Takuya Shimazaki

Tsuyama, J., Bunt, J., Richards, L. J., Iwanari, H., Mochizuki, Y., Hamakubo, T., Shimazaki, T. & Okano, H., 2015 9月 8, In: Stem cell reports. 5, 3, p. 365-377 13 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

2014

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

Tomioka, T., Shimazaki, T., Yamauchi, T., Oki, T., Ohgoh, M. & Okano, H., 2014 1月 10, In: Journal of Biological Chemistry. 289, 2, p. 1000-1010 11 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

Naka-Kaneda, H., Nakamura, S., Igarashi, M., Aoi, H., Kanki, H., Tsuyama, J., Tsutsumi, S., Aburatani, H., Shimazaki, T. & Okano, H., 2014 1月 28, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 4, p. 1604-1609 6 p.

研究成果: Article › 査読

44 被引用数 (Scopus)

2010

Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells

Tao, O., Shimazaki, T., Okada, Y., Naka, H., Kohda, K., Yuzaki, M., Mizusawa, H. & Okano, H., 2010 2月 1, In: Journal of neuroscience research. 88, 2, p. 234-247 14 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells

Sato, T., Shimazaki, T., Naka, H., Fukami, S. I., Satoh, Y., Okano, H., Irit, L., Schlessinger, J. & Gotoh, N., 2010 9月, In: Stem Cells. 28, 9, p. 1661-1673 13 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Regulation of adult neural progenitor cells by Galectin-1/β1 Integrin interaction

Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki, T., Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K. & Okano, H., 2010 6月, In: Journal of Neurochemistry. 113, 6, p. 1516-1524 9 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

Stromal cell-secreted factors promote the survival of embryonic stem cell-derived early neural stem/progenitor cells via the activation of MAPK and PI3K-Akt pathways

Ishii, S., Okada, Y., Kadoya, T., Matsuzaki, Y., Shimazaki, T. & Okano, H., 2010 3月, In: Journal of neuroscience research. 88, 4, p. 722-734 13 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

2009

Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: Properties and tumorigenicity after long-term in vitro maintenance

Ogawa, D., Okada, Y., Nakamura, M., Kanemura, Y., Okano, H. J., Matsuzaki, Y., Shimazaki, T., Ito, M., Ikeda, E., Tamiya, T., Nagao, S. & Okano, H., 2009 2月 1, In: Journal of neuroscience research. 87, 2, p. 307-317 11 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

2008

Consequence of the loss of Sox2 in the developing brain of the mouse

Miyagi, S., Masui, S., Niwa, H., Saito, T., Shimazaki, T., Okano, H., Nishimoto, M., Muramatsu, M., Iwama, A. & Okuda, A., 2008 8月 6, In: FEBS Letters. 582, 18, p. 2811-2815 5 p.

研究成果: Article › 査読

71 被引用数 (Scopus)

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

Naka, H., Nakamura, S., Shimazaki, T. & Okano, H., 2008 9月, In: Nature Neuroscience. 11, 9, p. 1014-1023 10 p.

研究成果: Article › 査読

173 被引用数 (Scopus)

Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation

Ozawa, Y., Nakao, K., Kurihara, T., Shimazaki, T., Shimmura, S., Ishida, S., Yoshimura, A., Tsubota, K. & Okano, H., 2008 9月 5, In: Journal of Biological Chemistry. 283, 36, p. 24561-24570 10 p.

研究成果: Article › 査読

53 被引用数 (Scopus)

Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells

Okada, Y., Matsumoto, A., Shimazaki, T., Enoki, R., Koizumi, A., Ishii, S., Itoyama, Y., Sobue, G. & Okano, H., 2008 12月, In: Stem Cells. 26, 12, p. 3086-3098 13 p.

研究成果: Article › 査読

138 被引用数 (Scopus)

2007

Epidermal growth factor signaling mediated by Grb2 associated binder1 is required for the spatiotemporally regulated proliferation of Olig2-expressing progenitors in the embryonic spinal cord

Hayakawa-Yano, Y., Nishida, K., Fukami, S., Gotoh, Y., Hirano, T., Nakagawa, T., Shimazaki, T. & Okanob, H., 2007 6月, In: Stem Cells. 25, 6, p. 1410-1422 13 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway

Kohno, D., Nakata, M., Maekawa, F., Fujiwara, K., Maejima, Y., Kuramochi, M., Shimazaki, T., Okano, H., Onaka, T. & Yada, T., 2007 5月, In: Endocrinology. 148, 5, p. 2251-2263 13 p.

研究成果: Article › 査読

114 被引用数 (Scopus)

Simian fetal brain progenitor cells for studying viral neuropathogenesis

Iwata, N., Yoshida, H., Tobiume, M., Ono, F., Shimazaki, T., Sata, T. & Nakajima, N., 2007 1月 1, In: Journal of NeuroVirology. 13, 1, p. 11-22 12 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

SOCS3 is required to temporally fine-tune photoreceptor cell differentiation

Ozawa, Y., Nakao, K., Shimazaki, T., Shimmura, S., Kurihara, T., Ishida, S., Yoshimura, A., Tsubota, K. & Okano, H., 2007 3月 15, In: Developmental Biology. 303, 2, p. 591-600 10 p.

