A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation

Hideki Nakasone, Junya Kanda, Shingo Yano, Yoshiko Atsuta, Hiroatsu Ago, Takahiro Fukuda, Kazuhiko Kakihana, Tatsuya Adachi, Toshiaki Yujiri, Shuichi Taniguchi, Jun Taguchi, Yasuo Morishima, Tokiko Nagamura, Hisashi Sakamaki, Takehiko Mori, Makoto Murata

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Bronchiolitis obliterans syndrome (BOS) is a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT). However, the pathogenesis and risks for the development of BOS have remained unclear. Therefore, a case-control study was conducted to investigate the risk factors for the development of BOS, which included the largest number of BOS cases; 196 patients with BOS were identified and compared with 1960 control recipients. The following were identified as significantly higher risk factors for the development of BOS: female recipients (OR 1.47, P = 0.019), ABO-mismatch HSCT (minor mismatch, OR 1.67, P = 0.015; major mismatch, OR 1.73, P = 0.012; bidirectional mismatch, OR 1.96, P = 0.018), busulfan+cyclophosphamide-based myeloablative conditioning (OR 1.74, P = 0.016), and acute graft-versus-host disease (GVHD) involving the skin (OR 1.55, P = 0.011). On the other hand, the risk for the development of BOS was significantly lower in patients receiving cord blood transplantation (OR 0.26, P = 0.0011). With respect to other target organs of chronic GVHD, ocular involvement was significantly associated with BOS (OR 2.53, P < 0.001). Prospective studies are required to elucidate the risk factors for the development of BOS, and future investigations should focus on finding a prophylactic approach against BOS based on these findings.

本文言語English
ページ(範囲)631-639
ページ数9
ジャーナルTransplant International
26
6
DOI
出版ステータスPublished - 2013 6

ASJC Scopus subject areas

  • Transplantation

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