Masanori Osawa

2022

Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

Sagae, T., Yokogawa, M., Sawazaki, R., Ishii, Y., Hosoda, N., Hoshino, S. I., Imai, S., Shimada, I. & Osawa, M., 2022 5月 1, In: Journal of Biological Chemistry. 298, 5, 101844.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

2021

Comprehensive Approach of ¹⁹F Nuclear Magnetic Resonance, Enzymatic, and in Silico Methods for Site-Specific Hit Selection and Validation of Fragment Molecules that Inhibit Methionine γ-Lyase Activity

Ikeda, K., Kezuka, Y., Nonaka, T., Yonezawa, T., Osawa, M. & Katoh, E., 2021 10月 14, In: Journal of Medicinal Chemistry. 64, 19, p. 14299-14310 12 p.

研究成果: Article › 査読

Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein–protein interaction-oriented library and machine learning

Shimizu, Y., Yonezawa, T., Sakamoto, J., Furuya, T., Osawa, M. & Ikeda, K., 2021 12月, In: Scientific reports. 11, 1, 7420.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

Matsumura, K., Shimomura, T., Kubo, Y., Oka, T., Kobayashi, N., Imai, S., Yanase, N., Akimoto, M., Fukuda, M., Yokogawa, M., Ikeda, K., Kurita, J. I., Nishimura, Y., Shimada, I. & Osawa, M., 2021 12月, In: BMC Molecular and Cell Biology. 22, 1, 3.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

2020

Conformational equilibrium shift underlies altered K⁺ channel gating as revealed by NMR

Iwahashi, Y., Toyama, Y., Imai, S., Itoh, H., Osawa, M., Inoue, M. & Shimada, I., 2020 12月 1, In: Nature communications. 11, 1, 5168.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

GZD824 inhibits GCN2 and sensitizes cancer cells to amino acid starvation stress

Kato, Y., Kunimasa, K., Takahashi, M., Harada, A., Nagasawa, I., Osawa, M., Sugimoto, Y. & Tomida, A., 2020 12月, In: Molecular Pharmacology. 98, 6, p. 669-676 8 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2019

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 12月 1, In: Nature communications. 10, 1, 2008.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

2018

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Sawazaki, R., Imai, S., Yokogawa, M., Hosoda, N., Hoshino, S. I., Mio, M., Mio, K., Shimada, I. & Osawa, M., 2018 12月 1, In: Scientific reports. 8, 1, 1455.

研究成果: Article › 査読

Open Access

15 被引用数 (Scopus)

Functional roles of Mg ²⁺ binding sites in ion-dependent gating of a Mg ²⁺ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 4月 3, In: eLife. 7, e31596.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3858-3863 6 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2017

ATP-dependent modulation of MgtE in Mg²⁺ homeostasis

Tomita, A., Zhang, M., Jin, F., Zhuang, W., Takeda, H., Maruyama, T., Osawa, M., Hashimoto, K. I., Kawasaki, H., Ito, K., Dohmae, N., Ishitani, R., Shimada, I., Yan, Z., Hattori, M. & Nureki, O., 2017 12月 1, In: Nature communications. 8, 1, 148.

研究成果: Article › 査読

Open Access

36 被引用数 (Scopus)

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2017 2月 22, In: Nature communications. 8, 14523.

研究成果: Article › 査読

Open Access

27 被引用数 (Scopus)

2016

Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel

Nozaki, T., Ozawa, S. I., Harada, H., Kimura, T., Osawa, M. & Shimada, I., 2016 11月 17, In: Scientific reports. 6, 37303.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

NMR Method for Characterizing Microsecond-to-Millisecond Chemical Exchanges Utilizing Differential Multiple-Quantum Relaxation in High Molecular Weight Proteins

Toyama, Y., Osawa, M., Yokogawa, M. & Shimada, I., 2016 3月 2, In: Journal of the American Chemical Society. 138, 7, p. 2302-2311 10 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

2015

Structural basis for the inhibition of voltage-dependent K⁺ channel by gating modifier toxin

Ozawa, S. I., Kimura, T., Nozaki, T., Harada, H., Shimada, I. & Osawa, M., 2015 9月 18, In: Scientific reports. 5, 14226.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

2014

Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state

Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2014 10月 1, In: Biomolecular NMR Assignments. 8, 2, p. 237-241 5 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Cross-saturation and transferred cross-saturation experiments

Ueda, T., Takeuchi, K., Nishida, N., Stampoulis, P., Kofuku, Y., Osawa, M. & Shimada, I., 2014 5月, In: Quarterly Reviews of Biophysics. 47, 2, p. 143-187 45 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Functional dynamics of cell surface membrane proteins

Nishida, N., Osawa, M., Takeuchi, K., Imai, S., Stampoulis, P., Kofuku, Y., Ueda, T. & Shimada, I., 2014 4月, In: Journal of Magnetic Resonance. 241, 1, p. 86-96 11 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT

Esaki, K., Yoshinaga, S., Tsuji, T., Toda, E., Terashima, Y., Saitoh, T., Kohda, D., Kohno, T., Osawa, M., Ueda, T., Shimada, I., Matsushima, K. & Terasawa, H., 2014 12月, In: FEBS Journal. 281, 24, p. 5552-5566 15 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2013

Backbone resonance assignments for the cytoplasmic region of the Mg ²⁺ transporter MgtE in the Mg²⁺-unbound state

Maruyama, T., Imai, S., Osawa, M., Hattori, M., Ishitani, R., Nureki, O. & Shimada, I., 2013 4月, In: Biomolecular NMR Assignments. 7, 1, p. 93-96 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

2012

Backbone resonance assignments for G protein α_i3 subunit in the GTP-bound state

Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2012 10月, In: Biomolecular NMR Assignments. 6, 2, p. 217-220 4 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay

Osawa, M., Hosoda, N., Nakanishi, T., Uchida, N., Kimura, T., Imai, S., Machiyama, A., Katada, T., Hoshino, S. I. & Shimada, I., 2012 11月, In: RNA. 18, 11, p. 1957-1967 11 p.

研究成果: Article › 査読

Open Access

19 被引用数 (Scopus)

Functional equilibrium of the KcsA structure revealed by NMR

Imai, S., Osawa, M., Mita, K., Toyonaga, S., Machiyama, A., Ueda, T., Takeuchi, K., Oiki, S. & Shimada, I., 2012 11月 16, In: Journal of Biological Chemistry. 287, 47, p. 39634-39641 8 p.

研究成果: Article › 査読

Open Access

44 被引用数 (Scopus)

Spatial distribution of cytoplasmic domains of the Mg ²⁺- transporter MgtE, in a solution lacking Mg ²⁺, revealed by paramagnetic relaxation enhancement

Imai, S., Maruyama, T., Osawa, M., Hattori, M., Ishitani, R., Nureki, O. & Shimada, I., 2012 10月, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 10, p. 1129-1135 7 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Structural basis for modulation of gating property of g protein-gated inwardly rectifying potassium ion channel (GIRK) by i/o-family G protein α subunit (Gα_i/o)

Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2012 6月 1, In: Journal of Biological Chemistry. 287, 23, p. 19537-19549 13 p.

研究成果: Article › 査読

Open Access

30 被引用数 (Scopus)

2011

NMR analyses of the Gβγ binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Yokogawa, M., Osawa, M., Takeuchi, K., Mase, Y. & Shimada, I., 2011 1月 21, In: Journal of Biological Chemistry. 286, 3, p. 2215-2223 9 p.

研究成果: Article › 査読

Open Access

41 被引用数 (Scopus)

Structure determination of a protein assembly by amino acid selective cross-saturation

Kanamori, E., Igarashi, S., Osawa, M., Fukunishi, Y., Shimada, I. & Nakamura, H., 2011 1月, In: Proteins: Structure, Function and Bioinformatics. 79, 1, p. 179-190 12 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2010

Backbone resonance assignments for the ligand binding subunit of the histidine permease complex (HisJ) from Escherichia coli, under histidine-bound and unbound states

Igarashi, S., Osawa, M., Ozawa, S. I. & Shimada, I., 2010 4月, In: Biomolecular NMR Assignments. 4, 1, p. 17-20 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers

Yoshiura, C., Kofuku, Y., Ueda, T., Mase, Y., Yokogawa, M., Osawa, M., Terashima, Y., Matsushima, K. & Shimada, I., 2010 5月 19, In: Journal of the American Chemical Society. 132, 19, p. 6768-6777 10 p.

研究成果: Article › 査読

62 被引用数 (Scopus)

Quantitative characterization of tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation

Ruan, L., Osawa, M., Hosoda, N., Imai, S., Machiyama, A., Katada, T., Hoshino, S. I. & Shimada, I., 2010 9月 3, In: Journal of Biological Chemistry. 285, 36, p. 27624-27631 8 p.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

Structural basis underlying the dual gate properties of KcsA

Imai, S., Osawa, M., Takeuchi, K. & Shimada, I., 2010 4月 6, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6216-6221 6 p.

研究成果: Article › 査読

Open Access

96 被引用数 (Scopus)

2009

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Yokogawa, M., Muramatsu, T., Takeuchi, K., Osawa, M. & Shimada, I., 2009 6月, In: Biomolecular NMR Assignments. 3, 1, p. 125-128 4 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Evidence for the direct interaction of spermine with the inwardly retifying potassium channel

Osawa, M., Yokogawa, M., Muramatsu, T., Mase, Y. & Shimada, I., 2009 9月 18, In: Journal of Biological Chemistry. 284, 38, p. 26117-26126 10 p.

