A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration

Yuri Sano, Hiroshi Satoh, Momoko Chiba, Atsuko Shinohara, Masahide Okamoto, Koji Serizawa, Hiroshi Nakashima, Kazuyuki Omae

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Although bismuth is widely used as a lead substitute in the industrial field, the toxicity of bismuth by inhalation is little known. We performed a 13-wk intratracheal intermittent bismuth dose toxicity study. Bismuth was administered at dose levels of 0, 0.8, 4, 20 mg/kg to male Crj:CD(SD)IGS rats (SPF) by intratracheal intermittent administration once a week for thirteen weeks to investigate its potential toxic effects; especially for specific adverse effects and changes related to pre-neoplastic lesions. Our results showed foreign body inflammation in the lungs, which was caused by intratracheal administration of bismuth, and physical changes related to pulmonary lesions; however, there were no serious changes in other organs. We concluded that dose-dependent, but not specific adverse effects, were attributable to bismuth inhalation in the rat.

本文言語English
ページ(範囲)242-248
ページ数7
ジャーナルJournal of occupational health
47
3
DOI
出版ステータスPublished - 2005 5

ASJC Scopus subject areas

  • 公衆衛生学、環境および労働衛生

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