• 12436 引用
  • 62 h指数
1991 …2019
Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1991 2019

2019

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

Kikuchi-Koike, R., Nagasaka, K., Tsuda, H., Ishii, Y., Sakamoto, M., Kikuchi, Y., Fukui, S., Miyagawa, Y., Hiraike, H., Kobayashi, T., Kinoshita, T., Kanai, Y., Shibata, T., Imoto, I., Inazawa, J., Matsubara, O. & Ayabe, T., 2019 5 30, : : BMC Cancer. 19, 1, 521.

研究成果: Article

公開
Comparative Genomic Hybridization
Chromosomes
Lymph Nodes
Breast Neoplasms
Survival
5 引用 (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 4 23, : : Cell Reports. 27, 4, p. 1265-1276.e4

研究成果: Article

公開
Organoids
Preclinical Drug Evaluations
Biliary Tract
Screening
Biomarkers

Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis

Tsumura, K., Arai, E., Tian, Y., Shibuya, A., Nishihara, H., Yotani, T., Yamada, Y., Takahashi, Y., Maeshima, A. M., Fujimoto, H., Nakagawa, T., Kume, H., Homma, Y., Yoshida, T. & Kanai, Y., 2019 11 25, : : Carcinogenesis. 40, 11, p. 1308-1319 12 p.

研究成果: Article

Urothelium
DNA Methylation
Genome
Neoplasms
Carcinoma
3 引用 (Scopus)

Genome-wide DNA methylation profile of early-onset endometrial cancer: Its correlation with genetic aberrations and comparison with late-onset endometrial cancer

Makabe, T., Arai, E., Hirano, T., Ito, N., Fukamachi, Y., Takahashi, Y., Hirasawa, A., Yamagami, W., Susumu, N., Aoki, D. & Kanai, Y., 2019 7 4, : : Carcinogenesis. 40, 5, p. 611-623 13 p.

研究成果: Article

公開
DNA Methylation
Endometrial Neoplasms
Genome
Genes
Neoplasms

Primary Peritoneal Low-grade Serous Carcinoma in a Patient with Lynch Syndrome: A Case Report

Makiuchi, S., Yoshida, H., Ishikawa, M., Kojima, N., Kanai, Y. & Kato, T., 2019 1 1, (Accepted/In press) : : International Journal of Gynecological Pathology.

研究成果: Article

Hereditary Nonpolyposis Colorectal Neoplasms
Carcinoma
Neoplasms
Germ-Line Mutation
Endometrial Neoplasms
1 引用 (Scopus)
Scirrhous Adenocarcinoma
Hepatocellular Carcinoma
Catenins
Neoplasms
Stem Cells
2018
7 引用 (Scopus)

ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death

Ueno, M., Shiomi, T., Mochizuki, S., Chijiiwa, M., Shimoda, M., Kanai, Y., Kataoka, F., Hirasawa, A., Susumu, N., Aoki, D. & Okada, Y., 2018 2 1, : : Cancer Science. 109, 2, p. 471-482 12 p.

研究成果: Article

Cisplatin
Cell Death
Carcinoma
Disintegrins
Metalloproteases
1 引用 (Scopus)
Arthropods
Prothrombin
Thrombin
Hemorrhage
Mutation
Adenoma
Adenocarcinoma
Neoplasms
Barrett Esophagus
Delayed Diagnosis
7 引用 (Scopus)

DBTSS/DBKERO for integrated analysis of transcriptional regulation

Suzuki, A., Kawano, S., Mitsuyama, T., Suyama, M., Kanai, Y., Shirahige, K., Sasaki, H., Tokunaga, K., Tsuchihara, K., Sugano, S., Nakai, K. & Suzuki, Y., 2018 1 1, : : Nucleic Acids Research. 46, D1, p. D229-D238

研究成果: Article

Databases
Human Genome
Nucleic Acid Regulatory Sequences
Nanopores
Encyclopedias

Epigenome mapping of human normal purified hepatocytes: Personal epigenome variation and genome-epigenome correlation

Arai, E., Miura, F., Totoki, Y., Yamashita, S., Tian, Y., Gotoh, M., Ojima, H., Nakagawa, H., Takahashi, Y., Nakamura, H., Hama, N., Kato, M., Kimura, H., Suzuki, Y., Ito, T., Shibata, T. & Kanai, Y., 2018 7 1, : : Epigenomics. 10, 7, p. 955-979 25 p.

研究成果: Article

Methylation
Hepatocytes
Histone Code
Genome
RNA Sequence Analysis

Feasibility of methylome analysis using small amounts of genomic DNA from formalin-fixed paraffin-embedded tissue

Ohara, K., Arai, E., Takahashi, Y., Fukamachi, Y., Ito, N., Maeshima, A. M., Fujimoto, H., Yoshida, T. & Kanai, Y., 2018 11 1, : : Pathology International. 68, 11, p. 633-635 3 p.

研究成果: Letter

Paraffin
Formaldehyde
DNA
3 引用 (Scopus)
Amniotic Fluid
Wound Healing
Cicatrix
Fetus
Stem Cells
9 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific Reports. 8, 1, 2821.

研究成果: Article

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
8 引用 (Scopus)
Emphysema
Smoke
Tobacco Products
Tumors
Lung
5 引用 (Scopus)

Novel method for DNA methylation analysis using high-performance liquid chromatography and its clinical application

Yotani, T., Yamada, Y., Arai, E., Tian, Y., Gotoh, M., Komiyama, M., Fujimoto, H., Sakamoto, M. & Kanai, Y., 2018 1 1, (Accepted/In press) : : Cancer Science.

研究成果: Article

DNA Methylation
High Pressure Liquid Chromatography
Renal Cell Carcinoma
Neoplasms
Cytosine

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study)

Okuma, Y., Morikawa, K., Tanaka, H., Yokoyama, T., Itani, H., Horiuchi, K., Nakagawa, H., Takahashi, N., Bessho, A., Soejima, K., Kishi, K., Togashi, A., Kanai, Y., Ueda, K., Horimoto, K., Matsutani, N. & Seki, N., 2018 1 1, (Accepted/In press) : : Thoracic Cancer.

研究成果: Article

Exosomes
Translational Medical Research
Non-Small Cell Lung Carcinoma
Biomarkers
Protein-Tyrosine Kinases
9 引用 (Scopus)

The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses

Kanai, Y., Nishihara, H., Miyagi, Y., Tsuruyama, T., Taguchi, K., Katoh, H., Takeuchi, T., Gotoh, M., Kuramoto, J., Arai, E., Ojima, H., Shibuya, A., Yoshida, T., Akahane, T., Kasajima, R., Morita, K. I., Inazawa, J., Sasaki, T., Fukayama, M. & Oda, Y., 2018 2 1, : : Pathology International. 68, 2, p. 63-90 28 p.

研究成果: Article

Guidelines
Pathology
Research
Formaldehyde
Medical Laboratory Personnel
2017

A novel diagnostic biomarker for human uterine leiomyosarcoma: PSMB9/β1i

Hayashi, T., Kawano, M., Sano, K., Ichimura, T., Gur, G., Yaish, P., Zharhary, D., Kanai, Y., Tonegawa, S., Shiozawa, T., Yaegashi, N. & Konishi, I., 2017 4 1, : : Chinese Clinical Oncology. 6, 2, p. 1-3 3 p.

研究成果: Letter

26 引用 (Scopus)

Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy

Yanagita, T., Murata, Y., Tanaka, D., Motegi, S. I., Arai, E., Daniwijaya, E. W., Hazama, D., Washio, K., Saito, Y., Kotani, T., Ohnishi, H., Oldenborg, P. A., Garcia, N. V., Miyasaka, M., Ishikawa, O., Kanai, Y., Komori, T. & Matozaki, T., 2017 1 1, : : JCI Insight. 2, 1, e89140.

