β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans

Juris J. Meier, Alexandra E. Butler, Yoshifumi Saisho, Travis Monchamp, Ryan Galasso, Anil Bhushan, Robert A. Rizza, Peter C. Butler

研究成果: Article査読

499 被引用数 (Scopus)

抄録

OBJECTIVE-Little is known about the capacity, mechanisms, or timing of growth in β-Cell mass in humans. We sought to establish if the predominant expansion of β-Cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant β-Cell replication. We also sought to establish if there is a secondary growth in β-Cell mass coincident with the accelerated somatic growth in adolescence. RESEARCH DESIGN AND METHODS-To address these questions, pancreas volume was determined from abdominal computer tomographies in 135 children aged 4 weeks to 20 years, and morphometric analyses were performed in human pancreatic tissue obtained at autopsy from 46 children aged 2 weeks to 21 years. RESULTS-We report that 1) β-Cell mass expands by several- fold from birth to adulthood, 2) islets grow in size rather than in number during this transition, 3) the relative rate of β-Cell growth is highest in infancy and gradually declines thereafter to adulthood with no secondary accelerated growth phase during adolescence, 4) β-Cell mass (and presumably growth) is highly variable between individuals, and 5) a high rate of β-Cell replication is coincident with the major postnatal expansion of β-Cell mass. CONCLUSIONS-These data imply that regulation of β-Cell replication during infancy plays a major role in β-Cell mass in adult humans.

本文言語English
ページ(範囲)1584-1594
ページ数11
ジャーナルDiabetes
57
6
DOI
出版ステータスPublished - 2008 6
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学

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