鎌田 徹治

研究成果

年別の研究成果 1989 1990 1994 1995 1996 1997 1998 2001 2021

• 34 Article
• 4 Review article
• 2 Comment/debate
• 1 Chapter
• 1 その他
  • 1 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2021

  Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding

  Nesi, D., Bush, M., Coller, B. S., Li, J., Kamata, T., Handa, M. & Walz, T., 2021 3月 24, In: Blood Advances. 5, 7, p. 1781-1790 10 p.

  研究成果: Article › 査読

  Open Access

  • Cryoelectron Microscopy 100%
  • Integrins 69%
  • Electron Microscopy 63%
  • Monoclonal Antibodies 53%
  • Ligands 52%
  2 被引用数 (Scopus)
• 2013

  Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

  Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 6月 20, In: PloS one. 8, 6, e66096.

  研究成果: Article › 査読

  • epitope mapping 100%
  • Epitope Mapping 90%
  • integrins 82%
  • Epitope 67%
  • Integrins 62%
  6 被引用数 (Scopus)
• 2010

  Structural requirements for activation in αIIbβ3 integrin

  Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 12月 3, In: Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Conformational Isomer 38%
  • Disulfides 18%
  • Glycosylation 18%
  • Fibrinogen 16%
  21 被引用数 (Scopus)
• 2008

  Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis

  Matsumoto, A., Kamata, T., Takagi, J., Iwasaki, K. & Yura, K., 2008 9月 15, In: Biophysical Journal. 95, 6, p. 2895-2908 14 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Extracellular Matrix 9%
  • Membrane Proteins 9%
  • Amino Acids 8%
  • Mutation 6%
  17 被引用数 (Scopus)
• 2005

  Membrane-proximal α/β stalk interactions differentially regulate integrin activation

  Kamata, T., Handa, M., Sato, Y., Ikeda, Y. & Aiso, S., 2005 7月 1, In: Journal of Biological Chemistry. 280, 26, p. 24775-24783 9 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Disulfide 87%
  • Ligands 74%
  • Divalent Cations 64%
  • Membranes 63%
  41 被引用数 (Scopus)
• 2004

  Critical cysteine residues for regulation of integrin αIIbβ3 are clustered in the epidermal growth factor domains of the β3 subunit

  Kamata, T., Ambo, H., Puzon-McLaughlin, W., Tieu, K. K., Handa, M., Ikeda, Y. & Takada, Y., 2004 3月 15, In: Biochemical Journal. 378, 3, p. 1079-1082 4 p.

  研究成果: Article › 査読

  • Cysteine Residue 100%
  • Epidermal Growth Factor 93%
  • Integrins 90%
  • Cysteine 90%
  • Disulfides 84%
  60 被引用数 (Scopus)
• 2002

  The role of the CPNKEKEC sequence in the β₂ subunit I domain in regulation of integrin α_Lβ₂ (LFA-1)

  Kamata, T., Tieu, K. K., Tarui, T., Puzon-McLaughlin, W., Hogg, N. & Takada, Y., 2002 3月 1, In: Journal of Immunology. 168, 5, p. 2296-2301 6 p.

  研究成果: Article › 査読

  Open Access

  • Lymphocyte Function-Associated Antigen-1 100%
  • Integrins 73%
  • Epitopes 66%
  • Intercellular Adhesion Molecule-1 53%
  • Disulfides 27%
  48 被引用数 (Scopus)
• 2001

  Amino Acid Residues in the α_IIb Subunit that Are Critical for Ligand Binding to Integrin α_IIbβ₃ Are Clustered in the β-Propeller Model

  Kamata, T., Tieu, K. K., Irie, A., Springer, T. A. & Takada, Y., 2001 11月 23, In: Journal of Biological Chemistry. 276, 47, p. 44275-44283 9 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Amino-Acid Residue 94%
  • Ligands 74%
  • Amino Acids 74%
  • Binding Site 21%
  71 被引用数 (Scopus)

• Platelet integrin αIIbβ3-ligand interactions: What can we learn from the structure?

  Kamata, T. & Takada, Y., 2001, In: International journal of hematology. 74, 4, p. 382-389 8 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Blood Platelets 82%
  • Ligands 74%
  • von Willebrand factor receptor 35%
  • Thrombosis 32%
  11 被引用数 (Scopus)

• Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

  Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y. & Hommel, U., 2001, In: Nature medicine. 7, 6, p. 687-692 6 p.

