Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity.
|ジャーナル||Angewandte Chemie - International Edition|
|出版ステータス||Published - 1999 12 16|
ASJC Scopus subject areas
- 化学 (全般)