A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid

Kohichi Takada, Junji Kato, Kunihiro Takanashi, Yutaka Kawano, Toshinori Okuda, Tuyoshi Hayashi, Hirotoshi Ishiwatari, Sho Takahashi, Koji Miyanishi, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Tetsuji Takayama, Minoru Takahashi, Aya Sasaki, Yoshiro Niitsu

研究成果: Article査読

抄録

A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.

本文言語English
ページ(範囲)304-309
ページ数6
ジャーナルActa Hepatologica Japonica
47
6
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 肝臓学

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