A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Masanori Sakaguchi, Tetsuro Shingo, Takuya Shimazaki, Hirotaka James Okano, Mieko Shiwa, Satoru Ishibashi, Hideyuki Oguro, Mikiko Ninomiya, Toshihiko Kadoya, Hidenori Horie, Akira Shibuya, Hidehiro Mizusawa, Françoise Poirier, Hiromitsu Nakauchi, Kazunobu Sawamoto, Hideyuki Okano

研究成果: Article査読

141 被引用数 (Scopus)

抄録

In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.

本文言語English
ページ(範囲)7112-7117
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
103
18
DOI
出版ステータスPublished - 2006 5月 2

ASJC Scopus subject areas

  • 一般

フィンガープリント

「A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル