κ-Opioid agonist inhibits phospholipase C, possibly via an inhibition of G-protein activity

Hidemi Misawa, Hiroshi Ueda, Masamichi Satoh

研究成果: Article査読

31 被引用数 (Scopus)

抄録

In synaptic membranes of guinea pig cerebellum, in which preparations U-50, 488H, a κ-opioid agonist inhibits G-protein activity, the same κ-agonist at 100 nM inhibited the phospholipase C (PLC) activity stimulated by 100 μM GTP in the presence of 10 μM Ca2+. The present study provides a unique hypothetical mechanism that the receptor-mediated inhibition of PLC is mediated by inhibition of G-protein activity.

本文言語English
ページ(範囲)324-327
ページ数4
ジャーナルNeuroscience Letters
112
2-3
DOI
出版ステータスPublished - 1990 5 4
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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