研究成果: Article › 査読

17 被引用数 (Scopus)

2006

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Sakaguchi, M., Shingo, T., Shimazaki, T., Okano, H. J., Shiwa, M., Ishibashi, S., Oguro, H., Ninomiya, M., Kadoya, T., Horie, H., Shibuya, A., Mizusawa, H., Poirier, F., Nakauchi, H., Sawamoto, K. & Okano, H., 2006 5月 2, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7112-7117 6 p.

研究成果: Article › 査読

141 被引用数 (Scopus)

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y. & Okano, H., 2006 7月, In: Nature medicine. 12, 7, p. 829-834 6 p.

研究成果: Article › 査読

685 被引用数 (Scopus)

Histopathological and behavioral improvement of murine mucopolysaccharidosis type VII by intracerebral transplantation of neural stem cells

Fukuhara, Y., Li, X. K., Kitazawa, Y., Inagaki, M., Matsuoka, K., Kosuga, M., Kosaki, R., Shimazaki, T., Endo, H., Umezawa, A., Okano, H., Takahashi, T. & Okuyama, T., 2006 3月, In: Molecular Therapy. 13, 3, p. 548-555 8 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

2005

Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart

Tomita, Y., Matsumura, K., Wakamatsu, Y., Matsuzaki, Y., Shibuya, I., Kawaguchi, H., Ieda, M., Kanakubo, S., Shimazaki, T., Ogawa, S., Osumi, N., Okano, H. & Fukuda, K., 2005 9月 26, In: Journal of Cell Biology. 170, 7, p. 1135-1146 12 p.

研究成果: Article › 査読

266 被引用数 (Scopus)

Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression

Uemura, O., Okada, Y., Ando, H., Guedj, M., Higashijima, S. I., Shimazaki, T., Chino, N., Okano, H. & Okamoto, H., 2005 2月 15, In: Developmental Biology. 278, 2, p. 587-606 20 p.

研究成果: Article › 査読

110 被引用数 (Scopus)

Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J. & Gotoh, N., 2005 11月 1, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 44, p. 15983-15988 6 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

Inhibition of glioma cell proliferation by neural stem cell factor

Suzuki, T., Izumoto, S., Wada, K., Fujimoto, Y., Maruno, M., Yamasaki, M., Kanemura, Y., Shimazaki, T., Okano, H. & Yoshimine, T., 2005 9月, In: Journal of Neuro-Oncology. 74, 3, p. 233-239 7 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers

Nagato, M., Heike, T., Kato, T., Yamanaka, Y., Yoshimoto, M., Shimazaki, T., Okano, H. & Nakahata, T., 2005 5月 15, In: Journal of neuroscience research. 80, 4, p. 456-466 11 p.

研究成果: Article › 査読

65 被引用数 (Scopus)

Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells

Yuasa, S., Itabashi, Y., Koshimizu, U., Tanaka, T., Sugimura, K., Kinoshita, M., Hattori, F., Fukami, S. I., Shimazaki, T., Okano, H., Ogawa, S. & Fukuda, K., 2005, In: Nature Biotechnology. 23, 5, p. 607-611 5 p.

研究成果: Article › 査読

254 被引用数 (Scopus)

2004

Blockade of Interleukin-6 Receptor Suppresses Reactive Astrogliosis and Ameliorates Functional Recovery in Experimental Spinal Cord Injury

Okada, S., Nakamura, M., Mikami, Y., Shimazaki, T., Mihara, M., Ohsugi, Y., Iwamoto, Y., Yoshizaki, K., Kishimoto, T., Toyama, Y. & Okano, H., 2004 4月 15, In: Journal of neuroscience research. 76, 2, p. 265-276 12 p.

研究成果: Article › 査読

190 被引用数 (Scopus)

Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina

Ozawa, Y., Nakao, K., Shimazaki, T., Takeda, J., Akira, S., Ishihara, K., Hirano, T., Oguchi, Y. & Okano, H., 2004 6月, In: Molecular and Cellular Neuroscience. 26, 2, p. 258-270 13 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils

Ishibashi, S., Sakaguchi, M., Kuroiwa, T., Yamasaki, M., Kanemura, Y., Shizuko, I., Shimazaki, T., Onodera, M., Okano, H. & Mizusawa, H., 2004 10月 15, In: Journal of neuroscience research. 78, 2, p. 215-223 9 p.

