杉本 芳一

研究成果

年別の研究成果 1979 1990 2003 2005 2006 2007 2009 2018 2020 2022

• 202 Article
• 13 Review article
• 2 Comment/debate

年別の研究成果

年別の研究成果

検索結果

• 2010

  Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer

  Usuda, J., Tsunoda, Y., Ichinose, S., Ishizumi, T., Ohtani, K., Maehara, S., Ono, S., Tsutsui, H., Ohira, T., Okunaka, T., Furukawa, K., Sugimoto, Y., Kato, H. & Ikeda, N., 2010 2月, In: Lung Cancer. 67, 2, p. 198-204 7 p.

  研究成果: Article › 査読

  • Photochemotherapy 100%
  • Lung Neoplasms 73%
  • Breast Neoplasms 59%
  • Dihematoporphyrin Ether 52%
  • Talaporfin 37%
  35 被引用数 (Scopus)

• Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a

  Yoshioka, H., Noguchi, K., Katayama, K., Mitsuhashi, J., Yamagoe, S., Fujimuro, M. & Sugimoto, Y., 2010 4月 16, In: Biochemical and Biophysical Research Communications. 394, 4, p. 1000-1005 6 p.

  研究成果: Article › 査読

  • Proteasome Inhibitor 100%
  • Cyclins 80%
  • Herpesviridae 77%
  • human CCNK protein 17%
  • Primary Effusion Lymphoma 11%
  3 被引用数 (Scopus)

• In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate

  Mitsuhashi, J., Hosoyama, H., Tsukahara, S., Katayama, K., Noguchi, K., Ito, Y., Hatake, K., Aiba, K., Takahashi, S. & Sugimoto, Y., 2010 7月 1, In: Journal of Gene Medicine. 12, 7, p. 596-603 8 p.

  研究成果: Article › 査読

  • Mitomycin C 100%
  • Methotrexate 88%
  • Mitomycin 78%
  • Multiple Drug Resistance 74%
  • Transplantation 54%
  2 被引用数 (Scopus)

• Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene

  Kawahara, H., Noguchi, K., Katayama, K., Mitsuhashi, J. & Sugimoto, Y., 2010 6月 1, In: Cancer science. 101, 6, p. 1493-1500 8 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 100%
  • Sunitinib 83%
  • Germ-Line Mutation 73%
  • Pharmacology 43%
  • Breast Neoplasms 41%
  28 被引用数 (Scopus)

• Tankyrase-1 assembly to large protein complexes blocks its telomeric function

  Hatsugai, K., Ohishi, T., Sugimoto, Y. & Seimiya, H., 2010 9月, In: FEBS Letters. 584, 18, p. 3885-3890 6 p.

  研究成果: Article › 査読

  • Tankyrases 100%
  • Block Like Crystal 39%
  • Fluorescence Microscopy 29%
  • Telomere 28%
  • Protein 24%
  4 被引用数 (Scopus)
• 2009

  Acyl-CoA synthetase as a cancer survival factor: Its inhibition enhances the efficacy of etoposide

  Mashima, T., Sato, S., Okabe, S., Miyata, S., Matsuura, M., Sugimoto, Y., Tsuruo, T. & Seimiya, H., 2009, In: Cancer science. 100, 8, p. 1556-1562 7 p.

  研究成果: Article › 査読

  • Coenzyme A Ligases 100%
  • Etoposide 70%
  • Neoplasms 21%
  • Glioma 13%
  • Apoptosis 13%
  48 被引用数 (Scopus)

• CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells

  Takeshita, A., Yamakage, N., Shinjo, K., Ono, T., Hirano, I., Nakamura, S., Shigeno, K., Tobita, T., Maekawa, M., Kiyoi, H., Naoe, T., Ohnishi, K., Sugimoto, Y. & Ohno, R., 2009, In: Leukemia. 23, 7, p. 1329-1336 8 p.

  研究成果: Article › 査読

  • Inotuzumab Ozogamicin 100%
  • Calicheamicins 94%
  • B-Lymphocytes 41%
  • Rituximab 39%
  • Antibodies 9%
  22 被引用数 (Scopus)

• CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: Analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma

  Takeshita, A., Shinjo, K., Yamakage, N., Ono, T., Hirano, I., Matsui, H., Shigeno, K., Nakamura, S., Tobita, T., Maekawa, M., Ohnishi, K., Sugimoto, Y., Kiyoi, H., Naoe, T. & Ohno, R., 2009 7月, In: British Journal of Haematology. 146, 1, p. 34-43 10 p.