研究成果: Article

公開
Immunotherapy
Anti-Idiotypic Antibodies
Neoplasms
Macrophages
Phagocytosis
8 引用 (Scopus)

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids

Nakaoka, T., Saito, Y., Shimamoto, Y., Muramatsu, T., Kimura, M., Kanai, Y. & Saito, H., 2017 4 1, : : Cancer Science. 108, 4, p. 678-684 7 p.

研究成果: Article

Organoids
Neoplasms
MicroRNAs
Neoplastic Stem Cells
Intestinal Mucosa
2 引用 (Scopus)

Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: A single-institutional methylome analysis using 1007 tissue specimens

Ohara, K., Arai, E., Takahashi, Y., Ito, N., Shibuya, A., Tsuta, K., Kushima, R., Tsuda, H., Ojima, H., Fujimoto, H., Watanabe, S. I., Katai, H., Kinoshita, T., Shibata, T., Kohno, T. & Kanai, Y., 2017 3 1, : : Carcinogenesis. 38, 3, p. 241-251 11 p.

研究成果: Article

DNA Methylation
Genes
Neoplasms
Histone Code
Gene Ontology
6 引用 (Scopus)

Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: Comparison with hepatitis virus-related carcinogenesis

Kuramoto, J., Arai, E., Tian, Y., Funahashi, N., Hiramoto, M., Nammo, T., Nozaki, Y., Takahashi, Y., Ito, N., Shibuya, A., Ojima, H., Sukeda, A., Seki, Y., Kasama, K., Yasuda, K. & Kanai, Y., 2017 3 1, : : Carcinogenesis. 38, 3, p. 261-270 10 p.

研究成果: Article

Hepatitis Viruses
DNA Methylation
Fatty Liver
Carcinogenesis
Genome
12 引用 (Scopus)

Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism

Shimoda, M., Yoshida, H., Mizuno, S., Hirozane, T., Horiuchi, K., Yoshino, Y., Hara, H., Kanai, Y., Inoue, S., Ishijima, M. & Okada, Y., 2017 5 1, : : American Journal of Pathology. 187, 5, p. 1162-1176 15 p.

研究成果: Article

CD44 Antigens
Hyaluronic Acid
Osteogenesis
Chondrocytes
Osteoclasts
10 引用 (Scopus)

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Shirasawa, H., Matsumura, N., Shimoda, M., Oki, S., Yoda, M., Tohmonda, T., Kanai, Y., Matsumoto, M., Nakamura, M. & Horiuchi, K., 2017 1 31, : : Scientific Reports. 7, 41552.

研究成果: Article

Platelet-Derived Growth Factor Receptors
Mesenchymal Stromal Cells
Humeral Head
Muscles
Rotator Cuff

Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

Iwao, Y., Ojima, H., Kobayashi, T., Kishi, Y., Nara, S., Esaki, M., Shimada, K., Hiraoka, N., Tanabe, M. & Kanai, Y., 2017 11 18, : : World Journal of Hepatology. 9, 32, p. 1227-1238 12 p.

研究成果: Article

Atrophy
Lysosomal-Associated Membrane Protein 2
Apoptosis
Liver
Cytochrome P-450 CYP2E1
7 引用 (Scopus)

The genomic and epigenomic landscape in thymic carcinoma

Saito, M., Fujiwara, Y., Asao, T., Honda, T., Shimada, Y., Kanai, Y., Tsuta, K., Kono, K., Watanabe, S., Ohe, Y. & Kohno, T., 2017 11 1, : : Carcinogenesis. 38, 11, p. 1084-1091 8 p., bgx094.

