抄録
We report a case of D-penicillamine induced herpetiform pemphigus. A 74-year-old female patient with rheumatoid arthritis had been receiving D-penicillamine therapy for 4 years and 8 months. After developing skin lesions, the patient was referred to our hospital. Physical examination revealed edematous erythema in annular patterns with blisters and vesicles on the trunk and extremities. A histological examination showed bullae and eosinophilic spongiosis in the epidermis. Direct and indirect immunofluorescence studies showed in vivo bound and circulating IgG anti-intercelluar space antibodies. An immunoblot analysis showed no specific positive reaction. Antibodies to both desmoglein (Dsg) 1 and Dsg 3 for initial serum were negative in ELISA. However, anti-Dsg 1 antibodies later became positive. The above mentioned laboratory and clinical data suggested a diagnosis of D-penicillamine induced herpetiform pemphigus in the present case.
本文言語 | English |
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ページ(範囲) | 126-129 |
ページ数 | 4 |
ジャーナル | Nishinihon Journal of Dermatology |
巻 | 65 |
号 | 2 |
DOI | |
出版ステータス | Published - 2003 |
ASJC Scopus subject areas
- 皮膚病学