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• Article

  Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders

  Okamoto, N., Miya, F., Tsunoda, T., Kato, M., Saitoh, S., Yamasaki, M., Shimizu, A., Torii, C., Kanemura, Y. & Kosaki, K., 2015 9月 1, In: Clinical Genetics. 88, 3, p. 288-292 5 p.

  研究成果: Article › 査読
  27 被引用数 (Scopus)

• Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience

  Bandoh, N., Akahane, T., Goto, T., Kono, M., Ichikawa, H., Sawada, T., Yamaguchi, T., Nakano, H., Kawase, Y., Kato, Y., Kamada, H., Harabuchi, Y., Shimizu, K. & Nishihara, H., 2018 12月, In: Oncology Letters. 16, 6, p. 7278-7286 9 p.

  研究成果: Article › 査読

  Open Access
  17 被引用数 (Scopus)

• Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

  and for the Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan, 2017 9月 29, In: Arthritis Research and Therapy. 19, 1, 218.

  研究成果: Article › 査読

  Open Access
  35 被引用数 (Scopus)

• Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

  Saito, A., Ooki, A., Nakamura, T., Onodera, S., Hayashi, K., Hasegawa, D., Okudaira, T., Watanabe, K., Kato, H., Onda, T., Watanabe, A., Kosaki, K., Nishimura, K., Ohtaka, M., Nakanishi, M., Sakamoto, T., Yamaguchi, A., Sueishi, K. & Azuma, T., 2018 1月 22, In: Stem Cell Research and Therapy. 9, 1, 12.

  研究成果: Article › 査読

  Open Access
  21 被引用数 (Scopus)

• Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

  Federici, S., Kredo-Russo, S., Valdés-Mas, R., Kviatcovsky, D., Weinstock, E., Matiuhin, Y., Silberberg, Y., Atarashi, K., Furuichi, M., Oka, A., Liu, B., Fibelman, M., Weiner, I. N., Khabra, E., Cullin, N., Ben-Yishai, N., Inbar, D., Ben-David, H., Nicenboim, J., Kowalsman, N., & 33 othersLieb, W., Kario, E., Cohen, T., Geffen, Y. F., Zelcbuch, L., Cohen, A., Rappo, U., Gahali-Sass, I., Golembo, M., Lev, V., Dori-Bachash, M., Shapiro, H., Moresi, C., Cuevas-Sierra, A., Mohapatra, G., Kern, L., Zheng, D., Nobs, S. P., Suez, J., Stettner, N., Harmelin, A., Zak, N., Puttagunta, S., Bassan, M., Honda, K., Sokol, H., Bang, C., Franke, A., Schramm, C., Maharshak, N., Sartor, R. B., Sorek, R. & Elinav, E., 2022 8月 4, In: Cell. 185, 16, p. 2879-2898.e24

  研究成果: Article › 査読
  23 被引用数 (Scopus)

• Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients

  Yagasaki, K., Komatsu, H., Soejima, K., Naoki, K., Kawada, I., Yasuda, H. & Hamamoto, Y., 2018 4月 1, In: Asia-Pacific Journal of Oncology Nursing. 5, 2, p. 172-177 6 p.

  研究成果: Article › 査読

  Open Access
  6 被引用数 (Scopus)

• Target identification of bioactive compounds

  Tashiro, E. & Imoto, M., 2012 3月 15, In: Bioorganic and Medicinal Chemistry. 20, 6, p. 1910-1921 12 p.

  研究成果: Article › 査読
  25 被引用数 (Scopus)

• Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca²⁺/calmodulin-dependent kinase kinase peptide

  Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M. B., Kainosho, M. & Ikura, M., 2001 9月 7, In: Journal of Molecular Biology. 312, 1, p. 59-68 10 p.

