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研究成果 2010 2019

  • 430 引用
  • 11 h指数
  • 29 Article
フィルター
Article
2019
1 引用 (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 1 1, (Accepted/In press) : : Cancer Chemotherapy and Pharmacology.

研究成果: Article

Chemotherapy
Non-Small Cell Lung Carcinoma
Cells
Drug Therapy
Mutation
6 引用 (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 1 1, : : Lung Cancer. 127, p. 146-152 7 p.

研究成果: Article

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Therapeutics
3 引用 (Scopus)

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. および8人, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 5 14, : : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

研究成果: Article

公開
Molecular Dynamics Simulation
Lung Neoplasms
Mutation
Pharmaceutical Preparations
Protein-Tyrosine Kinases

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 1 1, : : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

研究成果: Article

Dimerization
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Therapeutics
2018
5 引用 (Scopus)

A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy

Shinozaki, T., Iwami, E., Ikemura, S., Matsuzaki, T., Nakajima, T., Hashimoto, K. & Terashima, T., 2018 5 31, : : BMC Cancer. 18, 1, 620.

研究成果: Article

Carboplatin
Paclitaxel
Skin Diseases
Ascites
Non-Small Cell Lung Carcinoma

Lymph node collision tumor consisting of metastatic pulmonary adenocarcinoma and diffuse large b-cell lymphoma

Ikemura, S., Moriyama, M., Matsumoto, K., Nakayama, S., Matsuzaki, T., Nakajima, T., Sasaki, A., Miyauchi, J. & Terashima, T., 2018 1 1, : : Internal Medicine. 57, 8, p. 1135-1139 5 p.

研究成果: Article

Lymphoma, Large B-Cell, Diffuse
Lymph Nodes
Liver
Bone Marrow
Neoplasm Metastasis
2017
39 引用 (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 4 15, : : Cancer Research. 77, 8, p. 2078-2089 12 p.

研究成果: Article

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Alleles
Mutation
Lung Neoplasms
3 引用 (Scopus)

Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma

Ikemura, S., Aramaki, N., Fujii, S., Kirita, K., Umemura, S., Matsumoto, S., Yoh, K., Niho, S., Ohmatsu, H., Kuwata, T., Kojima, M., Ochiai, A., Betsuyaku, T., Tsuboi, M., Goto, K. & Ishii, G., 2017 1 1, : : Cancer Science. 108, 1, p. 136-142 7 p.

研究成果: Article

Lymphatic Metastasis
Tumor Microenvironment
Squamous Cell Carcinoma
Lymph Nodes
Lung

The prognostic factors for long-term (≥5 Years) survival in stage IV Non-small cell lung cancer

Matsuzaki, T., Ikemura, S., Chubachi, S., Nakayama, S., Iwami, E., Sato, M., Nakajima, T., Eguchi, K. & Terashima, T., 2017 4 20, : : Japanese Journal of Lung Cancer. 57, 2, p. 88-95 8 p.

研究成果: Article

Non-Small Cell Lung Carcinoma
Survival
Pharmaceutical Preparations
Disease-Free Survival
Retrospective Studies
2016
1 引用 (Scopus)
Carboplatin
Small Cell Lung Carcinoma
Chemoradiotherapy
Etoposide
Renal Dialysis
18 引用 (Scopus)

Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations

Saruwatari, K., Ikemura, S., Sekihara, K., Kuwata, T., Fujii, S., Umemura, S., Kirita, K., Matsumoto, S., Yoh, K., Niho, S., Ohmatsu, H., Ochiai, A., Kohrogi, H., Tsuboi, M., Goto, K. & Ishii, G., 2016 1 1, : : Lung Cancer. 91, p. 7-14 8 p.

