Takeshi Kanda

2022

Development of Alveolar Hemorrhage After Pfizer-BioNTech COVID-19 mRNA Vaccination in a Patient With Renal-Limited Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

Nishioka, K., Yamaguchi, S., Yasuda, I., Yoshimoto, N., Kojima, D., Kaneko, K., Aso, M., Nagasaka, T., Yoshida, E., Uchiyama, K., Tajima, T., Yoshino, J., Yoshida, T., Kanda, T. & Itoh, H., 2022 4月 8, In: Frontiers in Medicine. 9, 874831.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Effects of renin-angiotensin system inhibitors on the incidence of unplanned dialysis

Nakayama, T., Morimoto, K., Uchiyama, K., Kusahana, E., Washida, N., Azegami, T., Kanda, T., Yoshida, T. & Itoh, H., 2022 6月, In: Hypertension Research. 45, 6, p. 1018-1027 10 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Fibronectin Glomerulopathy Confused with Glomerular Endothelial Injury in a Patient with Takotsubo Cardiomyopathy

Azegami, T., Hashiguchi, A., Nakayama, T., Hayashi, K., Kanda, T. & Itoh, H., 2022, In: Internal Medicine. 61, 13, p. 2027-2032 6 p.

研究成果: Article › 査読

Open Access

Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage

Ida-Naitoh, M., Tokuyama, H., Futatsugi, K., Yasuda, M., Adachi, K., Kanda, T., Tanabe, Y., Wakino, S. & Itoh, H., 2022, (Accepted/In press) In: Kidney international.

研究成果: Article › 査読

1 被引用数 (Scopus)

Serum thymus and activation-regulated chemokine level is associated with the severity of chronic kidney disease-associated pruritus in patients undergoing peritoneal dialysis

Nakayama, T., Morimoto, K., Uchiyama, K., Kusahana, E., Washida, N., Azegami, T., Kanda, T., Yoshida, T. & Itoh, H., 2022 7月, In: Peritoneal Dialysis International. 42, 4, p. 415-424 10 p.

研究成果: Article › 査読

The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease

Takahashi, R., Kanda, T., Komatsu, M., Itoh, T., Minakuchi, H., Urai, H., Kuroita, T., Shigaki, S., Tsukamoto, T., Higuchi, N., Ikeda, M., Yamanaka, R., Yoshimura, N., Ono, T., Yukioka, H., Hasegawa, K., Tokuyama, H., Wakino, S. & Itoh, H., 2022 12月, In: Scientific reports. 12, 1, 6398.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

2021

Difficulty in managing nephrotic syndrome-associated cerebral venous thrombosis

Nakayama, T., Mitsuno, R., Torimitsu, T., Yoshimoto, N., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2021 2月 1, In: CEN case reports. 10, 1, p. 132-138 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Pre-emptive short-term nicotinamide mononucleotide treatment in a mouse model of diabetic nephropathy

Yasuda, I., Hasegawa, K., Sakamaki, Y., Muraoka, H., Kawaguchi, T., Kusahana, E., Ono, T., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2021 6月, In: Journal of the American Society of Nephrology. 32, 6, p. 1355-1370 16 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2020

The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial

Minakuchi, H., Wakino, S., Urai, H., Kurokochi, A., Hasegawa, K., Kanda, T., Tokuyama, H. & Itoh, H., 2020 12月 1, In: Scientific reports. 10, 1, 16626.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

2019

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Hishikawa, A., Hayashi, K., Abe, T., Kaneko, M., Yokoi, H., Azegami, T., Nakamura, M., Yoshimoto, N., Kanda, T., Sakamaki, Y. & Itoh, H., 2019 1月 29, In: Cell Reports. 26, 5, p. 1318-1332.e4

研究成果: Article › 査読

Open Access

17 被引用数 (Scopus)

Low birth weight is associated with decline in renal function in Japanese male and female adolescents

Murai-Takeda, A., Kanda, T., Azegami, T., Hirose, H., Inokuchi, M., Tokuyama, H., Wakino, S., Tokumura, M., Kawabe, H., Mori, M. & Itoh, H., 2019 12月 1, In: Clinical and experimental nephrology. 23, 12, p. 1364-1372 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy

Muraoka, H., Hasegawa, K., Sakamaki, Y., Minakuchi, H., Kawaguchi, T., Yasuda, I., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2019 4月 2, In: Cell Reports. 27, 1, p. 199-212.e5

研究成果: Article › 査読

Open Access

37 被引用数 (Scopus)

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

Tajima, T., Yoshifuji, A., Matsui, A., Itoh, T., Uchiyama, K., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2019 5月, In: Kidney international. 95, 5, p. 1120-1137 18 p.