  研究成果: Article › 査読
  94 被引用数 (Scopus)

• Targeting activated lymphocytes with an entirely human immunotoxin analogue: Human pancreatic RNase1-human IL-12 fusion

  Psarras, K., Ueda, M., Tanabe, M., Kitajima, M., Aiso, S., Komatsu, S. & Seno, M., 2000 6月, In: Cytokine. 12, 6, p. 786-790 5 p.

  研究成果: Article › 査読
  29 被引用数 (Scopus)

• Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity

  Kudo-Saito, C., Fuwa, T. & Kawakami, Y., 2016 7月 1, In: European Journal of Cancer. 62, p. 54-61 8 p.

  研究成果: Article › 査読
  10 被引用数 (Scopus)

• Targeting amino acid metabolic reprogramming via l-type amino acid transporter 1 (Lat1) for endocrine-resistant breast cancer

  Shindo, H., Harada-Shoji, N., Ebata, A., Sato, M., Soga, T., Miyashita, M., Tada, H., Kawai, M., Kosaka, S., Onuki, K., Usami, S., Furumoto, S., Hayashi, S., Abe, T., Suzuki, T., Ishida, T. & Sasano, H., 2021 9月 1, In: Cancers. 13, 17, 4375.

  研究成果: Article › 査読

  Open Access
  3 被引用数 (Scopus)

• Targeting and quality of nursing home care. A five-nation study

  Carpenter, G. I., Hirdes, J. P., Ribbe, M. W., Ikegami, N., Challis, D., Steel, K., Bernabei, R. & Fries, B., 1999 4月, In: Aging Clinical and Experimental Research. 11, 2, p. 83-89 7 p.

  研究成果: Article › 査読
  22 被引用数 (Scopus)

• Targeting AURKA in treatment of peritoneal tumor dissemination in gastrointestinal cancer

  Ozawa, H., Imazeki, H., Ogiwara, Y., Kawakubo, H., Fukuda, K., Kitagawa, Y. & Kudo-Saito, C., 2022 2月, In: Translational Oncology. 16, 101307.

  研究成果: Article › 査読

  Open Access
  2 被引用数 (Scopus)

• Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis

  Kitagawa, M., Fung, S. Y. S., Onishi, N., Saya, H. & Lee, S. H., 2013 6月 4, In: PloS one. 8, 6, e64826.

  研究成果: Article › 査読
  45 被引用数 (Scopus)

• Targeting brain regions of interest in functional near-infrared spectroscopy—Scalp-cortex correlation using subject-specific light propagation models

  Cai, L., Nitta, T., Yokota, S., Obata, T., Okada, E. & Kawaguchi, H., 2021 5月, In: Human Brain Mapping. 42, 7, p. 1969-1986 18 p.

  研究成果: Article › 査読

  Open Access
  2 被引用数 (Scopus)

• Targeting cancer chemotherapy using a monoclonal antibody (NCC‐LU‐243) conjugated with mitomycin C

  Kubota, T., Yamamoto, T., Takahara, T., Furukawa, T., Ishibiki, K., Kitajima, M., Shida, Y. & Nakatsubo, H., 1992 10月, In: Journal of Surgical Oncology. 51, 2, p. 75-80 6 p.

  研究成果: Article › 査読
  8 被引用数 (Scopus)

• Targeting cancer therapy in mice by use of newly developed immunoliposomes bearing adriamycin

  Hirota, M., Fukushima, K., Hiratani, K., Kadota, J., Kawano, K., Oka, M., Tomonaga, A., Hara, K., Sato, T. & Sunamoto, J., 1988, In: Journal of Liposome Research. 1, 1, p. 15-33 19 p.

  研究成果: Article › 査読
  10 被引用数 (Scopus)

• Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

  Clark, A. L., Kanekura, K., Lavagnino, Z., Spears, L. D., Abreu, D., Mahadevan, J., Yagi, T., Semenkovich, C. F., Piston, D. W. & Urano, F., 2017 12月 1, In: Scientific reports. 7, 1, 5611.