研究成果: Article

Tumor Microenvironment
Epidermal Growth Factor Receptor
Adenocarcinoma
Mutation
Neoplasms
1 引用 (Scopus)

The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung

Sekihara, K., Hishida, T., Ikemura, S., Saruwatari, K., Morise, M., Kuwata, T., Fujii, S., Kojima, M., Ochiai, A., Funai, K., Aokage, K., Yoshida, J., Tsuboi, M. & Ishii, G., 2016 5 1, : : Journal of Cancer Research and Clinical Oncology. 142, 5, p. 905-912 8 p.

研究成果: Article

Neuroendocrine Carcinoma
Stromal Cells
Blood Vessels
Lung
Recurrence
2015
6 引用 (Scopus)

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. および1人, Betsuyaku, T., 2015, : : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

研究成果: Article

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Chemotherapy
Cells
3 引用 (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 4 1, : : Japanese Journal of Clinical Oncology. 45, 4, p. 356-361 6 p.

研究成果: Article

irinotecan
Non-Small Cell Lung Carcinoma
Body Surface Area
Therapeutics
Disease-Free Survival
17 引用 (Scopus)

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Nakayama, S., Soejima, K., Yasuda, H., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Yamaguchi, N., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Naoki, K. & Betsuyaku, T., 2015 1 1, : : Anticancer Research. 35, 1, p. 261-268 8 p.

研究成果: Article

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Cell Proliferation
Cell Line
Messenger RNA
5 引用 (Scopus)

Long-term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR-mutant PC9 lung cancer cell line

Terai, H., Soejima, K., Yasuda, H., Sato, T., Naoki, K., Ikemura, S., Arai, D., Ohgino, K., Ishioka, K., Hamamoto, J., Kanai, Y. & Betsuyaku, T., 2015 1 1, : : International Journal of Oncology. 46, 1, p. 430-436 7 p.

研究成果: Article

DNA Methylation
Lung Neoplasms
Cell Line
Genes
Messenger RNA
11 引用 (Scopus)

Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

Hamamoto, J., Soejima, K., Naoki, K., Yasuda, H., Hayashi, Y., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Arai, D., Ishioka, K., Ohgino, K. & Betsuyaku, T., 2015 1 1, : : Cancer Science. 106, 1, p. 34-42 9 p.

研究成果: Article

Serine Proteases
Non-Small Cell Lung Carcinoma
Methylation
Carcinogenesis
Down-Regulation
2014
26 引用 (Scopus)

Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer

Yoda, S., Soejima, K., Hamamoto, J., Yasuda, H., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Naoki, K. & Betsuyaku, T., 2014, : : Lung Cancer. 85, 3, p. 366-372 7 p.

研究成果: Article

Claudin-1
Non-Small Cell Lung Carcinoma
Luciferases
Cell Line
Squamous Cell Carcinoma
28 引用 (Scopus)

Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer

Ohgino, K., Soejima, K., Yasuda, H., Hayashi, Y., Hamamoto, J., Naoki, K., Arai, D., Ishioka, K., Sato, T., Terai, H., Ikemura, S., Yoda, S., Tani, T., Kuroda, A. & Betsuyaku, T., 2014 1, : : Lung Cancer. 83, 1, p. 90-96 7 p.

研究成果: Article

Fibroblast Growth Factor 9
Non-Small Cell Lung Carcinoma
Fibroblast Growth Factors
Lung
Oligonucleotide Array Sequence Analysis
2013
Red Cross
Japan
Tuberculosis
Latent Tuberculosis
Sputum
118 引用 (Scopus)

Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC

Terai, H., Soejima, K., Yasuda, H., Nakayama, S., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Ikemura, S., Sato, T., Yoda, S., Satomi, R., Naoki, K. & Betsuyaku, T., 2013 7, : : Molecular Cancer Research. 11, 7, p. 759-767 9 p.

研究成果: Article

Fibroblast Growth Factor 2
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Cell Line
gefitinib
44 引用 (Scopus)

Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma

Hamamoto, J., Soejima, K., Yoda, S., Naoki, K., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Yasuda, H., Hayashi, Y., Sakamoto, M., Takebayashi, T. & Betsuyaku, T., 2013 8, : : Molecular Medicine Reports. 8, 2, p. 456-462 7 p.

