Takuya Shimazaki

Tsuyama, J., Bunt, J., Richards, L. J., Iwanari, H., Mochizuki, Y., Hamakubo, T., Shimazaki, T. & Okano, H., 2015 9 8, ： : Stem Cell Reports. 5, 3, p. 365-377 13 p.

研究成果: Article

24 引用（Scopus）

2014

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

Tomioka, T., Shimazaki, T., Yamauchi, T., Oki, T., Ohgoh, M. & Okano, H., 2014 1 10, ： : Journal of Biological Chemistry. 289, 2, p. 1000-1010 11 p.

研究成果: Article

2 引用（Scopus）

The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

Naka-Kaneda, H., Nakamura, S., Igarashi, M., Aoi, H., Kanki, H., Tsuyama, J., Tsutsumi, S., Aburatani, H., Shimazaki, T. & Okano, H., 2014 1 28, ： : Proceedings of the National Academy of Sciences of the United States of America. 111, 4, p. 1604-1609 6 p.

研究成果: Article

36 引用（Scopus）

2010

Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells

Tao, O., Shimazaki, T., Okada, Y., Naka, H., Kohda, K., Yuzaki, M., Mizusawa, H. & Okano, H., 2010 2 1, ： : Journal of neuroscience research. 88, 2, p. 234-247 14 p.

研究成果: Article

20 引用（Scopus）

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells

Sato, T., Shimazaki, T., Naka, H., Fukami, S. I., Satoh, Y., Okano, H., Irit, L., Schlessinger, J. & Gotoh, N., 2010 9, ： : Stem Cells. 28, 9, p. 1661-1673 13 p.

研究成果: Article

25 引用（Scopus）

Regulation of adult neural progenitor cells by Galectin-1/β1 Integrin interaction

Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki, T., Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K. & Okano, H., 2010 6, ： : Journal of Neurochemistry. 113, 6, p. 1516-1524 9 p.

研究成果: Article

21 引用（Scopus）

Stromal cell-secreted factors promote the survival of embryonic stem cell-derived early neural stem/progenitor cells via the activation of MAPK and PI3K-Akt pathways

Ishii, S., Okada, Y., Kadoya, T., Matsuzaki, Y., Shimazaki, T. & Okano, H., 2010 3 1, ： : Journal of neuroscience research. 88, 4, p. 722-734 13 p.

研究成果: Article

23 引用（Scopus）

2009

Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: Properties and tumorigenicity after long-term in vitro maintenance

Ogawa, D., Okada, Y., Nakamura, M., Kanemura, Y., Okano, H. J., Matsuzaki, Y., Shimazaki, T., Ito, M., Ikeda, E., Tamiya, T., Nagao, S. & Okano, H., 2009 2 1, ： : Journal of neuroscience research. 87, 2, p. 307-317 11 p.

研究成果: Article

23 引用（Scopus）

2008

Consequence of the loss of Sox2 in the developing brain of the mouse

Miyagi, S., Masui, S., Niwa, H., Saito, T., Shimazaki, T., Okano, H., Nishimoto, M., Muramatsu, M., Iwama, A. & Okuda, A., 2008 8 6, ： : FEBS Letters. 582, 18, p. 2811-2815 5 p.

研究成果: Article

67 引用（Scopus）

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

Naka, H., Nakamura, S., Shimazaki, T. & Okano, H., 2008 9 1, ： : Nature Neuroscience. 11, 9, p. 1014-1023 10 p.

研究成果: Article

152 引用（Scopus）

Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation

Ozawa, Y., Nakao, K., Kurihara, T., Shimazaki, T., Shimmura, S., Ishida, S., Yoshimura, A., Tsubota, K. & Okano, H., 2008 9 5, ： : Journal of Biological Chemistry. 283, 36, p. 24561-24570 10 p.

研究成果: Article

45 引用（Scopus）

Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells

Okada, Y., Matsumoto, A., Shimazaki, T., Enoki, R., Koizumi, A., Ishii, S., Itoyama, Y., Sobue, G. & Okano, H., 2008 12 1, ： : Stem Cells. 26, 12, p. 3086-3098 13 p.

