佐野坂 司

研究成果

年別の研究成果 2006 2009 2012 2017 2021 2022

• 1293 被引用数
• 19 h-index
• 32 Article
• 2 Review article

年別の研究成果

年別の研究成果

検索結果

• A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury

  Kamata, Y., Isoda, M., Sanosaka, T., Shibata, R., Ito, S., Okubo, T., Shinozaki, M., Inoue, M., Koya, I., Shibata, S., Shindo, T., Matsumoto, M., Nakamura, M., Okano, H., Nagoshi, N. & Kohyama, J., 2021 3月, In: Stem Cells Translational Medicine. 10, 3, p. 398-413 16 p.

  研究成果: Article › 査読

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Mental Competency 84%
  • Spinal Cord Injuries 84%
  • Neural Stem Cells 70%
  • Stem Cells 46%
  9 被引用数 (Scopus)

• Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification

  Asano, H., Aonuma, M., Sanosaka, T., Kohyama, J., Namihira, M. & Nakashima, K., 2009 11月, In: Stem Cells. 27, 11, p. 2744-2752 9 p.

  研究成果: Article › 査読

  • Tretinoin 100%
  • Astrocytes 89%
  • Epigenomics 85%
  • Leukemia Inhibitory Factor 65%
  • STAT3 Transcription Factor 39%
  86 被引用数 (Scopus)

• BMP-induced REST regulates the establishment and maintenance of astrocytic identity

  Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H. & Nakashima, K., 2010 4月 5, In: Journal of Cell Biology. 189, 1, p. 159-170 12 p.

  研究成果: Article › 査読

  • RE1-silencing transcription factor 100%
  • Bone Morphogenetic Proteins 95%
  • Astrocytes 72%
  • Maintenance 55%
  • Stem Cells 28%
  60 被引用数 (Scopus)

• Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome

  Okuno, H., Nakabayashi, K., Abe, K., Ando, T., Sanosaka, T., Kohyama, J., Akamatsu, W., Ohyama, M., Takahashi, T., Kosaki, K. & Okano, H., 2017 7月, In: Congenital anomalies. 57, 4, p. 96-103 8 p.

  研究成果: Article › 査読

  • Prader-Willi Syndrome 100%
  • Induced Pluripotent Stem Cells 83%
  • Methylation 37%
  • Chromosomes 32%
  • Genome 22%
  10 被引用数 (Scopus)

• CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

  Okuno, H., Mihara, F. R., Ohta, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., Takahashi, T., Wysocka, J., Kosaki, K. & Okano, H., 2017 11月 28, In: eLife. 6, e21114.

  研究成果: Article › 査読

  Open Access

  • CHARGE Syndrome 100%
  • Delamination 74%
  • Neural Crest 72%
  • Induced Pluripotent Stem Cells 70%
  • Disorder 53%
  33 被引用数 (Scopus)

• Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation

  Urayama, S., Semi, K., Sanosaka, T., Hori, Y., Namihira, M., Kohyama, J., Takizawa, T. & Nakashima, K., 2013, In: Cell structure and function. 38, 1, p. 55-66 12 p.

  研究成果: Article › 査読

  • Glial Fibrillary Acidic Protein 100%
  • Astrocytes 82%
  • Chromatin 79%
  • Genes 36%
  • Micrococcal Nuclease 26%
  34 被引用数 (Scopus)

• Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors

  Chai, M., Sanosaka, T., Okuno, H., Zhou, Z., Koya, I., Banno, S., Andoh-Noda, T., Tabata, Y., Shimamura, R., Hayashi, T., Ebisawa, M., Sasagawa, Y., Nikaido, I., Okano, H. & Kohyama, J., 2018 1月 15, In: Genes and Development. 32, 2, p. 165-180 16 p.

  研究成果: Article › 査読

  Open Access

  • DNA Helicases 100%
  • Chromatin 63%
  • Central Nervous System 53%
  • Stem Cells 52%
  • CHARGE Syndrome 22%
  19 被引用数 (Scopus)

• Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

  Namihira, M., Kohyama, J., Semi, K., Sanosaka, T., Deneen, B., Taga, T. & Nakashima, K., 2009 2月 17, In: Developmental Cell. 16, 2, p. 245-255 11 p.