  研究成果: Article › 査読

  • Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 100%
  • HLA Antigens 71%
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 67%
  • Integrins 65%
  • Allosteric Site 16%
  960 被引用数 (Scopus)
• 2000

  Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin α(IIb)β₃

  Puzon-McLaughlin, W., Kamata, T. & Takada, Y., 2000 3月 17, In: Journal of Biological Chemistry. 275, 11, p. 7795-7802 8 p.

  研究成果: Article › 査読

  • Antibody Binding Sites 100%
  • Integrins 64%
  • Ligands 48%
  • Binding Site 48%
  • Binding Sites 33%
  89 被引用数 (Scopus)
• 1999

  Interaction between collagen and the α₂ I-domain of integrin αβ1: Critical role of conserved residues in the metal ion-dependent adhesion site (MIDAS) region

  Kamata, T., Liddington, R. C. & Takada, Y., 1999 11月 5, In: Journal of Biological Chemistry. 274, 45, p. 32108-32111 4 p.

  研究成果: Article › 査読

  • Collagen 100%
  • Integrins 99%
  • Metals 91%
  • Ions 87%
  • Metal 47%
  43 被引用数 (Scopus)
• 1998

  Novel point mutations in the αIIb subunit (Phe²⁸⁹ → Ser, Glu³²⁴ → Lys and Gln⁷⁴⁷ → Pro) causing thrombasthenic phenotypes in four Japanese patients

  Ambo, H., Kamata, T., Handa, M., Kawai, Y., Oda, A., Murata, M., Takada, Y. & Ikeda, Y., 1998, In: British Journal of Haematology. 102, 3, p. 829-840 12 p.

  研究成果: Article › 査読

  • Thrombasthenia 100%
  • Point Mutation 63%
  • Phenotype 39%
  • Exons 32%
  • Complementary DNA 31%
  21 被引用数 (Scopus)

• Specific interaction of the recombinant disintegrin-like domain of MDC- 15 (Metargidin, ADAM-15) with integrin αvβ3

  Zhang, X. P., Kamata, T., Yokoyama, K., Puzon-McLaughlin, W. & Takada, Y., 1998 3月 27, In: Journal of Biological Chemistry. 273, 13, p. 7345-7350 6 p.

  研究成果: Article › 査読

  • Disintegrins 100%
  • Integrins 71%
  • arginyl-glycyl-aspartic acid 63%
  • Tripeptide 62%
  • Cell Communication 28%
  197 被引用数 (Scopus)

• Three novel integrin β3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients

  Ambo, H., Kamata, T., Handa, M., Taki, M., Kuwajima, M., Kawai, Y., Oda, A., Murata, M., Takada, Y., Watanabe, K. & Ikeda, Y., 1998 10月 29, In: Biochemical and Biophysical Research Communications. 251, 3, p. 763-768 6 p.

  研究成果: Article › 査読

  • Thrombasthenia 100%
  • Missense Mutation 67%
  • Integrins 61%
  • Mutation 55%
  • RNA Sequence Analysis 12%
  40 被引用数 (Scopus)
• 1997

  Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of the β subunit

  Takagi, J., Kamata, T., Meredith, J., Puzon-McLaughlin, W. & Takada, Y., 1997 8月 8, In: Journal of Biological Chemistry. 272, 32, p. 19794-19800 7 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Ligands 74%
  • Vitronectin 71%
  • Fibrinogen 50%
  • Ligand 46%
  111 被引用数 (Scopus)

• Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain: Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

  King, S. L., Kamata, T., Cunningham, J. A., Emsley, J., Liddington, R. C., Takada, Y. & Bergelson, J. M., 1997 11月 7, In: Journal of Biological Chemistry. 272, 45, p. 28518-28522 5 p.

  研究成果: Article › 査読

  • Integrin alpha2beta1 100%
  • Human Enterovirus B 82%
  • Collagen 56%
  • Integrins 55%
  • Metals 51%
  38 被引用数 (Scopus)

• Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode

  Irie, A., Kamata, T. & Takada, Y., 1997 7月 8, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 14, p. 7198-7203 6 p.

  研究成果: Article › 査読

  Open Access

  • Integrins 100%
  • Ligands 74%
  • Vascular Cell Adhesion Molecule-1 48%
  • Immobilized Cells 31%
  • Terminal Repeat Sequences 25%
  62 被引用数 (Scopus)
• 1996

  Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

  Huang, S., Kamata, T., Takada, Y., Ruggeri, Z. M. & Nemerow, G. R., 1996, In: Journal of Virology. 70, 7, p. 4502-4508 7 p.

  研究成果: Article › 査読

  • integrins 100%
  • Adenoviridae 91%
  • gene transfer 85%
  • Integrins 75%
  • Genes 32%
  217 被引用数 (Scopus)

• A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (αIIbβ3 integrin)

  Tokuhira, M., Handa, M., Kamata, T., Oda, A., Katayama, M., Tomiyama, Y., Murata, M., Kawai, Y., Watanabe, K. & Ikeda, Y., 1996 12月, In: Thrombosis and Haemostasis. 76, 6, p. 1038-1046 9 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Epitopes 90%
  • Blood Platelets 82%
  • Monoclonal Antibodies 77%
  • Antibodies 44%
  53 被引用数 (Scopus)

• Critical residues of integrin αIIb subunit for binding of αIIbβ3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3)

  Kamata, T., Irie, A., Tokuhira, M. & Takada, Y., 1996, In: Journal of Biological Chemistry. 271, 31, p. 18610-18615 6 p.

  研究成果: Article › 査読

  • Platelet Glycoprotein GPIIb-IIIa Complex 100%
  • Fibrinogen 76%
  • Integrins 74%
  • Glycoprotein 72%
  • Mutation 66%
  83 被引用数 (Scopus)
• 1995

  Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits

  Irie, A., Kamata, T., Puzon-McLaughlin, W. & Takada, Y., 1995, In: EMBO Journal. 14, 22, p. 5550-5556 7 p.

  研究成果: Article › 査読

  • Terminal Repeat Sequences 100%
  • Integrins 77%
  • Amino-Acid Residue 73%
  • Mutation 69%
  • Ligands 58%
  91 被引用数 (Scopus)

• Critical threonine and aspartic acid residues within the I domains of β2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3bi

  Kamata, T., Wright, R. & Takada, Y., 1995, In: Journal of Biological Chemistry. 270, 21, p. 12531-12535 5 p.

  研究成果: Article › 査読

  • Complement C3b 100%
  • Aspartic Acid Residue 97%
  • Threonine 77%
  • Intercellular Adhesion Molecule-1 72%
  • Aspartic Acid 71%
  87 被引用数 (Scopus)

• Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

  Kamata, T., Puzon, W. & Takada, Y., 1995, In: Biochemical Journal. 305, 3, p. 945-951 7 p.

  研究成果: Article › 査読

  • Integrin alpha4beta1 100%
  • Epitope 72%
  • Integrins 66%
  • Epitopes 60%
  • Binding Sites 54%
  125 被引用数 (Scopus)

• Platelet unresponsiveness to collagen: Involvement of glycoprotein Ia-IIa (α₂β₁ integrin) deficiency associated with a myeloproliferative disorder

  Handa, M., Watanabe, K., Kawai, Y., Kamata, T., Koyama, T., Nagai, H. & Ikeda, Y., 1995, In: Thrombosis and Haemostasis. 73, 3, p. 521-528 8 p.

  研究成果: Article › 査読

  • Integrin alpha2beta1 100%
  • Myeloproliferative Disorders 77%
  • Integrin alpha2 64%
  • Integrins 55%
  • Blood Platelets 46%
  84 被引用数 (Scopus)
• 1994

  Direct binding of collagen to the I domain of integrin α2β1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

  Kamata, T. & Takada, Y., 1994 10月 21, In: Journal of Biological Chemistry. 269, 42, p. 26006-26010 5 p.

  研究成果: Article › 査読

  • Integrin alpha2beta1 100%
  • Divalent Cations 71%
  • Collagen 56%
  • Integrins 55%
  • Monoatomic Dication 17%
  144 被引用数 (Scopus)

• Identification of putative ligand binding sites within I domain of integrin α2β1 (VLA-2, CD49b/CD29)

  Kamata, T., Puzon, W. & Takada, Y., 1994 4月 1, In: Journal of Biological Chemistry. 269, 13, p. 9659-9663 5 p.

