12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Taiko Oda, Jinzhong Xu, Kazuyo Ukai, Takahiro Nakazawa, Michio Namikoshi

研究成果: Article

2 引用 (Scopus)

抜粋

Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

元の言語English
ページ(範囲)317-320
ページ数4
ジャーナルMycoscience
51
発行部数4
DOI
出版物ステータスPublished - 2010 1 1

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

フィンガープリント 12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Oda, T., Xu, J., Ukai, K., Nakazawa, T., & Namikoshi, M. (2010). 12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity. Mycoscience, 51(4), 317-320. https://doi.org/10.1007/s10267-010-0035-x