2-Phenylquinoline–Sugar Hybrids as Photoswitchable α-Glucosidase Inhibitors

Takashi Kitamura, Mai Okuyama, Daisuke Takahashi, Kazunobu Toshima

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Purpose-designed 2-phenylquinoline (PQ)-sugar hybrids 1 and 2 were synthesized and evaluated for their photodegradation activities against an α-glucosidase target. The results indicated that PQ-mannose hybrid 2 selectively and effectively photodegraded α-glucosidase and significantly inhibited its enzymatic activity upon irradiation with long-wavelength UV light in the absence of any additives under neutral and aqueous conditions. Furthermore, 2 selectively and effectively inhibited α-glucosidase activity only with photo-irradiation even in complex cell lysate.

本文言語English
ページ(範囲)1409-1412
ページ数4
ジャーナルChemistry - An Asian Journal
14
9
DOI
出版ステータスPublished - 2019 5 2

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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