研究成果: Article

123 引用（Scopus）

2007

Epidermal growth factor signaling mediated by Grb2 associated binder1 is required for the spatiotemporally regulated proliferation of Olig2-expressing progenitors in the embryonic spinal cord

Hayakawa-Yano, Y., Nishida, K., Fukami, S., Gotoh, Y., Hirano, T., Nakagawa, T., Shimazaki, T. & Okanob, H., 2007 6 1, ： : Stem Cells. 25, 6, p. 1410-1422 13 p.

研究成果: Article

16 引用（Scopus）

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway

Kohno, D., Nakata, M., Maekawa, F., Fujiwara, K., Maejima, Y., Kuramochi, M., Shimazaki, T., Okano, H., Onaka, T. & Yada, T., 2007 5, ： : Endocrinology. 148, 5, p. 2251-2263 13 p.

研究成果: Article

105 引用（Scopus）

Simian fetal brain progenitor cells for studying viral neuropathogenesis

Iwata, N., Yoshida, H., Tobiume, M., Ono, F., Shimazaki, T., Sata, T. & Nakajima, N., 2007 1 1, ： : Journal of NeuroVirology. 13, 1, p. 11-22 12 p.

研究成果: Article

2 引用（Scopus）

SOCS3 is required to temporally fine-tune photoreceptor cell differentiation

Ozawa, Y., Nakao, K., Shimazaki, T., Shimmura, S., Kurihara, T., Ishida, S., Yoshimura, A., Tsubota, K. & Okano, H., 2007 3 15, ： : Developmental Biology. 303, 2, p. 591-600 10 p.

研究成果: Article

16 引用（Scopus）

2006

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Sakaguchi, M., Shingo, T., Shimazaki, T., Okano, H. J., Shiwa, M., Ishibashi, S., Oguro, H., Ninomiya, M., Kadoya, T., Horie, H., Shibuya, A., Mizusawa, H., Poirier, F., Nakauchi, H., Sawamoto, K. & Okano, H., 2006 5 2, ： : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7112-7117 6 p.

研究成果: Article

133 引用（Scopus）

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y. & Okano, H., 2006 7 1, ： : Nature medicine. 12, 7, p. 829-834 6 p.

研究成果: Article

590 引用（Scopus）

Histopathological and behavioral improvement of murine mucopolysaccharidosis type VII by intracerebral transplantation of neural stem cells

Fukuhara, Y., Li, X. K., Kitazawa, Y., Inagaki, M., Matsuoka, K., Kosuga, M., Kosaki, R., Shimazaki, T., Endo, H., Umezawa, A., Okano, H., Takahashi, T. & Okuyama, T., 2006 3 1, ： : Molecular Therapy. 13, 3, p. 548-555 8 p.

研究成果: Article

14 引用（Scopus）

2005

Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart

Tomita, Y., Matsumura, K., Wakamatsu, Y., Matsuzaki, Y., Shibuya, I., Kawaguchi, H., Ieda, M., Kanakubo, S., Shimazaki, T., Ogawa, S., Osumi, N., Okano, H. & Fukuda, K., 2005 9 26, ： : Journal of Cell Biology. 170, 7, p. 1135-1146 12 p.

研究成果: Article

252 引用（Scopus）

Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression

Uemura, O., Okada, Y., Ando, H., Guedj, M., Higashijima, S. I., Shimazaki, T., Chino, N., Okano, H. & Okamoto, H., 2005 2 15, ： : Developmental Biology. 278, 2, p. 587-606 20 p.

研究成果: Article

101 引用（Scopus）

Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J. & Gotoh, N., 2005 11 1, ： : Proceedings of the National Academy of Sciences of the United States of America. 102, 44, p. 15983-15988 6 p.

