β blockers in migraine prophylaxis

Toshihiko Shimizu

研究成果: Article査読

5 被引用数 (Scopus)

抄録

β blockers (β-adrenoceptor blockers) are known to be used for the prophylactic treatment of migraine. The improvement of migraine in the patients who recieved propranolol for angina pectoris revealed the effectiveness of propranolol in migraine prophylaxis. Many clinical trials have confirmed that propranolol is effective in the prophylactic treatment of migraine. Other β-blocking drugs, namely nadolol, metoprolol, atenolol, timolol and bisoprolol, have also been demonstrated to be effective in the prophylaxis of migraine. In contrast, several β blockers with intrinsic sympathetic activity (ISA), such as alprenolol, oxprenolol, pindolol and acebutolol, have not been demonstrated to be effective in migraine prophylaxis. In this review, we have descrived the pharmacologic background and pharmacokinetics of the β blockers that demonstrated a prophylactic effect for migraine will be described. We have also reviewed the results of clinical trials of β-blocking drugs for migraine.

本文言語English
ページ(範囲)1125-1130
ページ数6
ジャーナルBrain and Nerve
61
10
出版ステータスPublished - 2009 10 1

ASJC Scopus subject areas

  • 臨床神経学

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