研究成果: Article

Thymoma
Epigenomics
Mutation
Methylation
Exome
2016
2 引用 (Scopus)
Ataxia Telangiectasia
Osteoclasts
Bone and Bones
DNA Damage
Bone Resorption
4 引用 (Scopus)

Genomic landscape of experimental bladder cancer in rodents and its application to human bladder cancer: Gene amplification and potential overexpression of Cyp2a5/CYP2A6 are associated with the invasive phenotype

Kanemoto, K., Fukuta, K., Kawai, N., Tozawa, K., Ochiai, M., Okamoto, K., Ohnami, S., Sakamoto, H., Yoshida, T., Kanai, Y., Katoh, M., Yasui, T., Kohri, K., Kakizoe, T. & Nakagama, H., 2016 11 1, : : PLoS One. 11, 11, e0167374.

研究成果: Article

gene amplification
Gene Amplification
Neoplasm Genes
Urinary Bladder Neoplasms
Rodentia
30 引用 (Scopus)

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

Saito, K., Arai, E., Maekawa, K., Ishikawa, M., Fujimoto, H., Taguchi, R., Matsumoto, K., Kanai, Y. & Saito, Y., 2016 6 30, : : Scientific Reports. 6, 28932.

研究成果: Article

Renal Cell Carcinoma
Kidney
Lipids
Phospholipids
Phospholipid Ethers
5 引用 (Scopus)

Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma

Hori, S., Shimada, K., Ino, Y., Oguro, S., Esaki, M., Nara, S., Kishi, Y., Kosuge, T., Hattori, Y., Sukeda, A., Kitagawa, Y., Kanai, Y. & Hiraoka, N., 2016 12 1, : : Virchows Archiv. 469, 6, p. 621-634 14 p.

研究成果: Article

Adenocarcinoma
Necrosis
Adjuvant Chemotherapy
Disease-Free Survival
Survival
7 引用 (Scopus)

Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer

Kamino, H., Nakamura, Y., Tsuneki, M., Sano, H., Miyamoto, Y., Kitamura, N., Futamura, M., Kanai, Y., Taniguchi, H., Shida, D., Kanemitsu, Y., Moriya, Y., Yoshida, K., Arakawa, H., Zheng, M., Turton, K. B., Zhu, F., Li, Y., Grindle, K. M., Annis, D. S. および6人, Lu, L., Drennan, A. C., Tweardy, D. J., Bharadwaj, U., Mosher, D. F. & Rui, L., 2016 1 4, : : Oncogenesis. 5, p. e181

研究成果: Article

Quality Control
Colorectal Neoplasms
Mitochondria
Methylation
Reactive Oxygen Species
1 引用 (Scopus)

Molecular pathology and novel clinical therapy for uterine leiomyosarcoma

Hayashi, T., Kawano, M., Ichimura, T., Ida, K., Ando, H., Zharhary, D., Kanai, Y., Aburatani, H., Tonegawa, S., Shiozawa, T., Yaegashi, N. & Konishi, I., 2016 10 1, : : Anticancer Research. 36, 10, p. 4997-5007 11 p.

研究成果: Review article

Leiomyosarcoma
Molecular Pathology
Proteasome Endopeptidase Complex
Janus Kinase 1
STAT1 Transcription Factor
14 引用 (Scopus)

SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas

Ohtomo-Oda, R., Komatsu, S., Mori, T., Sekine, S., Hirajima, S., Yoshimoto, S., Kanai, Y., Otsuji, E., Ikeda, E. & Tsuda, H., 2016 3 1, : : Human Pathology. 49, p. 145-155 11 p.

