検索結果
2022
Akiyoshi, T. ,
Uchiyama, M. ,
Inada, R. ,
Imaoka, A. &
Ohtani, H. ,
2022 2月 ,
In: Drug Metabolism And Pharmacokinetics. 42 , 100429.
研究成果: Article › 査読
bergamottin
100%
Cytochrome P-450 CYP2C9
69%
Resveratrol
65%
Beverages
60%
Cytochrome P-450 CYP2C19
51%
Araki, N. ,
Morita, T. ,
Akiyoshi, T. ,
Kataoka, H. ,
Yajima, K. ,
Katayama, K. ,
Imaoka, A. &
Ohtani, H. ,
2022 10月 ,
In: Drug Metabolism And Pharmacokinetics. 46 , 100464.
研究成果: Article › 査読
narirutin
100%
naringenin
93%
Narirutin
89%
Naringenin
87%
prunin
78%
Hibino, H. ,
Sakiyama, N. ,
Makino, Y. ,
Makihara-Ando, R. ,
Horinouchi, H. ,
Fujiwara, Y. ,
Kanda, S. ,
Goto, Y. ,
Yoshida, T. ,
Okuma, Y. ,
Shinno, Y. ,
Murakami, S. ,
Hashimoto, H. ,
Akiyoshi, T. ,
Imaoka, A. ,
Ohe, Y. ,
Yamaguchi, M. &
Ohtani, H. ,
2022 4月 ,
In: European Journal of Clinical Pharmacology. 78 ,
4 ,
p. 613-621 9 p. 研究成果: Article › 査読
Aprepitant
100%
Cytochrome P-450 CYP3A
76%
Dexamethasone
61%
Cisplatin
60%
Lung Neoplasms
52%
Morita, T. ,
Akiyoshi, T. ,
Tsuchitani, T. ,
Kataoka, H. ,
Araki, N. ,
Yajima, K. ,
Katayama, K. ,
Imaoka, A. &
Ohtani, H. ,
2022 3月 16 ,
In: Journal of agricultural and food chemistry. 70 ,
10 ,
p. 3310-3320 11 p. 研究成果: Article › 査読
avicularin
100%
Avicularin
89%
Fexofenadine
82%
Vaccinium macrocarpon
75%
cranberries
64%
Tsuchitani, T. ,
Akiyoshi, T. ,
Imaoka, A. &
Ohtani, H. ,
2022 5月 1 ,
In: International journal of clinical pharmacology and therapeutics. 60 ,
5 ,
p. 217-224 8 p. 研究成果: Article › 査読
Artificial Membranes
100%
Caco-2 Cells
79%
Gastrointestinal Tract
58%
Cell Membrane
49%
Epithelial Cells
32%
2021
Yamaguchi, Y. ,
Akiyoshi, T. ,
Kawamura, G. ,
Imaoka, A. ,
Miyazaki, M. ,
Guengerich, F. P. ,
Nakamura, K. ,
Yamamoto, K. &
Ohtani, H. ,
2021 6月 ,
In: Drug Metabolism And Pharmacokinetics. 38 , 100384.
研究成果: Article › 査読
Azoles
100%
Azole
94%
Itraconazole
93%
Cytochrome P-450 CYP3A
89%
Cytochrome P450
83%
Tsuchitani, T. ,
Akiyoshi, T. ,
Imaoka, A. &
Ohtani, H. ,
2021 12月 ,
In: Journal of Pharmaceutical Health Care and Sciences. 7 ,
1 , 24.
研究成果: Article › 査読
Digoxin
100%
Irinotecan
99%
ATP Binding Cassette Transporter, Subfamily B, Member 1
92%
Biological Availability
25%
Dabigatran
24%
Sato, R. ,
Akiyoshi, T. ,
Morita, T. ,
Katayama, K. ,
Yajima, K. ,
Kataoka, H. ,
Imaoka, A. &
Ohtani, H. ,
2021 12月 ,
In: Drug Metabolism And Pharmacokinetics. 41 , 100416.
