Takeshi Akiyoshi

2022

Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity

Akiyoshi, T., Uchiyama, M., Inada, R., Imaoka, A. & Ohtani, H., 2022 2月, In: Drug Metabolism And Pharmacokinetics. 42, 100429.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants

Araki, N., Morita, T., Akiyoshi, T., Kataoka, H., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 10月, In: Drug Metabolism And Pharmacokinetics. 46, 100464.

研究成果: Article › 査読

1 被引用数 (Scopus)

Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants

Han, H., Akiyoshi, T., Morita, T., Kataoka, H., Katayama, K., Yajima, K., Imaoka, A. & Ohtani, H., 2022 12月, In: Drug Metabolism And Pharmacokinetics. 47, 100470.

研究成果: Article › 査読

Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant

Hibino, H., Sakiyama, N., Makino, Y., Makihara-Ando, R., Horinouchi, H., Fujiwara, Y., Kanda, S., Goto, Y., Yoshida, T., Okuma, Y., Shinno, Y., Murakami, S., Hashimoto, H., Akiyoshi, T., Imaoka, A., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2022 4月, In: European Journal of Clinical Pharmacology. 78, 4, p. 613-621 9 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Inhibitory Effects of Cranberry Juice and Its Components on Intestinal OATP1A2 and OATP2B1: Identification of Avicularin as a Novel Inhibitor

Morita, T., Akiyoshi, T., Tsuchitani, T., Kataoka, H., Araki, N., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 3月 16, In: Journal of agricultural and food chemistry. 70, 10, p. 3310-3320 11 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2022 5月, In: International journal of clinical pharmacology and therapeutics. 60, 5, p. 217-224 8 p.

研究成果: Article › 査読

2021

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants

Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100384.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2021 12月, In: Journal of Pharmaceutical Health Care and Sciences. 7, 1, 24.

研究成果: Article › 査読

Open Access

Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors

Sato, R., Akiyoshi, T., Morita, T., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A. & Ohtani, H., 2021 12月, In: Drug Metabolism And Pharmacokinetics. 41, 100416.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Estimation of absolute oral bioavailability without performing an intravenous clinical study

Ohtani, H., Iwata, R., Imaoka, A. & Akiyoshi, T., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100392.

研究成果: Article › 査読

Open Access

Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report

Hibino, H., Makino, Y., Sakiyama, N., Makihara-Ando, R., Hashimoto, H., Akiyoshi, T., Imaoka, A., Fujiwara, Y., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2021 4月, In: International journal of clinical pharmacology and therapeutics. 59, 4, p. 328-332 5 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach

Koinuma, K., Tsuchitani, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2021 3月, In: International journal of clinical pharmacology and therapeutics. 59, 3, p. 231-238 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Time-dependent inhibition of CYP3A4- mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

Akiyoshi, T., Naitou, R., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 12月, In: International journal of clinical pharmacology and therapeutics. 59, 12, p. 745-782 38 p.

研究成果: Article › 査読

2020

Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides

Morita, T., Akiyoshi, T., Sato, R., Uekusa, Y., Katayama, K., Yajima, K., Imaoka, A., Sugimoto, Y., Kiuchi, F. & Ohtani, H., 2020 12月 2, In: Journal of agricultural and food chemistry. 68, 48, p. 14182-14191 10 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs

Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11月 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1529-1536 8 p.

研究成果: Article › 査読

pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2

Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Profile of the inhibitory effects of gefitinib in CYP2D6 variants in vitro

Semba, Y., Akiyoshi, T., Hibino, H., Imaoka, A. & Ohtani, H., 2020 10月, In: International journal of clinical pharmacology and therapeutics. 58, 10, p. 539-542 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

2019

Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats

Ogata, Y., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 1月 1, In: Drug Metabolism And Pharmacokinetics.

研究成果: Article › 査読

1 被引用数 (Scopus)

Inhibitory kinetics of fruit components on CYP2C19 activity

Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 6月, In: Drug Metabolism And Pharmacokinetics. 34, 3, p. 181-186 6 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate

Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 11月 1, In: Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats

Imaoka, A., Seki, K., Akiyoshi, T. & Ohtani, H., 2019 2月, In: Drug Metabolism And Pharmacokinetics. 34, 1, p. 108-110 3 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2018

5-Fluororacil–Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate

Tsujii, K., Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2018 5月, In: Journal of Pharmaceutical Sciences. 107, 5, p. 1430-1433 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2017

5-Fluorouracil treatment alters the expression of intestinal transporters in rats

Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12月, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan

Ohtani, H., Mitsui, R., Akiyoshi, T., Imaoka, A., Abe, Y., Kanke, M., Nakamura, T., Foster, P. & Mochizuki, M., 2017 5月, In: Currents in Pharmacy Teaching and Learning. 9, 3, p. 452-459 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 10月, In: Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

2016

In silico evaluation of warfarin–bucolome therapy

Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In: Biopharmaceutics and Drug Disposition. p. 233-242 10 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

2015

Current status of illegal trade in pharmaceutical products on internet auction sites in japan and responses of site administrators to such transactions

Ohtani, H., Imaoka, A. & Akiyoshi, T., 2015 3月 1, In: Yakugaku Zasshi. 135, 3, p. 529-534 6 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6

Akiyoshi, T., Ishiuchi, M., Imaoka, A. & Ohtani, H., 2015 8月 1, In: Drug Metabolism And Pharmacokinetics. 30, 4, p. 321-324 4 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2014

Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption

Imaoka, A., Hattori, M., Akiyoshi, T. & Ohtani, H., 2014, In: Drug Metabolism And Pharmacokinetics. 29, 5, p. 414-418 5 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice

Kogure, N., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2014 10月 1, In: Biopharmaceutics and Drug Disposition. 35, 7, p. 373-381 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2013

Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population

Akiyoshi, T., Shimomura, Y., Masuda, S., Okamoto, Y., Hiura, S., Kato, H., Asayama, T. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 446-450 5 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants

Akiyoshi, T., Ito, M., Murase, S., Miyazaki, M., Peter Guengerich, F., Nakamura, K., Yamamoto, K. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 411-415 5 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

2011

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

Akiyoshi, T., Saito, T., Murase, S., Miyazaki, M., Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2011 4月, In: Drug Metabolism and Disposition. 39, 4, p. 724-728 5 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

2010

Stability of gabexate mesilate products: Influence of the addition of mannitol

Sakurai, M., Abe, H., Okamura, N., Inoue, Y., Akiyoshi, T., Matsuyama, K., Uchida, T. & Otsuka, M., 2010, In: Bio-Medical Materials and Engineering. 20, 1, p. 13-20 8 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

2009

Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts

Matzno, S., Nishiguchi, T., Akiyoshi, T., Anami, S., Nakabayashi, T. & Matsuyama, K., 2009 6月, In: Journal of Pharmacy and Pharmacology. 61, 6, p. 781-788 8 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

The potential of vitamin K₃ as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway

Akiyoshi, T., Matzno, S., Sakai, M., Okamura, N. & Matsuyama, K., 2009, In: Cancer Chemotherapy and Pharmacology. 65, 1, p. 143-150 8 p.

研究成果: Article › 査読

61 被引用数 (Scopus)

2008

An attempt to evaluate the effect of vitamin K₃ using as an enhancer of anticancer agents

Matzno, S., Yamaguchi, Y., Akiyoshi, T., Nakabayashi, T. & Matsuyama, K., 2008 6月, In: Biological and Pharmaceutical Bulletin. 31, 6, p. 1270-1273 4 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

2007

Effects of quinine on the intracellular calcium level and membrane potential of PC 12 cultures

Akiyoshi, T., Tanaka, N., Nakamura, T., Matzno, S., Shinozuka, K. & Uchida, T., 2007 11月, In: Journal of Pharmacy and Pharmacology. 59, 11, p. 1521-1526 6 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

2006

Clofibrate-induced apoptosis is mediated by Ca²⁺-dependent caspase-12 activation

Matzno, S., Yasuda, S., Kitada, Y., Akiyoshi, T., Tanaka, N., Juman, S., Shinozuka, K., Nakabayashi, T. & Matsuyama, K., 2006 3月 13, In: Life Sciences. 78, 16, p. 1892-1899 8 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

2003

Effect of quinine solutions on intracellular Ca²⁺ levels in neuro-2a cells - Conventional physiological method for the evaluation of bitterness

Nakamura, T., Akiyoshi, T., Tanaka, N., Shinozuka, K., Matzno, S., Nakabayashi, T., Matsuyama, K., Kashiwayanagi, M. & Uchida, T., 2003 11月, In: Biological and Pharmaceutical Bulletin. 26, 11, p. 1637-1640 4 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

2002

The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies

Nakamura, T., Tanigake, A., Miyanaga, Y., Ogawa, T., Akiyoshi, T., Matsuyama, K. & Uchida, T., 2002 12月, In: Chemical and Pharmaceutical Bulletin. 50, 12, p. 1589-1593 5 p.

研究成果: Article › 査読

70 被引用数 (Scopus)

秋好 健志

研究成果

検索結果

秋好健志