研究成果: Article

Neck
Head
Cell Proliferation
Carcinoma
Neoplasms
90 引用 (Scopus)

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Stunnenberg, H. G., Abrignani, S., Adams, D., de Almeida, M., Altucci, L., Amin, V., Amit, I., Antonarakis, S. E., Aparicio, S., Arima, T., Arrigoni, L., Arts, R., Asnafi, V., Badosa, M. E., Bae, J. B., Bassler, K., Beck, S., Berkman, B., Bernstein, B. E., Bilenky, M. および210人, Bird, A., Bock, C., Boehm, B., Bourque, G., Breeze, C. E., Brors, B., Bujold, D., Burren, O., Bussemakers, M. J., Butterworth, A., Campo, E., Carrillo-de-Santa-Pau, E., Chadwick, L., Chan, K. M., Chen, W., Cheung, T. H., Chiapperino, L., Choi, N. H., Chung, H. R., Clarke, L., Connors, J. M., Cronet, P., Danesh, J., Dermitzakis, M., Drewes, G., Durek, P., Dyke, S., Dylag, T., Eaves, C. J., Ebert, P., Eils, R., Eils, J., Ennis, C. A., Enver, T., Feingold, E. A., Felder, B., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Foo, R. S. Y., Fraser, P., Frontini, M., Furlong, E., Gakkhar, S., Gasparoni, N., Gasparoni, G., Geschwind, D. H., Glažar, P., Graf, T., Grosveld, F., Guan, X. Y., Guigo, R., Gut, I. G., Hamann, A., Han, B. G., Harris, R. A., Heath, S., Helin, K., Hengstler, J. G., Heravi-Moussavi, A., Herrup, K., Hill, S., Hilton, J. A., Hitz, B. C., Horsthemke, B., Hu, M., Hwang, J. Y., Ip, N. Y., Ito, T., Javierre, B. M., Jenko, S., Jenuwein, T., Joly, Y., Jones, S. J. M., Kanai, Y., Kang, H. G., Karsan, A., Kiemer, A. K., Kim, S. C., Kim, B. J., Kim, H. H., Kimura, H., Kinkley, S., Klironomos, F., Koh, I. U., Kostadima, M., Kressler, C., Kreuzhuber, R., Kundaje, A., Küppers, R., Larabell, C., Lasko, P., Lathrop, M., Lee, D. H. S., Lee, S., Lehrach, H., Leitão, E., Lengauer, T., Lernmark, Å., Leslie, R. D., Leung, G. K. K., Leung, D., Loeffler, M., Ma, Y., Mai, A., Manke, T., Marcotte, E. R., Marra, M. A., Martens, J. H. A., Martin-Subero, J. I., Maschke, K., Merten, C., Milosavljevic, A., Minucci, S., Mitsuyama, T., Moore, R. A., Müller, F., Mungall, A. J., Netea, M. G., Nordström, K., Norstedt, I., Okae, H., Onuchic, V., Ouellette, F., Ouwehand, W., Pagani, M., Pancaldi, V., Pap, T., Pastinen, T., Patel, R., Paul, D. S., Pazin, M. J., Pelicci, P. G., Phillips, A. G., Polansky, J., Porse, B., Pospisilik, J. A., Prabhakar, S., Procaccini, D. C., Radbruch, A., Rajewsky, N., Rakyan, V., Reik, W., Ren, B., Richardson, D., Richter, A., Rico, D., Roberts, D. J., Rosenstiel, P., Rothstein, M., Salhab, A., Sasaki, H., Satterlee, J. S., Sauer, S., Schacht, C., Schmidt, F., Schmitz, G., Schreiber, S., Schröder, C., Schübeler, D., Schultze, J. L., Schulyer, R. P., Schulz, M., Seifert, M., Shirahige, K., Siebert, R., Sierocinski, T., Siminoff, L., Sinha, A., Soranzo, N., Spicuglia, S., Spivakov, M., Steidl, C., Strattan, J. S., Stratton, M., Südbeck, P., Sun, H., Suzuki, N., Suzuki, Y., Tanay, A., Torrents, D., Tyson, F. L., Ulas, T., Ullrich, S., Ushijima, T., Valencia, A., Vellenga, E., Vingron, M., Wallace, C., Wallner, S., Walter, J., Wang, H., Weber, S., Weiler, N., Weller, A., Weng, A., Wilder, S., Wiseman, S. M., Wu, A. R., Wu, Z., Xiong, J., Yamashita, Y., Yang, X., Yap, D. Y., Yip, K. Y., Yip, S., Yoo, J. I., Zerbino, D., Zipprich, G. & Hirst, M., 2016 11 17, : : Cell. 167, 5, p. 1145-1149 5 p.