研究成果: Article › 査読

17 被引用数 (Scopus)

2008

Amino acid selective cross-saturation method for identification of proximal residue pairs in a protein-protein complex

Igarashi, S., Osawa, M., Takeuchi, K., Ozawa, S. I. & Shimada, I., 2008 9月 10, In: Journal of the American Chemical Society. 130, 36, p. 12168-12176 9 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

2007

Mechanism of mRNA deadenylation: Evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

Funakoshi, Y., Doi, Y., Hosoda, N., Uchida, N., Osawa, M., Shimada, I., Tsujimoto, M., Suzuki, T., Katada, T. & Hoshino, S. I., 2007 12月 1, In: Genes and Development. 21, 23, p. 3135-3148 14 p.

研究成果: Article › 査読

Open Access

140 被引用数 (Scopus)

Nickel binding to NikA: An additional binding site reconciles spectroscopy, calorimetry and crystallography

Addy, C., Ohara, M., Kawai, F., Kidera, A., Ikeguchi, M., Fuchigami, S., Osawa, M., Shimada, I., Park, S. Y., Tame, J. R. H. & Heddle, J. G., 2007 2月 1, In: Acta Crystallographica Section D: Biological Crystallography. 63, 2, p. 221-229 9 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Structural basis of the collagen-binding mode of discoidin domain receptor 2

Ichikawa, O., Osawa, M., Nishida, N., Goshima, N., Nomura, N. & Shimada, I., 2007 9月 19, In: EMBO Journal. 26, 18, p. 4168-4176 9 p.

研究成果: Article › 査読

88 被引用数 (Scopus)

Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)

Strahl, T., Huttner, I. G., Lusin, J. D., Osawa, M., King, D., Thorner, J. & Ames, J. B., 2007 10月 19, In: Journal of Biological Chemistry. 282, 42, p. 30949-30959 11 p.

研究成果: Article › 査読

55 被引用数 (Scopus)

2005

Mg²⁺ and Ca²⁺ differentially regulate DNA binding and dimerization of DREAM

Osawa, M., Dace, A., Tong, K. I., Valiveti, A., Ikura, M. & Ames, J. B., 2005 5月 6, In: Journal of Biological Chemistry. 280, 18, p. 18008-18014 7 p.

研究成果: Article › 査読

Open Access

95 被引用数 (Scopus)

2003

Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1

Huttner, I. G., Strahl, T., Osawa, M., King, D. S., Ames, J. B. & Thorner, J., 2003 2月 14, In: Journal of Biological Chemistry. 278, 7, p. 4862-4874 13 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

2001

Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3

Osawa, M., Tong, K. I., Lilliehook, C., Wasco, W., Buxbaum, J. D., Cheng, H. Y. M., Penninger, J. M., Ikura, M. & Ames, J. B., 2001 11月 2, In: Journal of Biological Chemistry. 276, 44, p. 41005-41013 9 p.

研究成果: Article › 査読

Open Access

113 被引用数 (Scopus)

Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca²⁺/calmodulin-dependent kinase kinase peptide

Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M. B., Kainosho, M. & Ikura, M., 2001 9月 7, In: Journal of Molecular Biology. 312, 1, p. 59-68 10 p.

研究成果: Article › 査読

94 被引用数 (Scopus)

2000

Mechanism of superoxide dismutase-like activity of Fe(II) and Fe(III) complexes of tetrakis-N,N,N',N'(2-pyridylmethyl)ethylenediamine

Hirano, T., Hirobe, M., Kobayashi, K., Odani, A., Yamauchi, O., Ohsawa, M., Satow, Y. & Nagano, T., 2000 2月, In: Chemical and Pharmaceutical Bulletin. 48, 2, p. 223-230 8 p.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

1999

A novel target recognition revealed by calmodulin in complex with Ca²⁺-calmodulin-dependent kinase kinase

Osawa, M., Tokumitsu, H., Swindells, M. B., Kurihara, H., Orita, M., Shibanuma, T., Furuya, T. & Ikura, M., 1999, In: Nature Structural Biology. 6, 9, p. 819-824 6 p.

研究成果: Article › 査読

234 被引用数 (Scopus)

Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding

Osawa, M., Kuwamoto, S., Izumi, Y., Yap, K. L., Ikura, M., Shibanuma, T., Yokokura, H., Hidaka, H. & Matsushima, N., 1999 1月 15, In: FEBS Letters. 442, 2-3, p. 173-177 5 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Symmetric covalent linkage of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) results in novel derivatives with increased inhibitory activities against calcium/calmodulin complex

Yokokura, H., Osawa, M., Inoue, T., Umezawa, I., Naito, Y., Ikura, M. & Hidaka, H., 1999, In: Drug Design and Discovery. 16, 3, p. 203-216 14 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

1998

Solution structure of calmodulin-W-7 complex: The basis of diversity in molecular recognition

Osawa, M., Swindells, M. B., Tanikawa, J., Tanaka, T., Mase, T., Furuya, T. & Ikura, M., 1998 2月 13, In: Journal of Molecular Biology. 276, 1, p. 165-176 12 p.

研究成果: Article › 査読

142 被引用数 (Scopus)

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