A Case of herpetiform pemphigus associated with autoimmune hemolytic anemia: Detection of autoantibodies against multiple epidermal antigens

K. Shimizu, T. Hashimoto, N. Wang, K. Watanabe, Y. Ohata, A. Kikuchi, M. Amagai, T. Nisliikawa

研究成果: Article査読

13 被引用数 (Scopus)

抄録

We report a case who was clinically and histopathologically diagnosed as herpetiform pemphigus (HP) and associated with autoimmune hemolytic anemia (AIHA). However, immunofluorescence studies demonstrated concurrent anti-cell-surface and anti-basement-membrane-zone antibodies in the patient’s serum. Immunochemical studies showed that the patient’s serum reacted with both the pemphigus foliaceus antigen and the two bullous pemphigoid antigens. Subsequently, the patient developed AIHA. Both anemia and skin lesions were successfully treated with oral prednisolone. We believe that this is the first case with HP in association with AIHA. The presence of autoantibodies against multiple antigens suggests an abnormal immunologic tolerance in the antibody production system in this patient.

本文言語English
ページ(範囲)179-182
ページ数4
ジャーナルDermatology
192
2
DOI
出版ステータスPublished - 1996 1

ASJC Scopus subject areas

  • Dermatology

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