研究成果: Comment/debate

Blueprints
Cells
Health
Epigenomics
2015
24 引用 (Scopus)

Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum

Matsubara, A., Ogawa, R., Suzuki, H., Oda, I., Taniguchi, H., Kanai, Y., Kushima, R. & Sekine, S., 2015 4 14, : : British Journal of Cancer. 112, 8, p. 1398-1404 7 p.

研究成果: Article

Metaplasia
Duodenum
Stomach
Adenocarcinoma
Mutation
10 引用 (Scopus)

Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas

Arai, E., Gotoh, M., Tian, Y., Sakamoto, H., Ono, M., Matsuda, A., Takahashi, Y., Miyata, S., Totsuka, H., Chiku, S., Komiyama, M., Fujimoto, H., Matsumoto, K., Yamada, T., Yoshida, T. & Kanai, Y., 2015 12 1, : : International Journal of Cancer. 137, 11, p. 2589-2606 18 p.

研究成果: Article

CpG Islands
Renal Cell Carcinoma
Phenotype
Aurora Kinase A
Aurora Kinases
57 引用 (Scopus)

An integrated prognostic classifier for Stage I lung adenocarcinoma based on mRNA, microRNA, and DNA methylation biomarkers

Robles, A. I., Arai, E., Mathé, E. A., Okayama, H., Schetter, A. J., Brown, D., Petersen, D., Bowman, E. D., Noro, R., Welsh, J. A., Edelman, D. C., Stevenson, H. S., Wang, Y., Tsuchiya, N., Kohno, T., Skaug, V., Mollerup, S., Haugen, A., Meltzer, P. S., Yokota, J. および2人, Kanai, Y. & Harris, C. C., 2015 7 4, : : Journal of Thoracic Oncology. 10, 7, p. 1037-1048 12 p.

研究成果: Article

DNA Methylation
MicroRNAs
Biomarkers
Methylation
Messenger RNA
3 引用 (Scopus)

Biological characterization of soft tissue sarcomas

Hayashi, T., Horiuchi, A., Sano, K., Kanai, Y., Yaegashi, N., Aburatani, H. & Konishi, I., 2015 12 1, : : Annals of Translational Medicine. 3, 22, 368.

研究成果: Letter

Sarcoma
Neoplasms
Biomarkers
Retinoblastoma
Gene Amplification
19 引用 (Scopus)

Epigenetic clustering of gastric carcinomas based on dna methylation profiles at the precancerous stage: Its correlation with tumor aggressiveness and patient outcome

Yamanoi, K., Arai, E., Tian, Y., Takahashi, Y., Miyata, S., Sasaki, H., Chiwaki, F., Ichikawa, H., Sakamoto, H., Kushima, R., Katai, H., Yoshida, T., Sakamoto, M. & Kanai, Y., 2015 5 1, : : Carcinogenesis. 36, 5, p. 509-520 12 p.

研究成果: Article

DNA Methylation
Epigenomics
Methylation
Cluster Analysis
Stomach
19 引用 (Scopus)

Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features

Hashimoto, T., Ogawa, R., Matsubara, A., Taniguchi, H., Sugano, K., Ushiama, M., Yoshida, T., Kanai, Y. & Sekine, S., 2015 11 1, : : Histopathology. 67, 5, p. 689-698 10 p.