  研究成果: Article › 査読

  Open Access

  • Demethylation 100%
  • Astrocytes 77%
  • Neurons 41%
  • Ligand 36%
  • NFI Transcription Factors 24%
  240 被引用数 (Scopus)

• Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

  Matsubara, T., Iga, T., Sugiura, Y., Kusumoto, D., Sanosaka, T., Tai-Nagara, I., Takeda, N., Fong, G. H., Ito, K., Ema, M., Okano, H., Kohyama, J., Suematsu, M. & Kubota, Y., 2022 4月 4, In: Journal of Experimental Medicine. 219, 4, e20211789.

  研究成果: Article › 査読

  • Odontogenesis 100%
  • Dentinogenesis 51%
  • Capillaries 46%
  • Tooth 45%
  • Odontoblasts 43%

• Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

  Andoh-Noda, T., Akamatsu, W., Miyake, K., Matsumoto, T., Yamaguchi, R., Sanosaka, T., Okada, Y., Kobayashi, T., Ohyama, M., Nakashima, K., Kurosawa, H., Kubota, T. & Okano, H., 2015 5月 27, In: Molecular brain. 8, 1, 31.

  研究成果: Article › 査読

  • Multipotent Stem Cells 100%
  • Rett Syndrome 99%
  • Neural Stem Cells 82%
  • Induced Pluripotent Stem Cells 47%
  • Methyl-CpG-Binding Protein 2 31%
  64 被引用数 (Scopus)

• DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

  Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., 2017 9月 19, In: Cell Reports. 20, 12, p. 2992-3003 12 p.

  研究成果: Article › 査読

  Open Access

  • Epigenome 100%
  • Demethylation 95%
  • Neural Stem Cells 89%
  • Mental Competency 77%
  • Epigenomics 70%
  28 被引用数 (Scopus)

• Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset

  Yoshimatsu, S., Nakajima, M., Qian, E., Sanosaka, T., Sato, T. & Okano, H., 2022 1月 21, In: Cells. 11, 3

  研究成果: Article › 査読

  Open Access

  • Callithrix 100%
  • Pluripotent Stem Cells 87%
  • Homologous Recombination 84%
  • Clustered Regularly Interspaced Short Palindromic Repeats 28%
  • Embryonic Stem Cells 26%

• Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

  Ito, K., Sanosaka, T., Igarashi, K., Ideta-Otsuka, M., Aizawa, A., Uosaki, Y., Noguchi, A., Arakawa, H., Nakashima, K. & Takizawa, T., 2016 4月 4, In: Scientific reports. 6, 23903.

  研究成果: Article › 査読

  • Glial Fibrillary Acidic Protein 100%
  • Astrocytes 82%
  • Genes 36%
  • Cluster Analysis 34%
  • Cell Nucleus 13%
  17 被引用数 (Scopus)

• Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells

  Sanosaka, T., Namihira, M., Asano, H., Kohyama, J., Aisaki, K., Igarashi, K., Kanno, J. & Nakashima, K., 2008 8月 26, In: Neuroscience. 155, 3, p. 780-788 9 p.

  研究成果: Article › 査読

  • Astrocytes 100%
  • AT-Hook Motifs 49%
  • Genes 43%
  • Leukemia Inhibitory Factor 26%
  • Telencephalon 12%
  36 被引用数 (Scopus)

• Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

  Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Takamura-Enya, T. & Yoshimura, A., 2017 8月 1, In: International immunology. 29, 8, p. 365-375 11 p., dxx049.

  研究成果: Article › 査読

  • Enzyme Induction 100%
  • Enzyme Activation 97%
  • Demethylation 92%
  • Catalytic Domain 34%
  • DNA Demethylation 27%
  42 被引用数 (Scopus)

• Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid

  Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. & Nakashima, K., 2012 1月, In: Neuroscience Research. 72, 1, p. 23-31 9 p.

  研究成果: Article › 査読

  • Mouse Embryonic Stem Cells 100%
  • Valproic Acid 88%
  • Neurons 50%
  • Histone Deacetylase Inhibitors 15%
  • Neurogenesis 14%
  36 被引用数 (Scopus)

• Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

  Kuwabara, T., Kagalwala, M. N., Onuma, Y., Ito, Y., Warashina, M., Terashima, K., Sanosaka, T., Nakashima, K., Gage, F. H. & Asashima, M., 2011 12月, In: EMBO Molecular Medicine. 3, 12, p. 742-754 13 p.

