Yoshiaki Furukawa

2022

Metal distribution in Cu/Zn-superoxide dismutase revealed by native mass spectrometry

Tajiri, M., Aoki, H., Shintani, A., Sue, K., Akashi, S. & Furukawa, Y., 2022 4月, In: Free Radical Biology and Medicine. 183, p. 60-68 9 p.

研究成果: Article › 査読

Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases

Kimura, S., Kamishina, H., Hirata, Y., Furuta, K., Furukawa, Y., Yamato, O., Maeda, S. & Kamatari, Y. O., 2022 5月, In: Biochimica et Biophysica Acta - General Subjects. 1866, 5, 130114.

研究成果: Article › 査読

1 被引用数 (Scopus)

Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission

Imamura, Y., Okuzumi, A., Yoshinaga, S., Hiyama, A., Furukawa, Y., Miyasaka, T., Hattori, N. & Nukina, N., 2022 12月, In: Communications biology. 5, 1, 636.

研究成果: Article › 査読

Open Access

2021

Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS

Hirose, M., Asano, M., Watanabe-Matsumoto, S., Yamanaka, K., Abe, Y., Yasui, M., Tokuda, E., Furukawa, Y. & Misawa, H., 2021 10月, In: Neuroscience Research. 171, p. 74-82 9 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

2020

Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation

Anzai, I., Tokuda, E., Handa, S., Misawa, H., Akiyama, S. & Furukawa, Y., 2020 2月 1, In: Free Radical Biology and Medicine. 147, p. 187-199 13 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2019

Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates

Tanaka, G., Yamanaka, T., Furukawa, Y., Kajimura, N., Mitsuoka, K. & Nukina, N., 2019 1月 15, In: Biochemical and Biophysical Research Communications. 508, 3, p. 729-734 6 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Sequence- and seed-structure-dependent polymorphic fibrils of alpha-synuclein

Tanaka, G., Yamanaka, T., Furukawa, Y., Kajimura, N., Mitsuoka, K. & Nukina, N., 2019 6月 1, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 6, p. 1410-1420 11 p.

研究成果: Article › 査読

Open Access

13 被引用数 (Scopus)

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

Tokuda, E., Takei, Y. I., Ohara, S., Fujiwara, N., Hozumi, I. & Furukawa, Y., 2019 11月 19, In: Molecular Neurodegeneration. 14, 1, 42.

研究成果: Article › 査読

Open Access

22 被引用数 (Scopus)

2018

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda, E., Nomura, T., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2018 6月, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2119-2130 12 p.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state

Fujiwara, N., Wagatsuma, M., Oba, N., Yoshihara, D., Tokuda, E., Sakiyama, H., Eguchi, H., Ichihashi, M., Furukawa, Y., Inoue, T. & Suzuki, K., 2018 10月, In: PloS one. 13, 10, e0205090.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

Tamaki, Y., Shodai, A., Morimura, T., Hikiami, R., Minamiyama, S., Ayaki, T., Tooyama, I., Furukawa, Y., Takahashi, R. & Urushitani, M., 2018 12月 1, In: Scientific reports. 8, 1, 6030.

研究成果: Article › 査読

38 被引用数 (Scopus)

Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metalassociated domain

Furukawa, Y., Lim, C., Tosha, T., Yoshida, K., Hagai, T., Akiyama, S., Watanabe, S., Nakagome, K. & Shiro, Y., 2018 9月, In: PloS one. 13, 9, e0204355.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

Okuzumi, A., Kurosawa, M., Hatano, T., Takanashi, M., Nojiri, S., Fukuhara, T., Yamanaka, T., Miyazaki, H., Yoshinaga, S., Furukawa, Y., Shimogori, T., Hattori, N. & Nukina, N., 2018 9月 19, In: Acta Neuropathologica Communications. 6, 1, p. 96 1 p.

研究成果: Article › 査読

Open Access

34 被引用数 (Scopus)

生体内銅イオン動態に着目した筋萎縮性側索硬化症の病理解明

Furukawa, Y., 2018, In: Seikagaku. 90, 3, p. 311-319 9 p.