研究成果: Article

53 引用（Scopus）

Inhibition of glioma cell proliferation by neural stem cell factor

Suzuki, T., Izumoto, S., Wada, K., Fujimoto, Y., Maruno, M., Yamasaki, M., Kanemura, Y., Shimazaki, T., Okano, H. & Yoshimine, T., 2005 9 1, ： : Journal of Neuro-Oncology. 74, 3, p. 233-239 7 p.

研究成果: Article

20 引用（Scopus）

Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers

Nagato, M., Heike, T., Kato, T., Yamanaka, Y., Yoshimoto, M., Shimazaki, T., Okano, H. & Nakahata, T., 2005 5 15, ： : Journal of neuroscience research. 80, 4, p. 456-466 11 p.

研究成果: Article

64 引用（Scopus）

Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells

Yuasa, S., Itabashi, Y., Koshimizu, U., Tanaka, T., Sugimura, K., Kinoshita, M., Hattori, F., Fukami, S. I., Shimazaki, T., Okano, H., Ogawa, S. & Fukuda, K., 2005, ： : Nature Biotechnology. 23, 5, p. 607-611 5 p.

研究成果: Article

236 引用（Scopus）

2004

Blockade of Interleukin-6 Receptor Suppresses Reactive Astrogliosis and Ameliorates Functional Recovery in Experimental Spinal Cord Injury

Okada, S., Nakamura, M., Mikami, Y., Shimazaki, T., Mihara, M., Ohsugi, Y., Iwamoto, Y., Yoshizaki, K., Kishimoto, T., Toyama, Y. & Okano, H., 2004 4 15, ： : Journal of neuroscience research. 76, 2, p. 265-276 12 p.

研究成果: Article

180 引用（Scopus）

Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina

Ozawa, Y., Nakao, K., Shimazaki, T., Takeda, J., Akira, S., Ishihara, K., Hirano, T., Oguchi, Y. & Okano, H., 2004 6 1, ： : Molecular and Cellular Neuroscience. 26, 2, p. 258-270 13 p.

研究成果: Article

41 引用（Scopus）

Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils

Ishibashi, S., Sakaguchi, M., Kuroiwa, T., Yamasaki, M., Kanemura, Y., Shizuko, I., Shimazaki, T., Onodera, M., Okano, H. & Mizusawa, H., 2004 10 15, ： : Journal of neuroscience research. 78, 2, p. 215-223 9 p.

研究成果: Article

139 引用（Scopus）

Implantation of Dendritic Cells in Injured Adult Spinal Cord Results in Activation of Endogenous Neural Stem/Progenitor Cells Leading to De Novo Neurogenesis and Functional Recovery

Mikami, Y., Okano, H., Sakaguchi, M., Nakamura, M., Shimazaki, T., Okano, H. J., Kawakami, Y., Toyama, Y. & Toda, M., 2004 5 15, ： : Journal of neuroscience research. 76, 4, p. 453-465 13 p.

研究成果: Article

67 引用（Scopus）

Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells

Yoshizaki, T., Inaji, M., Kouike, H., Shimazaki, T., Sawamoto, K., Ando, K., Date, I., Kobayashi, K., Suhara, T., Uchiyama, Y. & Okano, H., 2004 6 3, ： : Neuroscience Letters. 363, 1, p. 33-37 5 p.

研究成果: Article

75 引用（Scopus）

Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension

Nishino, J., Yamashita, K., Hashiguchi, H., Fujii, H., Shimazaki, T. & Hamada, H., 2004 5 5, ： : EMBO Journal. 23, 9, p. 1998-2008 11 p.

研究成果: Article

64 引用（Scopus）

Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells

Okada, Y., Shimazaki, T., Sobue, G. & Okano, H., 2004 11 1, ： : Developmental Biology. 275, 1, p. 124-142 19 p.

研究成果: Article

244 引用（Scopus）

2003

Biology and clinical application of neural stem cells

Shimazaki, T., 2003 12 30, ： : Hormone Research. 60, SUPPL. 3, p. 1-9 9 p.