  研究成果: Article › 査読

  Open Access

  • Olfactory Bulb 100%
  • Hippocampus 69%
  • Insulin 59%
  • Pancreas 37%
  • Insulin-Like Growth Factor Binding Protein 4 33%
  82 被引用数 (Scopus)

• Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

  Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 4月 26, In: International immunology. 31, 5, p. 335-347 13 p.

  研究成果: Article › 査読

  • Protein Transport 100%
  • Interleukin-17 95%
  • Regulatory T-Lymphocytes 89%
  • 5-hydroxymethylcytosine 45%
  • Immunoglobulin G 45%
  28 被引用数 (Scopus)

• Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons

  Setoguchi, H., Namihira, M., Kohyama, J., Asano, H., Sanosaka, T. & Nakashima, K., 2006 10月 1, In: Journal of neuroscience research. 84, 5, p. 969-979 11 p.

  研究成果: Article › 査読

  • Neuroepithelial Cells 100%
  • Carrier Proteins 82%
  • Glial Fibrillary Acidic Protein 61%
  • Neurons 59%
  • Astrocytes 51%
  52 被引用数 (Scopus)

• Neuropoietin induces neuroepithelial cells to differentiate into astrocytes via activation of STAT3

  Ohno, M., Kohyama, J., Namihira, M., Sanosaka, T., Takahashi, J. A., Hashimoto, N. & Nakashima, K., 2006 10月, In: Cytokine. 36, 1-2, p. 17-22 6 p.

  研究成果: Article › 査読

  • Neuroepithelial Cells 100%
  • STAT3 Transcription Factor 83%
  • Astrocytes 63%
  • Glycoprotein 63%
  • Marker 60%
  14 被引用数 (Scopus)

• Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species

  Yoshimatsu, S., Nakajima, M., Iguchi, A., Sanosaka, T., Sato, T., Nakamura, M., Nakajima, R., Arai, E., Ishikawa, M., Imaizumi, K., Watanabe, H., Okahara, J., Noce, T., Takeda, Y., Sasaki, E., Behr, R., Edamura, K., Shiozawa, S. & Okano, H., 2021 4月 13, In: Stem cell reports. 16, 4, p. 754-770 17 p.

  研究成果: Article › 査読

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Chemical Compound 95%
  • Transgenes 89%
  • Fibroblasts 65%
  • Callithrix 59%
  7 被引用数 (Scopus)

• Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation

  Semi, K., Sanosaka, T., Namihira, M. & Nakashima, K., 2018 4月 1, In: HAYATI Journal of Biosciences. 25, 2, p. 70-78 9 p.

  研究成果: Article › 査読

  • NFI Transcription Factors 100%
  • oligodendroglia 90%
  • Demethylation 80%
  • Oligodendroglia 74%
  • methylation 63%
  1 被引用数 (Scopus)

• Oxygen levels epigenetically regulate fate switching of neural precursor cells via hypoxia-inducible factor 1α-Notch signal interaction in the developing brain

  Mutoh, T., Sanosaka, T., Ito, K. & Nakashima, K., 2012 3月, In: Stem Cells. 30, 3, p. 561-569 9 p.

  研究成果: Article › 査読

  • Hypoxia-Inducible Factor 1 100%
  • Cell Hypoxia 99%
  • Demethylation 94%
  • Astrocytes 72%
  • Oxygen 56%
  37 被引用数 (Scopus)

• Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis

  Yuniarti, N., Juliandi, B., MuhChyi, C., Noguchi, H., Sanosaka, T. & Nakashima, K., 2013 9月, In: Neuroscience Research. 77, 1-2, p. 42-49 8 p.

  研究成果: Article › 査読

  • Vorinostat 100%
  • Histone Deacetylases 35%
  • Neurogenesis 21%
  • Stem Cells 14%
  • Neurons 12%
  7 被引用数 (Scopus)

• Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

  Juliandi, B., Tanemura, K., Igarashi, K., Tominaga, T., Furukawa, Y., Otsuka, M., Moriyama, N., Ikegami, D., Abematsu, M., Sanosaka, T., Tsujimura, K., Narita, M., Kanno, J. & Nakashima, K., 2015 12月 8, In: Stem cell reports. 5, 6, p. 996-1009 14 p.

