A carrier‐mediated transport system for benzylpenicillin in isolated hepatocytes

Akir Tsuji, Tetsuya Terasaki, Ikumi Tamai, Emi Nakashima, Kazuhiro Takanosu

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The transport mechanism of benzylpenicillin was studied in freshly prepared rat hepatocytes. The initial uptake rate followed both saturable and unsaturable transport processes. The Arrhenius plot of the initial uptake rate gave an activation energy of 16.8 kcal mol−1 (69 kJ mol−1). The benzylpenicillin uptake by hepatocytes was significantly inhibited by antimycin A, sodium cyanide, rotenone, 2,4‐dinitrophenol, phenoxymethylpenicillin, probenecid and Taurocholic acid. No significant inhibition was observed by acetylaminohippuric acid and several kinds of amino acids and dipeptides. The present study provides the first evidence for the the existence of a carrier‐mediated and energy‐dependent transport system of benzylpenicillin in the liver. 1985 Royal Pharmaceutical Society of Great Britain

本文言語English
ページ(範囲)55-57
ページ数3
ジャーナルJournal of Pharmacy and Pharmacology
37
1
DOI
出版ステータスPublished - 1985 1

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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