研究成果: Article › 査読

Open Access

65 被引用数 (Scopus)

2018

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

Umino, H., Hasegawa, K., Minakuchi, H., Muraoka, H., Kawaguchi, T., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2018 12月 1, In: Scientific reports. 8, 1, 6791.

研究成果: Article › 査読

Open Access

84 被引用数 (Scopus)

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD ⁺ metabolism

Komatsu, M., Kanda, T., Urai, H., Kurokochi, A., Kitahama, R., Shigaki, S., Ono, T., Yukioka, H., Hasegawa, K., Tokuyama, H., Kawabe, H., Wakino, S. & Itoh, H., 2018 12月 1, In: Scientific reports. 8, 1, 8637.

研究成果: Article › 査読

Open Access

48 被引用数 (Scopus)

2017

Association of kidney dysfunction with asymptomatic cerebrovascular abnormalities in a Japanese population with health checkups

Hayashi, K., Takayama, M., Kanda, T., Kashiwagi, K., Hishikawa, A., Iwao, Y. & Itoh, H., 2017, In: Circulation Journal. 81, 8, p. 1191-1197 7 p.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Investigation of metabolic factors associated with eGFR decline over 1 year in a Japanese population without CKD

Hayashi, K., Takayama, M., Abe, T., Kanda, T., Hirose, H., Shimizu-Hirota, R., Shiomi, E., Iwao, Y. & Itoh, H., 2017, In: Journal of atherosclerosis and thrombosis. 24, 8, p. 863-875 13 p.

研究成果: Article › 査読

Open Access

13 被引用数 (Scopus)

2016

Gut Lactobacillus protects against the progression of renal damage by modulating the gut environment in rats

Yoshifuji, A., Wakino, S., Irie, J., Tajima, T., Hasegawa, K., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2016 3月 1, In: Nephrology Dialysis Transplantation. 31, 3, p. 401-412 12 p.

研究成果: Article › 査読

Open Access

70 被引用数 (Scopus)

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules

Futatsugi, K., Tokuyama, H., Shibata, S., Naitoh, M., Kanda, T., Minakuchi, H., Yamaguchi, S., Hayashi, K., Minamishima, Y. A., Yanagita, M., Wakino, S. & Itoh, H., 2016 11月 9, In: Scientific reports. 6, 36533.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats

Minakuchi, H., Wakino, S., Hosoya, K., Sueyasu, K., Hasegawa, K., Shinozuka, K., Yoshifuji, A., Futatsugi, K., Komatsu, M., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2016 3月 1, In: Nephrology Dialysis Transplantation. 31, 3, p. 413-423 11 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Vitamin D deficiency with high intact PTH levels is more common in younger than in older women: A study of women aged 39–64 years

Miyamoto, T., Katsuyama, E., Kanagawa, H., Fujie, A., Miyamoto, H., Yoshida, S., Mori, T., Miyamoto, K., Sato, Y., Kobayashi, T., Nakamura, M., Matsumoto, M., Nishiwaki, Y., Hirose, H., Kanda, T., Saito, I. & Toyama, Y., 2016, In: Keio Journal of Medicine. 65, 2, p. 33-38 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

2015

Comparison of the effects of low-dose rosuvastatin on plasma levels of cholesterol and oxidized low-density lipoprotein in 3 ultracentrifugally separated low-density lipoprotein subfractions

Homma, K., Homma, Y., Ozawa, H., Shiina, Y., Shibata, T., Yoshida, T., Hasegawa, K., Kanda, T., Tokuyama, H., Wakino, S., Hayashi, K., Itoh, H. & Hori, S., 2015 11月 1, In: Journal of Clinical Lipidology. 9, 6, p. 751-757 7 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans

Hosoya, K., Minakuchi, H., Wakino, S., Fujimura, K., Hasegawa, K., Komatsu, M., Yoshifuji, A., Futatsugi, K., Shinozuka, K., Washida, N., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2015 4月 8, In: Kidney international. 87, 4, p. 749-760 12 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

2014

Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice

Fujimura, K., Wakino, S., Minakuchi, H., Hasegawa, K., Hosoya, K., Komatsu, M., Kaneko, Y., Shinozuka, K., Washida, N., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2014 4月 18, In: PloS one. 9, 4, e94373.

研究成果: Article › 査読

35 被引用数 (Scopus)

Rho-kinase contributes to pressure-induced constriction of renal microvessels

Homma, K., Hayashi, K., Wakino, S., Tokuyama, H., Kanda, T., Tatematsu, S., Hasegawa, K., Fujishima, S., Hori, S., Saruta, T. & Itoh, H., 2014, In: Keio Journal of Medicine. 63, 1, p. 1-12 12 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2013

Renal tubular sirt1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes

Hasegawa, K., Wakino, S., Simic, P., Sakamaki, Y., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Kubota, E., Tokuyama, H., Hayashi, K., Guarente, L. & Itoh, H., 2013 11月, In: Nature medicine. 19, 11, p. 1496-1504 9 p.

研究成果: Article › 査読

310 被引用数 (Scopus)

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice

Hasegawa, K., Wakino, S., Kimoto, M., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2013 6月, In: FASEB Journal. 27, 6, p. 2301-2315 15 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

2012

Variability of home blood pressure measurements between first and second measurements on one occasion, and factors related to variability

Kawabe, H., Kanda, T., Hirose, H. & Saito, I., 2012 7月, In: Clinical and Experimental Hypertension. 34, 4, p. 237-242 6 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

2011

Relationship between waist circumferences measured at the umbilical level and midway between the ribs and iliac crest: A solution to the debate on optimal waist circumference standards in the diagnostic criteria of Metabolic Syndrome in Japan

Yokoyama, H., Hirose, H., Kanda, T., Kawabe, H. & Saito, I., 2011, In: Journal of atherosclerosis and thrombosis. 18, 9, p. 735-743 9 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

2009

PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice

Kanda, T., Brown, J. D., Orasanu, G., Vogel, S., Gonzalez, F. J., Sartoretto, J., Michel, T. & Plutzky, J., 2009 1月 5, In: Journal of Clinical Investigation. 119, 1, p. 110-124 15 p.

研究成果: Article › 査読

128 被引用数 (Scopus)

2008

Renal cytochrome P450 as a determinant of impaired natriuresis by PPAR-γ ligands in ovariectomized obese rats

Yoshioka, K., Wakino, S., Homma, K., Kanda, T., Tatematsu, S., Hasegawa, K., Sugano, N., Ito, O., Omata, K., Saruta, T. & Hayashi, K., 2008 5月, In: Obesity. 16, 5, p. 965-971 7 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy

Sugano, N., Wakino, S., Kanda, T., Tatematsu, S., Homma, K., Yoshioka, K., Hasegawa, K., Hara, Y., Suetsugu, Y., Yoshizawa, T., Hara, Y., Utsunomiya, Y., Tokudome, G., Hosoya, T., Saruta, T. & Hayashi, K., 2008 4月, In: Kidney international. 73, 7, p. 826-834 9 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

2007

PPARs and their metabolic modulation: New mechanisms for transcriptional regulation?

Ahmed, W., Ziouzenkova, O., Brown, J., Devchand, P., Francis, S., Kadakia, M., Kanda, T., Orasanu, G., Sharlach, M., Zandbergen, F. & Plutzky, J., 2007 8月, In: Journal of Internal Medicine. 262, 2, p. 184-198 15 p.

研究成果: Article › 査読

Open Access

116 被引用数 (Scopus)

Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease

Tatematsu, S., Wakino, S., Kanda, T., Homma, K., Yoshioka, K., Hasegawa, K., Sugano, N., Kimoto, M., Saruta, T. & Hayashi, K., 2007 3月, In: Journal of the American Society of Nephrology. 18, 3, p. 741-749 9 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

2006

Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells

Hasegawa, K., Wakino, S., Tanaka, T., Kimoto, M., Tatematsu, S., Kanda, T., Yoshioka, K., Homma, K., Sugano, N., Kurabayashi, M., Saruta, T. & Hayashi, K., 2006 7月, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 7, p. 1488-1494 7 p.

研究成果: Article › 査読

72 被引用数 (Scopus)

Rho-kinase as a molecular target for insulin resistance and hypertension

Kanda, T., Wakino, S., Homma, K., Yoshioka, K., Tatematsu, S., Hasegawa, K., Takamatsu, I., Sugano, N., Hayashi, K. & Saruta, T., 2006 1月 1, In: FASEB Journal. 20, 1, p. 169-171 3 p.

研究成果: Article › 査読

92 被引用数 (Scopus)

2005

Divergent action of calcium channel blockers on ATP-binding cassette protein expression

Hasegawa, K., Wakino, S., Kanda, T., Yoshioka, K., Tatematsu, S., Homma, K., Takamatsu, I., Sugano, N. & Hayashi, K., 2005 12月 1, In: Journal of Cardiovascular Pharmacology. 46, 6, p. 787-793 7 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats

Wakino, S., Hayashi, K., Tatematsu, S., Hasegawa, K., Takamatsu, I., Kanda, T., Homma, K., Yoshioka, K., Sugano, N. & Saruta, T., 2005 3月, In: Hypertension Research. 28, 3, p. 255-262 8 p.