研究成果: Article › 査読

2017

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai, I., Tokuda, E., Mukaiyama, A., Akiyama, S., Endo, F., Yamanaka, K., Misawa, H. & Furukawa, Y., 2017 3月 1, In: Protein Science. 26, 3, p. 484-496 13 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase

Fukuoka, M., Tokuda, E., Nakagome, K., Wu, Z., Nagano, I. & Furukawa, Y., 2017 10月, In: Journal of Inorganic Biochemistry. 175, p. 208-216 9 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Tokuda, E., Anzai, I., Nomura, T., Toichi, K., Watanabe, M., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2017 1月 5, In: Molecular Neurodegeneration. 12, 1, 2.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31

Ishiguro, T., Sato, N., Ueyama, M., Fujikake, N., Sellier, C., Kanegami, A., Tokuda, E., Zamiri, B., Gall-Duncan, T., Mirceta, M., Furukawa, Y., Yokota, T., Wada, K., Taylor, J. P., Pearson, C. E., Charlet-Berguerand, N., Mizusawa, H., Nagai, Y. & Ishikawa, K., 2017 4月 5, In: Neuron. 94, 1, p. 108-124.e7

研究成果: Article › 査読

Open Access

74 被引用数 (Scopus)

2016

A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43

Furukawa, Y., Suzuki, Y., Fukuoka, M., Nagasawa, K., Nakagome, K., Shimizu, H., Mukaiyama, A. & Akiyama, S., 2016 2月 3, In: Scientific reports. 6, 20576.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Conformational disorder of the most immature Cu, Zn-superoxide dismutase leading to amyotrophic lateral sclerosis

Furukawa, Y., Anzai, I., Akiyama, S., Imai, M., Cruz, F. J. C., Saio, T., Nagasawa, K., Nomura, T. & Ishimori, K., 2016 2月 19, In: Journal of Biological Chemistry. 291, 8, p. 4144-4155 12 p.

研究成果: Article › 査読

Open Access

26 被引用数 (Scopus)

Copper homeostasis as a therapeutic target in amyotrophic lateral sclerosis with SOD1 mutations

Tokuda, E. & Furukawa, Y., 2016 5月 1, In: International Journal of Molecular Sciences. 17, 5, 636.

研究成果: Article › 査読

Screening of drugs inhibiting in vitro oligomerization of Cu/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis

Anzai, I., Toichi, K., Tokuda, E., Mukaiyama, A., Akiyama, S. & Furukawa, Y., 2016 8月 9, In: Frontiers in Molecular Biosciences. 3, AUG, 40.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

2015

Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis

Ogawa, M., Shidara, H., Oka, K., Kurosawa, M., Nukina, N. & Furukawa, Y., 2015 7月 13, In: Biochemical and Biophysical Research Communications. 463, 4, p. 1196-1202 7 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

2014

A primary role for disulfide formation in the productive folding of prokaryotic Cu,,Zn-superoxide dismutase

Sakurai, Y., Anzai, I. & Furukawa, Y., 2014, In: Journal of Biological Chemistry. 289, 29, p. 20139-20149 11 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

A seeded propagation of Cu, Zn-superoxide dismutase aggregates in amyotrophic lateral sclerosis

Ogawa, M. & Furukawa, Y., 2014 3月 18, In: Frontiers in Cellular Neuroscience. 8, MAR, 83.

研究成果: Article › 査読

21 被引用数 (Scopus)

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis

Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y., 2014 1月 10, In: Journal of Biological Chemistry. 289, 2, p. 1192-1202 11 p.

研究成果: Article › 査読

81 被引用数 (Scopus)

2013

Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis

Toichi, K., Yamanaka, K. & Furukawa, Y., 2013 2月 15, In: Journal of Biological Chemistry. 288, 7, p. 4970-4980 11 p.

研究成果: Article › 査読

52 被引用数 (Scopus)

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis

Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N., 2013 8月 19, In: FEBS Letters. 587, 16, p. 2500-2505 6 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis

Furukawa, Y., 2013 11月 27, In: Frontiers in Cellular Neuroscience. 7, NOV, 240.

研究成果: Article › 査読

3 被引用数 (Scopus)

2012

Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates

Ding, F., Furukawa, Y., Nukina, N. & Dokholyan, N. V., 2012 8月 24, In: Journal of Molecular Biology. 421, 4-5, p. 548-560 13 p.

研究成果: Article › 査読

63 被引用数 (Scopus)

Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates

Mitomi, Y., Nomura, T., Kurosawa, M., Nukina, N. & Furukawa, Y., 2012 10月 5, In: Journal of Biological Chemistry. 287, 41, p. 34764-34775 12 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

2011

A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N., 2011 5月 27, In: Journal of Biological Chemistry. 286, 21, p. 18664-18672 9 p.

研究成果: Article › 査読

180 被引用数 (Scopus)

Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site

Furukawa, Y., Kaneko, K. & Nukina, N., 2011 12月, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1812, 12, p. 1577-1583 7 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties

Furukawa, Y., Kaneko, K. & Nukina, N., 2011 8月 5, In: Journal of Biological Chemistry. 286, 31, p. 27236-27246 11 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

2010

Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

Yamanaka, T., Tosaki, A., Miyazaki, H., Kurosawa, M., Furukawa, Y., Yamada, M. & Nukina, N., 2010 2月 25, In: Human molecular genetics. 19, 11, p. 2099-2112 14 p., ddq087.

