A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings

Hiroshi Nishihara, Matsuyoshi Nakasato, Hiroki Sawa, Hiromi Murakami, Daisuke Yamamoto, Kenji Moriyama, Norifumi Kato, Ikuo Hashimoto, Hajime Kamada, Shinya Tanaka

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Lymphomatoid granulomatosis (LYG) in the central nervous system (CNS) is an uncommon lymphoproliferative disorder with low grade malignant potential. Here we report a case of CNS-LYG, in particular, its characteristics of radioisotope imaging and pathological findings. A 65-year-old man complained of visual disturbance and homonymous hemianopsia was designated. CT and MRI revealed an edematous, enhanced irregular and nodular lesion in the right occipital and parietal lobes. Although 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan showed low uptake in the lesion, Methionine (MET)-PET scan indicated high uptake. Proton magnetic resonance spectroscopy (1H-MRS) at 3T revealed a decrease of the peak of the N-acetylaspartate (NAA), suggesting a possible neoplastic lesion. The patient was diagnosed with CNS-LYG based on the surgically removed material showing perivascular infiltration of CD3-positive small T-lymphocytes with granulomatous lesions. The post-operative steroid therapy was effective and the recurrence or exacerbation has not been observed by radiological imaging until now.

本文言語English
ページ(範囲)275-278
ページ数4
ジャーナルJournal of Neuro-Oncology
93
2
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 神経学
  • 臨床神経学
  • 癌研究

フィンガープリント

「A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル