Hisakazu Ohtani

2022

Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity

Akiyoshi, T., Uchiyama, M., Inada, R., Imaoka, A. & Ohtani, H., 2022 2月, In: Drug Metabolism And Pharmacokinetics. 42, 100429.

研究成果: Article › 査読

1 被引用数 (Scopus)

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants

Araki, N., Morita, T., Akiyoshi, T., Kataoka, H., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 10月, In: Drug Metabolism And Pharmacokinetics. 46, 100464.

研究成果: Article › 査読

Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant

Hibino, H., Sakiyama, N., Makino, Y., Makihara-Ando, R., Horinouchi, H., Fujiwara, Y., Kanda, S., Goto, Y., Yoshida, T., Okuma, Y., Shinno, Y., Murakami, S., Hashimoto, H., Akiyoshi, T., Imaoka, A., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2022 4月, In: European Journal of Clinical Pharmacology. 78, 4, p. 613-621 9 p.

研究成果: Article › 査読

Inhibitory Effects of Cranberry Juice and Its Components on Intestinal OATP1A2 and OATP2B1: Identification of Avicularin as a Novel Inhibitor

Morita, T., Akiyoshi, T., Tsuchitani, T., Kataoka, H., Araki, N., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 3月 16, In: Journal of agricultural and food chemistry. 70, 10, p. 3310-3320 11 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2022 5月 1, In: International journal of clinical pharmacology and therapeutics. 60, 5, p. 217-224 8 p.

研究成果: Article › 査読

2021

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants

Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100384.

研究成果: Article › 査読

2 被引用数 (Scopus)

Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2021 12月, In: Journal of Pharmaceutical Health Care and Sciences. 7, 1, 24.

研究成果: Article › 査読

Open Access

Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors

Sato, R., Akiyoshi, T., Morita, T., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A. & Ohtani, H., 2021 12月, In: Drug Metabolism And Pharmacokinetics. 41, 100416.

研究成果: Article › 査読

2 被引用数 (Scopus)

Estimation of absolute oral bioavailability without performing an intravenous clinical study

Ohtani, H., Iwata, R., Imaoka, A. & Akiyoshi, T., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100392.

研究成果: Article › 査読

Open Access

Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report

Hibino, H., Makino, Y., Sakiyama, N., Makihara-Ando, R., Hashimoto, H., Akiyoshi, T., Imaoka, A., Fujiwara, Y., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2021 4月, In: International journal of clinical pharmacology and therapeutics. 59, 4, p. 328-332 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach

Koinuma, K., Tsuchitani, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2021 3月, In: International journal of clinical pharmacology and therapeutics. 59, 3, p. 231-238 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Time-dependent inhibition of CYP3A4- mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

Akiyoshi, T., Naitou, R., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 12月, In: International journal of clinical pharmacology and therapeutics. 59, 12, p. 745-782 38 p.

研究成果: Article › 査読

2020

Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides

Morita, T., Akiyoshi, T., Sato, R., Uekusa, Y., Katayama, K., Yajima, K., Imaoka, A., Sugimoto, Y., Kiuchi, F. & Ohtani, H., 2020 12月 2, In: Journal of agricultural and food chemistry. 68, 48, p. 14182-14191 10 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs

Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11月 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1529-1536 8 p.

研究成果: Article › 査読

pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2

Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Profile of the inhibitory effects of gefitinib in CYP2D6 variants in vitro

Semba, Y., Akiyoshi, T., Hibino, H., Imaoka, A. & Ohtani, H., 2020 10月, In: International journal of clinical pharmacology and therapeutics. 58, 10, p. 539-542 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

2019

Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats

Ogata, Y., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 1月 1, In: Drug Metabolism And Pharmacokinetics.

研究成果: Article › 査読

1 被引用数 (Scopus)

Inhibitory kinetics of fruit components on CYP2C19 activity

Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 6月, In: Drug Metabolism And Pharmacokinetics. 34, 3, p. 181-186 6 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate

Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 11月 1, In: Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats

Imaoka, A., Seki, K., Akiyoshi, T. & Ohtani, H., 2019 2月, In: Drug Metabolism And Pharmacokinetics. 34, 1, p. 108-110 3 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2018

5-Fluororacil–Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate

Tsujii, K., Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2018 5月, In: Journal of Pharmaceutical Sciences. 107, 5, p. 1430-1433 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2017

5-Fluorouracil treatment alters the expression of intestinal transporters in rats

Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12月, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Analysis of the mechanism of prolonged persistence of drug interaction between terbinafine and amitriptyline or nortriptyline

Mikami, A., Hori, S., Ohtani, H. & Sawada, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 7, p. 1010-1020 11 p.

研究成果: Article › 査読

Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan

Ohtani, H., Mitsui, R., Akiyoshi, T., Imaoka, A., Abe, Y., Kanke, M., Nakamura, T., Foster, P. & Mochizuki, M., 2017 5月, In: Currents in Pharmacy Teaching and Learning. 9, 3, p. 452-459 8 p.

研究成果: Article › 査読

Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice

Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In: Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.

