β-Carboline-Carbohydrate hybrids: Molecular design, chemical synthesis and evaluation of novel DNA photocleavers

Kazunobu Toshima, Yukiko Okuno, Yoko Nakajima, Shuichi Matsumura

研究成果: Article

32 引用 (Scopus)

抜粋

β-Carboline present in β-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and β-carboline-carbohydrate hybrid system was effective for DNA cleavage.

元の言語English
ページ(範囲)671-673
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
12
発行部数4
DOI
出版物ステータスPublished - 2002 2 25

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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