研究成果: Article

17 引用（Scopus）

Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells

Chojnacki, A., Shimazaki, T., Gregg, C., Weinmaster, G. & Weiss, S., 2003 3 1, ： : Journal of Neuroscience. 23, 5, p. 1730-1741 12 p.

研究成果: Article

143 引用（Scopus）

Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos

Kokuzawa, J., Yoshimura, S., Kitajima, H., Shinoda, J., Kaku, Y., Iwama, T., Morishita, R., Shimazaki, T., Okano, H., Kunisada, T. & Sakai, N., 2003 9 1, ： : Molecular and Cellular Neuroscience. 24, 1, p. 190-197 8 p.

研究成果: Article

40 引用（Scopus）

Transplantation of neural stem cells into epileptic brain

Matsumoto, Y., Sindo, A., Kawai, N., Kunishio, K., Nagao, S., Miyazaki, T., Itano, T., Okada, Y., Shimazaki, T. & Okano, H., 2003 6 1, ： : International Congress Series. 1252, C, p. 489-492 4 p.

研究成果: Article

3 引用（Scopus）

2002

Flow cytometric analysis of neural stem cells in the developing and adult mouse brain

Murayama, A., Matsuzaki, Y., Kawaguchi, A., Shimazaki, T. & Okano, H., 2002 9 15, ： : Journal of neuroscience research. 69, 6, p. 837-847 11 p.

研究成果: Article

106 引用（Scopus）

Isolation and transplantation of dopaminergic neurons and neural stem cells

Okano, H., Yoshizaki, T., Shimazaki, T. & Sawamoto, K., 2002 10 1, ： : Parkinsonism and Related Disorders. 9, 1, p. 23-28 6 p.

研究成果: Article

16 引用（Scopus）

2001

Brain from bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent

Kohyama, J., Abe, H., Shimazaki, T., Koizumi, A., Nakashima, K., Gojo, S., Taga, T., Okano, H., Hata, J. I. & Umezawa, A., 2001 10, ： : Differentiation. 68, 4-5, p. 235-244 10 p.

研究成果: Article

270 引用（Scopus）

EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord

Represa, A., Shimazaki, T., Simmonds, M. & Weiss, S., 2001 12 1, ： : European Journal of Neuroscience. 14, 3, p. 452-462 11 p.

研究成果: Article

32 引用（Scopus）

Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells

Shingo, T., Todd Sorokan, S., Shimazaki, T. & Weiss, S., 2001 12 15, ： : Journal of Neuroscience. 21, 24, p. 9733-9743 11 p.

研究成果: Article

公開

566 引用（Scopus）

The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells

Shimazaki, T., Shingo, T. & Weiss, S., 2001 10 1, ： : Journal of Neuroscience. 21, 19, p. 7642-7653 12 p.

研究成果: Article

公開

242 引用（Scopus）

2000

The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells

Nakamura, Y., Sakakibara, S. I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R. & Okano, H., 2000 1 1, ： : Journal of Neuroscience. 20, 1, p. 283-293 11 p.

研究成果: Article

公開

258 引用（Scopus）

1999

A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation

Shimazaki, T., Arsenijevic, Y., Ryan, A. K., Rosenfeld, M. G. & Weiss, S., 1999 1 15, ： : EMBO Journal. 18, 2, p. 444-456 13 p.

研究成果: Article

48 引用（Scopus）

GFRα3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion

Nishino, J., Mochida, K., Ohfuji, Y., Shimazaki, T., Meno, C., Ohishi, S., Matsuda, Y., Fujii, H., Saijoh, Y. & Hamada, H., 1999 8, ： : Neuron. 23, 4, p. 725-736 12 p.

研究成果: Article

101 引用（Scopus）

1993

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential

Shimazaki, T., Okazawa, H., Fujii, H., Ikeda, M., Tamai, K., McKay, R. D. G., Muramatsu, M. & Hamada, H., 1993, ： : EMBO Journal. 12, 12, p. 4489-4498 10 p.

研究成果: Article

69 引用（Scopus）

島崎 琢也

島崎琢也