A case of an inflammatory variant of epidermolysis bullosa acquisita: Chronic bullous dermatosis associated with nonscarring mucosal blisters and circulating IgG anti-type-VII-collagen antibody

Yasutaka Tokuda, M. Amagai, H. Yaoita, S. Kawachi, T. Ito, I. Matsuyama, S. Tsuchiya, T. Saida

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A 42-year-old man showed prominent blistering lesions of the mouth and esophagus in addition to a few bullous lesions of the skin. Direct immunofluorescence microscopy revealed distinct linear deposition of IgG and C3 at the epidermal basement membrane zone where slight deposition of IgA and IgM was also observed. In direct immunoelectron-microscopic examination, antibody was detected in the sublamina densa of the basement membrane zone. Immunoblot analysis with dermal extracts demonstrated that the patient's serum contained circulating IgG antibodies against the 290-kD protein, which comigrated with type VII collagen. The lesions healed without any scars. The results of these studies corresponded to the laboratory findings in epidermolysis bullosa acquisita (EBA), although the clinical features were distinct from classic EBA.

本文言語English
ページ(範囲)58-61
ページ数4
ジャーナルDermatology
197
1
DOI
出版ステータスPublished - 1998 7 27

ASJC Scopus subject areas

  • Dermatology

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