A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate

Kunihiro Yamaoka, Kazuyoshi Saito, Kentaro Hanami, Shingo Nakayamada, Masao Nawata, Shigeru Iwata, Taeko Azuma, Yoshiya Tanaka

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effect of high dose oral steroid, methylprednisolone pulse therapy, and cyclophosphamide was temporary and her conditioning was worsening. Finally we added methotrexate to the immunosuppressive treatment and achieved reduction of disease activity. This case illustrates the potentially fatal sudden onset of airway inflammation that can occur with this disorder, and the effectiveness of methotrexate.

本文言語English
ページ(範囲)144-147
ページ数4
ジャーナルModern rheumatology
17
2
DOI
出版ステータスPublished - 2007 4月

ASJC Scopus subject areas

  • リウマチ学

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