研究成果: Article › 査読

144 被引用数 (Scopus)

Implantation of Dendritic Cells in Injured Adult Spinal Cord Results in Activation of Endogenous Neural Stem/Progenitor Cells Leading to De Novo Neurogenesis and Functional Recovery

Mikami, Y., Okano, H., Sakaguchi, M., Nakamura, M., Shimazaki, T., Okano, H. J., Kawakami, Y., Toyama, Y. & Toda, M., 2004 5月 15, In: Journal of neuroscience research. 76, 4, p. 453-465 13 p.

研究成果: Article › 査読

69 被引用数 (Scopus)

Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells

Yoshizaki, T., Inaji, M., Kouike, H., Shimazaki, T., Sawamoto, K., Ando, K., Date, I., Kobayashi, K., Suhara, T., Uchiyama, Y. & Okano, H., 2004 6月 3, In: Neuroscience Letters. 363, 1, p. 33-37 5 p.

研究成果: Article › 査読

75 被引用数 (Scopus)

Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension

Nishino, J., Yamashita, K., Hashiguchi, H., Fujii, H., Shimazaki, T. & Hamada, H., 2004 5月 5, In: EMBO Journal. 23, 9, p. 1998-2008 11 p.

研究成果: Article › 査読

82 被引用数 (Scopus)

Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells

Okada, Y., Shimazaki, T., Sobue, G. & Okano, H., 2004 11月 1, In: Developmental Biology. 275, 1, p. 124-142 19 p.

研究成果: Article › 査読

264 被引用数 (Scopus)

2003

Biology and clinical application of neural stem cells

Shimazaki, T., 2003 12月 30, In: Hormone Research. 60, SUPPL. 3, p. 1-9 9 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells

Chojnacki, A., Shimazaki, T., Gregg, C., Weinmaster, G. & Weiss, S., 2003 3月 1, In: Journal of Neuroscience. 23, 5, p. 1730-1741 12 p.

研究成果: Article › 査読

Open Access

147 被引用数 (Scopus)

Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos

Kokuzawa, J., Yoshimura, S., Kitajima, H., Shinoda, J., Kaku, Y., Iwama, T., Morishita, R., Shimazaki, T., Okano, H., Kunisada, T. & Sakai, N., 2003 9月 1, In: Molecular and Cellular Neuroscience. 24, 1, p. 190-197 8 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Transplantation of neural stem cells into epileptic brain

Matsumoto, Y., Sindo, A., Kawai, N., Kunishio, K., Nagao, S., Miyazaki, T., Itano, T., Okada, Y., Shimazaki, T. & Okano, H., 2003 6月 1, In: International Congress Series. 1252, C, p. 489-492 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

2002

Flow cytometric analysis of neural stem cells in the developing and adult mouse brain

Murayama, A., Matsuzaki, Y., Kawaguchi, A., Shimazaki, T. & Okano, H., 2002 9月 15, In: Journal of neuroscience research. 69, 6, p. 837-847 11 p.

研究成果: Article › 査読

107 被引用数 (Scopus)

Isolation and transplantation of dopaminergic neurons and neural stem cells

Okano, H., Yoshizaki, T., Shimazaki, T. & Sawamoto, K., 2002 10月 1, In: Parkinsonism and Related Disorders. 9, 1, p. 23-28 6 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2001

Brain from bone: Efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent

Kohyama, J., Abe, H., Shimazaki, T., Koizumi, A., Nakashima, K., Gojo, S., Taga, T., Okano, H., Hata, J. I. & Umezawa, A., 2001 10月, In: Differentiation. 68, 4-5, p. 235-244 10 p.

研究成果: Article › 査読

274 被引用数 (Scopus)

EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord

Represa, A., Shimazaki, T., Simmonds, M. & Weiss, S., 2001, In: European Journal of Neuroscience. 14, 3, p. 452-462 11 p.

研究成果: Article › 査読

32 被引用数 (Scopus)

Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells

Shingo, T., Todd Sorokan, S., Shimazaki, T. & Weiss, S., 2001 12月 15, In: Journal of Neuroscience. 21, 24, p. 9733-9743 11 p.

研究成果: Article › 査読

Open Access

595 被引用数 (Scopus)

The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells

Shimazaki, T., Shingo, T. & Weiss, S., 2001 10月 1, In: Journal of Neuroscience. 21, 19, p. 7642-7653 12 p.

研究成果: Article › 査読

Open Access

252 被引用数 (Scopus)

2000

The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells

Nakamura, Y., Sakakibara, S. I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R. & Okano, H., 2000 1月 1, In: Journal of Neuroscience. 20, 1, p. 283-293 11 p.

研究成果: Article › 査読

Open Access

269 被引用数 (Scopus)

1999

A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation

Shimazaki, T., Arsenijevic, Y., Ryan, A. K., Rosenfeld, M. G. & Weiss, S., 1999 1月 15, In: EMBO Journal. 18, 2, p. 444-456 13 p.

研究成果: Article › 査読

49 被引用数 (Scopus)

島崎 琢也

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島崎琢也