2-Phenylquinoline-carbohydrate hybrids: Molecular design, chemical synthesis, and evaluation of a new family of light-activatable DNA-cleaving agents

Kazunobu Toshima, Ryusuke Takano, Yutaka Maeda, Masataka Suzuki, Akira Asai, Shuichi Matsumura

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.

本文言語English
ページ(範囲)3733-3735
ページ数3
ジャーナルAngewandte Chemie - International Edition
38
24
DOI
出版ステータスPublished - 1999 12 16

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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