  研究成果: Article › 査読

  • Inotuzumab Ozogamicin 100%
  • B-Cell Chronic Lymphocytic Leukemia 57%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 37%
  • Cell Line 32%
  • Non-Hodgkin's Lymphoma 12%
  51 被引用数 (Scopus)

• Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export

  Katayama, R., Koike, S., Sato, S., Sugimoto, Y., Tsuruo, T. & Fujita, N., 2009 11月, In: Cancer science. 100, 11, p. 2060-2068 9 p.

  研究成果: Article › 査読

  • dofequidar 100%
  • Side-Population Cells 72%
  • Fumarates 67%
  • Irinotecan 35%
  • Breast Neoplasms 30%
  65 被引用数 (Scopus)

• Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus

  Kato, N., Suzuki, H., Takagi, H., Asami, Y., Kakeya, H., Uramoto, M., Usui, T., Takahashi, S., Sugimoto, Y. & Osada, H., 2009 3月 23, In: ChemBioChem. 10, 5, p. 920-928 9 p.

  研究成果: Article › 査読

  • Fumitremorgin C 100%
  • tryptoquivaline 75%
  • Aspergillus fumigatus 63%
  • Cytochromes 58%
  • Cytochrome 44%
  58 被引用数 (Scopus)

• Oral fluoropyrimidine S-1 combined with leucovorin is a promising therapy for colorectal cancer: Evidence from a xenograft model of folate-depleted mice

  Tsukioka, S., Uchida, J., Tsujimoto, H., Nakagawa, F., Sugimoto, Y., Oka, T. & Kiniwa, M., 2009 8月 31, In: Molecular Medicine Reports. 2, 3, p. 393-398 6 p.

  研究成果: Article › 査読

  • 5-Fluorouracil 100%
  • Leucovorin 99%
  • Folic Acid 82%
  • Heterografts 74%
  • Colorectal Neoplasms 65%
  13 被引用数 (Scopus)

• Pharmacological interplay between breast cancerresistance protein and gefitinib in epidermalgrowth factor receptor signaling

  Katayama, K., Shibata, K., Mitsuhashi, J., Noguchi, K. & Sugimoto, Y., 2009 4月, In: Anticancer research. 29, 4, p. 1059-1066 8 p.

  研究成果: Article › 査読

  • Gefitinib 100%
  • Breast 60%
  • Pharmacology 53%
  • Proteins 29%
  • ErbB Receptors 27%
  15 被引用数 (Scopus)

• Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions

  Mashima, T., Sato, S., Sugimoto, Y., Tsuruo, T. & Seimiya, H., 2009 1月 8, In: Oncogene. 28, 1, p. 9-19 11 p.

  研究成果: Article › 査読

  • acyl CoA synthetase 5 100%
  • Acidosis 49%
  • Glioma 43%
  • Cell Survival 36%
  • Midkine 24%
  54 被引用数 (Scopus)

• Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib

  Noguchi, K., Kawahara, H., Kaji, A., Katayama, K., Mitsuhashi, J. & Sugimoto, Y., 2009 9月, In: Cancer science. 100, 9, p. 1701-1707 7 p.

  研究成果: Article › 査読

  • Erlotinib Hydrochloride 100%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 86%
  • Drug Resistance 72%
  • Mitoxantrone 55%
  • K562 Cells 33%
  62 被引用数 (Scopus)
• 2008

  Breast cancer-resistance protein expression using immunohistochemical staining and treatment by gefitinib for non-small cell lung cancer

  Oikawa, T., Ohira, T., Usuda, J., Suga, Y., Nakajima, E., Saijo, T., Tsuboi, M., Hirano, T., Sugimoto, Y. & Kato, H., 2008 4月, In: Journal of Tokyo Medical University. 66, 2, p. 224-230 7 p.