研究成果: Article

Adenomatous Polyposis Coli
Upper Gastrointestinal Tract
Gastric Mucosa
Adenoma
Polyps
48 引用 (Scopus)

Frequent MED12 mutations in phyllodes tumours of the breast

Yoshida, M., Sekine, S., Ogawa, R., Yoshida, H., Maeshima, A., Kanai, Y., Kinoshita, T. & Ochiai, A., 2015 5 12, : : British Journal of Cancer. 112, 10, p. 1703-1708 6 p.

研究成果: Article

Phyllodes Tumor
Fibroadenoma
Breast
Mutation
Breast Neoplasms
12 引用 (Scopus)

Heat shock protein 90 is a potential therapeutic target in cholangiocarcinoma

Shirota, T., Ojima, H., Hiraoka, N., Shimada, K., Rokutan, H., Arai, Y., Kanai, Y., Miyagawa, S. & Shibata, T., 2015 9 1, : : Molecular Cancer Therapeutics. 14, 9, p. 1985-1993 9 p.

研究成果: Article

HSP90 Heat-Shock Proteins
Cholangiocarcinoma
Therapeutics
Heterografts
Growth
62 引用 (Scopus)

Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer

Hiraoka, N., Ino, Y., Yamazaki-Itoh, R., Kanai, Y., Kosuge, T. & Shimada, K., 2015 5 26, : : British Journal of Cancer. 112, 11, p. 1782-1790 9 p.

研究成果: Article

Pancreatic Ductal Carcinoma
Pancreatic Neoplasms
Neoplasms
Pericytes
Tumor Microenvironment
5 引用 (Scopus)

Long-term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR-mutant PC9 lung cancer cell line

Terai, H., Soejima, K., Yasuda, H., Sato, T., Naoki, K., Ikemura, S., Arai, D., Ohgino, K., Ishioka, K., Hamamoto, J., Kanai, Y. & Betsuyaku, T., 2015 1 1, : : International Journal of Oncology. 46, 1, p. 430-436 7 p.

研究成果: Article

DNA Methylation
Lung Neoplasms
Cell Line
Genes
Messenger RNA
29 引用 (Scopus)

Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells

Sakamoto, A., Hino, S., Nagaoka, K., Anan, K., Takase, R., Matsumori, H., Ojima, H., Kanai, Y., Arita, K. & Nakao, M., 2015 4 1, : : Cancer Research. 75, 7, p. 1445-1456 12 p.

研究成果: Article

Lysine
Hepatocellular Carcinoma
Epigenomics
Neoplasms
Mitochondrial Genes
7 引用 (Scopus)

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

Sato, T., Soejima, K., Arai, E., Hamamoto, J., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Naoki, K., Kohno, T., Tsuta, K., Watanabe, S. I., Kanai, Y. & Betsuyaku, T., 2015 9 1, : : Oncology Reports. 34, 3, p. 1137-1145 9 p.

研究成果: Article

DNA Methylation
Non-Small Cell Lung Carcinoma
Messenger RNA
decitabine
Protein Tyrosine Phosphatases
24 引用 (Scopus)

TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast

Yoshida, M., Ogawa, R., Yoshida, H., Maeshima, A., Kanai, Y., Kinoshita, T., Hiraoka, N. & Sekine, S., 2015 10 20, : : British Journal of Cancer. 113, 8, p. 1244-1248 5 p.

研究成果: Article

Phyllodes Tumor
Fibroadenoma
Breast
Mutation
Fibroepithelial Neoplasms

The excision repair cross-complementation group 1

Sakamoto, Y., Ojima, H., Morizane, C., Kanai, Y. & Okusaka, T., 2015 3 1, : : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 485-490 6 p.

研究成果: Article

Biliary Tract Neoplasms
Endonucleases
DNA-Binding Proteins
Tumor Biomarkers
Non-Small Cell Lung Carcinoma
6 引用 (Scopus)
Urinary Tract
Urinary Bladder Neoplasms
Carcinoma
Recurrence
Neoplasms