Toshiro Sato

2013

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 10月 16, In: EMBO Journal. 32, 20, p. 2708-2721 14 p.

研究成果: Article › 査読

460 被引用数 (Scopus)

2012

CCR9⁺ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 9月, In: Immunology Letters. 147, 1-2, p. 75-79 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 2月 1, In: Development. 139, 3, p. 465-474 10 p.

研究成果: Article › 査読

73 被引用数 (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 1月, In: Nature Methods. 9, 1, p. 81-83 3 p.

研究成果: Article › 査読

224 被引用数 (Scopus)

Dll1 + secretory progenitor cells revert to stem cells upon crypt damage

Van Es, J. H., Sato, T., Van De Wetering, M., Lyubimova, A., Yee Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., Van Den Born, M., Korving, J., Martens, A. C. M., Barker, N., Van Oudenaarden, A. & Clevers, H., 2012 10月, In: Nature Cell Biology. 14, 10, p. 1099-1104 6 p.

研究成果: Article › 査読

540 被引用数 (Scopus)

Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis

Hukuhara, K., Kanai, T., Hayashi, A., Mikami, Y., Sujino, T., Mizuno, S., Handa, T., Matsuoka, K., Hisamatsu, T., Sato, T. & Hibi, T., 2012 11月 2, In: Biochemical and Biophysical Research Communications. 427, 4, p. 694-700 7 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 ⁺ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 4月, In: Nature medicine. 18, 4, p. 618-623 6 p.

研究成果: Article › 査読

569 被引用数 (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 6月, In: Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 9月, In: FEBS Journal. 279, 18, p. 3475-3487 13 p.

研究成果: Article › 査読

68 被引用数 (Scopus)

The use of infliximab in the prevention of postsurgical recurrence in polysurgery Crohn's disease patients: A pilot open-labeled prospective study

Sakuraba, A., Sato, T., Matsukawa, H., Okamoto, S., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 7月, In: International journal of colorectal disease. 27, 7, p. 947-952 6 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

2011

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 10月, In: Nature medicine. 17, 10, p. 1225-1227 3 p.

研究成果: Article › 査読

496 被引用数 (Scopus)

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., Van Es, J. H., Van Den Brink, S., Van Houdt, W. J., Pronk, A., Van Gorp, J., Siersema, P. D. & Clevers, H., 2011 11月, In: Gastroenterology. 141, 5, p. 1762-1772 11 p.

研究成果: Article › 査読

Open Access

2076 被引用数 (Scopus)

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., Van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., Van Den Born, M., Barker, N., Shroyer, N. F., Van De Wetering, M. & Clevers, H., 2011 1月 20, In: Nature. 469, 7330, p. 415-418 4 p.

研究成果: Article › 査読

1710 被引用数 (Scopus)

2010

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D. & Clevers, H., 2010 10月, In: Cell. 143, 1, p. 134-144 11 p.

研究成果: Article › 査読

Open Access

1320 被引用数 (Scopus)

Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., Danenberg, E., van den Brink, S., Korving, J., Abo, A., Peters, P. J., Wright, N., Poulsom, R. & Clevers, H., 2010 1月 8, In: Cell stem cell. 6, 1, p. 25-36 12 p.

研究成果: Article › 査読

Open Access

1110 被引用数 (Scopus)

2009

Granulocyte and monocyte adsorption apheresis therapy modulates monocyte-derived dendritic cell function in patients with ulcerative colitis

Iwakami, Y., Sakuraba, A., Sato, T., Takada, Y., Izumiya, M., Ichikawa, H. & Hibi, T., 2009 4月 1, In: Therapeutic Apheresis and Dialysis. 13, 2, p. 138-146 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., Van De Wetering, M., Barker, N., Stange, D. E., Van Es, J. H., Abo, A., Kujala, P., Peters, P. J. & Clevers, H., 2009 5月 14, In: Nature. 459, 7244, p. 262-265 4 p.

研究成果: Article › 査読

4088 被引用数 (Scopus)

Th1/Th17 Immune Response Is Induced by Mesenteric Lymph Node Dendritic Cells in Crohn's Disease

Sakuraba, A., Sato, T., Kamada, N., Kitazume, M., Sugita, A. & Hibi, T., 2009 11月, In: Gastroenterology. 137, 5, p. 1736-1745 10 p.

研究成果: Article › 査読

182 被引用数 (Scopus)

2008

A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis

Sakuraba, A., Sato, T., Naganuma, M., Morohoshi, Y., Matsuoka, K., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2008 1月 1, In: Journal of gastroenterology. 43, 1, p. 51-56 6 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Current View: Intestinal Stem Cells and Signaling

Scoville, D. H., Sato, T., He, X. C. & Li, L., 2008 3月, In: Gastroenterology. 134, 3, p. 849-864 16 p.

研究成果: Article › 査読

338 被引用数 (Scopus)

Unique CD14⁺ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

Kamada, N., Hisamatsu, T., Okamoto, S., Chinen, H., Kobayashi, T., Sato, T., Sakuraba, A., Kitazume, M. T., Sugita, A., Koganei, K., Akagawa, K. S. & Hibi, T., 2008 6月 2, In: Journal of Clinical Investigation. 118, 6, p. 2269-2280 12 p.

研究成果: Article › 査読

508 被引用数 (Scopus)

2007

Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients

Matsuoka, K., Iwao, Y., Mori, T., Sakuraba, A., Yajima, T., Hisamatsu, T., Okamoto, S., Morohoshi, Y., Izumiya, M., Ichikawa, H., Sato, T., Inoue, N., Ogata, H. & Hibi, T., 2007 2月 1, In: American Journal of Gastroenterology. 102, 2, p. 331-337 7 p.

研究成果: Article › 査読

167 被引用数 (Scopus)

Lamina Propria c-kit⁺ Immune Precursors Reside in Human Adult Intestine and Differentiate Into Natural Killer Cells

Chinen, H., Matsuoka, K., Sato, T., Kamada, N., Okamoto, S., Hisamatsu, T., Kobayashi, T., Hasegawa, H., Sugita, A., Kinjo, F., Fujita, J. & Hibi, T., 2007 8月, In: Gastroenterology. 133, 2, p. 559-573 15 p.

研究成果: Article › 査読

75 被引用数 (Scopus)

PTEN-deficient intestinal stem cells initiate intestinal polyposis

He, X. C., Yin, T., Grindley, J. C., Tian, Q., Sato, T., Tao, W. A., Dirisina, R., Porter-Westpfahl, K. S., Hembree, M., Johnson, T., Wiedemann, L. M., Barrett, T. A., Hood, L., Wu, H. & Li, L., 2007 2月, In: Nature genetics. 39, 2, p. 189-198 10 p.

研究成果: Article › 査読

366 被引用数 (Scopus)

2006

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

Morohoshi, Y., Matsuoka, K., Chinen, H., Kamada, N., Sato, T., Hisamatsu, T., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2006 4月, In: Journal of gastroenterology. 41, 4, p. 318-324 7 p.

研究成果: Article › 査読

56 被引用数 (Scopus)

2005

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

Kamada, N., Hisamatsu, T., Okamoto, S., Sato, T., Matsuoka, K., Arai, K., Nakai, T., Hasegawa, A., Inoue, N., Watanabe, N., Akagawa, K. S. & Hibi, T., 2005 11月 15, In: Journal of Immunology. 175, 10, p. 6900-6908 9 p.

研究成果: Article › 査読

183 被引用数 (Scopus)

Nonpathogenic Escherichia coli strain Nissle 1917 prevents murine acute and chronic colitis

Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. & Hibi, T., 2005 5月, In: Inflammatory bowel diseases. 11, 5, p. 455-463 9 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

Sato, T., Nakai, T., Tamura, N., Okamoto, S., Matsuoka, K., Sakuraba, A., Fukushima, T., Uede, T. & Hibi, T., 2005 9月, In: Gut. 54, 9, p. 1254-1262 9 p.

研究成果: Article › 査読

106 被引用数 (Scopus)

2004

Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes

Okazawa, A., Kanai, T., Nakamaru, K., Sato, T., Inoue, N., Ogata, H., Iwao, Y., Ikeda, M., Kawamura, T., Makita, S., Uraushihara, K., Okamoto, R., Yamazaki, M., Kurimoto, M., Ishii, H., Watanabe, M. & Hibi, T., 2004 5月, In: Clinical and Experimental Immunology. 136, 2, p. 269-276 8 p.

研究成果: Article › 査読

49 被引用数 (Scopus)

Hyperexpression of Inducible Costimulator and Its Contribution on Lamina Propria T Cells in Inflammatory Bowel Disease

Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R. A., Fukushima, T., Ishii, H. & Hibi, T., 2004 3月, In: Gastroenterology. 126, 3, p. 829-839 11 p.

研究成果: Article › 査読

Open Access

42 被引用数 (Scopus)

T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction or Th1 mediated immunopathology in Crohn's disease

Matsuoka, K., Inoue, N., Sato, T., Okamoto, S., Hisamatsu, T., Kishi, Y., Sakuraba, A., Hitotsumatsu, O., Ogata, H., Koganei, K., Fukushima, T., Kanai, T., Watanabe, M., Ishii, H. & Hibi, T., 2004 9月, In: Gut. 53, 9, p. 1303-1308 6 p.

研究成果: Article › 査読

119 被引用数 (Scopus)

2003

Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice

Takagi, H., Kanai, T., Okazawa, A., Kishi, Y., Sato, T., Takaishi, H., Inoue, N., Ogata, H., Iwao, Y., Hoshino, K., Takeda, K., Akira, S., Watanabe, M., Ishii, H. & Hibi, T., 2003 8月 1, In: Scandinavian Journal of Gastroenterology. 38, 8, p. 837-844 8 p.

研究成果: Article › 査読

127 被引用数 (Scopus)

2001

Interleukin-18 and Crohn's disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T. & Hibi, T., 2001 2月 6, In: Digestion. 63, SUPPL. 1, p. 37-42 6 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001, In: Gastroenterology. 121, 4, p. 875-888 14 p.

研究成果: Article › 査読

167 被引用数 (Scopus)

Restricted V_H gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis

Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H. & Hibi, T., 2001, In: Gastroenterology. 121, 1, p. 15-23 9 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

2000

The role of IL-18 on the pathogenesis of Crohn’s disease

Hibi, T., Kana, T., Watanabe, M., Okazawa, S. & Sato, T., 2000, In: Japanese Journal of Clinical Immunology. 23, 6, p. 607-610 4 p.

研究成果: Article › 査読

Open Access

佐藤 俊朗

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佐藤俊朗