α1-Antichymotrypsin gene polymorphism and risk for Alzheimer's disease

T. Muramatsu, S. Matsushita, H. Arai, H. Sasaki, S. Higuchi

研究成果: Article査読

37 被引用数 (Scopus)

抄録

α1-Antichymotrypsin (ACT), a component of the senile plaque of the Alzheimer's disese (AD) brain, has a possible role as a molecular chaperone in developing AD pathology. This study was a search for the possible association of the two structural polymorphisms of ACT, Ala15 → Thr and Met389 → Val in the Japanese population. In 101 AD patients, genotype and allele frequencies of the two polymorphisms did not differ from those of 104 age-matched healthy controls. However, in those subjects in which the apolipoprotein ε4 allele was absent, the frequency of the Ala15 homozygote was significantly higher in the AD patients than in controls. This suggests that the Ala15 homozygote state may be a susceptibility marker for AD, interacting with apolipoprotein E genotype.

本文言語English
ページ(範囲)1205-1210
ページ数6
ジャーナルJournal of Neural Transmission
103
10
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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