研究成果: Article › 査読

102 被引用数 (Scopus)

Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats - Studies in the isolated perfused hydronephrotic kidney

Hayashi, K., Wakino, S., Ozawa, Y., Homma, K., Kanda, T., Okubo, K., Takamatsu, I., Tatematsu, S., Kumagai, H. & Saruta, T., 2005 6月, In: Keio Journal of Medicine. 54, 2, p. 102-108 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Role of Rho-kinase and p27 in angiotensin II-induced vascular injury

Kanda, T., Hayashi, K., Wakino, S., Homma, K., Yoshioka, K., Hasegawa, K., Sugano, N., Tatematsu, S., Takamatsu, I., Mitsuhashi, T. & Saruta, T., 2005 4月, In: Hypertension. 45, 4 SUPPL., p. 724-729 6 p.

研究成果: Article › 査読

53 被引用数 (Scopus)

2004

Beneficial action of candesartan cilexetil plus amlodipine or ACE inhibitors in chronic nondiabetic renal disease

Homma, K., Hayashi, K., Kanda, T., Yoshioka, K., Takamatsu, I., Tatematsu, S., Kumagai, H., Wakino, S. & Saruta, T., 2004 12月, In: Journal of Human Hypertension. 18, 12, p. 879-884 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Free Radical Activity Depends on Underlying Vasoconstrictors in Renal Microcirculation

Ozawa, Y., Hayashi, K., Wakino, S., Kanda, T., Homma, K., Takamatsu, I., Tatematsu, S., Yoshioka, K. & Saruta, T., 2004 4月 1, In: Clinical and Experimental Hypertension. 26, 3, p. 219-229 11 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats

Ozawa, Y., Hayashi, K., Kanda, T., Homma, K., Takamatsu, I., Tatematsu, S., Yoshioka, K., Kumagai, H., Wakino, S. & Saruta, T., 2004 10月 1, In: Nephrology. 9, 5, p. 272-277 6 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2.

Wakino, S., Hayashi, K., Kanda, T., Tatematsu, S., Homma, K., Yoshioka, K., Takamatsu, I. & Saruta, T., 2004 9月 3, In: Circulation research. 95, 5, p. e45-55

研究成果: Article › 査読

91 被引用数 (Scopus)

2003

Cellular Mechanism for Mibefradil-Induced Vasodilation of Renal Microcirculation: Studies in the Isolated Perfused Hydronephrotic Kidney

Hayashi, K., Ozawa, Y., Wakino, S., Kanda, T., Homma, K., Takamatsu, I., Tatematsu, S. & Saruta, T., 2003 12月 1, In: Journal of Cardiovascular Pharmacology. 42, 6, p. 697-702 6 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Differing anti-proteinuric action of candesartan and losartan in chronic renal disease

Matsuda, H., Hayashi, K., Homma, K., Yoshioka, K., Kanda, T., Takamatsu, I., Tatematsu, S., Wakino, S. & Saruta, T., 2003 11月, In: Hypertension Research. 26, 11, p. 875-880 6 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats

Kanda, T., Wakino, S., Hayashi, K., Homma, K., Ozawa, Y. & Saruta, T., 2003 12月, In: Kidney international. 64, 6, p. 2009-2019 11 p.

研究成果: Article › 査読

92 被引用数 (Scopus)

Vessel- and vasoconstrictor-dependent role of Rho/Rho-kinase in renal microvascular tone

Nakamura, A., Hayashi, K., Ozawa, Y., Fujiwara, K., Okubo, K., Kanda, T., Wakino, S. & Saruta, T., 2003 8月 22, In: Journal of Vascular Research. 40, 3, p. 244-251 8 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

2002

Altered renal microvascular response in Zucker obese rats

Hayashi, K., Kanda, T., Homma, K., Tokuyama, H., Okubo, K., Takamatsu, I., Tatematsu, S., Kumagai, H. & Saruta, T., 2002 12月 1, In: Metabolism: clinical and experimental. 51, 12, p. 1553-1561 9 p.

研究成果: Article › 査読

45 被引用数 (Scopus)

Distinct role of nitric oxide and endothelium-derived hyperpolarizing factor in renal microcirculation: Studies in the isolated perfused hydronephrotic kidney

Ozawa, Y., Hayashi, K., Nagahama, T., Fujiwara, K., Kanda, T., Homma, K. & Saruta, T., 2002, In: Nephron. 92, 4, p. 905-913 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

神田 武志

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神田武志