研究成果: Article › 査読
Kinetics
100%
pH Value
58%
Estrone 3-Sulfate
20%
Fexofenadine
19%
Gefitinib
18%
Bioavailability
100%
Biological Availability
92%
Clinical Studies
71%
Clearance
63%
Drug
46%
Hibino, H. ,
Makino, Y. ,
Sakiyama, N. ,
Makihara-Ando, R. ,
Hashimoto, H. ,
Akiyoshi, T. ,
Imaoka, A. ,
Fujiwara, Y. ,
Ohe, Y. ,
Yamaguchi, M. &
Ohtani, H. ,
2021 4月 ,
In: International journal of clinical pharmacology and therapeutics. 59 ,
4 ,
p. 328-332 5 p. 研究成果: Article › 査読
Aprepitant
100%
Amlodipine
86%
Atrioventricular Block
78%
Lung Neoplasms
52%
Drug Interactions
26%
Koinuma, K. ,
Tsuchitani, T. ,
Imaoka, A. ,
Akiyoshi, T. &
Ohtani, H. ,
2021 3月 ,
In: International journal of clinical pharmacology and therapeutics. 59 ,
3 ,
p. 231-238 8 p. 研究成果: Article › 査読
Validation Studies
100%
Drug Interactions
88%
Computer Simulation
85%
Area Under Curve
73%
Enzymes
49%
Akiyoshi, T. ,
Naitou, R. ,
Imaoka, A. ,
Miyazaki, M. ,
Guengerich, F. P. ,
Nakamura, K. ,
Yamamoto, K. &
Ohtani, H. ,
2021 12月 ,
In: International journal of clinical pharmacology and therapeutics. 59 ,
12 ,
p. 745-782 38 p. 研究成果: Article › 査読
Macrolides
100%
Cytochrome P-450 CYP3A
99%
Midazolam
98%
Testosterone
77%
Anti-Bacterial Agents
57%
2020
Morita, T. ,
Akiyoshi, T. ,
Sato, R. ,
Uekusa, Y. ,
Katayama, K. ,
Yajima, K. ,
Imaoka, A. ,
Sugimoto, Y. ,
Kiuchi, F. &
Ohtani, H. ,
2020 12月 2 ,
In: Journal of agricultural and food chemistry. 68 ,
48 ,
p. 14182-14191 10 p. 研究成果: Article › 査読
narirutin
100%
Narirutin
89%
Flavanone Glycoside
86%
flavanone
80%
Citrus
68%
Ohtani, H. ,
Nakamura, K. ,
Imaoka, A. &
Akiyoshi, T. ,
2020 11月 1 ,
In: European Journal of Clinical Pharmacology. 76 ,
11 ,
p. 1529-1536 8 p. 研究成果: Article › 査読
Charcoal
100%
Pharmaceutical Preparations
33%
Drug Interactions
22%
Pharmacokinetics
17%
Enterohepatic Circulation
16%
Morita, T. ,
Akiyoshi, T. ,
Sato, R. ,
Katayama, K. ,
Yajima, K. ,
Kataoka, H. ,
Imaoka, A. ,
Sugimoto, Y. &
Ohtani, H. ,
2020 4月 ,
In: Drug Metabolism And Pharmacokinetics. 35 ,
2 ,
p. 220-227 8 p. 研究成果: Article › 査読
Anions
100%
Polypeptide
76%
Kinetics
67%
Peptides
59%
Estrone 3-Sulfate
41%
Semba, Y. ,
Akiyoshi, T. ,
Hibino, H. ,
Imaoka, A. &
Ohtani, H. ,
2020 10月 ,
In: International journal of clinical pharmacology and therapeutics. 58 ,
10 ,
p. 539-542 4 p. 研究成果: Article › 査読
Cytochrome P-450 CYP2D6
100%
Gefitinib
99%
In Vitro Techniques
34%
Dextromethorphan
28%
Psychological Inhibition
24%
2019
Phenobarbital
100%
Charcoal
96%
Drug Interactions
76%
Food
56%
Enteral
52%
Seki, H. ,
Akiyoshi, T. ,
Imaoka, A. &
Ohtani, H. ,
2019 6月 ,
In: Drug Metabolism And Pharmacokinetics. 34 ,
3 ,
p. 181-186 6 p. 研究成果: Article › 査読
Cytochrome P450
100%
Cytochrome P-450 Enzyme System
91%
bergamottin
89%
Fruit
88%
Kinetics
67%
Hattori, T. ,
Imaoka, A. ,
Akiyoshi, T. &
Ohtani, H. ,
2019 11月 1 ,
In: Biopharmaceutics and Drug Disposition. 40 ,
9 ,
p. 315-324 10 p. 研究成果: Article › 査読
Dabigatran Etexilate
100%
Dabigatran
70%
Irinotecan
62%
Bioavailability
25%
ATP Binding Cassette Transporter, Subfamily B, Member 1
19%
Imaoka, A. ,
Seki, K. ,
Akiyoshi, T. &
Ohtani, H. ,
2019 2月 ,
In: Drug Metabolism And Pharmacokinetics. 34 ,
1 ,
p. 108-110 3 p. 研究成果: Article › 査読
Amlodipine
100%
Charcoal
86%
Drug Interactions
68%
Eating
53%
Food
50%
2018
Tsujii, K. ,
Hattori, T. ,
Imaoka, A. ,
Akiyoshi, T. &
Ohtani, H. ,
2018 5月 ,
In: Journal of Pharmaceutical Sciences. 107 ,
5 ,
p. 1430-1433 4 p. 研究成果: Article › 査読
Dabigatran Etexilate
100%
Dabigatran
70%
Anticoagulant
63%
Anticoagulants
49%
Activated Partial Thromboplastin Time
32%
2017
Yotsumoto, K. ,
Akiyoshi, T. ,
Wada, N. ,
Imaoka, A. &
Ohtani, H. ,
2017 12月 ,
In: Biopharmaceutics and Drug Disposition. 38 ,
9 ,
p. 509-516 8 p. 研究成果: Article › 査読
5-Fluorouracil
100%
Fluorouracil
79%
Digoxin
58%
ATP Binding Cassette Transporter, Subfamily B, Member 1
45%
Drug
43%
Mikami, A. ,
Hori, S. ,
Ohtani, H. &
Sawada, Y. ,
2017 ,
In: Biological and Pharmaceutical Bulletin. 40 ,
7 ,
p. 1010-1020 11 p. 研究成果: Article › 査読
Terbinafine
100%
Nortriptyline
89%
Amitriptyline
84%
Drug Interactions
58%
Drug
31%
Ohtani, H. ,
Mitsui, R. ,
Akiyoshi, T. ,
Imaoka, A. ,
Abe, Y. ,
Kanke, M. ,
Nakamura, T. ,
Foster, P. &
Mochizuki, M. ,
2017 5月 ,
In: Currents in Pharmacy Teaching and Learning. 9 ,
3 ,
p. 452-459 8 p. 研究成果: Article › 査読
Pharmacy Students
100%
Japan
59%
Pharmaceutical
52%
Students
36%
Diagnostic Self Evaluation
24%
Suzuki, S. ,
Aono, I. ,
Imai, N. ,
Kuwabara, A. ,
Kenda, Y. ,
Matsumoto, M. ,
Yoshida, A. ,
Watanabe, A. ,
Takagi, A. ,
Kobayashi, N. ,
Saeki, H. ,
Ohtani, H. ,
Nakamur, T. &
Kizud, J. ,
2017 ,
In: Yakugaku Zasshi. 137 ,
11 ,
p. 1391-1408 18 p. 研究成果: Article › 査読
Communication
100%
Counseling
93%
Pharmaceutical
80%
Students
77%
Pharmacy Education
42%
Ishikawa, Y. ,
Akiyoshi, T. ,
Imaoka, A. &
Ohtani, H. ,
2017 10月 ,
In: Biopharmaceutics and Drug Disposition. 38 ,
7 ,
p. 420-425 6 p. 研究成果: Article › 査読
Erythromycin
100%
Cytochrome P-450 CYP3A
85%
Cytochrome P450
80%
Kinetics
54%
Nifedipine
33%
2016
bucolome
100%
(S)-Warfarin
84%
Computer Simulation
47%
Warfarin
44%
Clearance
36%
2015
Administrative Personnel
100%
Internet
94%
Japan
80%
Pharmaceutical
71%
Pharmaceutical Preparations
40%
Akiyoshi, T. ,
Ishiuchi, M. ,
Imaoka, A. &
Ohtani, H. ,
2015 8月 1 ,
In: Drug Metabolism And Pharmacokinetics. 30 ,
4 ,
p. 321-324 4 p. 研究成果: Article › 査読
Terbinafine
100%
Cytochrome P-450 CYP2D6
75%
Cytochrome P450
63%
Drug Interactions
14%
Drug
11%
2014
Imaoka, A. ,
Hattori, M. ,
Akiyoshi, T. &
Ohtani, H. ,
2014 ,
In: Drug Metabolism And Pharmacokinetics. 29 ,
