3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico

Emiyu Ogawa, Yuko Uno, Keishi Ohtani, Sachio Maehara, Kentaro Imai, Shotaro Ono, Jitsuo Usuda, Tsunenori Arai

研究成果: Conference contribution

抄録

We studied a 3-compartment dynamic model of talaporfin sodium pharmacokinetics in silico. Drug distribution might change after intravenous injection from plasma to interstitial space and then into myocardial cells. We have developed a new cardiac ablation using photosensitization reaction with laser irradiation shortly after talaporfin sodium injection. We think that the major cell-killing factor in our cardiac ablation would be an oxidation by singlet oxygen produced in the interstitial space in myocardium with laser irradiation shortly after the photosensitizer administration. So that the talaporfin sodium concentration change in time in the interstitial space should be investigated. We constructed the pharmacokinetics dynamic model composed by 3-compartments, that is, plasma, interstitial space, and cell. We measured talaporfin sodium fluorescence time change in human skin by our developed fluorescence measurement system in vivo. Using the measured concentration data in plasma and skin in human, we verified the calculation accuracy of our in silico model. We compared the simulated transition tendency of talaporfin sodium concentration from interstitial space to cells in our in silico model with the reported uptake tendency using cultured myocardial cell. We identified the transition coefficients between plasma, interstitial space, and cell compartment, and metabolization coefficient from plasma by the fitting with measured data.

本文言語English
ホスト出版物のタイトルOptical Methods for Tumor Treatment and Detection
ホスト出版物のサブタイトルMechanisms and Techniques in Photodynamic Therapy XXVI
編集者David H. Kessel, Tayyaba Hasan
出版社SPIE
ISBN(電子版)9781510605350
DOI
出版ステータスPublished - 2017
イベントOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI - San Francisco, United States
継続期間: 2017 1 282017 1 29

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10047
ISSN(印刷版)1605-7422

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
国/地域United States
CitySan Francisco
Period17/1/2817/1/29

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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