β-Catenin mutations in pulmonary blastomas: Association with morule formation

Shigeki Sekine, Tatsuhiro Shibata, Yoshihiro Matsuno, Arafumi Maeshima, Genichiro Ishii, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article査読

73 被引用数 (Scopus)

抄録

To elucidate the contribution of β-catenin gene mutation to the development of pulmonary blastomas, we analysed mutations in three well-differentiated fetal adenocarcinomas (WDFAs) and six biphasic pulmonary blastomas (BPBs). For comparison, eight clear-cell adenocarcinomas with fetal lung features were also examined. β-Catenin gene mutations were found in all three WDFAs, two BPBs, and none of the clear-cell adenocarcinomas with fetal lung features. All tumours with mutations had a common histological feature, namely morule formation, and showed a characteristic heterogeneous β-catenin expression pattern that was revealed by immunohistochemistry. Strong nuclear/cytoplasmic expression of β-catenin was seen in clustered cells in the morular areas and in single cells in glands, and was associated with neuroendocrine differentiation. As β-catenin mutations are rare among lung tumours, this distinctive genetic feature, which is also immunohistochemically detectable as overexpression with a heterogeneous pattern, has diagnostic significance. The presence of this common genetic alteration found in both WDFA and BPB implies a histogenetic linkage between these tumours.

本文言語English
ページ(範囲)214-221
ページ数8
ジャーナルJournal of Pathology
200
2
DOI
出版ステータスPublished - 2003 6 1
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

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