A case of atypical POEMS syndrome without polyneuropathy

Ryuji Morizane, Hiroyuki Sasamura, Hitoshi Minakuchi, Yujiro Takae, Haruhito Kikuchi, Naomi Yoshiya, Akinori Hashiguchi, Konosuke Konishi, Shinichiro Okamoto, Hiroshi Itoh

研究成果: Article査読

14 被引用数 (Scopus)

抄録

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome is a rare hematological disease associated with overproduction of pro-inflammatory cytokines. Under the current nomenclature and diagnostic criteria for POEMS syndrome, the presence of characteristic polyneuropathy is required for diagnosis. We report a 43-year-old Japanese woman with organomegaly, endocrinopathy, M-protein, skin lesions, as well as typical renal lesions and sclerotic bone lesions. Of note, neurological examinations and peripheral nerve conduction tests were normal in this patient. In view of the overwhelming number of otherwise characteristic signs and symptoms, we made a provisional diagnosis of 'atypical POEMS syndrome without polyneuropathy'. If further similar cases are reported in the future, reconsideration of the nomenclature and/or diagnostic criteria for POEMS syndrome may be required.

本文言語English
ページ(範囲)452-455
ページ数4
ジャーナルEuropean Journal of Haematology
80
5
DOI
出版ステータスPublished - 2008 5月 1

ASJC Scopus subject areas

  • 血液学

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