  研究成果: Article › 査読

  • Gefitinib 100%
  • Non-Small Cell Lung Carcinoma 71%
  • Staining and Labeling 51%
  • Breast Neoplasms 50%
  • Mutation 44%

• Folylpolyglutamate synthase and γ-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity

  Sakamoto, E., Tsukioka, S., Oie, S., Kobunai, T., Tsujimoto, H., Sakamoto, K., Okayama, Y., Sugimoto, Y., Oka, T., Fukushima, M. & Oka, T., 2008 1月 25, In: Biochemical and Biophysical Research Communications. 365, 4, p. 801-807 7 p.

  研究成果: Article › 査読

  • folylpolyglutamate synthetase 100%
  • 5-Fluorouracil 69%
  • Leucovorin 68%
  • Folate 68%
  • Hydrolases 68%
  27 被引用数 (Scopus)

• FOXO transcription factor-dependent p15^INK4b and p19 ^INK4d expression

  Katayama, K., Nakamura, A., Sugimoto, Y., Tsuruo, T. & Fujita, N., 2008 3月 13, In: Oncogene. 27, 12, p. 1677-1686 10 p.

  研究成果: Article › 査読

  • Forkhead Transcription Factors 100%
  • Phosphatidylinositol 3-Kinases 49%
  • Cell Cycle Checkpoints 49%
  • Apoptosis 46%
  • Gastrin-Secreting Cells 32%
  56 被引用数 (Scopus)
• 2007

  Additive antitumor effect of concurrent treatment of 4-hydroxy tamoxifen with 5-fluorouracil but not with doxorubicin in estrogen receptor-positive breast cancer cells

  Kurebayashi, J., Nukatsuka, M., Nagase, H., Nomura, T., Hirono, M., Yamamoto, Y., Sugimoto, Y., Oka, T. & Sonoo, H., 2007 3月, In: Cancer Chemotherapy and Pharmacology. 59, 4, p. 515-525 11 p.

  研究成果: Article › 査読

  • afimoxifene 100%
  • Tamoxifen 91%
  • 5-Fluorouracil 81%
  • Estrogen 72%
  • Doxorubicin 70%
  17 被引用数 (Scopus)

• Benefits of TS-1 plus leucovorin combination therapy for colorectal cancer: evaluation of therapeutic effect of TS-1 and leucovorin combination therapy using rodent model fed a low folate diet

  Tsujimoto, H., Tsukioka, S., Koizumi, K., Nakagawa, F., Uchida, J., Sugimoto, Y., Oka, T., Fukushima, M. & Watanabe, T., 2007 3月, In: Gan to kagaku ryoho. Cancer & chemotherapy. 34, 3, p. 413-418 6 p.

  研究成果: Article › 査読

  • titanium silicide 100%
  • Leucovorin 76%
  • Folic Acid 62%
  • Rodentia 52%
  • Therapeutic Uses 52%
  2 被引用数 (Scopus)

• Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

  Usuda, J., Ohira, T., Suga, Y., Oikawa, T., Ichinose, S., Inoue, T., Ohtani, K., Maehara, S., Imai, K., Kubota, M., Tsunoda, Y., Tsutsui, H., Furukawa, K., Okunaka, T., Sugimoto, Y. & Kato, H., 2007 11月, In: Lung Cancer. 58, 2, p. 296-299 4 p.

  研究成果: Article › 査読

  • Gefitinib 100%
  • Non-Small Cell Lung Carcinoma 71%
  • Codon 52%
  • Breast Neoplasms 50%
  • ErbB Receptors 50%
  28 被引用数 (Scopus)

• Contrasting effects of extended low dose versus standard dose shorter course UFT chemotherapy on microscopic versus macroscopic established tumors: Implications for optimal postoperative adjuvant chemotherapy

  Uchida, J., Okabe, H., Nakano, K., Fujioka, A., Saito, H., Sugimoto, Y., Oka, T. & Fukushima, M., 2007 8月, In: Oncology reports. 18, 2, p. 313-319 7 p.

  研究成果: Article › 査読

  Open Access

  • Adjuvant Chemotherapy 100%
  • Lewis Lung Carcinoma 66%
  • Drug Therapy 58%
  • Neoplasms 31%
  • 1-UFT protocol 30%
  3 被引用数 (Scopus)

• Expression of cancer cachexia-related factors in human cancer xenografts: An immunohistochemical analysis

  Kamoshida, S., Watanabe, K., Suzuki, M., Mizutani, Y., Sakamoto, K., Sugimoto, Y., Oka, T., Fukushima, M. & Tsutsumi, Y., 2007 1月 10, In: Biomedical Research. 27, 6, p. 275-281 7 p.