  研究成果: Article › 査読

  Open Access
  21 被引用数 (Scopus)

• Targeting chemotherapy of brain tumor using liposome-encapsulated cisplatin—Part 1. Substances associated with liposomes to target brain tumor

  Shibata, S., Jinnouchi, T., Ochi, A., Mori, K., Sato, T. & Sunamoto, J., 1990, In: Drug Delivery System. 5, 2, p. 83-87 5 p.

  研究成果: Article › 査読

• Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling

  Sanchez-Lopez, E., Flashner-Abramson, E., Shalapour, S., Zhong, Z., Taniguchi, K., Levitzki, A. & Karin, M., 2016 5月 19, In: Oncogene. 35, 20, p. 2634-2644 11 p.

  研究成果: Article › 査読
  97 被引用数 (Scopus)

• Targeting fibroblast growth factor receptor 3 enhances radiosensitivity in human squamous cancer cells

  Uzawa, K., Ishigami, T., Fushimi, K., Kawata, T., Shinozuka, K., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Ito, H. & Tanzawa, H., 2011 10月 27, In: Oncogene. 30, 43, p. 4447-4452 6 p.

  研究成果: Article › 査読
  21 被引用数 (Scopus)

• Targeting FSTL1 prevents tumor bone metastasis and consequent immune dysfunction

  Kudo-Saito, C., Fuwa, T., Murakami, K. & Kawakami, Y., 2013 10月 15, In: Cancer Research. 73, 20, p. 6185-6193 9 p.

  研究成果: Article › 査読
  51 被引用数 (Scopus)

• Targeting inducible costimulator expressed on CXCR5⁺PD-1⁺ T_H cells suppresses the progression of pemphigus vulgaris

  Kim, A. R., Han, D., Choi, J. Y., Seok, J., Kim, S. E., Seo, S. H., Takahashi, H., Amagai, M., Park, S. H., Kim, S. C., Shin, E. C. & Kim, J. H., 2020 11月, In: Journal of Allergy and Clinical Immunology. 146, 5, p. 1070-1079.e8

  研究成果: Article › 査読

  Open Access
  20 被引用数 (Scopus)

• Targeting MUC1-C inhibits TWIst1 signaling in triple-negative breast cancer

  Hata, T., Rajabi, H., Yamamoto, M., Jin, C., Ahmad, R., Zhang, Y., Kui, L., Li, W., Yasumizu, Y., Hong, D., Miyo, M., Hiraki, M., Maeda, T., Suzuki, Y., Takahashi, H., Samur, M. & Kufe, D., 2019, In: Molecular cancer therapeutics. 18, 10, p. 1744-1754 11 p.

  研究成果: Article › 査読

  Open Access
  35 被引用数 (Scopus)

• Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells

  Kimura, N., Miyakawa, Y., Kohmura, K., Umezawa, K., Ikeda, Y. & Kizaki, M., 2007 11月 1, In: Leukemia Research. 31, 11, p. 1529-1535 7 p.

  研究成果: Article › 査読
  14 被引用数 (Scopus)

• Targeting of cancer stem cells by differentiation therapy

  Arima, Y., Nobusue, H. & Saya, H., 2020 8月 1, In: Cancer science. 111, 8, p. 2689-2695 7 p.

  研究成果: Article › 査読

  Open Access
  19 被引用数 (Scopus)

• Targeting of liposomes carrying recombinant fragments of platelet membrane glycoprotein Ibα to immobilized von Willebrand factor under flow conditions

  Nishiya, T., Murata, M., Handa, M. & Ikeda, Y., 2000 4月 21, In: Biochemical and Biophysical Research Communications. 270, 3, p. 755-760 6 p.

  研究成果: Article › 査読
  27 被引用数 (Scopus)

• Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

  Oyaizu-Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 8月 1, In: Molecular and cellular biology. 37, 16, e00248-17.