  研究成果: Article › 査読

  Open Access

  • Valproic Acid 100%
  • Anticonvulsant 80%
  • Neurogenesis 73%
  • Anticonvulsants 65%
  • Cognitive Dysfunction 56%
  50 被引用数 (Scopus)

• Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions

  Isoda, M., Kohyama, J., Iwanami, A., Sanosaka, T., Sugai, K., Yamaguchi, R., Matsumoto, T., Nakamura, M. & Okano, H., 2016 9月 1, In: Neuroscience Research. 110, p. 18-28 11 p.

  研究成果: Article › 査読

  • Neuroepithelial Cells 100%
  • Peripheral Blood Stem Cells 87%
  • Neural Stem Cells 58%
  • Blood Cells 56%
  • Stem Cells 50%
  11 被引用数 (Scopus)

• Single-cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential

  Lam, M., Sanosaka, T., Lundin, A., Imaizumi, K., Etal, D., Karlsson, F. H., Clausen, M., Cairns, J., Hicks, R., Kohyama, J., Kele, M., Okano, H. & Falk, A., 2019 12月 1, In: Genes to Cells. 24, 12, p. 836-847 12 p.

  研究成果: Article › 査読

  Open Access

  • Neural Stem Cells 100%
  • Induced Pluripotent Stem Cells 50%
  • Cell Line 46%
  • Population 34%
  • Neuroglia 19%
  7 被引用数 (Scopus)

• SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia

  Takouda, J., Katada, S., Imamura, T., Sanosaka, T. & Nakashima, K., 2021 12月, In: Pharmacology Research and Perspectives. 9, 6, e00749.

  研究成果: Article › 査読

  Open Access

  • Neural Stem Cells 100%
  • Leukemia Inhibitory Factor 71%
  • Transcription Factors 67%
  • Astrocytes 65%
  • Glial Fibrillary Acidic Protein 39%
  2 被引用数 (Scopus)

• Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

  Kawamura, Y., Katada, S., Noguchi, H., Yamamoto, H., Sanosaka, T., Iihara, K. & Nakashima, K., 2017 11月, In: FEBS Letters. 591, 22, p. 3709-3720 12 p.

  研究成果: Article › 査読

  • Retinoic Acid 100%
  • Meninges 98%
  • Neural Stem Cells 85%
  • Marker 66%
  • Astrocytes 52%
  4 被引用数 (Scopus)

• Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells

  Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., Semi, K., Namihira, M., Komiya, S., Smith, A. & Nakashima, K., 2012 6月, In: Stem Cells. 30, 6, p. 1163-1173 11 p.

  研究成果: Article › 査読

  • Induced Pluripotent Stem Cells 100%
  • Spinal Cord Injuries 84%
  • Transplantation 67%
  • Stem Cells 65%
  • Neural Stem Cells 59%
  176 被引用数 (Scopus)

• Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation

  Saito, A., Kanemoto, S., Kawasaki, N., Asada, R., Iwamoto, H., Oki, M., Miyagi, H., Izumi, S., Sanosaka, T., Nakashima, K. & Imaizumi, K., 2012, In: Nature communications. 3, 967.

  研究成果: Article › 査読

  • poly(divinyl-co-N-vinylpyrrolidinone) 100%
  • Unfolded Protein Response 73%
  • Astrocytes 54%
  • proteins 47%
  • Transcription Factors 44%
  51 被引用数 (Scopus)

• Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells

  Iida, T., Iwanami, A., Sanosaka, T., Kohyama, J., Miyoshi, H., Nagoshi, N., Kashiwagi, R., Toyama, Y., Matsumoto, M., Nakamura, M. & Okano, H., 2017 5月, In: Stem Cells. 35, 5, p. 1316-1327 12 p.

  研究成果: Article › 査読

  • Neural Stem Cells 100%
  • DNA Methylation 88%
  • Epigenomics 77%
  • Induced Pluripotent Stem Cells 75%
  • Stem Cells 65%
  22 被引用数 (Scopus)