  研究成果: Article › 査読

  • Cachexia 100%
  • Heterografts 73%
  • Weight 43%
  • Leukemia Inhibitory Factor 36%
  • Neoplasms 26%
  13 被引用数 (Scopus)

• Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: Transporter specificity and structure-activity relationship

  Katayama, K., Masuyama, K., Yoshioka, S., Hasegawa, H., Mitsuhashi, J. & Sugimoto, Y., 2007 11月, In: Cancer Chemotherapy and Pharmacology. 60, 6, p. 789-797 9 p.

  研究成果: Article › 査読

  • Structure-Activity Relationship 100%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 93%
  • Flavonoids 86%
  • Flavonoid 81%
  • Drug Resistance 78%
  96 被引用数 (Scopus)

• Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray

  Watanabe, T., Kobunai, T., Toda, E., Kanazawa, T., Kazama, Y., Tanaka, J., Tanaka, T., Yamamoto, Y., Hata, K., Kojima, T., Yokoyama, T., Konishi, T., Okayama, Y., Sugimoto, Y., Oka, T., Sasaki, S., Ajioka, Y., Muto, T. & Nagawa, H., 2007 1月 15, In: Clinical Cancer Research. 13, 2 I, p. 415-420 6 p.

  研究成果: Article › 査読

  • Oligonucleotide Array Sequence Analysis 100%
  • Ulcerative Colitis 94%
  • Transcriptome 88%
  • Colorectal Neoplasms 76%
  • Mucous Membrane 14%
  57 被引用数 (Scopus)

• Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs

  Ooyama, A., Okayama, Y., Takechi, T., Sugimoto, Y., Oka, T. & Fukushima, M., 2007 4月, In: Cancer science. 98, 4, p. 577-583 7 p.

  研究成果: Article › 査読

  • Fluorouracil 100%
  • Thymidylate Synthase 99%
  • Drug Resistance 95%
  • Genome 70%
  • Pharmaceutical Preparations 43%
  25 被引用数 (Scopus)

• Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

  Katayama, K., Yoshioka, S., Tsukahara, S., Mitsuhashi, J. & Sugimoto, Y., 2007 7月 1, In: Molecular cancer therapeutics. 6, 7, p. 2092-2102 11 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 100%
  • Mitogen-Activated Protein Kinases 90%
  • U 0126 71%
  • Down-Regulation 63%
  • MDR Genes 62%
  127 被引用数 (Scopus)

• Pilot study of MDR1 gene transfer into hematopoietic stem cells and chemoprotection in metastatic breast cancer patients

  Takahashi, S., Aiba, K., Ito, Y., Hatake, K., Nakane, M., Kobayashi, T., Minowa, S., Shibata, H., Mitsuhashi, J., Tsukahara, S., Ishikawa, E., Suzuki, R., Tsuruo, T. & Sugimoto, Y., 2007 10月, In: Cancer science. 98, 10, p. 1609-1616 8 p.

  研究成果: Article › 査読

  • MDR Genes 100%
  • Multiple Drug Resistance 75%
  • Hematopoietic Stem Cells 71%
  • Breast Neoplasms 46%
  • Docetaxel 27%
  15 被引用数 (Scopus)

• Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer

  Mitsuhashi, J., Tsukahara, S., Suzuki, R., Oh-Hara, Y., Nishi, S., Hosoyama, H., Katayama, K., Noguchi, K., Minowa, S., Shibata, H., Ito, Y., Hatake, K., Aiba, K., Takahashi, S. & Sugimoto, Y., 2007 10月 1, In: Human Gene Therapy. 18, 10, p. 895-906 12 p.

  研究成果: Article › 査読

  • Docetaxel 100%
  • Genetic Therapy 82%
  • Clone Cells 71%
  • Neoplasm Genes 58%
  • Retroviridae 58%
  7 被引用数 (Scopus)

• The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein

  Yoshioka, S., Katayama, K., Okawa, C., Takahashi, S., Tsukahara, S., Mitsuhashi, J. & Sugimoto, Y., 2007 6月, In: Pharmaceutical research. 24, 6, p. 1108-1117 10 p.

  研究成果: Article › 査読

  • human ABCG2 protein 100%
  • Germ-Line Mutation 60%
  • Mutation 45%
  • SN-38 43%
  • Resistance 33%
  27 被引用数 (Scopus)
• 2006

  A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

  Mutoh, K., Mitsuhashi, J., Kimura, Y., Tsukahara, S., Ishikawa, E., Sai, K., Ozawa, S., Sawada, J. I., Ueda, K., Katayama, K. & Sugimoto, Y., 2006 4月, In: Molecular cancer therapeutics. 5, 4, p. 877-884 8 p.

  研究成果: Article › 査読

  • MDR Genes 100%
  • Germ-Line Mutation 81%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 79%
  • 3T3 Cells 39%
  • Genes 29%
  13 被引用数 (Scopus)

• Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers

  Watanabe, T., Kobunai, T., Toda, E., Yamamoto, Y., Kanazawa, T., Kazama, Y., Tanaka, J., Tanaka, T., Konishi, T., Okayama, Y., Sugimoto, Y., Oka, T., Sasaki, S., Muto, T. & Nagawa, H., 2006 10月 15, In: Cancer Research. 66, 20, p. 9804-9808 5 p.

  研究成果: Article › 査読

  • Microsatellite Instability 100%
  • Transcriptome 74%
  • Colorectal Neoplasms 64%
  • Methylation 27%
  • Neoplasms 26%
  91 被引用数 (Scopus)

• Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells

  Mutoh, K., Tsukahara, S., Mitsuhashi, J., Katayama, K. & Sugimoto, Y., 2006 11月, In: Cancer science. 97, 11, p. 1198-1204 7 p.

  研究成果: Article › 査読

  • MDR Genes 100%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 79%
  • Estradiol 63%
  • Estrogens 59%
  • Down-Regulation 50%
  87 被引用数 (Scopus)

• Expression of chemoresistance-related proteins in α-fetoprotein- producing adenocarcinoma of the digestive organs

  Kamoshida, S., Suzuki, M., Sakurai, Y., Ochiai, M., Kimura, F., Kuwao, S., Sakamoto, K., Sugimoto, Y., Fukushima, M. & Tsutsumi, Y., 2006 10月, In: Oncology reports. 16, 4, p. 721-727 7 p.

  研究成果: Article › 査読

  Open Access

  • Fetal Proteins 100%
  • Thymidine Phosphorylase 68%
  • Adenocarcinoma 55%
  • Metallothionein 48%
  • 3-acetylpyridine adenine dinucleotide 48%
  11 被引用数 (Scopus)

• Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs

  Ooyama, A., Takechi, T., Toda, E., Nagase, H., Okayama, Y., Kitazato, K., Sugimoto, Y., Oka, T. & Fukushima, M., 2006 6月, In: Cancer science. 97, 6, p. 510-522 13 p.

  研究成果: Article › 査読

  • Fluorouracil 100%
  • Heterografts 93%
  • Gene Expression 62%
  • Dihydrouracil Dehydrogenase (NADP) 44%
  • Pharmaceutical Preparations 43%
  17 被引用数 (Scopus)

• Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin

  Ichikawa, W., Ooyama, A., Toda, E., Sugimoto, Y., Oka, T., Takahashi, T., Shimizu, M., Sasaki, Y. & Hirayama, R., 2006 12月, In: Cancer Chemotherapy and Pharmacology. 58, 6, p. 794-801 8 p.

  研究成果: Article › 査読

  • Ferredoxins 100%
  • Ferredoxin 80%
  • 5-Fluorouracil 78%
  • Leucovorin 78%
  • Fluorouracil 62%
  10 被引用数 (Scopus)

• hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil

  Sasaki, S., Watanabe, T., Kobunai, T., Konishi, T., Nagase, H., Sugimoto, Y., Oka, T. & Nagawa, H., 2006 5月, In: Oncology reports. 15, 5, p. 1293-1298 6 p.