研究成果: Article

MicroRNAs
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Lung
Adenocarcinoma
2012

A case of elderly advanced squamous cell lung carcinoma successfully treated with nedaplatin and S-1 combination chemotherapy

Terai, H., Soejima, K., Naoki, K., Ikemura, S., Ogura-Tomomatsu, H., Sato, T., Asano, K. & Betsuyaku, T., 2012 3, : : Japanese Journal of Cancer and Chemotherapy. 39, 3, p. 429-432 4 p.

研究成果: Article

Combination Drug Therapy
Squamous Cell Carcinoma
Lung
Thorax
Neoplasm Metastasis
2011
2 引用 (Scopus)

A phase i study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients

Yoda, S., Soejima, K., Yasuda, H., Naoki, K., Kawada, I., Watanabe, H., Nakachi, I., Satomi, R., Nakayama, S., Ikemura, S., Terai, H., Sato, T., Morosawa, M. & Asano, K., 2011 3, : : Cancer Chemotherapy and Pharmacology. 67, 3, p. 717-722 6 p.

研究成果: Article

irinotecan
Non-Small Cell Lung Carcinoma
Cells
Toxicity
Body Surface Area
16 引用 (Scopus)

Bronchoscopic Microsampling is a Useful Complementary Diagnostic Tool for Detecting Lung Cancer

Yasuda, H., Soejima, K., Nakayama, S., Kawada, I., Nakachi, I., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Watanabe, H., Naoki, K., Hayashi, Y. & Ishizaka, A., 2011 4, : : Lung Cancer. 72, 1, p. 32-38 7 p.

研究成果: Article

Lung Neoplasms
Tumor Suppressor Genes
Serum
Epigenomics
Mutation
43 引用 (Scopus)

The PCR-invader method (structure-specific 5 nuclease-based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens; Comparison with direct sequencing

Naoki, K., Soejima, K., Okamoto, H., Hamamoto, J., Hida, N., Nakachi, I., Yasuda, H., Nakayama, S., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T. & Watanabe, K., 2011 8, : : International Journal of Clinical Oncology. 16, 4, p. 335-344 10 p.

研究成果: Article

erbB-1 Genes
Lung Neoplasms
Polymerase Chain Reaction
Mutation
Non-Small Cell Lung Carcinoma
2010
15 引用 (Scopus)

Distinct epigenetic regulation of tumor suppressor genes in putative cancer stem cells of solid tumors

Yasuda, H., Soejima, K., Watanabe, H., Kawada, I., Nakachi, I., Yoda, S., Nakayama, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Suzuki, S., Matsuzaki, Y., Naoki, K. & Ishizaka, A., 2010 12, : : International Journal of Oncology. 37, 6, p. 1537-1546 10 p.

研究成果: Article

Neoplastic Stem Cells
Tumor Suppressor Genes
Epigenomics
Chromatin
Neoplasms

FDG-PET imaging of benign pulmonary diseases

Terai, H., Soejima, K., Naoki, K., Kawada, I., Nakachi, I., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Sato, T., Ishizaka, A. & Yasuda, H., 2010, : : Japanese Journal of Clinical Radiology. 55, 1, p. 163-172 10 p.

研究成果: Article

Positron-Emission Tomography
Lung Diseases
Mediastinal Diseases
Radiation Pneumonitis
Pneumoconiosis
19 引用 (Scopus)

The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-met inhibition

Nakachi, I., Naoki, K., Soejima, K., Kawada, I., Watanabe, H., Yasuda, H., Nakayama, S., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T. & Ishizaka, A., 2010 8, : : Molecular Cancer Research. 8, 8, p. 1142-1151 10 p.

研究成果: Article

Receptor Protein-Tyrosine Kinases
Sirolimus
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Cell Line