  研究成果: Article › 査読
  8 被引用数 (Scopus)

• Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

  Jain, V., Yogavel, M., Kikuchi, H., Oshima, Y., Hariguchi, N., Matsumoto, M., Goel, P., Touquet, B., Jumani, R. S., Tacchini-Cottier, F., Harlos, K., Huston, C. D., Hakimi, M. A. & Sharma, A., 2017 10月 3, In: Structure. 25, 10, p. 1495-1505.e6

  研究成果: Article › 査読

  Open Access
  46 被引用数 (Scopus)

• Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

  Ozaki, K. I., Awazu, M., Tamiya, M., Iwasaki, Y., Harada, A., Kugisaki, S., Tanimura, S. & Kohno, M., 2016 4月 15, In: American Journal of Physiology - Endocrinology and Metabolism. 310, 8, p. E643-E651

  研究成果: Article › 査読

  Open Access
  91 被引用数 (Scopus)

• Targeting the HGF/MET Axis counters primary resistance to KIT inhibition in KIT-mutant melanoma

  Oba, J., Kim, S. H., Wang, W. L., Macedo, M. P., Carapeto, F., McKean, M. A., Van Arnam, J., Eterovic, A. K., Sen, S., Kale, C. R., Yu, X., Haymaker, C. L., Routbort, M., Haydu, L. E., Bernatchez, C., Lazar, A. J., Grimm, E. A., Hong, D. S. & Woodman, S. E., 2018, In: JCO Precision Oncology. 2, p. 1-8 8 p.

  研究成果: Article › 査読
  12 被引用数 (Scopus)

• Targeting the Janus kinases in rheumatoid arthritis: Focus on tofacitinib

  Yamaoka, K. & Tanaka, Y., 2014 1月, In: Expert Opinion on Pharmacotherapy. 15, 1, p. 103-113 11 p.

  研究成果: Article › 査読
  17 被引用数 (Scopus)

• Targeting therapy using monoclonal antibody directed against growth factor receptors

  Jinno, H., Ueda, M., Enomoto, K., Ikeda, T. & Kitajima, M., 1993 9月, In: Human cell : official journal of Human Cell Research Society. 6, 3, p. 188-193 6 p.

  研究成果: Article › 査読
  1 被引用数 (Scopus)

• Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods

  Arai, M. A., Morita, K., Kawano, H., Makita, Y., Hashimoto, M., Suganami, A., Tamura, Y., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2020 12月 1, In: Scientific reports. 10, 1, 1381.

  研究成果: Article › 査読

  Open Access
  6 被引用数 (Scopus)

• Target-selective degradation of oligosaccharides by a light-activated small-molecule-lectin hybrid

  Ishii, M., Matsumura, S. & Toshima, K., 2007 11月 21, In: Angewandte Chemie - International Edition. 46, 44, p. 8396-8399 4 p.

  研究成果: Article › 査読
  24 被引用数 (Scopus)

• Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

  Suzuki, A., Tsumura, K., Tsuzuki, T., Matsumura, S. & Toshima, K., 2007 1月 1, In: Chemical Communications. 41, p. 4260-4262 3 p.

  研究成果: Article › 査読
  18 被引用数 (Scopus)

• Target-selective degradation of proteins by porphyrins upon visible photo-irradiation

  Tanimoto, S., Matsumura, S. & Toshima, K., 2008, In: Chemical Communications. 31, p. 3678-3680 3 p.

  研究成果: Article › 査読
  26 被引用数 (Scopus)

• Target-Selective Fluorescence Imaging and Photocytotoxicity against H₂O₂ High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent

  Takagi, R., Takeda, A., Takahashi, D. & Toshima, K., 2017 10月 18, In: Chemistry - An Asian Journal. 12, 20, p. 2656-2659 4 p.