  研究成果: Article › 査読

  Open Access

  • HCT116 Cells 100%
  • Fluorouracil 74%
  • Apoptosis 39%
  • Death Domain Receptors 31%
  • Proteins 28%
  3 被引用数 (Scopus)

• Modification of pyrimidine derivatives from antiviral agents to antitumor agents

  Kimura, H., Katoh, T., Kajimoto, T., Node, M., Hisaki, M., Sugimoto, Y., Majima, T., Uehara, Y. & Yamori, T., 2006 1月 1, In: Anticancer research. 26, 1 A, p. 91-97 7 p.

  研究成果: Article › 査読

  • pyrimidine 100%
  • Antineoplastic Agents 78%
  • Antiviral Agents 69%
  • diethyl phosphate 53%
  • 2,4-diaminopyrimidine 53%
  24 被引用数 (Scopus)

• Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma

  Sakurai, Y., Sakamoto, K., Sugimoto, Y., Yoshida, I., Masui, T., Tonomura, S., Inaba, K., Shoji, M., Nakamura, Y., Uyama, I., Komori, Y., Ochiai, M., Matsuura, S., Tanaka, H., Oka, T. & Fukushima, M., 2006 6月, In: Cancer science. 97, 6, p. 492-498 7 p.

  研究成果: Article › 査読

  • Orotate Phosphoribosyltransferase 100%
  • Fluorouracil 54%
  • Stomach 40%
  • Enzyme-Linked Immunosorbent Assay 39%
  • Carcinoma 37%
  10 被引用数 (Scopus)
• 2005

  A novel cinnamic acid derivative that inhibits Cdc25 dual-specificity phosphatase activity

  Aoyagi, Y., Masuko, N., Ohkubo, S., Kitade, M., Nagai, K., Okazaki, S., Wierzba, K., Terada, T., Sugimoto, Y. & Yamada, Y., 2005 9月, In: Cancer science. 96, 9, p. 614-619 6 p.

  研究成果: Article › 査読

  • TPY-835 100%
  • cdc25 Phosphatases 63%
  • cinnamic acid 61%
  • Dual-Specificity Phosphatases 59%
  • Cell Cycle Checkpoints 14%
  21 被引用数 (Scopus)

• Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata

  Morita, H., Koyama, K., Sugimoto, Y. & Kobayashi, J., 2005 2月 15, In: Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1051-1054 4 p.

  研究成果: Article › 査読

  • Stilbenoid 100%
  • Antimitotic 95%
  • Antimitotic Agents 92%
  • Stilbenes 91%
  • lusianthridin 73%
  63 被引用数 (Scopus)

• Establishment of enzyme-linked immunosorbent assay for quantification of orotate phosphoribosyltransferase in gastric carcinoma

  Sakurai, Y., Sakamoto, K., Sugimoto, Y., Yoshida, I., Masui, T., Tonomura, S., Inaba, K., Shoji, M., Nakamura, Y., Uyama, I., Komori, Y., Ochiai, M., Matsuura, S., Tanaka, H., Oka, T. & Fukushima, M., 2005 7月, In: Gan to kagaku ryoho. Cancer & chemotherapy. 32, 7, p. 1017-1022 6 p.

  研究成果: Article › 査読

  • Orotate Phosphoribosyltransferase 100%
  • Fluorouracil 46%
  • Stomach 40%
  • Enzyme-Linked Immunosorbent Assay 39%
  • Carcinoma 37%
  1 被引用数 (Scopus)

• Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2

  Imai, Y., Ishikawa, E., Asada, S. & Sugimoto, Y., 2005 1月 15, In: Cancer Research. 65, 2, p. 596-604 9 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 100%
  • Estrogens 53%
  • Down-Regulation 45%
  • Breast Neoplasms 41%
  • Proteins 22%
  149 被引用数 (Scopus)

• Heat-assisted stretching of paraffin sections on hot plate weakens immunoreactivity of orotate phosphoribosyltransferase

  Kamoshida, S., Sakamoto, N., Matsuoka, H., Sakurai, Y., Sakamoto, K., Sugimoto, Y., Fukushima, M. & Tsutsumi, Y., 2005, In: Acta Histochemica et Cytochemica. 38, 1, p. 69-74 6 p.

