δ-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits

Eitaro Kodani, Yu Ting Xuan, Ken Shinmura, Hitoshi Takano, Xian Liang Tang, Roberto Bolli

研究成果: Article

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Although activation of δ-opioid receptors is known to induce both early and late preconditioning (PC) against myocardial infarction, the mechanisms for this salubrious effect are unclear. Furthermore, it is unknown whether δ-opioid receptors can also induce late PC against myocardial stunning. By using conscious rabbits (n = 120) in this study, we found that the δ-opioid receptor agonist (±)-4-{(α-R*)- α-[(2S*,5R*)- 4-allyl-2,5-dimethyl-1-piperazinyl]-3-hydroxybenzyl}-N,N-diethylbenzamide (BW-373U86) induced late PC against myocardial stunning 24 h after treatment and that this effect was abolished by the selective cyclooxygenase-2 (COX-2) inhibitors N-[2-(cyclohexyloxy)4-nitrophenyl]methanesulfonamide (NS-398) and celecoxib. This protective effect was also abrogated by the selective δ1-opioid receptor antagonist 7-benzylidenenaltrexone, indicating that the δ1-opioid receptor is necessary for BW-373U86-induced late PC. BW-373U86 did not induce early PC against stunning. In addition, BW-373U86 induced late PC against infarction, which was blocked by NS-398. At 24 h after BW-373U86 administration, myocardial COX-2 protein expression and PGE2 and 6-keto-PGF levels were significantly increased. These results demonstrate that activation of δ-opioid receptors induces late PC against both stunning and infarction via a COX-2-dependent mechanism.

元の言語English
ページ(範囲)H1943-H1957
ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
283
発行部数5 52-5
DOI
出版物ステータスPublished - 2002 11 1

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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