A case of generalized acanthosis nigricans with positive lupus erythematosus-related autoantibodies and antimicrosomal antibody: Autoimmune acanthosis nigricans?

Y. Kondo, N. Umegaki, M. Terao, H. Murota, T. Kimura, I. Katayama

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjgren's syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy.

本文言語English
ページ(範囲)85-91
ページ数7
ジャーナルCase Reports in Dermatology
4
1
DOI
出版ステータスPublished - 2012 1

ASJC Scopus subject areas

  • Dermatology

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