研究成果: Article › 査読

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 10月, In: Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2016

In silico evaluation of warfarin–bucolome therapy

Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In: Biopharmaceutics and Drug Disposition. p. 233-242 10 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2015

Current status of illegal trade in pharmaceutical products on internet auction sites in japan and responses of site administrators to such transactions

Ohtani, H., Imaoka, A. & Akiyoshi, T., 2015 3月 1, In: Yakugaku Zasshi. 135, 3, p. 529-534 6 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6

Akiyoshi, T., Ishiuchi, M., Imaoka, A. & Ohtani, H., 2015 8月 1, In: Drug Metabolism And Pharmacokinetics. 30, 4, p. 321-324 4 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2014

Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption

Imaoka, A., Hattori, M., Akiyoshi, T. & Ohtani, H., 2014, In: Drug Metabolism And Pharmacokinetics. 29, 5, p. 414-418 5 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice

Kogure, N., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2014 10月 1, In: Biopharmaceutics and Drug Disposition. 35, 7, p. 373-381 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2013

Characterization of transplacental transfer of paroxetine in perfused human placenta: Development of a pharmacokinetic model to evaluate tapered dosing

Nagai, M., Ohtani, H., Satoh, H., Matsuoka, S., Hori, S., Fujii, T., Taketani, Y. & Sawada, Y., 2013 12月, In: Drug Metabolism and Disposition. 41, 12, p. 2124-2132 9 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population

Akiyoshi, T., Shimomura, Y., Masuda, S., Okamoto, Y., Hiura, S., Kato, H., Asayama, T. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 446-450 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants

Akiyoshi, T., Ito, M., Murase, S., Miyazaki, M., Peter Guengerich, F., Nakamura, K., Yamamoto, K. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 411-415 5 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine

Mikami, A., Ohtani, H., Hori, S. & Sawada, Y., 2013 5月 1, In: International Journal of Clinical Pharmacology and Therapeutics. 51, 5, p. 374-382 9 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2012

Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies

Shintaku, K., Hori, S., Satoh, H., Tsukimori, K., Nakano, H., Fujii, T., Taketani, Y., Ohtani, H. & Sawada, Y., 2012 2月, In: British journal of clinical pharmacology. 73, 2, p. 248-256 9 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

2011

Bottom-up modeling and simulation of tacrolimus clearance: Prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power

Ohtani, H., Barter, Z., Minematsu, T., Makuuchi, M., Sawada, Y. & Rostami-Hodjegan, A., 2011 12月, In: Biopharmaceutics and Drug Disposition. 32, 9, p. 498-506 9 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

Akiyoshi, T., Saito, T., Murase, S., Miyazaki, M., Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2011 4月, In: Drug Metabolism and Disposition. 39, 4, p. 724-728 5 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

Model analysis of tulobuterol patch formulations to explain the influence of drug release rate and transdermal transfer rate on the plasma concentration profile

Watanabe, T., Satoh, H., Hori, S., Miki, A., Ohtani, H. & Sawada, Y., 2011, In: Yakugaku Zasshi. 131, 10, p. 1483-1492 10 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2010

Drug interactions

Ohtani, H., 2010 7月, In: Japanese Journal of Clinical Pharmacology and Therapeutics. 41, 4, p. 159-165 7 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids

Tamaki, H., Satoh, H., Hori, S., Ohtani, H. & Sawada, Y., 2010, In: Drug Metabolism And Pharmacokinetics. 25, 2, p. 170-179 10 p.

研究成果: Article › 査読

45 被引用数 (Scopus)

Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam

Toi, A., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2010 6月, In: International journal of clinical pharmacology and therapeutics. 48, 6, p. 356-366 11 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Saturable binding of finasteride to steroid 5a-reductase as determinant of nonlinear pharmacokinetics

Suzuki, R., Satoh, H., Ohtani, H., Hori, S. & Yasufumi, S., 2010 1月 1, In: Drug Metabolism And Pharmacokinetics. 25, 2, p. 208-213 6 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

2009

Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

Suzuki, K., Doki, K., Homma, M., Tamaki, H., Hori, S., Ohtani, H., Sawada, Y. & Kohda, Y., 2009 1月, In: British journal of clinical pharmacology. 67, 1, p. 44-49 6 p.

研究成果: Article › 査読

125 被引用数 (Scopus)

Development and evaluation of an internet-based educational system about herbs and dietary supplements through periodical distribution of information to health professionals

Asahina, Y., Hori, S., Ohtani, H. & Sawada, Y., 2009 6月, In: Yakugaku Zasshi. 129, 6, p. 773-780 8 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease

Sugahara, H., Maebara, C., Ohtani, H., Handa, M., Ando, K., Mine, K., Kubo, C., Ieiri, I. & Sawada, Y., 2009 7月, In: European Journal of Clinical Pharmacology. 65, 7, p. 699-704 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Inhibitory effects of herbal extracts on the activity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3)

Nagai, M., Fukamachi, T., Tsujimoto, M., Ogura, K., Hiratsuka, A., Ohtani, H., Hori, S. & Sawada, Y., 2009 1月, In: Biological and Pharmaceutical Bulletin. 32, 1, p. 105-109 5 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents

Kim, J., Ohtani, H., Tsujimoto, M. & Sawada, Y., 2009, In: Drug Metabolism And Pharmacokinetics. 24, 2, p. 167-174 8 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Transplacental pharmacokinetics of diclofenac in perfused human placenta.

Shintaku, K., Hori, S., Tsujimoto, M., Nagata, H., Satoh, S., Tsukimori, K., Nakano, H., Fujii, T., Taketani, Y., Ohtani, H. & Sawada, Y., 2009 5月, In: Drug metabolism and disposition: the biological fate of chemicals. 37, 5, p. 962-968 7 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

2008

A questionnaire survey of patients comparing the usability of brand-name and generic ketoprofen tapes

Saita, A., Inoue, A., Ishibashi, H., Tominaga, K., Hori, S., Miki, A., Ohtani, H., Ono, N. & Sawada, Y., 2008 5月, In: Yakugaku Zasshi. 128, 5, p. 795-803 9 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

大谷 壽一

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大谷壽一