  研究成果: Article › 査読

  • Orotate Phosphoribosyltransferase 100%
  • Orotate 87%
  • Paraffin 52%
  • Alkane 47%
  • Plate Like Crystal 44%
  7 被引用数 (Scopus)

• Napthalimidobenzamide DB-51630: A novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity

  Suzuki, K., Nagasawa, H., Uto, Y., Sugimoto, Y., Noguchi, K., Wakida, M., Wierzba, K., Terada, T., Asao, T., Yamada, Y., Kitazato, K. & Hori, H., 2005 6月 2, In: Bioorganic and Medicinal Chemistry. 13, 12, p. 4014-4021 8 p.

  研究成果: Article › 査読

  • DNA Sequence 100%
  • Binding Agent 84%
  • Gene Expression 57%
  • DNA 53%
  • Neoplasms 31%
  31 被引用数 (Scopus)

• p53-defective tumors with a functional apoptosome-mediated pathway: A new therapeutic target

  Mashima, T., Oh-hara, T., Sato, S., Mochizuki, M., Sugimoto, Y., Yamazaki, K., Hamada, J. I., Tada, M., Moriuchi, T., Ishikawa, Y., Kato, Y., Tomoda, H., Yamori, T. & Tsuruo, T., 2005 5月 18, In: Journal of the National Cancer Institute. 97, 10, p. 765-777 13 p.

  研究成果: Article › 査読

  Open Access

  • Apoptosomes 100%
  • Coenzyme A Ligases 31%
  • Neoplasms 20%
  • Cytochromes c 16%
  • Caspases 15%
  90 被引用数 (Scopus)

• Preparation of anti-OPRT antibody for immunochemical detection

  Sakamoto, K., Sugimoto, Y., Miyadera, K., Oka, T. & Fukushima, M., 2005 5月, In: Gan to kagaku ryoho. Cancer & chemotherapy. 32, 5, p. 653-658 6 p.

  研究成果: Article › 査読

  • Anti-Idiotypic Antibodies 100%
  • Fluorouracil 85%
  • Orotate Phosphoribosyltransferase 52%
  • Proteins 43%
  • Neoplasms 38%
  7 被引用数 (Scopus)

• Preparation of anti-orotate phosphoribosyltransferase antibody and its application to immunochemical detection in human tumor cells.

  Sakamoto, K., Sugimoto, Y., Miyadera, K., Oka, T. & Fukushima, M., 2005 8月, In: International journal of molecular medicine. 16, 2, p. 245-249 5 p.

  研究成果: Article › 査読

  • Orotate Phosphoribosyltransferase 100%
  • Antibodies 31%
  • Neoplasms 18%
  • Fluorouracil 18%
  • Proteins 9%
  9 被引用数 (Scopus)

• Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2

  Kage, K., Fujita, T. & Sugimoto, Y., 2005 12月, In: Cancer science. 96, 12, p. 866-872 7 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 100%
  • Breast Neoplasms 41%
  • Irinotecan 38%
  • Western Blotting 22%
  • ATP-Binding Cassette Transporters 19%
  80 被引用数 (Scopus)
• 2004

  Antimetastatic and anticancer activity of S-1, a new oral dihydropyrimidine-dehydrogenase-inhibiting fluoropyrimidine, alone and in combination with paclitaxel in an orthotopically implanted human breast cancer model.

  Nukatsuka, M., Fujioka, A., Nakagawa, F., Oshimo, H., Kitazato, K., Uchida, J., Sugimoto, Y., Nagayama, S. & Fukushima, M., 2004 12月, In: International journal of oncology. 25, 6, p. 1531-1536 6 p.

  研究成果: Article › 査読

  • Dihydrouracil Dehydrogenase (NADP) 100%
  • Paclitaxel 67%
  • Breast Neoplasms 42%
  • Capecitabine 42%
  • Fluorouracil 23%
  30 被引用数 (Scopus)

• Gefinitib reverses breast cancer resistance protein-mediated drug resistance

  Yanase, K., Tsukahara, S., Asada, S., Ishikawa, E., Imai, Y. & Sugimoto, Y., 2004 9月 1, In: Molecular cancer therapeutics. 3, 9, p. 1119-1125 7 p.

  研究成果: Article › 査読

  • Drug Resistance 100%
  • Gefitinib 93%
  • Breast Neoplasms 69%
  • Irinotecan 40%
  • Proteins 40%
  180 被引用数 (Scopus)