Pureに変更を加えた場合、すぐここに表示されます。

研究成果 2000 2019

フィルター
Article
2019
1 引用 (Scopus)

Cnnm4 deficiency suppresses Ca 2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5 16, : : Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article

Colon
Epithelium
Cell Proliferation
Capsaicin
Epidermal Growth Factor Receptor
17 引用 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. および2人, Sato, T. & Kanai, T., 2019 1 1, (Accepted/In press) : : Nature Microbiology.

研究成果: Article

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
1 引用 (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 7 1, : : Cancer science. 110, 7, p. 2156-2165 10 p.

研究成果: Article

公開
Interleukin-13
Carcinogenesis
Obesity
Colorectal Neoplasms
Cytokines
2018
18 引用 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2 1, : : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Peyer's Patches
Cell Differentiation
Epithelium
Organoids
25 引用 (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. および3人, Koo, B. K., Kanai, T. & Sato, T., 2018 8 9, : : Cell. 174, 4, p. 856-869.e17

研究成果: Article

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
Organoids
Genetic engineering
Genetic Engineering
Electroporation
Plasmids
19 引用 (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 3 13, : : Stem Cell Reports. 10, 3, p. 1088-1101 14 p.

研究成果: Article

Organoids
Stem Cells
Tissue
Medical problems
Insulin
11 引用 (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 12 6, : : Cell Stem Cell. 23, 6, p. 787-793.e6

研究成果: Article

Organoids
Small Cytoplasmic RNA
Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Sequence Analysis
67 引用 (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 1 1, (Accepted/In press) : : Cell Stem Cell.

研究成果: Article

Organoids
Stem Cell Niche
Stem Cell Factor
Disease Progression
Adenocarcinoma
9 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific Reports. 8, 1, 2821.

研究成果: Article

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
3 引用 (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 1 1, : : Glycobiology. 28, 1, p. 21-31 11 p.

研究成果: Article

Colorectal Neoplasms
Cell growth
Binding Sites
Cells
Carbohydrates
24 引用 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2 1, : : Cell Stem Cell. 22, 2, p. 171-176.e5

研究成果: Article

Colon
Epithelium
Organoids
Stem Cells
Heterografts
2017
35 引用 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. および19人, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5 1, : : Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article

Epithelial Cells
Filamins
Mitochondrial Membrane Potential
Intestinal Mucosa
Lactic Acid
21 引用 (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 6 1, : : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

研究成果: Article

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
13 引用 (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 8 15, : : Cell Reports. 20, 7, p. 1513-1524 12 p.

研究成果: Article

Dysbiosis
Alopecia
Lactobacillus
Biotin
Physiology
151 引用 (Scopus)

Visualization and targeting of LGR5 + human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 5 11, : : Nature. 545, 7653, p. 187-192 6 p.

研究成果: Article

Neoplastic Stem Cells
Colonic Neoplasms
Neoplasms
Colorectal Neoplasms
Organoids
2016
152 引用 (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 6 2, : : Cell Stem Cell. 18, 6, p. 827-838 12 p.

研究成果: Article

Organoids
Colorectal Neoplasms
Carcinogenesis
Transcriptome
Heterografts
46 引用 (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 2 23, : : eLife. 5, FEBRUARY2016, e11621.

研究成果: Article

Wnt Proteins
Colony-Forming Units Assay
Detergents
Albumins
Assays
19 引用 (Scopus)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 9 21, : : Nature Communications. 7, 12887.

研究成果: Article

Hedgehogs
notches
Tyrosine
tyrosine
Phosphorylation
13 引用 (Scopus)

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, : : Journal of Cell Biology. 212, 3, p. 297-306 10 p.

研究成果: Article

Carrier Proteins
Epithelial Cells
Small Intestine
Dynamins
Lysosomes
15 引用 (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 5 4, : : Scientific Reports. 6, 25311.

研究成果: Article

Organoids
DNA Methylation
Neoplasms
DNA
Interferons
9 引用 (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. および5人, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 8 4, : : Cell Stem Cell. 19, 2, p. 205-216 12 p.

研究成果: Article

Stem Cell Niche
Wnt Signaling Pathway
Equidae
Colorectal Neoplasms
Stem Cells
35 引用 (Scopus)

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 4 4, : : Developmental Cell. 37, 1, p. 47-57 11 p.

研究成果: Article

Catenins
Regeneration
Carcinogenesis
Methylation
Proteins
215 引用 (Scopus)

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., De Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A., Van Der Laan, L. J. W. および8人, De Jonge, J., Ijzermans, J. N. M., Vries, R. G., Van De Wetering, M., Stratton, M. R., Clevers, H., Cuppen, E. & Van Boxtel, R., 2016 1 1, : : Nature. 538, 7624, p. 260-264 5 p.

研究成果: Article

Adult Stem Cells
Mutation
Small Intestine
Colon
Mutation Rate
29 引用 (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 10 1, : : PLoS Genetics. 12, 10, e1006349.

研究成果: Article

Endoplasmic Reticulum Stress
homeostasis
endoplasmic reticulum
transporters
stem cells
2015
13 引用 (Scopus)

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 2 1, : : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

研究成果: Article

Organoids
Intestinal Mucosa
Paneth Cells
Growth
Stem cells
7 引用 (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 5 6, : : Digestion. 91, 3, p. 233-238 6 p.

