(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol

Hiroyuki Hosomi, Shigeru Ohba, Ken Ohmori, Tetsuo Obitsu, Yasuyuki Ogawa, Yuichi Ishikawa, Shosuke Yamamura, Shigeru Nishiyama

研究成果: Article査読

抄録

The absolute configuration of (-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol was determined, and it was prepared in a synthetic study concerning the natural products bryostatins. It was observed that two independent molecules showed similar conformations, except for the orientation of the methoxy groups. The absolute structure of the compound was determined based on a Flack parameter value of 0.0 (1), which was consistent with the expected absolute configuration of 3S produced by Sharpless asymmetric epoxidation protcol.

本文言語English
ページ(範囲)e140-e141
ジャーナルActa Crystallographica Section C: Crystal Structure Communications
56
4
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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「(-)-(3S)-4-(2-{[4,4-Dimethoxy-6-(benzyloxymethyl)perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)- Pentan-1-ol」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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