用数 (Scopus) -
Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease
Sugahara, H., Maebara, C., Ohtani, H., Handa, M., Ando, K., Mine, K., Kubo, C., Ieiri, I. & Sawada, Y., 2009 7, In: European Journal of Clinical Pharmacology. 65, 7, p. 699-704 6 p.研究成果: Article › 査読
11 被引用数 (Scopus) -
Inhibitory effects of herbal extracts on the activity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3)
Nagai, M., Fukamachi, T., Tsujimoto, M., Ogura, K., Hiratsuka, A., Ohtani, H., Hori, S. & Sawada, Y., 2009 1, In: Biological and Pharmaceutical Bulletin. 32, 1, p. 105-109 5 p.研究成果: Article › 査読
14 被引用数 (Scopus) -
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents
Kim, J., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2009, In: Drug Metabolism And Pharmacokinetics. 24, 2, p. 167-174 8 p.研究成果: Article › 査読
18 被引用数 (Scopus) -
Transplacental pharmacokinetics of diclofenac in perfused human placenta.
Shintaku, K., Hori, S., Tsujimoto, M., Nagata, H., Satoh, S., Tsukimori, K., Nakano, H., Fujii, T., Taketani, Y., Ohtani, H. & Sawada, Y., 2009 5, In: Drug metabolism and disposition: the biological fate of chemicals. 37, 5, p. 962-968 7 p.研究成果: Article › 査読
13 被引用数 (Scopus) -
2008
A questionnaire survey of patients comparing the usability of brand-name and generic ketoprofen tapes
Saita, A., Inoue, A., Ishibashi, H., Tominaga, K., Hori, S., Miki, A., Ohtani, H., Ono, N. & Sawada, Y., 2008 5, In: Yakugaku Zasshi. 128, 5, p. 795-803 9 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Bitterness of the mixture of clarithromycin dry syrup and carbocisteine preparation-difference between branded and generic drugs
Matsuo, R., Tanaka, S., Kanou, M., Isono, K., Tanaka, Y., Taura, T., Asada, Y., Akamine, Y., Sawai, H., Kinosita, M., Sudou, T., Kunoki, Y., Miki, A., Hori, S., Satoh, H., Ohtani, H. & Sawada, Y., 2008 3, In: Yakugaku Zasshi. 128, 3, p. 479-485 7 p.研究成果: Article › 査読
2 被引用数 (Scopus) -
Effects of uremic serum and uremic toxins on hepatic uptake of digoxin
Tsujimoto, M., Kinoshita, Y., Hirata, S., Otagiri, M., Ohtani, H. & Sawada, Y., 2008 10, In: Therapeutic Drug Monitoring. 30, 5, p. 576-582 7 p.研究成果: Article › 査読
29 被引用数 (Scopus) -
Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea
Tanaka, M., Kobayashi, D., Murakami, Y., Ozaki, N., Suzuki, T., Iwata, N., Haraguchi, K., Ieiri, I., Kinukawa, N., Hosoi, M., Ohtani, H., Sawada, Y. & Mine, K., 2008 3, In: International Journal of Neuropsychopharmacology. 11, 2, p. 261-267 7 p.研究成果: Article › 査読
54 被引用数 (Scopus) -
Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure
Tsujimoto, M., Dan, Y., Hirata, S., Ohtani, H. & Sawada, Y., 2008, In: Drug Metabolism And Pharmacokinetics. 23, 6, p. 406-411 6 p.研究成果: Article › 査読
20 被引用数 (Scopus) -
The first case of phenytoin intoxication associated with the concomitant use of phenytoin and TS-1, a combination preparation of tegafur, gimeracil, and oteracil potassium
Tsuda, A., Fujiyama, J., Miki, A., Hori, S., Ohtani, H. & Sawada, Y., 2008 8 1, In: Cancer Chemotherapy and Pharmacology. 62, 3, p. 427-432 6 p.研究成果: Article › 査読
10 被引用数 (Scopus) -
2007
Antacid interaction with new quinolones: Dose regimen recommendations based on pharmacokinetic, model of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations
Miyata, K., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2007 1, In: International journal of clinical pharmacology and therapeutics. 45, 1, p. 63-70 8 p.研究成果: Article › 査読
11 被引用数 (Scopus) -
Assessment of α1-adrenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory
Ito, K., Ohtani, H. & Sawada, Y., 2007 4, In: British journal of clinical pharmacology. 63, 4, p. 394-403 10 p.研究成果: Article › 査読
6 被引用数 (Scopus)