A case of atypical POEMS syndrome without polyneuropathy

Ryuji Morizane, Hiroyuki Sasamura, Hitoshi Minakuchi, Yujiro Takae, Haruhito Kikuchi, Naomi Yoshiya, Akinori Hashiguchi, Konosuke Konishi, Shinichiro Okamoto, Hiroshi Itoh

研究成果: Article

12 引用 (Scopus)


POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

ジャーナルEuropean Journal of Haematology
出版物ステータスPublished - 2008 5 1

ASJC Scopus subject areas

  • Hematology

フィンガープリント A case of atypical POEMS syndrome without polyneuropathy' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Morizane, R., Sasamura, H., Minakuchi, H., Takae, Y., Kikuchi, H., Yoshiya, N., Hashiguchi, A., Konishi, K., Okamoto, S., & Itoh, H. (2008). A case of atypical POEMS syndrome without polyneuropathy. European Journal of Haematology, 80(5), 452-455. https://doi.org/10.1111/j.1600-0609.2008.01045.x