2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling

Naomi Mori, Kazufumi Toume, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

研究成果: Article査読

21 被引用数 (Scopus)

抄録

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC50 2.9 μM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 μM.

本文言語English
ページ(範囲)234-236
ページ数3
ジャーナルJournal of Natural Medicines
65
1
DOI
出版ステータスPublished - 2011 1
外部発表はい

ASJC Scopus subject areas

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

フィンガープリント

「2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル