β-Cell mass and turnover in humans: Effects of obesity and aging

Yoshifumi Saisho, Alexandra E. Butler, Erica Manesso, David Elashoff, Robert A. Rizza, Peter C. Butler

研究成果: Article査読

259 被引用数 (Scopus)

抄録

OBJECTIVE - We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS - We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. RESULTS - β-Cell mass is increased by ∼50%with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age. CONCLUSIONS - β-Cell mass in human obesity increases by ∼50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.

本文言語English
ページ(範囲)111-117
ページ数7
ジャーナルDiabetes care
36
1
DOI
出版ステータスPublished - 2013 1
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 高度および特殊看護

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