  研究成果: Article › 査読

  • Integrin alpha2beta1 100%
  • Human Enterovirus B 61%
  • Collagen 56%
  • Integrins 55%
  • Binding Sites 45%
  149 被引用数 (Scopus)

• Rapid improvement of coagulopathy by all‐trans retinoic acid in acute promyelocytic leukemia

  Kawai, Y., Watanabe, K., Kizaki, M., Murata, M., Kamata, T., Uchida, H., Moriki, T., Yokoyama, K., Tokuhira, M., Nakajima, H., Handa, M. & Ikeda, Y., 1994 7月, In: American journal of hematology. 46, 3, p. 184-188 5 p.

  研究成果: Article › 査読

  • Acute Promyelocytic Leukemia 100%
  • Tretinoin 81%
  • Hemostatics 37%
  • Fibrin Fibrinogen Degradation Products 24%
  • Disseminated Intravascular Coagulation 20%
  33 被引用数 (Scopus)
• 1993

  Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation

  Ikeda, Y., Handa, M., Kamata, T., Kawano, K., Kawai, Y., Watanabe, K., Kawakami, K., Sakai, K., Fukuyama, M., Itagaki, I., Yoshioka, A. & Ruggeri, Z. M., 1993, In: Thrombosis and Haemostasis. 69, 5, p. 496-502 7 p.

  研究成果: Article › 査読

  • Platelet Membrane Glycoprotein IIb 100%
  • von Willebrand Factor 74%
  • Platelet Aggregation 67%
  • Ions 55%
  • Calcium 46%
  161 被引用数 (Scopus)
• 1992

  Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia

  Hayashida, T., Araki, Y., Kawano, K., Kamata, T., Kawai, Y., Takeuchi, K., Watanabe, K., Okamoto, S. & Ogawa, T., 1992 11月, In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 33, 11, p. 1679-1684 6 p.

  研究成果: Article › 査読

  • Leukemia, Monocytic, Acute 100%
  • Lymphoma 28%
  • Monocyte-Macrophage Precursor Cells 27%
  • Histocytochemistry 22%
  • Diplopia 20%
  3 被引用数 (Scopus)
• 1991

  The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

  Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Anbo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K. & Ruggeri, Z. M., 1991 4月, In: Journal of Clinical Investigation. 87, 4, p. 1234-1240 7 p.

  研究成果: Article › 査読

  Open Access

  • von Willebrand Factor 100%
  • Platelet Aggregation 91%
  • Fibrinogen 87%
  • Platelet Glycoprotein GPIIb-IIIa Complex 76%
  • Blood Platelets 70%
  533 被引用数 (Scopus)
• 1990

  Effects of anti-platelet agents on shear-induced platelet aggregation

  Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Anyasu, H., Araki, Y., kawaiY & Watanabe, K., 1990 6月 1, In: [Rinsho ketsueki] The Japanese journal of clinical hematology. 31, 6, p. 787-792 6 p.

  研究成果: Article › 査読

• Enhancing effect by heparin on shear-induced platelet aggregation

  Kawano, K., Ikeda, Y., Handa, M., Kamata, T., Anbo, H., Araki, Y., Kawai, Y., Watanabe, K., Itagaki, I., Kawakami, K., Fukuyama, M. & Sakai, K., 1990 1月 1, In: Seminars in Thrombosis and Hemostasis. 16, SUPPL., p. 60-65 6 p.

  研究成果: Article › 査読

  • Platelet Aggregation 100%
  • Heparin 89%
  • Bernard-Soulier Syndrome 46%
  • Afibrinogenemia 46%
  • von Willebrand Diseases 37%
  12 被引用数 (Scopus)
• 1989

  Role of membrane glycoproteins in the interaction of blood platelets with the vessel wall--the study on platelet adhesion to in vitro cultured subendothelial matrix.

  Kawai, Y., Handa, M., Nagai, H., Kamata, T., Anbo, H., Kawano, K., Araki, Y., Yamamoto, M., Ikeda, Y. & Watanabe, K., 1989 12月, In: Acta Haematologica Japonica. 52, 8, p. 1312-1321 10 p.

  研究成果: Article › 査読

  • Membrane Glycoproteins 100%
  • Blood Platelets 68%
  • Integrin alpha2 45%
  • In Vitro Techniques 38%
  • Blocking Antibodies 21%
  5 被引用数 (Scopus)