12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Taiko Oda, Jinzhong Xu, Kazuyo Ukai, Takahiro Nakazawa, Michio Namikoshi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Roridin E is a well-known macrocyclic trichothecene mycotoxin possessing potent antiproliferative activity against cancer cell lines. 12′-Hydroxyroridin E was isolated from a marine-derived fungus, Myrothecium roridum 98F42. The cytotoxicities of these two compounds were tested against human monocytic THP-1, human promyelocytic leukemia HL-60, and Chinese hamster V79 cells, and roridin E exhibited more than 1000-fold stronger cytotoxicity than its 12′-OH derivative; therefore, it was suggested that the 12′-position is closely involved in the cytotoxicity of these compounds.

本文言語English
ページ(範囲)317-320
ページ数4
ジャーナルMycoscience
51
4
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • 生態、進化、行動および分類学

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