A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate

Kunihiro Yamaoka, Kazuyoshi Saito, Kentaro Hanami, Shingo Nakayamada, Masao Nawata, Shigeru Iwata, Taeko Azuma, Yoshiya Tanaka

研究成果: Article

12 引用 (Scopus)

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Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effect of high dose oral steroid, methylprednisolone pulse therapy, and cyclophosphamide was temporary and her conditioning was worsening. Finally we added methotrexate to the immunosuppressive treatment and achieved reduction of disease activity. This case illustrates the potentially fatal sudden onset of airway inflammation that can occur with this disorder, and the effectiveness of methotrexate.

元の言語English
ページ(範囲)144-147
ページ数4
ジャーナルModern rheumatology
17
発行部数2
DOI
出版物ステータスPublished - 2007 4 1

ASJC Scopus subject areas

  • Rheumatology

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