  研究成果: Article › 査読
  11 被引用数 (Scopus)

• Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone-PhoSL hybrid

  Okuyama, M., Ueno, H., Kobayashi, Y., Kawagishi, H., Takahashi, D. & Toshima, K., 2016, In: Chemical Communications. 52, 10, p. 2169-2172 4 p.

  研究成果: Article › 査読
  10 被引用数 (Scopus)

• Target-selective photo-degradation of a sialyl Lewis a (sLe^a) conjugate and photo-cytotoxicity against sLe^a positive cancer cells using an anthraquinone-antibody hybrid

  Takahashi, D., Nagao, T., Sotokawa, S. & Toshima, K., 2016, In: MedChemComm. 7, 6, p. 1224-1228 5 p.

  研究成果: Article › 査読
  2 被引用数 (Scopus)

• Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

  Tanimoto, S., Sakai, S., Kudo, E., Okada, S., Matsumura, S., Takahashi, D. & Toshima, K., 2012 5月, In: Chemistry - An Asian Journal. 7, 5, p. 911-914 4 p.

  研究成果: Article › 査読
  24 被引用数 (Scopus)

• Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

  Tanimoto, S., Sakai, S., Matsumura, S., Takahashi, D. & Toshima, K., 2008, In: Chemical Communications. 44, p. 5767-5769 3 p.

  研究成果: Article › 査読
  57 被引用数 (Scopus)

• Target-selective photodegradation of oligosaccharides by a fullerene-boronic acid hybrid upon visible light irradiation

  Takahashi, D., Hirono, S. & Toshima, K., 2011 11月 14, In: Chemical Communications. 47, 42, p. 11712-11714 3 p.

  研究成果: Article › 査読
  12 被引用数 (Scopus)

• Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

  Okochi, A., Tanimoto, S., Takahashi, D. & Toshima, K., 2013 6月 11, In: Chemical Communications. 49, 54, p. 6027-6029 3 p.

  研究成果: Article › 査読
  8 被引用数 (Scopus)

• Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

  Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M. & Ishiguro, N., 2018 10月, In: International Journal of Rheumatic Diseases. 21, 10, p. 1801-1808 8 p.

  研究成果: Article › 査読
  4 被引用数 (Scopus)

• Targets of treatment in the acute phase of cerebral infarction

  Tanaka, K., Fukuuchi, Y., Nogawa, S., Ito, D., Suzuki, S., Dembo, T. & Kosakai, A., 2001 12月 1, In: Clinical Neurology. 41, 12, p. 1052-1054 3 p.

  研究成果: Article › 査読
  4 被引用数 (Scopus)

• TARZAN: An FMIPv6 implementation using link layer abstractions

  Mitsuya, K., Teraoka, F., Murai, J. & Mitani, K., 2007 12月 1, In: Computer Software. 24, 4, p. 123-138 16 p.

  研究成果: Article › 査読

• TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically relevant EGFR mutations

  Udagawa, H., Hasako, S., Ohashi, A., Fujioka, R., Hakozaki, Y., Shibuya, M., Abe, N., Komori, T., Haruma, T., Terasaka, M., Fujita, R., Hashimoto, A., Funabashi, K., Yasuda, H., Miyadera, K., Goto, K., Costa, D. B. & Kobayashi, S. S., 2019, In: Molecular Cancer Research. 17, 11, p. 2233-2243 11 p.

  研究成果: Article › 査読
  32 被引用数 (Scopus)

• Task description and control for redundant system by oblique coordinate control

  Sakaino, S., Sato, T. & Ohnishi, K., 2010 9月 28, In: ieej transactions on industry applications. 130, 8, p. 1015-1021+9

  研究成果: Article › 査読
  6 被引用数 (Scopus)

• Task preservation of multi-degree-of-freedom motion using interaction mode control

  Katsura, S. & Ohishi, K., 2008 1月 1, In: EPE Journal (European Power Electronics and Drives Journal). 18, 1, p. 16-24 9 p.

  研究成果: Article › 査読