5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Benjamin Adam Samuels, Christoph Anacker, Alice Hu, Marjorie R. Levinstein, Anouchka Pickenhagen, Theodore Tsetsenis, Noelia Madroñal, Zoe R. Donaldson, Liam John Drew, Alex Dranovsky, Cornelius T. Gross, Kenji Tanaka, René Hen

研究成果: Article

74 引用 (Scopus)

抜粋

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also contribute. We deleted the serotonin 1A receptor (5HT1AR, a receptor required for the SSRI response) specifically from DG GCs and found that the effects of the SSRI fluoxetine on behavior and the hypothalamic-pituitary-adrenal (HPA) axis were abolished. By contrast, mice lacking 5HT1ARs only in young adult-born GCs (abGCs) showed normal fluoxetine responses. Notably, 5HT1AR-deficient mice engineered to express functional 5HT1ARs only in DG GCs responded to fluoxetine, indicating that 5HT1ARs in DG GCs are sufficient to mediate an antidepressant response. Taken together, these data indicate that both mature DG GCs and young abGCs must be engaged for an antidepressant response.

元の言語English
ページ(範囲)1606-1616
ページ数11
ジャーナルNature Neuroscience
18
発行部数11
DOI
出版物ステータスPublished - 2015 11 1

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Samuels, B. A., Anacker, C., Hu, A., Levinstein, M. R., Pickenhagen, A., Tsetsenis, T., Madroñal, N., Donaldson, Z. R., Drew, L. J., Dranovsky, A., Gross, C. T., Tanaka, K., & Hen, R. (2015). 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nature Neuroscience, 18(11), 1606-1616. https://doi.org/10.1038/nn.4116