5 ,
p. 414-418 5 p. 研究成果: Article › 査読
Ciprofloxacin
100%
Adsorption
93%
Cations
87%
Metals
74%
Metal Ion
54%
Kogure, N. ,
Akiyoshi, T. ,
Imaoka, A. &
Ohtani, H. ,
2014 10月 1 ,
In: Biopharmaceutics and Drug Disposition. 35 ,
7 ,
p. 373-381 9 p. 研究成果: Article › 査読
Citrus paradisi
100%
Drug Interactions
64%
Area Under Curve
53%
Pharmacokinetics
49%
Nisoldipine
37%
2013
Nagai, M. ,
Ohtani, H. ,
Satoh, H. ,
Matsuoka, S. ,
Hori, S. ,
Fujii, T. ,
Taketani, Y. &
Sawada, Y. ,
2013 12月 ,
In: Drug Metabolism and Disposition. 41 ,
12 ,
p. 2124-2132 9 p. 研究成果: Article › 査読
Paroxetine
100%
Human Development
71%
Placenta
61%
Pharmacokinetics
50%
Mothers
9%
Akiyoshi, T. ,
Shimomura, Y. ,
Masuda, S. ,
Okamoto, Y. ,
Hiura, S. ,
Kato, H. ,
Asayama, T. &
Ohtani, H. ,
2013 ,
In: Drug Metabolism And Pharmacokinetics. 28 ,
5 ,
p. 446-450 5 p. 研究成果: Article › 査読
Aromatase Inhibitor
100%
Aromatase Inhibitors
83%
Bone Density
60%
Breast Neoplasms
42%
Population
26%
Akiyoshi, T. ,
Ito, M. ,
Murase, S. ,
Miyazaki, M. ,
Peter Guengerich, F. ,
Nakamura, K. ,
Yamamoto, K. &
Ohtani, H. ,
2013 ,
In: Drug Metabolism And Pharmacokinetics. 28 ,
5 ,
p. 411-415 5 p. 研究成果: Article › 査読
Clarithromycin
100%
Erythromycin
87%
Cytochrome P-450 CYP3A
74%
Cytochrome P450
70%
Kinact
26%
Mikami, A. ,
Ohtani, H. ,
Hori, S. &
Sawada, Y. ,
2013 5月 1 ,
In: International Journal of Clinical Pharmacology and Therapeutics. 51 ,
5 ,
p. 374-382 9 p. 研究成果: Article › 査読
Paroxetine
100%
Cytochrome P-450 CYP2D6
98%
Drug Interactions
76%
Pharmacokinetics
58%
Metoprolol
56%
2012
Shintaku, K. ,
Hori, S. ,
Satoh, H. ,
Tsukimori, K. ,
Nakano, H. ,
Fujii, T. ,
Taketani, Y. ,
Ohtani, H. &
Sawada, Y. ,
2012 2月 ,
In: British journal of clinical pharmacology. 73 ,
2 ,
p. 248-256 9 p. 研究成果: Article › 査読
Ductus Arteriosus
100%
Perfusion
78%
Anti-Inflammatory Agents
76%
Kinetics
74%
Antipyrine
62%
2011
Ohtani, H. ,
Barter, Z. ,
Minematsu, T. ,
Makuuchi, M. ,
Sawada, Y. &
Rostami-Hodjegan, A. ,
2011 12月 ,
In: Biopharmaceutics and Drug Disposition. 32 ,
9 ,
p. 498-506 9 p. 研究成果: Article › 査読
Hematocrit
100%
Sex Distribution
88%
Cytochrome P-450 CYP3A
81%
Clearance
77%
Tacrolimus
77%
Akiyoshi, T. ,
Saito, T. ,
Murase, S. ,
Miyazaki, M. ,
Murayama, N. ,
Yamazaki, H. ,
Guengerich, F. P. ,
Nakamura, K. ,
Yamamoto, K. &
Ohtani, H. ,
2011 4月 ,
In: Drug Metabolism and Disposition. 39 ,
4 ,
p. 724-728 5 p. 研究成果: Article › 査読
Itraconazole
100%
Cimetidine
96%
Cytochrome P-450 CYP3A
76%
Cytochrome P450
72%
Testosterone
39%
Watanabe, T. ,
Satoh, H. ,
Hori, S. ,
Miki, A. ,
Ohtani, H. &
Sawada, Y. ,
2011 ,
In: Yakugaku Zasshi. 131 ,
10 ,
p. 1483-1492 10 p. 研究成果: Article › 査読
tulobuterol
100%
Transdermal
72%
Plasma Concentration
64%
Concentration Profile
63%
Drug Liberation
54%
2010
Tamaki, H. ,
Satoh, H. ,
Hori, S. ,
Ohtani, H. &
Sawada, Y. ,
2010 ,
In: Drug Metabolism And Pharmacokinetics. 25 ,
2 ,
p. 170-179 10 p. 研究成果: Article › 査読
Isoflavonoid
100%
Breast Neoplasms
43%
Resistance
42%
Protein Transport
32%
Protein
28%
Toi, A. ,
Ohtani, H. ,
Tsujimoto, M. &
Sawada, Y. ,
2010 6月 ,
In: International journal of clinical pharmacology and therapeutics. 48 ,
6 ,
p. 356-366 11 p. 研究成果: Article › 査読
Triazolam
100%
Itraconazole
80%
Pharmacokinetics
50%
hydroxyitraconazole
32%
Cytochrome P-450 CYP3A
28%
Suzuki, R. ,
Satoh, H. ,
Ohtani, H. ,
Hori, S. &
Yasufumi, S. ,
2010 1月 1 ,
In: Drug Metabolism And Pharmacokinetics. 25 ,
2 ,
p. 208-213 6 p. 研究成果: Article › 査読
Finasteride
100%
Steroid
55%
Oxidoreductases
55%
Pharmacokinetics
45%
Steroids
45%
2009
Suzuki, K. ,
Doki, K. ,
Homma, M. ,
Tamaki, H. ,
Hori, S. ,
Ohtani, H. ,
Sawada, Y. &
Kohda, Y. ,
2009 1月 ,
In: British journal of clinical pharmacology. 67 ,
1 ,
p. 44-49 6 p. 研究成果: Article › 査読
Proton Pump Inhibitors
100%
Methotrexate
86%
ATP Binding Cassette Transporter, Subfamily G, Member 2
17%
Rabeprazole
16%
Pantoprazole
16%
Asahina, Y. ,
Hori, S. ,
Ohtani, H. &
Sawada, Y. ,
2009 6月 ,
In: Yakugaku Zasshi. 129 ,
6 ,
p. 773-780 8 p. 研究成果: Article › 査読
Information Dissemination
100%
Dietary Supplements
86%
Internet
81%
Health
41%
Postal Service
23%
Sugahara, H. ,
Maebara, C. ,
Ohtani, H. ,
Handa, M. ,
Ando, K. ,
Mine, K. ,
Kubo, C. ,
Ieiri, I. &
Sawada, Y. ,
2009 7月 ,
In: European Journal of Clinical Pharmacology. 65 ,
7 ,
p. 699-704 6 p. 研究成果: Article › 査読
Alprazolam
100%
Fluvoxamine
98%
Cytochrome P-450 CYP2D6
88%
Smoking
51%
Non-Smokers
17%
Nagai, M. ,
Fukamachi, T. ,
Tsujimoto, M. ,
Ogura, K. ,
Hiratsuka, A. ,
Ohtani, H. ,
Hori, S. &
Sawada, Y. ,
2009 1月 ,
In: Biological and Pharmaceutical Bulletin. 32 ,
1 ,
p. 105-109 5 p. 研究成果: Article › 査読
Sulfotransferases
100%
Ritodrine
87%
Human Activities
71%
Dopamine
66%
Protein Isoforms
57%
Kim, J. ,
Ohtani, H. ,
Tsujimoto, M. &
Sawada, Y. ,
2009 ,
In: Drug Metabolism And Pharmacokinetics. 24 ,
2 ,
p. 167-174 8 p. 研究成果: Article › 査読
Convulsion
100%
Zaltoprofen
87%
Prulifloxacin
84%
Loxoprofen
84%
Lornoxicam
79%
Shintaku, K. ,
Hori, S. ,
Tsujimoto, M. ,
Nagata, H. ,
Satoh, S. ,
Tsukimori, K. ,
Nakano, H. ,
Fujii, T. ,
Taketani, Y. ,
Ohtani, H. &
Sawada, Y. ,
2009 5月 ,
In: Drug metabolism and disposition: the biological fate of chemicals. 37 ,
5 ,
p. 962-968 7 p. 研究成果: Article › 査読
Diclofenac
100%
Placenta
75%
Pharmacokinetics
61%
Antipyrine
38%
Lactic Acid
32%
2008
Saita, A. ,
Inoue, A. ,
Ishibashi, H. ,
Tominaga, K. ,
Hori, S. ,
Miki, A. ,
Ohtani, H. ,
Ono, N. &
Sawada, Y. ,
2008 5月 ,
In: Yakugaku Zasshi. 128 ,
5 ,
p. 795-803 9 p. 研究成果: Article › 査読
Ketoprofen
100%
Names
68%
Pharmacy
29%
Pharmacists
14%
Application
13%