研究成果: Article › 査読

37 被引用数 (Scopus)

Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis

Furukawa, Y., Kaneko, K., Yamanaka, K. & Nukina, N., 2010 7月 16, In: Journal of Biological Chemistry. 285, 29, p. 22221-22231 11 p.

研究成果: Article › 査読

76 被引用数 (Scopus)

2009

Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases

Furukawa, Y., Kaneko, K., Matsumoto, G., Kurosawa, M. & Nukina, N., 2009 4月 22, In: Journal of Neuroscience. 29, 16, p. 5153-5162 10 p.

研究成果: Article › 査読

74 被引用数 (Scopus)

2008

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis

Furukawa, Y., Kaneko, K., Yamanaka, K., O'Halloran, T. V. & Nukina, N., 2008 8月 29, In: Journal of Biological Chemistry. 283, 35, p. 24167-24176 10 p.

研究成果: Article › 査読

155 被引用数 (Scopus)

RNA-binding protein TLS is a major nuclear aggregate-interacting protein in Huntingtin exon 1 with expanded polyglutamine-expressing cells

Doi, H., Okamura, K., Bauer, P. O., Furukawa, Y., Shimizu, H., Kurosawa, M., Machida, Y., Miyazaki, H., Mitsui, K., Kuroiwa, Y. & Nukina, N., 2008 3月 7, In: Journal of Biological Chemistry. 283, 10, p. 6489-6500 12 p.

研究成果: Article › 査読

100 被引用数 (Scopus)

2006

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

Deng, H. X., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G. H., Khan, M. S., Hung, W. Y., Bigio, E. H., Lukas, T., Dal Canto, M. C., O'Halloran, T. V. & Siddique, T., 2006 5月 2, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7142-7147 6 p.

研究成果: Article › 査読

342 被引用数 (Scopus)

Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice

Furukawa, Y., Fu, R., Deng, H. X., Siddique, T. & O'Halloran, T. V., 2006 5月 2, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7148-7153 6 p.

研究成果: Article › 査読

173 被引用数 (Scopus)

2005

Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation

Furukawa, Y. & O'Halloran, T. V., 2005 4月 29, In: Journal of Biological Chemistry. 280, 17, p. 17266-17274 9 p.

研究成果: Article › 査読

201 被引用数 (Scopus)

Electron transfer reaction in a single protein molecule observed by total internal reflection fluorescence microscopy

Furukawa, Y., Ban, T., Hamada, D., Ishimori, K., Goto, Y. & Morishima, I., 2005 2月 23, In: Journal of the American Chemical Society. 127, 7, p. 2098-2103 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

2004

Oxygen-induced maturation of SOD1: A key role for disulfide formation by the copper chaperone CCS

Furukawa, Y., Torres, A. S. & O'Halloran, T. V., 2004 7月 21, In: EMBO Journal. 23, 14, p. 2872-2881 10 p.

研究成果: Article › 査読

285 被引用数 (Scopus)

The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status

Arnesano, F., Banci, L., Bertini, I., Martinelli, M., Furukawa, Y. & O'Halloran, T. V., 2004 11月 12, In: Journal of Biological Chemistry. 279, 46, p. 47998-48003 6 p.

研究成果: Article › 査読

206 被引用数 (Scopus)

2003

Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria

Field, L. S., Furukawa, Y., O'Halloran, T. V. & Culotta, V. C., 2003 7月 25, In: Journal of Biological Chemistry. 278, 30, p. 28052-28059 8 p.

研究成果: Article › 査読

181 被引用数 (Scopus)

2002

Investigation of the electron-transfer mechanism by cross-linking between Zn-substituted myoglobin and cytochrome b₅

Furukawa, Y., Matsuda, F., Ishimori, K. & Morishima, I., 2002 4月 17, In: Journal of the American Chemical Society. 124, 15, p. 4008-4019 12 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Oxidation-state-dependent protein docking between cytochrome c and cytochrome b₅: High-pressure laser flash photolysis study

Furukawa, Y., Ishimori, K. & Morishima, I., 2002 8月 6, In: Biochemistry. 41, 31, p. 9824-9832 9 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

2001

The role of water molecules in the association of cytochrome P450cam with putidaredoxin. An osmotic pressure study

Furukawa, Y. & Morishima, I., 2001 4月 20, In: Journal of Biological Chemistry. 276, 16, p. 12983-12990 8 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

2000

Electron transfer reactions in Zn-substituted cytochrome P450cam

Furukawa, Y., Ishimori, K. & Morishima, I., 2000 9月 12, In: Biochemistry. 39, 36, p. 10996-11004 9 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

古川 良明

研究成果

検索結果

古川良明