研究成果: Article

Crohn Disease
Recurrence
Therapeutics
Infliximab
Remission Induction
59 引用 (Scopus)

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 10 29, : : Nature Protocols. 10, 10, p. 1474-1485 12 p.

研究成果: Article

Organoids
Genetic engineering
Genetic Engineering
Electroporation
Genes
10 引用 (Scopus)

Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 6 1, : : Cancer Prevention Research. 8, 6, p. 492-501 10 p.

研究成果: Article

Stomach
Carcinogenesis
Oxidative Stress
Reactive Oxygen Species
Metaplasia
60 引用 (Scopus)
Organoids
Stem Cell Niche
Stem Cells
Carcinogenesis
Epithelium
352 引用 (Scopus)

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015, : : Nature Medicine. 21, 3, p. 256-262 7 p.

研究成果: Article

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Human Engineering
Tumors
Colorectal Neoplasms
39 引用 (Scopus)

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

Oshima, H., Nakayama, M., Han, T. S., Naoi, K., Ju, X., Maeda, Y., Robine, S., Tsuchiya, K., Sato, T., Sato, H., Taketo, M. M. & Oshima, M., 2015 2 15, : : Cancer Research. 75, 4, p. 766-776 11 p.

研究成果: Article

Intestinal Neoplasms
Epithelium
Epithelial Cells
Dextran Sulfate
Intestinal Mucosa
2014
3 引用 (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 10 1, : : Inflammatory Bowel Diseases. 20, 10, p. 1820-1827 8 p.

研究成果: Article

Th1 Cells
Colitis
T-Lymphocytes
Th17 Cells
Cell Count
5 引用 (Scopus)
Stomach Neoplasms
Seeds
Apoptosis
In Situ Nick-End Labeling
Heterografts
36 引用 (Scopus)

Cross-talk between RORγt + innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease

Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014, : : Inflammatory Bowel Diseases. 20, 8, p. 1426-1434 9 p.

研究成果: Article

Crohn Disease
Macrophages
Lymphocytes
interleukin-22
Mucous Membrane
32 引用 (Scopus)

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 5 15, : : Cancer Research. 74, 10, p. 2882-2891 10 p.

研究成果: Article

Stem Cells
Catenins
Colorectal Neoplasms
Intestinal Neoplasms
Induced Pluripotent Stem Cells
9 引用 (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 1 2, : : PLoS One. 9, 1, e84619.

研究成果: Article

Macrophages
dendritic cells
Liver
Dendritic Cells
macrophages
41 引用 (Scopus)

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, : : Nature Communications. 5, 6728.

研究成果: Article

stem cells
Stem cells
Stomach
Transcription Factors
Stem Cells
2013
96 引用 (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 6 12, : : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

研究成果: Article

Clostridium butyricum
Colitis
Interleukin-10
Macrophages
Mucous Membrane

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 2, : : Immunology Letters. 150, 1-2, p. 123-129 7 p.

研究成果: Article

Colitis
Dendritic Cells
Bone Marrow
Immune Tolerance
Antigen Presentation
13 引用 (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 8, : : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

研究成果: Article

Intestinal Absorption
Pharmaceutical Preparations
Metoprolol
Atenolol
Ulcerative Colitis
20 引用 (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Cho, H., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 4 23, : : PLoS One. 8, 4, e62853.

研究成果: Article

hepatitis
Liver
Hepatitis
T-cells
Lymphocytes
602 引用 (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 2 14, : : Nature. 494, 7436, p. 247-250 4 p.

研究成果: Article

Organoids
Regeneration
Stem Cells
Liver
Bile Ducts
31 引用 (Scopus)
Tacrolimus
Ulcerative Colitis
Steroids
Remission Induction
Colectomy
67 引用 (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 5, : : Immunology. 139, 1, p. 19-29 11 p.

研究成果: Article

Bile Acids and Salts
Crohn Disease
Mucous Membrane
Macrophages
Cytokines
261 引用 (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 10 16, : : EMBO Journal. 32, 20, p. 2708-2721 14 p.

研究成果: Article

Organoids
Ducts
Pancreas
Stem cells
Stem Cells
2012
5 引用 (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 9, : : Immunology Letters. 147, 1-2, p. 75-79 5 p.

研究成果: Article

Bacterial Infections
Sepsis
Peritoneal Macrophages
Macrophages
Punctures
59 引用 (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 2 1, : : Development. 139, 3, p. 465-474 10 p.

研究成果: Article

Endoderm
Stomach
Aptitude
Morphogenesis
Organoids
169 引用 (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 1, : : Nature Methods. 9, 1, p. 81-83 3 p.

研究成果: Article

Organoids
Retroviridae
Cell culture
Gene expression
Small Intestine
371 引用 (Scopus)

Dll1 + secretory progenitor cells revert to stem cells upon crypt damage

Van Es, J. H., Sato, T., Van De Wetering, M., Lyubimova, A., Yee Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., Van Den Born, M., Korving, J., Martens, A. C. M., Barker, N., Van Oudenaarden, A. & Clevers, H., 2012 10, : : Nature Cell Biology. 14, 10, p. 1099-1104 6 p.

研究成果: Article

Stem Cells
Organoids
Enterocytes
Clone Cells
Ligands